Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells

Biochemical and Biophysical Research Communications

Volumn 470, Issue 1, 2016, Pages 181-186

  Lee, Gibok ^a   Oh, Taek In ^a   Um, Ki Bum ^a   Yoon, Hyeshin ^a   Son, Jaekyoung ^b   Kim, Byeong Mo ^c   Kim, Hong Il ^a   Kim, Hackyoung ^a   Kim, Young Jun ^a   Lee, Chang Soo ^a   Lim, Ji Hong ^a  

^a Konkuk University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

Apoptosis; ER stress; ROS; USP7 inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; REACTIVE OXYGEN METABOLITE; UBIQUITIN THIOLESTERASE; USP7 PROTEIN, HUMAN;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; DRUG EFFECTS; ENDOPLASMIC RETICULUM STRESS; HUMAN; METABOLISM; NEOPLASMS, EXPERIMENTAL; OXIDATIVE STRESS; PATHOLOGY; TUMOR CELL LINE; UBIQUITINATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HUMANS; NEOPLASMS, EXPERIMENTAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 84956573213     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.01.021     Document Type: Article

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