Nontypeable haemophilus influenzae-induced MyD88 short expression is regulated by positive IKKβ and CREB pathways and negative ERK1/2 pathway

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Andrews, Carla S ^a   Miyata, Masanori ^a   Susuki Miyata, Seiko ^a   Lee, Byung Cheol ^a   Komatsu, Kensei ^a   Li, Jian Dong ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; I KAPPA B KINASE BETA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYELOID DIFFERENTIATION FACTOR 88; I KAPPA B KINASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LUNG; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; NONTYPEABLE HAEMOPHILUS INFLUENZAE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; COMPLICATION; HAEMOPHILUS INFECTION; HAEMOPHILUS INFLUENZAE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; EPITHELIAL CELLS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; I-KAPPA B KINASE; INFLAMMATION; LUNG; MAP KINASE SIGNALING SYSTEM; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MYELOID DIFFERENTIATION FACTOR 88;

EID: 84956602835     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0144840     Document Type: Article

References (34)

1. Knight DA, Yang IA, Ko FW, Lim TK (2012) Year in review 2011: asthma, chronic obstructive pulmonary disease and airway biology. Respirology 17: 563-572. doi: 10.1111/j.1440-1843.2012.02126.x PMID: 22248232
2. Rubinstein AL, Irazola VE, Bazzano LA, Sobrino E, Calandrelli M, Lanas F, et al. (2011) Detection and follow-up of chronic obstructive pulmonary disease (COPD) and risk factors in the Southern Cone of Latin America: the pulmonary risk in South America (PRISA) study. BMC Pulm Med 11: 34. doi: 10. 1186/1471-2466-11-34 PMID: 21627849
3. Barbu C, Iordache M, Man MG (2011) Inflammation in COPD: pathogenesis, local and systemic effects. Rom J Morphol Embryol 52: 21-27. PMID: 21424028
4. Foxwell AR, Kyd JM, Cripps AW (1998) Nontypeable Haemophilus influenzae: pathogenesis and prevention. Microbiol Mol Biol Rev 62: 294-308. PMID: 9618443
5. Alikhan MM, Lee FE (2014) Understanding nontypeable Haemophilus influenzae and chronic obstructive pulmonary disease. Curr Opin Pulm Med 20: 159-164. doi: 10.1097/MCP.0000000000000023 PMID: 24441573
6. Schumacher SK, Marchant CD, Loughlin AM, Bouchet V, Stevenson A, Pelton SI (2012) Prevalence and genetic diversity of nontypeable haemophilus influenzae in the respiratory tract of infants and primary caregivers. Pediatr Infect Dis J 31: 145-149. doi: 10.1097/INF.0b013e31823aaeb3 PMID: 22051860
7. Ito M, Hotomi M, Maruyama Y, Hatano M, Sugimoto H, Yoshizaki T, et al. (2010) Clonal spread of betalactamase-producing amoxicillin-clavulanate-resistant (BLPACR) strains of non-typeable Haemophilus influenzae among young children attending a day care in Japan. Int J Pediatr Otorhinolaryngol 74: 901-906. doi: 10.1016/j.ijporl.2010.05.008 PMID: 20846501
8. Hallstrand TS, Hackett TL, Altemeier WA, Matute-Bello G, Hansbro PM, Knight DA (2014) Airway epithelial regulation of pulmonary immune homeostasis and inflammation. Clin Immunol 151: 1-15. doi: 10.1016/j.clim.2013.12.003 PMID: 24503171
9. Proud D, Leigh R (2011) Epithelial cells and airway diseases. Immunol Rev 242: 186-204. doi: 10. 1111/j.1600-065X.2011.01033.x PMID: 21682746
10. Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384. doi: 10.1038/ni.1863 PMID: 20404851
11. Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, et al. (2007) Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. PLoS One 2: e1032. PMID: 17925880
12. Lugade AA, Bogner PN, Murphy TF, Thanavala Y (2011) The role of TLR2 and bacterial lipoprotein in enhancing airway inflammation and immunity. Front Immunol 2 doi: 10.3389/fimmu.2011.00010 PMID: 22566801
13. Mogensen TH (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22: 240-273, Table of Contents. doi: 10.1128/CMR.00046-08 PMID: 19366914
14. Jono H, Lim JH, Chen LF, Xu H, Trompouki E, Pan ZK, et al. (2004) NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway. J Biol Chem 279: 36171-36174. PMID: 15226292
15. Liew FY, Xu D, Brint EK, O'Neill LA (2005) Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 5: 446-458. PMID: 15928677
16. Janssens S, Burns K, Tschopp J, Beyaert R (2002) Regulation of interleukin-1-And lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. Curr Biol 12: 467-471. PMID: 11909531
17. Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R, Tschopp J (2003) Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med 197: 263-268. PMID: 12538665
18. Janssens S, Burns K, Vercammen E, Tschopp J, Beyaert R (2003) MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB-And AP-1-dependent gene expression. FEBS Lett 548: 103-107. PMID: 12885415
19. Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, et al. (2001) Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha/beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci U S A 98: 8774-8779. PMID: 11438700
20. Cohen P (2014) The TLR and IL-1 signalling network at a glance. J Cell Sci 127: 2383-2390. doi: 10. 1242/jcs.149831 PMID: 24829146
21. Newton K, Dixit VM (2012) Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol 4: a006049. doi: 10.1101/cshperspect.a006049 PMID: 22296764
22. Jundi K, Greene CM (2015) Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease. Biomolecules 5: 1386-1398. doi: 10.3390/biom5031386 PMID: 26140537
23. Johannessen M, Delghandi MP, Moens U (2004) What turns CREB on? Cell Signal 16: 1211-1227. PMID: 15337521
24. Sanin DE, Prendergast CT, Mountford AP (2015) IL-10 production in macrophages is regulated by a TLR-driven CREB-mediated mechanism that is linked to genes involved in cell metabolism. J Immunol 195: 1218-1232. doi: 10.4049/jimmunol.1500146 PMID: 26116503
25. Wang B, Cleary PP, Xu H, Li JD (2003) Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways. Infect Immun 71: 5523-5530. PMID: 14500470
26. Wang WY, Komatsu K, Huang Y, Wu J, Zhang W, Lee JY, et al. (2014) CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK. PLoS One 9: e112516. doi: 10.1371/journal.pone.0112516 PMID: 25389768
27. Adib-Conquy M, Adrie C, Fitting C, Gattolliat O, Beyaert R, Cavaillon JM (2006) Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Crit Care Med 34: 2377-2385. PMID: 16850005
28. Oeckinghaus A, Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1: a000034. doi: 10.1101/cshperspect.a000034 PMID: 20066092
29. Bonizzi G, Karin M (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25: 280-288. PMID: 15145317
30. Susuki-Miyata S, Miyata M, Lee BC, Xu H, Kai H, Yan C, et al. (2015) Cross-talk between PKA-C? and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi. Proc Natl Acad Sci U S A 112: 1800-1809.
31. Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, et al. (2015) Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. Nat Commun 6: 6062. doi: 10.1038/ncomms7062 PMID: 25585690
32. Ha U, Lim JH, Jono H, Koga T, Srivastava A, Malley R, et al. (2007) A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol 178: 1736-1747. PMID: 17237423
33. Lee J, Komatsu K, Lee BC, Lim JH, Jono H, Xu H, et al. (2012) Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem 287: 22799-22811. doi: 10.1074/jbc.M111.337378 PMID: 22610099
34. Komatsu K, Lee JY, Miyata M, Hyang Lim J, Jono H, Koga T, et al. (2013) Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD. Nat Commun 4: 1684. doi: 10.1038/ncomms2674 PMID: 23575688