Bioprocess development for canine adenovirus type 2 vectors

Gene Therapy

Volumn 20, Issue 4, 2013, Pages 353-360

  Fernandes, P ^a,b   Peixoto, C ^b   Santiago, V M ^b   Kremer, E J ^c   Coroadinha, A S ^a,b   Alves, P M ^a,b  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^c CNRS   (France)

Author keywords

canine adenovirus; chromatography; GMP compliant; MDCK; production and purification; scale up

Indexed keywords

ADENOVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOPROCESS; BIOREACTOR; CANINE ADENOVIRUS; CANINE ADENOVIRUS TYPE 2; CELL COUNT; CELL GROWTH; CELL VIABILITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CULTURE MEDIUM; GROWTH; KIDNEY CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; VIRUS PARTICLE; VIRUS PURIFICATION;

ADENOVIRIDAE; ANIMALS; DOGS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MADIN DARBY CANINE KIDNEY CELLS;

CANINE ADENOVIRUS; CANINE ADENOVIRUS TYPE 2; CANIS FAMILIARIS; CHICKEN ANEMIA VIRUS; HUMAN ADENOVIRUS;

EID: 84875922065     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2012.52     Document Type: Article

References (32)

1. Dormond E, Perrier M, Kamen A. From the first to the third generation adenoviral vector: what parameters are governing the production yield? Biotechnol Adv 2009; 27: 133-144.
2. Kremer EJ, Boutin S, Chillon M, Danos O. Canine adenovirus vectors: an alternative for adenovirus-mediated gene transfer. J Virol 2000; 74: 505-512.
3. Perreau M, Kremer EJ. Frequency, proliferation, and activation of human memory T cells induced by a nonhuman adenovirus. J Virol 2005; 79: 14595-14605.
4. Soudais C, Boutin S, Kremer EJ. Characterization of cis-acting sequences involved in canine adenovirus packaging. Mol Ther 2001; 3: 631-640.
5. Bru T, Salinas S, Kremer EJ. An update on canine adenovirus type 2 and its vectors. Viruses 2010; 2: 2134-2153.
6. Soudais C, Laplace-Builhe C, Kissa K, Kremer EJ. Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo. Faseb J 2001; 15: 2283-2285.
7. Falkner E, Appl H, Eder C, Losert UM, Schoffl H, Pfaller W. Serum free cell culture: the free access online database. Toxicol In Vitro 2006; 20: 395-400.
8. Armendariz-Borunda J, Bastidas-Ramirez BE, Sandoval-Rodriguez A, Gonzalez-Cuevas J, Gomez-Meda B, Garcia-Banuelos J. Production of first generation ade-noviral vectors for preclinical protocols: amplification, purification and functional titration. J Biosci Bioeng 2011; 112: 415-421.
9. Eglon M, McGrath B, O'Brien T. HPLC purification of adenoviral vectors. Methods Mol Biol 2010; 594: 395-408.
10. Eglon MN, Duffy AM, O'Brien T, Strappe PM. Purification of adenoviral vectors by combined anion exchange and gel filtration chromatography. J Gene Med 2009; 11: 978-989.
11. Forcic D, Brgles M, Ivancic-Jelecki J, Santak M, Halassy B, Barut M et al. Concentration and purification of rubella virus using monolithic chromatographic support. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879: 981-986.
12. Iyer G, Ramaswamy S, Asher D, Mehta U, Leahy A, Chung F et al. Reduced surface area chromatography for flow-through purification of viruses and virus like particles. J Chromatogr A 2011; 1218: 3973-3981.
13. Genzel Y, Fischer M, Reichl U. Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture. Vaccine 2006; 24: 3261-3272.
14. Tree JA, Richardson C, Fooks AR, Clegg JC, Looby D. Comparison of large-scale mammalian cell culture systems with egg culture for the production of influenza virus A vaccine strains. Vaccine 2001; 19: 3444-3450.
15. Genzel Y, Behrendt I, Konig S, Sann H, Reichl U. Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture. Vaccine 2004; 22: 2202-2208.
16. Genzel Y, Ritter JB, Konig S, Alt R, Reichl U. Substitution of glutamine by pyruvate to reduce ammonia formation and growth inhibition of mammalian cells. Bio-technol Prog 2005; 21: 58-69.
17. Chillon M, Kremer EJ. Trafficking and propagation of canine adenovirus vectors lacking a known integrin-interacting motif. Hum Gene Ther 2001; 12: 1815-1823.
18. Nadeau I, Kamen A. Production of adenovirus vector for gene therapy. Biotechnol Adv 2003; 20: 475-489.
19. Ferreira TB, Ferreira AL, Carrondo MJ, Alves PM. Effect of re-feed strategies and non-ammoniagenic medium on adenovirus production at high cell densities. J Biotechnol 2005; 119: 272-280.
20. Altaras NE, Aunins JG, Evans RK, Kamen A, Konz JO, Wolf JJ. Production and formulation of adenovirus vectors. Adv Biochem Eng Biotechnol 2005; 99: 193-260.
21. Kamen A, Henry O. Development and optimization of an adenovirus production process. J Gene Med 2004; 6: 184-192.
22. Schoehn G, El Bakkouri M, Fabry CM, Billet O, Estrozi LF, Le L et al. Three-dimensional structure of canine adenovirus serotype 2 capsid. J Virol 2008; 82: 3192-3203.
23. Segura MM, Kamen AA, Garnier A. Overview of current scalable methods for purification of viral vectors. Methods Mol Biol 2011; 737: 89-116.
24. Silva AC, Peixoto C, Lucas T, Kuppers C, Cruz PE, Alves PM et al. Adenovirus vector production and purification. Curr Gene Ther 2010; 10: 437-455.
25. Lusky M. Good manufacturing practice production of adenoviral vectors for clinical trials. Hum Gene Ther 2005; 16: 281-291.
26. Peixoto C, Ferreira TB, Sousa MF, Carrondo MJ, Alves PM. Towards purification of adenoviral vectors based on membrane technology. Biotechnol Prog 2008; 24: 1290-1296.
27. Goerke AR, To BC, Lee AL, Sagar SL, Konz JO. Development of a novel adenovirus purification process utilizing selective precipitation of cellular DNA. Biotechnol Bioeng 2005; 91: 12-21.
28. Klonjkowski B, Gilardi-Hebenstreit P, Hadchouel J, Randrianarison V, Boutin S, Yeh P et al. A recombinant E1-deleted canine adenoviral vector capable of trans-duction and expression of a transgene in human-derived cells and in vivo. Human Gene Ther 1997; 8: 2103-2115.
29. Ferreira TB, Perdigao R, Silva AC, Zhang C, Aunins JG, Carrondo MJ et al. 293 cell cycle synchronisation adenovirus vector production. Biotechnol Prog 2009; 25: 235-243.
30. Soudais C, Skander N, Kremer EJ. Long-term in vivo transduction of neurons throughout the rat CNS using novel helper-dependent CAV-2 vectors. FASEB J 2004; 18: 391-393.
31. Segura MM, Monfar M, Puig M, Mennechet F, Ibanes S, Chillon M. A real-time PCR assay for quantification of canine adenoviral vectors. J Virol Methods 2010; 163: 129-136.
32. Salinas S, Bilsland LG, Henaff D, Weston AE, Keriel A, Schiavo G et al. CAR-associated vesicular transport of an adenovirus in motor neuron axons. PLoS pathogens 2009; 5: e1000442.