Production of oncolytic adenovirus and human mesenchymal stem cells in a single-use, Vertical-Wheel bioreactor system: Impact of bioreactor design on performance of microcarrier-based cell culture processes

Biotechnology Progress

Volumn 31, Issue 6, 2015, Pages 1600-1612

  Sousa, Marcos F Q ^a,b   Silva, Marta M ^a,b   Giroux, Daniel ^c   Hashimura, Yas ^c   Wesselschmidt, Robin ^c   Lee, Brian ^c   Roldão, António ^a,b   Carrondo, Manuel J T ^b,d   Alves, Paula M ^a,b   Serra, Margarida ^a,b  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^c PBS Biotech   (United States)

^d UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Anchorage dependent cell cultures; HMSC; Microcarriers; Onco Ad5; Scalability; Single use bioreactor; Vertical wheel bioreactor

Indexed keywords

ANCHORAGES (FOUNDATIONS); BIOCONVERSION; BIOREACTORS; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELLS; CYTOLOGY; GROWTH KINETICS; SCALABILITY; SHEAR STRESS; STEM CELLS; TISSUE ENGINEERING; VIRUSES; WHEELS;

ANCHORAGE-DEPENDENT CELLS; HMSC; MICROCARRIERS; ONCO-AD5; SINGLE USE;

CELL ENGINEERING;

ONCOLYTIC VIRUS;

ADENOVIRIDAE; BIOREACTOR; CELL CULTURE TECHNIQUE; CYTOLOGY; DEVICES; EQUIPMENT DESIGN; HUMAN; HYDRODYNAMICS; ISOLATION AND PURIFICATION; MESENCHYMAL STROMA CELL; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE;

ADENOVIRIDAE; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; EQUIPMENT DESIGN; HUMANS; HYDRODYNAMICS; MESENCHYMAL STROMAL CELLS; ONCOLYTIC VIRUSES;

EID: 84956595618     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2158     Document Type: Article

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