Complex regulation of the fibroblast growth factor-binding protein in MDA-MB-468 breast cancer cells by CCAAT/enhancer-binding protein β

Cancer Research

Volumn 63, Issue 7, 2003, Pages 1696-1705

  Kagan, Benjamin L ^a   Henke, Ralf T ^a   Cabal Manzano, Rafael ^a   Stoica, Gerald E ^a   Nguyen, Quang ^a   Wellstein, Anton ^a   Riegel, Anna Tate ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BINDING SITE; BREAST CARCINOMA; BREAST DEVELOPMENT; CANCER CELL; CANCER INVASION; CARCINOMA IN SITU; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA BINDING; EXTRACELLULAR MATRIX; GENE CONTROL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

BINDING SITES; BREAST NEOPLASMS; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM INVASIVENESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037382327     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Folkman, J., and Klagsburn, M. Angiogenic factors. Science (Wash. DC), 235: 442-447, 1987.
2. Liotta, L. A., Steeg, P. S., and Stetler-Stevenson, W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64: 327-336, 1991.
3. Folkman, J. How is blood vessel growth regulated in normal and neoplastic tissue? G. H. A. Clowes memorial Award lecture. Cancer Res., 46: 467-473, 1986.
4. Fidler, I. J., and Ellis, L. M. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell, 79: 185-188, 1994.
5. Baird, A., and Klagsbrun, M. The fibroblast growth factor family. Cancer Cells (Cold Spring Harbor), 3: 239-243, 1991.
6. Gospodarowicz, D., Ferrara, N., Schweigerer, L., and Neufeld, G. Structural characterization and biological functions of fibroblast growth factor. Endocr. Rev., 8: 95-114, 1987.
7. Vlodavsky, I., Folkman, J., Sullivan, R., Fridman, R., Ishai-Michaeli, R., Sasse, J., and Klagsbrun, M. Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc. Natl. Acad. Sci. USA, 84: 2292-2296, 1987.
8. Rogelj, S., Klagsbrun, M., Atzmon, R., Kurokawa, M., Haimovitz, A., Fuks, Z., and Vlodavsky, I. Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells. J. Cell Biol., 109: 823-831, 1989.
9. Saksela, O., Moscatelli, D., Sommer, A., and Rifkin, D. B. Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J. Cell Biol., 107: 743-751, 1988.
10. Kiefer, M. C., Stephans, J. C., Crawford, K., Okino, K., and Barr, P. J. Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor. Proc. Natl. Acad. Sci. USA, 87: 6985-6989, 1990.
11. Wu, D. Q., Kan, M. K., Sato, G. H., Okamoto, T., and Sato, J. D. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. J. Biol. Chem., 266: 16778-16785, 1991.
12. Czubayko, F., Smith, R. V., Chung, H. C., and Wellstein, A. Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors. J. Biol. Chem., 269: 28243-28248, 1994.
13. Tassi, E., Al-Attar, A., Aigner, A., Swift, M. R., McDonnell, K., Karavanov, A., and Wellstein, A. Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. J. Biol. Chem., 276: 40247-40253, 2001.
14. Czubayko, F., Liaudet-Coopman, E. D., Aigner, A., Tuveson, A. T., Berchem, G. J., and Wellstein, A. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. Nat. Med., 3: 1137-1140, 1997.
15. Kurtz, A., Wang, H. L., Darwiche, N., Harris, V., and Wellstein, A. Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis. Oncogene, 14: 2671-2681, 1997.
16. Harris, V. K., Coticchia, C. M., Kagan, B. L., Ahmad, S., Wellstein, A., and Riegel, A. T. Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways. J. Biol. Chem., 275: 10802-10811, 2000.
17. Harris, V. K., Liaudet-Coopman, E. D., Boyle, B. J., Wellstein, A., and Riegel, A. T. Phorbol ester-induced transcription of a fibroblast growth factor- binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements. J. Biol. Chem., 273: 19130-19139, 1998.
18. Poli, V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J. Biol. Chem., 273: 29279-29282, 1998.
19. Diehl, A. M. Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth. J. Biol. Chem., 273: 30843-30846, 1998.
20. Descombes, P., and Schibler, U. A liver-enriched transcriptional activator protein. LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell, 67: 569-579, 1991.
21. Descombes, P., Chojkler, M., Lichtsteiner, S., Falvey, E., and Schibler, U. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev., 4: 1541-1551, 1990.
22. Seagroves, T. N., Krnacik, S., Raught, B., Gay, J., Burgess-Beusse, B., Darlington, G. J., and Rosen, J. M. C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev., 12: 1917-1928, 1998.
23. Zahnow, C. A., Cardiff, R. D., Laucirica, R., Medina, D., and Rosen, J. M. A role for CCAAT/enhancer binding protein β-liver-enriched inhibitory protein in mammary epithelial cell proliferation. Cancer Res., 61: 261-269, 2001.
24. Zahnow, C. A., Younes, P., Laucirica, R., and Rosen, J. M. Overexpression of C/EBPβ-LIP, a naturally occurring, dominant- negative transcription factor, in human breast cancer. J. Natl. Cancer Inst., 89: 1887-1891, 1997.
25. D'Amico, T. A., and Harpole, D. H., Jr. Molecular biology of esophageal cancer. Chest Surg. Clin. N. Am., 10: 451-469, 2000.
26. Nemunaitis, J., and O'Brien. J. Head and neck cancer: gene therapy approaches. Part II: genes delivered. Expert Opin. Biol. Ther., 2: 311-324, 2002.
27. Sartorelli, A. C. The 1985 Walter Hubert lecture. Malignant cell differentiation as a potential therapeutic approach. Br. J. Cancer, 52: 293-302, 1985.
28. Sainsbury, J. R., Farndon, J. R., Needham, G. K., Malcolm, A. J., and Harris, A. L. Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet, 1: 1398-1402, 1987.
29. Piccart, M., Lohrisch, C., Di Leo, A., and Larsimont, D. The predictive value of HER2 in breast cancer. Oncology, 61(Suppl. 2): 73-82, 2001.
30. Unger, E. R., Budgeon, L. R., Myerson, D., and Brigati, D. J. Viral diagnosis by in situ hybridization. Description of a rapid simplified colorimetric method. Am. J. Surg. Pathol., 10: 1-8, 1986.
31. Panoskaltsis-Mortari, A., and Bucy, R. P. In situ hybridization with digoxigenin-labeled RNA probes: facts and artifacts. Biotechniques, 18: 300-307, 1995.
32. Baldino, F., Jr., Chesselet, M. F., and Lewis, M. E. High-resolution in situ hybridization histochemistry. Methods Enzymol., 168: 761-777, 1989.
33. Kozak, M. Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res., 9: 5233-5262, 1981.
34. Kozak, M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell, 44: 283-292, 1986.
35. Raja, R. H., Paterson, A. J., Shin, T. H., and Kudlow, J. E. Transcriptional regulation of the human transforming growth factor- α gene. Mol. Endocrinol., 5: 514-520, 1991.
36. Harris, V. K. Transcriptional regulation of the angiogenic factor FGF-BP in squamous cell carcinoma. Ph. D. Thesis. Washington, DC: Georgetown University, 1998.
37. Harris, V. K., Kagan, B. L., Ray, R., Coticchia, C. M., Liaudet-Coopman, E. D., Wellstein, A., and Tate Riegel, A. Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription. Oncogene, 20: 1730-1738, 2001.
38. Bonfil, R. D., Vinyals, A., Bustuoabad, O. D., Llorens, A., Benavides, F. J., Gonzalez-Garrigues, M., and Fabra, A. Stimulation of angiogenesis as an explanation of Matrigel-enhanced tumorigenicity. Int. J. Cancer, 58: 233-239, 1994.
39. Filmus, J., Pollak, M. N., Cailleau, R., and Buick, R. N. MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF. Biochem. Biophys. Res. Commun., 128: 898-905, 1985.
40. Shao, Z. M., Wu, J., Shen, Z. Z., and Barsky, S. H. Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines. Anticancer Res., 18: 1435-1439, 1998.
41. Davies, S. P., Reddy, H., Caivano, M., and Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J., 351: 95-105, 2000.
42. Kobayashi, E., Ando, K., Nakano, H., Iida, T., Ohno, H., Morimoto, M., and Tamaoki, T. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J. Antibiot. (Tokyo), 42: 1470-1474, 1989.
43. Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., and Lee, J. C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 364: 229-233, 1995.
44. Kumar, S., McDonnell, P. C., Gum, R. J., Hand, A. T., Lee, J. C., and Young, P. R. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun., 235: 533-538, 1997.
45. Duncia, J. V., Santella, J. B., III, Higley, C. A., Pitts, W. J., Wityak, J., Frietze, W. E., Rankin, F. W., Sun, J. H., Earl, R. A., Tabaka, A. C., Teleha, C. A., Blom, K. F., Favata, M. F., Manos, E. J., Daulerio, A. J., Stradley, D. A., Horiuchi, K., Copeland, R. A., Scherle, P. A., Trzaskos, J. M., Magolda, R. L., Trainor, G. L., Wexler, R. R., Hobbs, F. W., and Olson, R. E. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg. Med. Chem. Lett., 8: 2839-2844, 1998.
46. Amoui, M., Draber, P., and Draberova, L. Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc εRI- and Thy-1-mediated activation of rat basophilic leukemia cells. Eur. J. Immunol., 27: 1881-1886, 1997.
47. Harris, V. K., Coticchia, C. M., List, H. J., Wellstein, A., and Riegel, A. T. Mitogen-induced expression of the fibroblast growth factor-binding protein is transcriptionally repressed through a non-canonical E-box element. J. Biol. Chem., 275: 28539-28548, 2000.
48. Raingeaud, J., Whitmarsh, A. J., Barrett, T., Derijard, B., and Davis, R. J. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol, 16: 1247-1255, 1996.
49. Shaheen, R. M., Davis, D. W., Liu, W., Zebrowski, B. K., Wilson, M. R., Bucana, C. D., McConkey, D. J., McMahon, G., and Ellis, L. M. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res., 59: 5412-5416, 1999.
50. Brown, L. F., Berse, B., Jackman, R. W., Tognazzi, K., Manseau, E. J., Senger, D. R., and Dvorak, H. F. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res., 53: 4727-4735, 1993.
51. Berger, M. S., Locher, G. W., Saurer, S., Gullick, W. J., Waterfield, M. D., Groner, B., and Hynes, N. E. Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading. Cancer Res., 48: 1238-1243, 1988.
52. Guerin, M., Barrois, M., Terrier, M. J., Spielmann, M., and Riou, G. Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis. Oncogene Res., 3: 21-31, 1988.
53. van de Vijver, M. J., Peterse, J. L., Mooi, W. J., Wisman, P., Lomans, J., Dalesio, O., and Nusse, R. Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N. Engl. J. Med., 319: 1239-1245, 1988.
54. Paik, S. Clinical significance of erbB-2 (HER-2/neu) protein. Cancer Investig., 10: 575-579, 1992.
55. Efimova, T., LaCelle, P., Welter, J. F., and Eckert, R. L. Regulation of human involucrin promoter activity by a protein kinase C. Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J. Biol. Chem., 273: 24387-24395, 1998.
56. Nagao, M., Yamauchi, J., Kaziro, Y., and Itoh, H. Involvement of protein kinase C and Src family tyrosine kinase in Gαq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. J. Biol. Chem., 273: 22892-22898, 1998.
57. Lange, C. A., Richer, J. K., Shen, T., and Horwitz, K. B. Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways. J. Biol. Chem., 273: 31308-31316, 1998.
58. Hazzalin, C. A., Cano, E., Cuenda, A., Barratt, M. J., Cohen, P., and Mahadevan, L. C. p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient. Curr. Biol., 6: 1028-1031, 1996.
59. Talukder, A. H., Jorgensen, H. F., Mandal, M., Mishra, S. K., Vadlamudi, R. K., Clark, B. F., Mendelsohn, J., and Kumar, R. Regulation of elongation factor-1α expression by growth factors and anti-receptor blocking antibodies. J. Biol. Chem., 276: 5636-5642, 2001.
60. Hazzalin, C. A., Cuenda, A., Cano, E., Cohen, P., and Mahadevan, L. C. Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli. Oncogene, 15: 2321-2331, 1997.
61. Piwien-Pilipuk, G., Van Mater, D., Ross, S. E., MacDougald, O. A., and Schwartz, J. Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein β by modulating Akt and glycogen synthase kinase-3. J. Biol. Chem., 276: 19664-19671, 2001.
62. Lekstrom-Himes, J., and Xanthopoulos, K. G. Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J. Biol. Chem., 273: 28545-28548, 1998.
63. Engelman, J. A., Lisanti, M. P., and Scherer, P. E. Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J. Biol. Chem., 273: 32111-32120, 1998.
64. Derijard, B., Raingeaud, J., Barrett, T., Wu, I. H., Han, J., Ulevitch, R. J., and Davis, R. J. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science (Wash. DC), 267: 682-685, 1995.
65. Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., and Davis, R. J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem., 270: 7420-7426, 1995.
66. Wang, X. Z., and Ron, D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science (Wash. DC), 272: 1347-1349, 1996.
67. Mudgett, J. S., Ding, J., Guh-Siesel, L., Chartrain, N. A., Yang, L., Gopal, S., and Shen, M. M. Essential role for p38α mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. USA, 97: 10454-10459, 2000.
68. Jung, Y. D., Liu, W., Reinmuth, N., Ahmad, S. A., Fan, F., Gallick, G. E., and Ellis, L. M. Vascular endothelial growth factor is upregulated by interleukin-1 β in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. Angiogenesis, 4: 155-162, 2001.