C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site

Archives of Biochemistry and Biophysics

Volumn 503, Issue 2, 2010, Pages 207-212

  Ma, Jianhong ^a   Martin, John D ^b   Xue, Yu ^a   Lor, Leng A ^b   Kennedy Wilson, Karen M ^b   Sinnamon, Robert H ^b   Ho, Thau F ^b   Zhang, Guofeng ^b   Schwartz, Benjamin ^b   Tummino, Peter J ^a   Lai, Zhihong ^c  

^a GLAXOSMITHKLINE   (United States)

^b Departments of Biological Reagents and Assay Development   (United States)

^c Worldwide Clinical Trials   (United States)

Author keywords

Deubiquitination; HAUSP; Mdm2; P53; Second binding site; USP7

Indexed keywords

GLUTATHIONE; HEPES SIMPLEX VIRUS ASSOCIATED UBIQUITIN SPECIFIC PROTEASE; PROTEIN MDM2; PROTEIN P53; PROTEINASE; UNCLASSIFIED DRUG; HYBRID PROTEIN; MDM2 PROTEIN, HUMAN; PROTEIN BINDING; UBIQUITIN THIOLESTERASE; USP7 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; UBIQUITINATION; CHEMISTRY; COMPARATIVE STUDY; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; TUMOR SUPPRESSOR GENE;

AMINO ACID MOTIFS; BINDING SITES; CATALYTIC DOMAIN; GENES, P53; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 77957020954     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2010.08.020     Document Type: Article

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