Evaluation of the effect of chronic hydrodynamical stresses on cultures of suspensed CHO-6E6 cells

Biotechnology and Bioengineering

Volumn 102, Issue 4, 2009, Pages 1119-1130

  Godoy Silva, Ruben ^a   Mollet, Mike ^a,b   Chalmers, Jeffrey J ^a,c  

^a Ohio State University   (United States)

^b MEDIMMUNE   (United States)

^c UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

Animal cell; Chinese hamster ovary (CHO); Energy dissipation rate; Hydrodynamicforces; Shear stress

Indexed keywords

ANIMAL CELL; BATCH CULTURES; BIOPROCESS; CHINESE HAMSTER OVARY (CHO); CHO CELLS; CHRONIC EXPOSURES; CONTINUOUS EXPOSURES; ENERGY DISSIPATION RATE; HYDRODYNAMICFORCES; MICRO-FLUIDIC DEVICES; ORDERS OF MAGNITUDES; RECYCLE FLOWS; RECYCLE LOOPS; SECOND-GENERATIONS; STAGE OF GROWTHS;

ANIMAL CELL CULTURE; BATCH CELL CULTURE; BIOREACTORS; CELLS; DENSITY MEASUREMENT (SPECIFIC GRAVITY); DISSOLUTION; DISSOLVED OXYGEN; ELECTRON ENERGY LOSS SPECTROSCOPY; ENERGY DISSIPATION; ENERGY DISSIPATORS; FLUID DYNAMICS; FLUIDIC DEVICES; HYDRODYNAMICS; INDUSTRIAL CHEMICALS; RECYCLING; SHEAR STRESS; STRENGTH OF MATERIALS;

CELL CULTURE;

ACCURACY; ANIMAL CELL; ARTICLE; BIOPROCESS; BIOREACTOR; CELL KILLING; CELL STRESS; CHO CELL; CONTROLLED STUDY; EVALUATION; HYDRODYNAMICS; LONG TERM EXPOSURE; MICROFLUIDICS; NONHUMAN; ANIMAL; CELL PROLIFERATION; CELL SURVIVAL; CRICETULUS; CULTURE TECHNIQUE; HAMSTER; PHYSIOLOGICAL STRESS;

ANIMALIA; CRICETULUS GRISEUS;

ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; STRESS, PHYSIOLOGICAL;

EID: 60549090400     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22146     Document Type: Article

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