Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels

FASEB Journal

Volumn 26, Issue 8, 2012, Pages 3473-3482

  Boutin, Alisa ^a   Allen, Michael D ^a   Neumann, Susanne ^a   Gershengorn, Marvin C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Inositolmonophosphate; TRH receptor

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INOSITOL PHOSPHATE; PROTIRELIN RECEPTOR; PROTIRELIN RECEPTOR 1; PROTIRELIN RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; INOSITOL PHOSPHATES; MICE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, THYROTROPIN-RELEASING HORMONE; SIGNAL TRANSDUCTION;

EID: 84864754839     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-207860     Document Type: Article

References (34)

1. Hausdorff, W. P., Caron, M. G., and Lefkowitz, R. J. (1990) Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J. 4, 2881-2889 (Pubitemid 120012534)
2. Calebiro, D., Nikolaev, V. O., Gagliani, M. C., de Filippis, T., Dees, C., Tacchetti, C., Persani, L., and Lohse, M. J. (2009) Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol. 7, e1000172
3. Ferrandon, S., Feinstein, T. N., Castro, M., Wang, B., Bouley, R., Potts, J. T., Gardella, T. J., and Vilardaga, J. P. (2009) Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat. Chem. Biol. 5, 734-742
4. Mullershausen, F., Zecri, F., Cetin, C., Billich, A., Guerini, D., and Seuwen, K. (2009) Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat. Chem. Biol. 5, 428-434
5. Neumann, S., Geras-Raaka, E., Marcus-Samuels, B., and Gershengorn, M. C. (2010) Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization. FASEB J. 24, 2347-2354
6. Feinstein, T. N., Wehbi, V. L., Ardura, J. A., Wheeler, D. S., Ferrandon, S., Gardella, T. J., and Vilardaga, J. P. (2011) Retromer terminates the generation of cAMP by internalized PTH receptors. Nat. Chem. Biol. 7, 278-284
7. Boutin, A., Allen, M. D., Geras-Raaka, E., Huang, W., Neumann, S., and Gershengorn, M. C. (2011) Thyrotropin receptor stimulates internalization- independent persistent phosphoinositide signaling. Mol. Pharmacol. 80, 240-246
8. Werthmann, R. C., Volpe, S., Lohse, M. J., and Calebiro, D. (2012) Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells. FASEB J. 26, 2043-2048
9. Seifert, R., and Wenzel-Seifert, K. (2002) Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn Schmiedebergs Arch. Pharmacol. 366, 381-416 (Pubitemid 35251788)
10. Tao, Y. X. (2008) Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics. Pharmacol. Ther. 120, 129-148
11. 2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 268, 4625-4636
12. Sun, Y., Lu, X., and Gershengorn, M. C. (2003) Thyrotropin-releasing hormone receptors-similarities and differences. J. Mol. Endocrinol. 30, 87-97
13. Neumann, S., Raaka, B. M., and Gershengorn, M. C. (2010) Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists. Methods Enzymol. 485, 147-160
14. Wang, W., and Gershengorn, M. C. (1999) Rat TRH receptor type 2 exhibits higher basal signaling activity than TRH receptor type 1. Endocrinology 140, 4916-4919 (Pubitemid 30666162)
15. Robbins, A. K., and Horlick, R. A. (1998) Macrophage scavenger receptor confers an adherent phenotype to cells in culture. Biotechniques 25, 240-244 (Pubitemid 28371412)
16. 4-*S. J. Biol. Chem. 276, 4227-4235
17. Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N., Palmer, A. E., and Tsien, R. Y. (2004) Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22, 1567-1572 (Pubitemid 40039460)
18. Gershengorn, M. C., Heinflink, M., Nussenzveig, D. R., Hinkle, P. M., and Falck-Pedersen, E. (1994) Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool. Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer. J. Biol. Chem. 269, 6779-6783
19. Engel, S., Skoumbourdis, A. P., Childress, J., Neumann, S., Deschamps, J. R., Thomas, C. J., Colson, A. O., Costanzi, S., and Gershengorn, M. C. (2008) A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists. J. Am. Chem. Soc. 130, 5115-5123 (Pubitemid 351537071)
20. Sun, Y., and Gershengorn, M. C. (2002) Correlation between basal signaling and internalization of thyrotropin-releasing hormone receptors: evidence for involvement of similar receptor conformations. Endocrinology 143, 2886-2892
21. Hanyaloglu, A. C., Seeber, R. M., Kohout, T. A., Lefkowitz, R. J., and Eidne, K. A. (2002) Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes-differential regulation of β-arrestins 1 and 2. J. Biol. Chem. 277, 50422-50430 (Pubitemid 36042194)
22. Jones, B. W., and Hinkle, P. M. (2008) Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences. Mol. Pharmacol. 74, 195-202 (Pubitemid 351872170)
23. Gershengorn, M. C., and Osman, R. (1996) Molecular and cellular biology of thyrotropin-releasing hormone (TRH) receptors. Physiol. Rev. 76, 175-191 (Pubitemid 26048281)
24. Rosenbaum, D. M., Rasmussen, S. G., and Kobilka, B. K. (2009) The structure and function of G-protein-coupled receptors. Nature 459, 356-363
25. Wess, J., Nanavati, S., Vogel, Z., and Maggio, R. (1993) Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor. EMBO J. 12, 331-338 (Pubitemid 23042412)
26. Schwartz, T. W., Frimurer, T. M., Holst, B., Rosenkilde, M. M., and Elling, C. E. (2006) Molecular mechanism of 7TM receptor activation-a global toggle switch model. Annu. Rev. Pharmacol. Toxicol. 46, 481-519 (Pubitemid 43271198)
27. Waters, C. M., Long, J., Gorshkova, I., Fujiwara, Y., Connell, M., Belmonte, K. E., Tigyi, G., Natarajan, V., Pyne, S., and Pyne, N. J. (2006) Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. FASEB J. 20, 509-511 (Pubitemid 46671232)
28. Carter, P. H., Petroni, B. D., Gensure, R. C., Schipani, E., Potts, J. T., Jr., and Gardella, T. J. (2001) Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations. Endocrinology 142, 1534-1545 (Pubitemid 32299682)
29. 2 dopamine receptor in a reconstituted system. J. Biol. Chem. 265, 4507-4514
30. Burstein, E. S., Spalding, T. A., and Brann, M. R. (1997) Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins. Mol. Pharmacol. 51, 312-319 (Pubitemid 27074153)
31. Whalen, E. J., Rajagopal, S., and Lefkowitz, R. J. (2011) Therapeutic potential of beta-arrestin- and G protein-biased agonists. Trends Mol. Med. 17, 126-139
32. Lu, X. P., Bidaud, I., Ladram, A., and Gershengorn, M. C. (2003) Pharmacological studies of thyrotropin-releasing hormone (TRH) receptors from Xenopus laevis: is xTRHR3 a TRH receptor? Endocrinology 144, 1842-1846 (Pubitemid 36543322)
33. Mekuchi, M., Saito, Y., Aoki, Y., Masuda, T., Iigo, M., and Yanagisawa, T. (2011) Molecular cloning, gene structure, molecular evolution and expression analyses of thyrotropin-releasing hormone receptors from medaka (Oryzias latipes). Gen. Comp. Endocrinol. 170, 374-380
34. Gloriam, D. E., Fredriksson, R., and Schioth, H. B. (2007) The G protein-coupled receptor subset of the rat genome. BMC Genomics 8, 338