Glyco-genes change expression in cancer through aberrant methylation

Biochimica et Biophysica Acta - General Subjects

Volumn 1860, Issue 8, 2016, Pages 1776-1785

  Vojta, Aleksandar ^a   Samaržija, Ivana ^a   Bočkor, Luka ^a   Zoldoš, Vlatka ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Cancer; DNA methylation; Epigenetics; Gene expression; Protein glycosylation

Indexed keywords

GLYCAN; MANNOSIDASE; N ACETYLGALACTOSAMINE; SIALYLTRANSFERASE; DNA; TUMOR PROTEIN;

ARTICLE; BRAIN CANCER; BRAIN METASTASIS; BREAST CANCER; CANCER GROWTH; CANCER PROGNOSIS; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GALNT14 GENE; GALNT3 GENE; GALNT6 GENE; GALNT7 GENE; GENE; GENE EXPRESSION; GLYCO GENE; GLYCOSYLATION; LIVER CELL CARCINOMA; LUNG CANCER; LYMPH NODE METASTASIS; MALIGNANT TRANSFORMATION; MAN1A1 GENE; MAN1C1 GENE; MELANOMA; MGAT3 GENE; MGAT5B GENE; PRIORITY JOURNAL; PROMOTER REGION; ST3GAL2 GENE; ST6GAL1 GENE; ST8SIA3 GENE; UTERINE CERVIX CANCER; BIOSYNTHESIS; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETIC EPIGENESIS; GENETICS; HUMAN; MALE; METABOLISM; NEOPLASM;

DATABASES, GENETIC; DNA METHYLATION; DNA, NEOPLASM; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; NEOPLASM PROTEINS; NEOPLASMS; PROMOTER REGIONS, GENETIC;

EID: 84956525817     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2016.01.002     Document Type: Article

References (96)

1. K.W. Moremen, M. Tiemeyer, and A.V. Nairn Vertebrate protein glycosylation: diversity, synthesis and function Nat. Rev. Mol. Cell Biol. 13 2012 448 462
2. L.A. Lasky Selectins: interpreters of cell-specific carbohydrate information during inflammation Science 258 1992 964 969
3. J.D. Marth, and P.K. Grewal Mammalian glycosylation in immunity Nat. Rev. Immunol. 8 2008 874 887
4. J. Mitoma, X. Bao, B. Petryanik, P. Schaerli, J.M. Gauguet, S.Y. Yu, H. Kawashima, H. Saito, K. Ohtsubo, J.D. Marth, K.H. Khoo, U.H. von Andrian, J.B. Lowe, and M. Fukuda Critical functions of N-glycans in l-selectin-mediated lymphocyte homing and recruitment Nat. Immunol. 8 2007 409 418
5. A. Helenius, and M. Aebi Intracellular functions of N-linked glycans Science 291 2001 2364 2369
6. A. Knezevic, O. Gornik, O. Polasek, M. Pucic, I. Redzic, M. Novokmet, P.M. Rudd, A.F. Wright, H. Campbell, I. Rudan, and G. Lauc Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans Glycobiology 20 2010 959 969
7. G. Lauc, A. Vojta, and V. Zoldos Epigenetic regulation of glycosylation is the quantum mechanics of biology Biochim. Biophys. Acta 1840 2014 65 70
8. R. Apweiler, H. Hermjakob, and N. Sharon On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database Biochim. Biophys. Acta 1473 1999 4 8
9. E. Maverakis, K. Kim, M. Shimoda, M.E. Gershwin, F. Patel, R. Wilken, S. Raychaudhuri, L.R. Ruhaak, and C.B. Lebrilla Glycans in the immune system and the altered glycan theory of autoimmunity: a critical review J. Autoimmun. 57 2015 1 13
10. National Research Council (U.S.). Committee on Assessing the Importance and Impact of Glycomics and Glycosciences, National Research Council (U.S.). Board on Chemical Sciences and Technology, National Research Council (U.S.). Board on Life Sciences Transforming Glycoscience: A Roadmap for the Future 2012 National Academies Press Washington, D.C.
11. T. Horvat, V. Zoldos, and G. Lauc Evolutional and clinical implications of the epigenetic regulation of protein glycosylation Clin. Epigenetics 2 2011 425 432
12. S.R. Stowell, T. Ju, and R.D. Cummings Protein glycosylation in cancer Annu. Rev. Pathol. 10 2015 473 510
13. R. Seidenfaden, A. Krauter, F. Schertzinger, R. Gerardy-Schahn, and H. Hildebrandt Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions Mol. Cell. Biol. 23 2003 5908 5918
14. S. Tsuboi, S. Hatakeyama, C. Ohyama, and M. Fukuda Two opposing roles of O-glycans in tumor metastasis Trends Mol. Med. 18 2012 224 232
15. M.L. de Leoz, L.J. Young, H.J. An, S.R. Kronewitter, J. Kim, S. Miyamoto, A.D. Borowsky, H.K. Chew, and C.B. Lebrilla High-mannose glycans are elevated during breast cancer progression Mol. Cell. Proteomics 10 2011 M110 002717
16. T. Huanna, Z. Tao, W. Xiangfei, A. Longfei, X. Yuanyuan, W. Jianhua, Z. Cuifang, J. Manjing, C. Wenjing, Q. Shaochuan, X. Feifei, L. Naikang, Z. Jinchao, and W. Chen GALNT14 mediates tumor invasion and migration in breast cancer cell MCF-7 Mol. Carcinog. 2014
17. P.M. Drake, W. Cho, B. Li, A. Prakobphol, E. Johansen, N.L. Anderson, F.E. Regnier, B.W. Gibson, and S.J. Fisher Sweetening the pot: adding glycosylation to the biomarker discovery equation Clin. Chem. 56 2010 223 236
18. G. Durand, and N. Seta Protein glycosylation and diseases: blood and urinary oligosaccharides as markers for diagnosis and therapeutic monitoring Clin. Chem. 46 2000 795 805
19. J.-h. Rho, and P. Lampe High-throughput analysis of plasma hybrid markers for early detection of cancers Proteomes 2 2014 1
20. S.S. Pinho, and C.A. Reis Glycosylation in cancer: mechanisms and clinical implications Nat. Rev. Cancer 15 2015 540 555
21. M. Anugraham, F. Jacob, S. Nixdorf, A.V. Everest-Dass, V. Heinzelmann-Schwarz, and N.H. Packer Specific glycosylation of membrane proteins in epithelial ovarian cancer cell lines: glycan structures reflect gene expression and DNA methylation status Mol. Cell. Proteomics 13 2014 2213 2232
22. T. Horvat, M. Dezeljin, I. Redzic, D. Barisic, M. Herak Bosnar, G. Lauc, and V. Zoldos Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors PLoS One 8 2013 e54672
23. T. Horvat, A. Muzinic, D. Barisic, M.H. Bosnar, and V. Zoldos Epigenetic modulation of the HeLa cell membrane N-glycome Biochim. Biophys. Acta 1820 2012 1412 1419
24. J. Kristic, F. Vuckovic, C. Menni, L. Klaric, T. Keser, I. Beceheli, M. Pucic-Bakovic, M. Novokmet, M. Mangino, K. Thaqi, P. Rudan, N. Novokmet, J. Sarac, S. Missoni, I. Kolcic, O. Polasek, I. Rudan, H. Campbell, C. Hayward, Y. Aulchenko, A. Valdes, J.F. Wilson, O. Gornik, D. Primorac, V. Zoldos, T. Spector, and G. Lauc Glycans are a novel biomarker of chronological and biological ages J. Gerontol. A Biol. Sci. Med. Sci. 69 2014 779 789
25. R. Saldova, E. Dempsey, M. Perez-Garay, K. Marino, J.A. Watson, A. Blanco-Fernandez, W.B. Struwe, D.J. Harvey, S.F. Madden, R. Peracaula, A. McCann, and P.M. Rudd 5-AZA-2′-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer Epigenetics 6 2011 1362 1372
26. R. Edgar, M. Domrachev, and A.E. Lash Gene expression omnibus: NCBI gene expression and hybridization array data repository Nucleic Acids Res. 30 2002 207 210
27. J. Shen, S. Wang, Y.J. Zhang, H.C. Wu, M.G. Kibriya, F. Jasmine, H. Ahsan, D.P. Wu, A.B. Siegel, H. Remotti, and R.M. Santella Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips Epigenetics 8 2013 34 43
28. T. Fleischer, A. Frigessi, K.C. Johnson, H. Edvardsen, N. Touleimat, J. Klajic, M.L. Riis, V.D. Haakensen, F. Warnberg, B. Naume, A. Helland, A.L. Borresen-Dale, J. Tost, B.C. Christensen, and V.N. Kristensen Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis Genome Biol. 15 2014 435
29. D.M. Marzese, R.A. Scolyer, J.L. Huynh, S.K. Huang, H. Hirose, K.K. Chong, E. Kiyohara, J. Wang, N.P. Kawas, N.C. Donovan, K. Hata, J.S. Wilmott, R. Murali, M.E. Buckland, B. Shivalingam, J.F. Thompson, D.L. Morton, D.F. Kelly, and D.S. Hoon Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis Hum. Mol. Genet. 23 2014 226 238
30. S.A. Farkas, N. Milutin-Gasperov, M. Grce, and T.K. Nilsson Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer Epigenetics 8 2013 1213 1225
31. J. Shi, C.N. Marconett, J. Duan, P.L. Hyland, P. Li, Z. Wang, W. Wheeler, B. Zhou, M. Campan, D.S. Lee, J. Huang, W. Zhou, T. Triche, L. Amundadottir, A. Warner, A. Hutchinson, P.H. Chen, B.S. Chung, A.C. Pesatori, D. Consonni, P.A. Bertazzi, A.W. Bergen, M. Freedman, K.D. Siegmund, B.P. Berman, Z. Borok, N. Chatterjee, M.A. Tucker, N.E. Caporaso, S.J. Chanock, I.A. Laird-Offringa, and M.T. Landi Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue Nature Commun. 5 2014 3365
32. J. Sandoval, J. Mendez-Gonzalez, E. Nadal, G. Chen, F.J. Carmona, S. Sayols, S. Moran, H. Heyn, M. Vizoso, A. Gomez, M. Sanchez-Cespedes, Y. Assenov, F. Muller, C. Bock, M. Taron, J. Mora, L.A. Muscarella, T. Liloglou, M. Davies, M. Pollan, M.J. Pajares, W. Torre, L.M. Montuenga, E. Brambilla, J.K. Field, L. Roz, M. Lo Iacono, G.V. Scagliotti, R. Rosell, D.G. Beer, and M. Esteller A prognostic DNA methylation signature for stage I non-small-cell lung cancer J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 31 2013 4140 4147
33. S. Roessler, H.L. Jia, A. Budhu, M. Forgues, Q.H. Ye, J.S. Lee, S.S. Thorgeirsson, Z. Sun, Z.Y. Tang, L.X. Qin, and X.W. Wang A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients Cancer Res. 70 2010 10202 10212
34. S. Roessler, E.L. Long, A. Budhu, Y. Chen, X. Zhao, J. Ji, R. Walker, H.L. Jia, Q.H. Ye, L.X. Qin, Z.Y. Tang, P. He, K.W. Hunter, S.S. Thorgeirsson, P.S. Meltzer, and X.W. Wang Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival Gastroenterology 142 2012 957 966 e912
35. Y.H. Wang, T.Y. Cheng, T.Y. Chen, K.M. Chang, V.P. Chuang, and K.J. Kao Plasmalemmal vesicle associated protein (PLVAP) as a therapeutic target for treatment of hepatocellular carcinoma BMC Cancer 14 2014 815
36. I.B. Pau Ni, Z. Zakaria, R. Muhammad, N. Abdullah, N. Ibrahim, N. Aina Emran, N. Hisham Abdullah, and S.N. Syed Hussain Gene expression patterns distinguish breast carcinomas from normal breast tissues: the Malaysian context Pathol. Res. Pract. 206 2010 223 228
37. C.S. Schuetz, M. Bonin, S.E. Clare, K. Nieselt, K. Sotlar, M. Walter, T. Fehm, E. Solomayer, O. Riess, D. Wallwiener, R. Kurek, and H.J. Neubauer Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis Cancer Res. 66 2006 5278 5286
38. C. Clarke, S.F. Madden, P. Doolan, S.T. Aherne, H. Joyce, L. O'Driscoll, W.M. Gallagher, B.T. Hennessy, M. Moriarty, J. Crown, S. Kennedy, and M. Clynes Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis Carcinogenesis 34 2013 2300 2308
39. L. Xu, S.S. Shen, Y. Hoshida, A. Subramanian, K. Ross, J.P. Brunet, S.N. Wagner, S. Ramaswamy, J.P. Mesirov, and R.O. Hynes Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases Mol. Cancer Res. 6 2008 760 769
40. L. Scotto, G. Narayan, S.V. Nandula, H. Arias-Pulido, S. Subramaniyam, A. Schneider, A.M. Kaufmann, J.D. Wright, B. Pothuri, M. Mansukhani, and V.V. Murty Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression Genes Chromosom. Cancer 47 2008 755 765
41. R Core Team R: A Language and Environment for Statistical Computing 2014 R Foundation for Statistical Computing Vienna, Austria
42. H. Mizuno, K. Kitada, K. Nakai, and A. Sarai PrognoScan: a new database for meta-analysis of the prognostic value of genes BMC Med. Genet. 2 2009 18
43. C.Y. Park, A. Krishnan, Q. Zhu, A.K. Wong, Y.-S. Lee, and O.G. Troyanskaya Tissue-aware data integration approach for the inference of pathway interactions in metazoan organisms Bioinformatics 31 2015 1093 1101
44. T.R. Golub, D.K. Slonim, P. Tamayo, C. Huard, M. Gaasenbeek, J.P. Mesirov, H. Coller, M.L. Loh, J.R. Downing, M.A. Caligiuri, C.D. Bloomfield, and E.S. Lander Molecular classification of cancer: class discovery and class prediction by gene expression monitoring Science 286 1999 531 537
45. A. Mehta, P. Norton, H. Liang, M.A. Comunale, M. Wang, L. Rodemich-Betesh, A. Koszycki, K. Noda, E. Miyoshi, and T. Block Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue: a publication of the American Association for Cancer Research, cosponsored by the Americn Society of Preventive Oncology Cancer Epidemiol. Biomarkers Prev. 21 2012 925 933
46. B. Blomme, C. Van Steenkiste, N. Callewaert, and H. Van Vlierberghe Alteration of protein glycosylation in liver diseases J. Hepatol. 50 2009 592 603
47. I. Brockhausen Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions EMBO Rep. 7 2006 599 604
48. J.H. Park, T. Nishidate, K. Kijima, T. Ohashi, K. Takegawa, T. Fujikane, K. Hirata, Y. Nakamura, and T. Katagiri Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis Cancer Res. 70 2010 2759 2769
49. R.P. Pangeni, P. Channathodiyil, D.S. Huen, L.W. Eagles, B.K. Johal, D. Pasha, N. Hadjistephanou, O. Nevell, C.L. Davies, A.I. Adewumi, H. Khanom, I.S. Samra, V.C. Buzatto, P. Chandrasekaran, T. Shinawi, T.P. Dawson, K.M. Ashton, C. Davis, A.R. Brodbelt, M.D. Jenkinson, I. Bieche, F. Latif, J.L. Darling, T.J. Warr, and M.R. Morris The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain Clin. Epigenetics 7 2015 57
50. R.Q. Peng, H.Y. Wan, H.F. Li, M. Liu, X. Li, and H. Tang MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-alpha-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 J. Biol. Chem. 287 2012 14301 14309
51. Y.C. Chen, R.L. Huang, Y.K. Huang, Y.P. Liao, P.H. Su, H.C. Wang, C.C. Chang, Y.W. Lin, M.H. Yu, T.Y. Chu, and H.C. Lai Methylomics analysis identifies epigenetically silenced genes and implies an activation of beta-catenin signaling in cervical cancer Int. J. Cancer J. Int. du Cancer 135 2014 117 127
52. J.N. Arnold, R. Saldova, M.C. Galligan, T.B. Murphy, Y. Mimura-Kimura, J.E. Telford, A.K. Godwin, and P.M. Rudd Novel glycan biomarkers for the detection of lung cancer J. Proteome Res. 10 2011 1755 1764
53. B. Bartling, V. Vanhooren, S. Dewaele, C. Libert, H.S. Hofmann, J. Haerting, S. Nuding, R.E. Silber, A. Simm, and C.C. Chen Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma Cancer Biomark. 10 2011 145 154 Section A of Disease Markers
54. J.A. Vasseur, J.A. Goetz, W.R. Alley Jr., and M.V. Novotny Smoking and lung cancer-induced changes in N-glycosylation of blood serum proteins Glycobiology 22 2012 1684 1708
55. Y.C. Liu, H.Y. Yen, C.Y. Chen, C.H. Chen, P.F. Cheng, Y.H. Juan, C.H. Chen, K.H. Khoo, C.J. Yu, P.C. Yang, T.L. Hsu, and C.H. Wong Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells Proc. Natl. Acad. Sci. U. S. A. 108 2011 11332 11337
56. A. Vojta, and V. Zoldos Adaptation or malignant transformation: the two faces of epigenetically mediated response to stress BioMed Res. Int. 2013 2013 954060
57. K. Shimodaira, J. Nakayama, N. Nakamura, O. Hasebe, T. Katsuyama, and M. Fukuda Carcinoma-associated expression of core 2 beta-1,6-N-acetylglucosaminyltransferase gene in human colorectal cancer: role of O-glycans in tumor progression Cancer Res. 57 1997 5201 5206
58. S. Julien, C. Lagadec, M.A. Krzewinski-Recchi, G. Courtand, X. Le Bourhis, and P. Delannoy Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration Breast Cancer Res. Treat. 90 2005 77 84
59. J. Dennis, C. Waller, R. Timpl, and V. Schirrmacher Surface sialic acid reduces attachment of metastatic tumour cells to collagen type IV and fibronectin Nature 300 1982 274 276
60. S. Nadanaka, C. Sato, K. Kitajima, K. Katagiri, S. Irie, and T. Yamagata Occurrence of oligosialic acids on integrin alpha 5 subunit and their involvement in cell adhesion to fibronectin J. Biol. Chem. 276 2001 33657 33664
61. L. Chen, W. Zhang, N. Fregien, and M. Pierce The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase V and expression of its cell surface oligosaccharide products Oncogene 17 1998 2087 2093
62. M. Granovsky, J. Fata, J. Pawling, W.J. Muller, R. Khokha, and J.W. Dennis Suppression of tumor growth and metastasis in Mgat5-deficient mice Nat. Med. 6 2000 306 312
63. Y.S. Kim, Y.H. Ahn, K.J. Song, J.G. Kang, J.H. Lee, S.K. Jeon, H.C. Kim, J.S. Yoo, and J.H. Ko Overexpression and beta-1,6-N-acetylglucosaminylation-initiated aberrant glycosylation of TIMP-1: a "double whammy" strategy in colon cancer progression J. Biol. Chem. 287 2012 32467 32478
64. D. Li, Y. Li, X. Wu, Q. Li, J. Yu, J. Gen, and X.L. Zhang Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4 + T cells and macrophages J. Immunol. 180 2008 3158 3165
65. T. Liu, S. Zhang, J. Chen, K. Jiang, Q. Zhang, K. Guo, and Y. Liu The transcriptional profiling of glycogenes associated with hepatocellular carcinoma metastasis PLoS One 9 2014 e107941
66. I.O. Potapenko, V.D. Haakensen, T. Luders, A. Helland, I. Bukholm, T. Sorlie, V.N. Kristensen, O.C. Lingjaerde, and A.L. Borresen-Dale Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression Mol. Oncol. 4 2010 98 118
67. X. Zhou, H. Chen, Q. Wang, L. Zhang, and J. Zhao Knockdown of Mgat5 inhibits CD133 + human pulmonary adenocarcinoma cell growth in vitro and in vivo Clin. Invest. Med. 34 2011 E155 E162
68. K.L. Abbott, K. Troupe, I. Lee, and M. Pierce Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb Exp. Cell Res. 312 2006 2837 2850
69. J.K. Lee, R.T. Matthews, J.M. Lim, K. Swanier, L. Wells, and J.M. Pierce Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V J. Biol. Chem. 287 2012 28526 28536
70. S.S. Pinho, J. Figueiredo, J. Cabral, S. Carvalho, J. Dourado, A. Magalhaes, F. Gartner, A.M. Mendonfa, T. Isaji, J. Gu, F. Carneiro, R. Seruca, N. Taniguchi, and C.A. Reis E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V Biochim. Biophys. Acta 1830 2013 2690 2700
71. S.S. Pinho, P. Oliveira, J. Cabral, S. Carvalho, D. Huntsman, F. Gartner, R. Seruca, C.A. Reis, and C. Oliveira Loss and recovery of Mgat3 and GnT-III mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions PLoS One 7 2012 e33191
72. X. Li, J. Wang, W. Li, Y. Xu, D. Shao, Y. Xie, W. Xie, T. Kubota, H. Narimatsu, and Y. Zhang Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-alpha-d-galactosamine:polypeptide N-acetylgalactosaminyltransferases Glycobiology 22 2012 602 615
73. K.W. Wagner, E.A. Punnoose, T. Januario, D.A. Lawrence, R.M. Pitti, K. Lancaster, D. Lee, M. von Goetz, S.F. Yee, K. Totpal, L. Huw, V. Katta, G. Cavet, S.G. Hymowitz, L. Amler, and A. Ashkenazi Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL Nat. Med. 13 2007 1070 1077
74. E.L. Stone, M.N. Ismail, S.H. Lee, Y. Luu, K. Ramirez, S.M. Haslam, S.B. Ho, A. Dell, M. Fukuda, and J.D. Marth Glycosyltransferase function in core 2-type protein O glycosylation Mol. Cell. Biol. 29 2009 3770 3782
75. S. Tuupanen, U.A. Hanninen, J. Kondelin, P. von Nandelstadh, T. Cajuso, A.E. Gylfe, R. Katainen, T. Tanskanen, H. Ristolainen, J. Bohm, J.P. Mecklin, H. Jarvinen, L. Renkonen-Sinisalo, C.L. Andersen, M. Taipale, J. Taipale, P. Vahteristo, K. Lehti, E. Pitkanen, and L.A. Aaltonen Identification of 33 candidate oncogenes by screening for base-specific mutations Br. J. Cancer 111 2014 1657 1662
76. N. Berois, C.H. Gattolliat, E. Barrios, L. Capandeguy, S. Douc-Rasy, D. Valteau-Couanet, J. Benard, and E. Osinaga GALNT9 gene expression is a prognostic marker in neuroblastoma patients Clin. Chem. 59 2013 225 233
77. H. Takamaru, E. Yamamoto, H. Suzuki, M. Nojima, R. Maruyama, H.O. Yamano, K. Yoshikawa, T. Kimura, T. Harada, M. Ashida, R. Suzuki, H. Yamamoto, M. Kai, T. Tokino, T. Sugai, K. Imai, M. Toyota, and Y. Shinomura Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer Cancer Prev. Res. 5 2012 1203 1212
78. Z.Q. Wang, M. Bachvarova, C. Morin, M. Plante, J. Gregoire, M.C. Renaud, A. Sebastianelli, and D. Bachvarov Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation Oncotarget 5 2014 544 560
79. O. Suzuki, M. Abe, and Y. Hashimoto Sialylation by beta-galactoside alpha-2,6-sialyltransferase and N-glycans regulate cell adhesion and invasion in human anaplastic large cell lymphoma Int. J. Oncol. 46 2015 973 980
80. O. Suzuki, Y. Nozawa, T. Kawaguchi, and M. Abe UDP-GlcNAc2-epimerase regulates cell surface sialylation and cell adhesion to extracellular matrix in Burkitt's lymphoma Int. J. Oncol. 20 2002 1005 1011
81. P.D. Bos, X.H. Zhang, C. Nadal, W. Shu, R.R. Gomis, D.X. Nguyen, A.J. Minn, M.J. van de Vijver, W.L. Gerald, J.A. Foekens, and J. Massague Genes that mediate breast cancer metastasis to the brain Nature 459 2009 1005 1009
82. R.A. Kroes, H. He, M.R. Emmett, C.L. Nilsson, F.E. Leach 3rd, I.J. Amster, A.G. Marshall, and J.R. Moskal Overexpression of ST6GalNAcV, a ganglioside-specific alpha2,6-sialyltransferase, inhibits glioma growth in vivo Proc. Natl. Acad. Sci. U. S. A. 107 2010 12646 12651
83. S. Zang, R. Guo, R. Xing, L. Zhang, W. Li, M. Zhao, J. Fang, F. Hu, B. Kang, Y. Ren, Y. Zhuang, S. Liu, R. Wang, X. Li, Y. Yu, J. Cheng, and Y. Lu Identification of differentially-expressed genes in intestinal gastric cancer by microarray analysis Genomics Proteomics Bioinformatics 12 2014 276 283
84. P.-H. Wang Altered glycosylation in cancer: sialic acids and sialyltransferases J. Cancer Mol. 1 2005 73 81
85. Y.I. Kawamura, M. Toyota, R. Kawashima, T. Hagiwara, H. Suzuki, K. Imai, Y. Shinomura, T. Tokino, R. Kannagi, and T. Dohi DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer Gastroenterology 135 2008 142 151 e143
86. P. Antony, M. Rose, A. Heidenreich, R. Knuchel, N.T. Gaisa, and E. Dahl Epigenetic inactivation of ST6GAL1 in human bladder cancer BMC Cancer 14 2014 901
87. M.K. Sethi, M. Thaysen-Andersen, J.T. Smith, M.S. Baker, N.H. Packer, W.S. Hancock, and S. Fanayan Comparative N-glycan profiling of colorectal cancer cell lines reveals unique bisecting GlcNAc and alpha-2,3-linked sialic acid determinants are associated with membrane proteins of the more metastatic/aggressive cell lines J. Proteome Res. 13 2014 277 288
88. L. He, C. Fan, A. Kapoor, A.J. Ingram, A.P. Rybak, R.C. Austin, J. Dickhout, J.C. Cutz, J. Scholey, and D. Tang Alpha-mannosidase 2C1 attenuates PTEN function in prostate cancer cells Nat. Commun. 2 2011 307
89. C. Tellez, M. McCarty, M. Ruiz, and M. Bar-Eli Loss of activator protein-2α results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma J. Biol. Chem. 278 2003 46632 46642
90. C.S. Tellez, D.W. Davis, V.G. Prieto, J.E. Gershenwald, M.M. Johnson, M.F. McCarty, and M. Bar-Eli Quantitative analysis of melanocytic tissue array reveals inverse correlation between activator protein-2[alpha] and protease-activated receptor-1 expression during melanoma progression J. Investig. Dermatol. 127 2006 387 393
91. M. Koslowski, Ö. Türeci, S. Biesterfeld, G. Seitz, C. Huber, and U. Sahin Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein β (C/EBPβ) isoform 2 J. Biol. Chem. 284 2009 28607 28615
92. B.L. Kagan, R.T. Henke, R. Cabal-Manzano, G.E. Stoica, Q. Nguyen, A. Wellstein, and A.T. Riegel Complex regulation of the fibroblast growth factor-binding protein in MDA-MB-468 breast cancer cells by CCAAT/enhancer-binding protein β Cancer Res. 63 2003 1696 1705
93. C.A. Zahnow CCAAT/enhancer-binding protein β: its role in breast cancer and associations with receptor tyrosine kinases Expert Rev. Mol. Med. 11 2009 e12-e12
94. P. Laurent-puig, O. Plomteux, O. Bluteau, F. Zinzindohoué, E. Jeannot, K. Dahan, A. Kartheuser, C. Chapusot, P.-h. Cugnenc, and J. Zucman-rossi Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability Gastroenterology 124 2003 1311 1314
95. T. Ninomiya, H. Yoshitake, S. Kiyofumi, O. Kyosuke, Y. Seitetsu, N. Hidekazu, T. Taiki, K. Masato, and I. Hiroshi Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma J. Hepatol. 25 1996 445 453
96. G. Lauc, A. Essafi, J.E. Huffman, C. Hayward, A. Knezevic, J.J. Kattla, O. Polasek, O. Gornik, V. Vitart, J.L. Abrahams, M. Pucic, M. Novokmet, I. Redzic, S. Campbell, S.H. Wild, F. Borovecki, W. Wang, I. Kolcic, L. Zgaga, U. Gyllensten, J.F. Wilson, A.F. Wright, N.D. Hastie, H. Campbell, P.M. Rudd, and I. Rudan Genomics meets glycomics - the first GWAS study of human N-glycome identifies HNF1alpha as a master regulator of plasma protein fucosylation PLoS Genet. 6 2010 e1001256