Gq/11 α and Gs α mediate distinct physiological responses to central melanocortins

Journal of Clinical Investigation

Volumn 126, Issue 1, 2016, Pages 40-49

  Li, Yong Qi ^a   Shrestha, Yogendra ^a   Pandey, Mritunjay ^a   Chen, Min ^a   Kablan, Ahmed ^a   Gavrilova, Oksana ^a   Offermanns, Stefan ^b   Weinstein, Lee S ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CHOLESTEROL; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CRE RECOMBINASE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA Q; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA11; INOSITOL PHOSPHATE; INOSITOL TRISPHOSPHATE; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; MESSENGER RNA; PROTEIN; SINGLE MINDED HOMOLOG 1 PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADRENAL INSUFFICIENCY; AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY HEIGHT; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; CORTICOTROPIN BLOOD LEVEL; DISEASE SEVERITY; ENERGY EXPENDITURE; ENZYME ACTIVATION; FAT MASS; FATTY ACID BLOOD LEVEL; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; GENE EXPRESSION; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HEART RATE; HORMONAL REGULATION; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLEPTINEMIA; HYPERPHAGIA; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; INSULIN METABOLISM; INSULIN RESISTANCE; MALE; METABOLIC REGULATION; MOUSE; NEUROPHYSIOLOGY; NONHUMAN; OBESITY; PARAVENTRICULAR THALAMIC NUCLEUS; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESTING ENERGY EXPENDITURE; SIGNAL TRANSDUCTION; SUPRAOPTIC NUCLEUS; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; AGONISTS; ANIMAL; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; CHOLESTEROL; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN RESISTANCE; MELANOCORTINS; MICE; MICE, KNOCKOUT; OBESITY; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PITUITARY-ADRENAL SYSTEM; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 84956650447     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76348     Document Type: Article

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