A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells

Biotechnology and Bioengineering

Volumn 111, Issue 6, 2014, Pages 1116-1127

  Dos Santos, Francisco ^a,d   Campbell, Andrew ^b   Fernandes Platzgummer, Ana ^a   Andrade, Pedro Z ^a,d   Gimble, Jeffrey M ^c   Wen, Yuan ^b   Boucher, Shayne ^b   Vemuri, Mohan C ^b   Da Silva, Cláudia L ^a   Cabral, Joaquim M S ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b Life Technologies Corporation   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d Cell2B Advanced Therapeutics SA   (Portugal)

Author keywords

Bioreactor; Expansion; Mesenchymal stem stromal cells; Microcarriers; Scale up; Xenogeneic free

Indexed keywords

BIOCONVERSION; BIOREACTORS; CELLS; EXPANSION; METABOLISM; OPTIMIZATION; PRODUCTION ENGINEERING;

BIOPROCESS ENGINEERING; BIOREACTOR CULTURES; METABOLIC PATTERNS; MICROCARRIERS; MONITORING AND CONTROL; PRODUCTION PROCESS; SCALE-UP; XENOGENEIC-FREE;

CYTOLOGY;

5' NUCLEOTIDASE; B7 ANTIGEN; CD31 ANTIGEN; DISSOLVED OXYGEN; ENDOGLIN; GROWTH FACTOR; HLA DR ANTIGEN; THY 1 ANTIGEN;

ADIPOSE TISSUE CELL; ARTICLE; CELL COUNT; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CELL RENEWAL; FED BATCH CULTURE; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELL; MESENCHYMAL STROMA CELL; NORMAL HUMAN; NUTRIENT; STEM CELL EXPANSION; STIRRED REACTOR; XENO-FREE CULTURE; BIOREACTOR; CULTURE TECHNIQUE; PHYSIOLOGY; PROCEDURES; STROMA CELL;

BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; HUMANS; IMMUNOPHENOTYPING; MESENCHYMAL STROMAL CELLS; STROMAL CELLS;

EID: 84899649027     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25187     Document Type: Article

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