G sα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with G sα mutations

Endocrinology

Volumn 153, Issue 9, 2012, Pages 4256-4265

  Chen, Min ^a   Berger, Alta ^a   Kablan, Ahmed ^b   Zhang, Jiandi ^a   Gavrilova, Oksana ^a   Weinstein, Lee S ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; LIOTHYRONINE; MELANOCORTIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; THYROXINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENERGY EXPENDITURE; ENERGY METABOLISM; FATTY ACID BLOOD LEVEL; FEMALE; FREE THYROXINE INDEX; GENE DELETION; GLUCOSE METABOLISM; HAPLOINSUFFICIENCY; HETEROZYGOTE; HOMOZYGOTE; HORMONE BLOOD LEVEL; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; INSULIN BLOOD LEVEL; LIOTHYRONINE BLOOD LEVEL; MALE; MATING; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; THERMOGENESIS; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT CHANGE; WHITE ADIPOSE TISSUE; ANIMAL; EATING; GENETICS; HYPOTHALAMUS; METABOLISM; MOUSE MUTANT; MUTATION; PHYSIOLOGY;

ANIMALS; BODY COMPOSITION; EATING; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HYPOTHALAMUS; MALE; MICE; MICE, KNOCKOUT; MUTATION; OBESITY; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS;

EID: 84865426628     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1113     Document Type: Article

References (37)

1. Weinstein LS, Chen M, Xie T, Liu J 2006 Genetic diseases associated with heterotrimeric G proteins. Trends Pharmacol Sci 27:260-266
2. s in the development of human obesity. J Clin Endocrinol Metab 92:1073-1079
3. Chen M, Gavrilova O, Liu J, Xie T, Deng C, Nguyen AT, Nackers LM, Lorenzo J, Shen L, Weinstein LS 2005 Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci USA 102:7386-7391 (Pubitemid 40696387)
4. Carel JC, Le Stunff C, Condamine L, Mallet E, Chaussain JL, Adnot P, Garabédian M, Bougnéres P 1999 Resistance to the lipolytic action of epinephrine: a new feature of protein Gs deficiency. J Clin Endocrinol Metab 84:4127-4131 (Pubitemid 30644204)
5. Dekelbab BH, Aughton DJ, Levine MA 2009 Pseudohypoparathyroidism type 1A and morbid obesity in infancy. Endocr Pract 15:249-253
6. sα and its role in metabolic regulation. Cell Metab 9:548-555
7. Butler AA, Cone RD 2002 The melanocortin receptors: lessons from knockout models. Neuropeptides 36:77-84
8. Nogueíras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH 2007 The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest 117:3475-3488 (Pubitemid 350097003)
9. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S 2003 Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1095 (Pubitemid 36337319)
10. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141 (Pubitemid 27180337)
11. Obici S, Feng Z, Tan J, Liu L, Karkanias G, Rossetti L 2001 Central melanocortin receptors regulate insulin action. J Clin Invest 108:1079-1085 (Pubitemid 32946082)
12. Fan W, Dinulescu DM, Butler AA, Zhou J, Marks DL, Cone RD 2000 The central melanocortin system can directly regulate serum insulin levels. Endocrinology 141:3072-3079 (Pubitemid 32268993)
13. Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, Palmiter RD 1999 Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21:119-122 (Pubitemid 29036297)
14. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD 1994 Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8:1298-1308 (Pubitemid 24335073)
15. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK 2003 Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457:213-235 (Pubitemid 36158283)
16. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW 2006 Central nervous system control of food intake and body weight. Nature 443:289-295 (Pubitemid 44435142)
17. Cone RD 2005 Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578 (Pubitemid 40594196)
18. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB 2005 Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123:493-505 (Pubitemid 41546678)
19. Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W, Weinstein LS 2005 Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency. J Clin Invest 115:3217-3227 (Pubitemid 41567586)
20. Voss-Andreae A, Murphy JG, Ellacott KL, Stuart RC, Nillni EA, Cone RD, Fan W 2007 Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue. Endocrinology 148:1550-1560 (Pubitemid 46457101)
21. Butler AA, Cone RD 2003 Knockout studies defining different roles for melanocortin receptors in energy homeostasis. Ann NY Acad Sci 994:240-245 (Pubitemid 36793873)
22. Weide K, Christ N, Moar KM, Arens J, Hinney A, Mercer JG, Eiden S, Schmidt I 2003 Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice. Physiol Genomics 13:47-56 (Pubitemid 37129168)
23. Chiappini F, Cunha LL, Harris JC, Hollenberg AN 2011 Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity. J Biol Chem 286:8094-8105
24. Michaud JL, Boucher F, Melnyk A, Gauth'er F, Goshu E, Lévy E, Mitchell GA, Himms-Hagen J, Fan CM 2001 Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus. Hum Mol Genet 10:1465-1473 (Pubitemid 32684888)
25. Holder Jr JL, Butte NF, Zinn AR 2000 Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum Mol Genet 9:101-108 (Pubitemid 30145294)
26. Kublaoui BM, Holder Jr JL, Gemelli T, Zinn AR 2006 Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons. Mol Endocrinol 20:2483-2492 (Pubitemid 44496416)
27. Kublaouí BM, Holder Jr JL, Tolson KP, Gemelli T, Zinn AR 2006 SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake. Endocrinology 147:4542-4549 (Pubitemid 44402157)
28. Peters MF, Scott CW 2009 Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivity. J Biomol Screen 14:246-255
29. Newman EA, Chai BX, Zhang W, Li JY, Ammori JB, Mulholland MW 2006 Activation of the melanocortin-4 receptor mobilizes intracellular free calcium in immortalized hypothalamic neurons. J Surg Res 132:201-207
30. Fan W, Voss-Andreae A, Cao WH, Morrison SF 2005 Regulation of thermogenesis by the central melanocortin system. Peptides 26:1800-1813 (Pubitemid 41354538)
31. Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD 2001 Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4:605-611 (Pubitemid 32507374)
32. Ward KR, Bardgett JF, Wolfgang L, Stocker SD 2011 Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus. Hypertension 57:435-441
33. Martin DS, Haywood JR 1992 Sympathetic nervous system activation by glutamate injections into the paraventricular nucleus. Brain Res 577:261-267
34. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjøorbaek C, Elmquist JK, Flier JS, Hollenberg AN 2001 Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 107:111-120 (Pubitemid 32047420)
35. Fan W, Morrison SF, Cao WH, Yu P 2007 Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area. Brain Res 1179:61-69 (Pubitemid 47633501)
36. Nakamura K, Matsumura K, Kobayashi S, Kaneko T 2005 Sympathetic premotor neurons mediating thermoregulatory functions. Neurosci Res 51:1-8 (Pubitemid 39642873)
37. Loewy AD 1981 Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res 222:129-133 (Pubitemid 11059707)