-
1
-
-
77954883105
-
Near-infrared fluorescent probe for imaging of pancreatic beta cells
-
COI: 1:CAS:528:DC%2BC3cXotVeku74%3D, PID: 20583828
-
Reiner T, Kohler RH, Liew CW et al (2010) Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjug Chem 21:1362–1368
-
(2010)
Bioconjug Chem
, vol.21
, pp. 1362-1368
-
-
Reiner, T.1
Kohler, R.H.2
Liew, C.W.3
-
2
-
-
85017695158
-
Evaluation of Cu-64 and Ga-68 radiolabeled glucagon-like peptide-1 receptor agonists as PET tracers for pancreatic beta cell imaging
-
Bandara N, Zheleznyak A, Cherukuri K, et al. (2015) Evaluation of Cu-64 and Ga-68 radiolabeled glucagon-like peptide-1 receptor agonists as PET tracers for pancreatic beta cell imaging. Mol Imaging Biol
-
(2015)
Mol Imaging Biol
-
-
Bandara, N.1
Zheleznyak, A.2
Cherukuri, K.3
-
3
-
-
77956212073
-
What are the potential benefits of clinical beta-cell imaging in diabetes mellitus?
-
PID: 20146664
-
Goke B (2010) What are the potential benefits of clinical beta-cell imaging in diabetes mellitus? Curr Pharm Des 16:1547–1549
-
(2010)
Curr Pharm Des
, vol.16
, pp. 1547-1549
-
-
Goke, B.1
-
4
-
-
55649108628
-
Imaging the pancreas: from ex vivo to non-invasive technology
-
COI: 1:STN:280:DC%2BD1cjhvFKgug%3D%3D, PID: 18777169
-
Holmberg D, Ahlgren U (2008) Imaging the pancreas: from ex vivo to non-invasive technology. Diabetologia 51:2148–2154
-
(2008)
Diabetologia
, vol.51
, pp. 2148-2154
-
-
Holmberg, D.1
Ahlgren, U.2
-
6
-
-
77954988574
-
Imaging of beta-cell mass and function
-
COI: 1:CAS:528:DC%2BC3cXhtVWmu73J, PID: 20554742
-
Ichise M, Harris PE (2010) Imaging of beta-cell mass and function. J Nucl Med 51:1001–1004
-
(2010)
J Nucl Med
, vol.51
, pp. 1001-1004
-
-
Ichise, M.1
Harris, P.E.2
-
7
-
-
84859640488
-
F-18-Labelled exendin to image GLP-1 receptor-expressing tissues: from niche to blockbuster?
-
PID: 22170323
-
Boerman OC, Gotthardt M (2012) F-18-Labelled exendin to image GLP-1 receptor-expressing tissues: from niche to blockbuster? Eur J Nucl Med Mol Imaging 39:461–462
-
(2012)
Eur J Nucl Med Mol Imaging
, vol.39
, pp. 461-462
-
-
Boerman, O.C.1
Gotthardt, M.2
-
8
-
-
0022475906
-
The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom
-
COI: 1:STN:280:DyaL283kvVCgtw%3D%3D, PID: 3522324
-
Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS (1986) The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29:267–274
-
(1986)
Diabetologia
, vol.29
, pp. 267-274
-
-
Foulis, A.K.1
Liddle, C.N.2
Farquharson, M.A.3
Richmond, J.A.4
Weir, R.S.5
-
9
-
-
84940105815
-
Distinct roles of beta cell mass and function during type 1 diabetes onset and remission
-
COI: 1:CAS:528:DC%2BC2MXhtVSiu7fO, PID: 25605805
-
Chmelova H, Cohrs CM, Chouinard JA et al (2015) Distinct roles of beta cell mass and function during type 1 diabetes onset and remission. Diabetes 64:2148–2160
-
(2015)
Diabetes
, vol.64
, pp. 2148-2160
-
-
Chmelova, H.1
Cohrs, C.M.2
Chouinard, J.A.3
-
11
-
-
77953388365
-
Pancreatic islet plasticity interspecies comparison of islet architecture and composition
-
PID: 20657742
-
Steiner DJ, Kim A, Miller K, Hara M (2010) Pancreatic islet plasticity interspecies comparison of islet architecture and composition. Islets 2:135–145
-
(2010)
Islets
, vol.2
, pp. 135-145
-
-
Steiner, D.J.1
Kim, A.2
Miller, K.3
Hara, M.4
-
12
-
-
84872035827
-
Beta-cell mass and turnover in humans effects of obesity and aging
-
PID: 22875233
-
Saisho Y, Butler AE, Manesso E et al (2013) Beta-cell mass and turnover in humans effects of obesity and aging. Diabetes Care 36:111–117
-
(2013)
Diabetes Care
, vol.36
, pp. 111-117
-
-
Saisho, Y.1
Butler, A.E.2
Manesso, E.3
-
13
-
-
34250618363
-
In vivo multimodal imaging of transplanted pancreatic islets
-
COI: 1:CAS:528:DC%2BD28XhtFOitbnJ, PID: 17406265
-
Medarova Z, Evgenov NV, Dai G et al (2006) In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc 1:429–435
-
(2006)
Nat Protoc
, vol.1
, pp. 429-435
-
-
Medarova, Z.1
Evgenov, N.V.2
Dai, G.3
-
14
-
-
0025778295
-
Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons
-
COI: 1:CAS:528:DyaK3MXkt1OjtLc%3D, PID: 2040383
-
McCulloch DK, Koerker DJ, Kahn SE et al (1991) Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons. Diabetes 40:673–679
-
(1991)
Diabetes
, vol.40
, pp. 673-679
-
-
McCulloch, D.K.1
Koerker, D.J.2
Kahn, S.E.3
-
15
-
-
77956221358
-
Development of radiotracers for the determination of the beta-cell mass in vivo
-
COI: 1:CAS:528:DC%2BC3cXmvFCnt7g%3D, PID: 20146667
-
Brom M, Andraojc K, Oyen WJG et al (2010) Development of radiotracers for the determination of the beta-cell mass in vivo. Curr Pharm Des 16:1561–1567
-
(2010)
Curr Pharm Des
, vol.16
, pp. 1561-1567
-
-
Brom, M.1
Andraojc, K.2
Oyen, W.J.G.3
-
16
-
-
62449183526
-
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls
-
COI: 1:CAS:528:DC%2BD1MXktVynsr4%3D, PID: 19223416
-
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med 50:382–389
-
(2009)
J Nucl Med
, vol.50
, pp. 382-389
-
-
Goland, R.1
Freeby, M.2
Parsey, R.3
-
17
-
-
0019400455
-
The pancreatic islets in diabetes
-
COI: 1:STN:280:DyaL3M7gs1KlsQ%3D%3D, PID: 7006384
-
Gepts W, Lecompte PM (1981) The pancreatic islets in diabetes. Am J Med 70:105–115
-
(1981)
Am J Med
, vol.70
, pp. 105-115
-
-
Gepts, W.1
Lecompte, P.M.2
-
18
-
-
0942289897
-
Systematic screening of potential beta-cell imaging agents
-
COI: 1:CAS:528:DC%2BD2cXntVGgtg%3D%3D, PID: 14751228
-
Sweet IR, Cook DL, Lernmark A et al (2004) Systematic screening of potential beta-cell imaging agents. Biochem Biophys Res Commun 314:976–983
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 976-983
-
-
Sweet, I.R.1
Cook, D.L.2
Lernmark, A.3
-
19
-
-
0035487329
-
Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes
-
COI: 1:CAS:528:DC%2BD3MXntlGhur0%3D, PID: 11574403
-
Moore A, Bonner-Weir S, Weissleder R (2001) Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. Diabetes 50:2231–2236
-
(2001)
Diabetes
, vol.50
, pp. 2231-2236
-
-
Moore, A.1
Bonner-Weir, S.2
Weissleder, R.3
-
20
-
-
23044456342
-
In vitro and in vivo evaluation of novel glibenclamide derivatives as imaging agents for the non-invasive assessment of the pancreatic islet cell mass in animals and humans
-
COI: 1:CAS:528:DC%2BD2MXmslCmsb4%3D, PID: 16025400
-
Schneider S, Feilen PJ, Schreckenberger M et al (2005) In vitro and in vivo evaluation of novel glibenclamide derivatives as imaging agents for the non-invasive assessment of the pancreatic islet cell mass in animals and humans. Exp Clin Endocrinol Diabetes 113:388–395
-
(2005)
Exp Clin Endocrinol Diabetes
, vol.113
, pp. 388-395
-
-
Schneider, S.1
Feilen, P.J.2
Schreckenberger, M.3
-
21
-
-
38349073954
-
VMAT2 gene expression and function as it applies to imaging beta-cell mass
-
COI: 1:CAS:528:DC%2BD1cXlt1amtg%3D%3D, PID: 17665159
-
Harris PE, Ferrara C, Barba P et al (2008) VMAT2 gene expression and function as it applies to imaging beta-cell mass. J Mol Med 86:5–16
-
(2008)
J Mol Med
, vol.86
, pp. 5-16
-
-
Harris, P.E.1
Ferrara, C.2
Barba, P.3
-
22
-
-
33745221211
-
Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model
-
COI: 1:CAS:528:DC%2BD28XlsFWrtLg%3D, PID: 16710474
-
Souza F, Simpson N, Raffo A et al (2006) Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest 116:1506–1513
-
(2006)
J Clin Invest
, vol.116
, pp. 1506-1513
-
-
Souza, F.1
Simpson, N.2
Raffo, A.3
-
23
-
-
84855473709
-
Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands
-
COI: 1:CAS:528:DC%2BC38Xkt1KqtA%3D%3D, PID: 22143775
-
Virostko J, Henske J, Vinet L et al (2011) Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands. Proc Natl Acad Sci U S A 108:20719–20724
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 20719-20724
-
-
Virostko, J.1
Henske, J.2
Vinet, L.3
-
24
-
-
79961244260
-
Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog
-
COI: 1:CAS:528:DC%2BC3MXhtVenu7fI, PID: 21768367
-
Reiner T, Thurber G, Gaglia J et al (2011) Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A 108:12815–12820
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 12815-12820
-
-
Reiner, T.1
Thurber, G.2
Gaglia, J.3
-
25
-
-
84870985165
-
Imaging of beta-cell mass and insulitis in insulin-dependent (type 1) diabetes mellitus
-
PID: 22889646
-
Di Gialleonardo V, de Vries EF, Di Girolamo M et al (2012) Imaging of beta-cell mass and insulitis in insulin-dependent (type 1) diabetes mellitus. Endocr Rev 33:892–919
-
(2012)
Endocr Rev
, vol.33
, pp. 892-919
-
-
Di Gialleonardo, V.1
de Vries, E.F.2
Di Girolamo, M.3
-
26
-
-
34748871424
-
Partial volume correction of standardized uptake values and the dual time point in FDG-PET imaging: should these be routinely employed in assessing patients with cancer?
-
PID: 17522857
-
Basu S, Alavi A (2007) Partial volume correction of standardized uptake values and the dual time point in FDG-PET imaging: should these be routinely employed in assessing patients with cancer? Eur J Nucl Med Mol Imaging 34:1527–1529
-
(2007)
Eur J Nucl Med Mol Imaging
, vol.34
, pp. 1527-1529
-
-
Basu, S.1
Alavi, A.2
-
27
-
-
34047192093
-
Novel quantitative techniques for assessing regional and global function and structure based on modern imaging modalities: implications for normal variation, aging and diseased states
-
PID: 17418154
-
Basu S, Zaidi H, Houseni M et al (2007) Novel quantitative techniques for assessing regional and global function and structure based on modern imaging modalities: implications for normal variation, aging and diseased states. Semin Nucl Med 37:223–239
-
(2007)
Semin Nucl Med
, vol.37
, pp. 223-239
-
-
Basu, S.1
Zaidi, H.2
Houseni, M.3
-
28
-
-
0023223873
-
Positron emission tomography in aging and dementia: effect of cerebral atrophy
-
COI: 1:STN:280:DyaL2s7pslKisA%3D%3D, PID: 3494824
-
Chawluk JB, Alavi A, Dann R et al (1987) Positron emission tomography in aging and dementia: effect of cerebral atrophy. J Nucl Med 28:431–437
-
(1987)
J Nucl Med
, vol.28
, pp. 431-437
-
-
Chawluk, J.B.1
Alavi, A.2
Dann, R.3
-
29
-
-
0036454017
-
Use of a corrected standardized uptake value based on the lesion size on CT permits accurate characterization of lung nodules on FDG-PET
-
PID: 12458399
-
Hickeson M, Yun MJ, Matthies A et al (2002) Use of a corrected standardized uptake value based on the lesion size on CT permits accurate characterization of lung nodules on FDG-PET. Eur J Nucl Med Mol Imaging 29:1639–1647
-
(2002)
Eur J Nucl Med Mol Imaging
, vol.29
, pp. 1639-1647
-
-
Hickeson, M.1
Yun, M.J.2
Matthies, A.3
-
30
-
-
67651177441
-
A recovery coefficient method for partial volume correction of PET images
-
PID: 19367446
-
Srinivas SM, Dhurairaj T, Basu S et al (2009) A recovery coefficient method for partial volume correction of PET images. Ann Nucl Med 23:341–348
-
(2009)
Ann Nucl Med
, vol.23
, pp. 341-348
-
-
Srinivas, S.M.1
Dhurairaj, T.2
Basu, S.3
-
31
-
-
0025957221
-
Analysis of brain and cerebrospinal-fluid volumes with MR imaging: impact on PET data correction for atrophy. Part II. Aging and Alzheimer dementia
-
COI: 1:STN:280:DyaK3M%2FnsV2ltg%3D%3D, PID: 1984290
-
Tanna NK, Kohn MI, Horwich DN et al (1991) Analysis of brain and cerebrospinal-fluid volumes with MR imaging: impact on PET data correction for atrophy. Part II. Aging and Alzheimer dementia. Radiology 178:123–130
-
(1991)
Radiology
, vol.178
, pp. 123-130
-
-
Tanna, N.K.1
Kohn, M.I.2
Horwich, D.N.3
-
32
-
-
6044234743
-
Non-invasive imaging of beta cell mass: a quantitative analysis
-
PID: 15628819
-
Sweet IR, Cook DL, Lernmark A et al (2004) Non-invasive imaging of beta cell mass: a quantitative analysis. Diabetes Technol Ther 6:652–659
-
(2004)
Diabetes Technol Ther
, vol.6
, pp. 652-659
-
-
Sweet, I.R.1
Cook, D.L.2
Lernmark, A.3
-
33
-
-
84876721784
-
Efficient 18F-labeling of synthetic exendin-4 analogues for imaging beta cells
-
COI: 1:CAS:528:DC%2BC38Xht1KitL%2FE, PID: 23997998
-
Keliher EJ, Reiner T, Thurber GM et al (2012) Efficient 18F-labeling of synthetic exendin-4 analogues for imaging beta cells. ChemistryOpen 1:177–183
-
(2012)
ChemistryOpen
, vol.1
, pp. 177-183
-
-
Keliher, E.J.1
Reiner, T.2
Thurber, G.M.3
-
34
-
-
84904427412
-
In vivo imaging of GLP-1R with a targeted bimodal PET/fluorescence imaging agent
-
COI: 1:CAS:528:DC%2BC2cXosFait7Y%3D, PID: 24856928
-
Brand C, Abdel-Atti D, Zhang Y et al (2014) In vivo imaging of GLP-1R with a targeted bimodal PET/fluorescence imaging agent. Bioconjug Chem 25:1323–1330
-
(2014)
Bioconjug Chem
, vol.25
, pp. 1323-1330
-
-
Brand, C.1
Abdel-Atti, D.2
Zhang, Y.3
-
35
-
-
0026648961
-
Isolation and characterization of exendin-4, an exendin-3 analog, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
-
COI: 1:CAS:528:DyaK38XktVantbw%3D, PID: 1313797
-
Eng J, Kleinman WA, Singh L et al (1992) Isolation and characterization of exendin-4, an exendin-3 analog, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 267:7402–7405
-
(1992)
J Biol Chem
, vol.267
, pp. 7402-7405
-
-
Eng, J.1
Kleinman, W.A.2
Singh, L.3
-
36
-
-
33751515577
-
A new technique for in vivo imaging of specific GLP-1 binding sites: first results in small rodents
-
COI: 1:CAS:528:DC%2BD28Xht12rsLjO, PID: 16930741
-
Gotthardt M, Lalyko G, van Eerd-Vismale J et al (2006) A new technique for in vivo imaging of specific GLP-1 binding sites: first results in small rodents. Regul Pept 137:162–167
-
(2006)
Regul Pept
, vol.137
, pp. 162-167
-
-
Gotthardt, M.1
Lalyko, G.2
van Eerd-Vismale, J.3
-
37
-
-
0027184119
-
Exendin-4 is a high potency agonist and truncated exendin-(9–39)-amide an antagonist at the glucagon-like peptide 1-(7–36)-amide receptor of insulin-secreting beta-cells
-
COI: 1:STN:280:DyaK3sznsV2lsw%3D%3D, PID: 8396143
-
Goke R, Fehmann HC, Linn T et al (1993) Exendin-4 is a high potency agonist and truncated exendin-(9–39)-amide an antagonist at the glucagon-like peptide 1-(7–36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 268:19650–19655
-
(1993)
J Biol Chem
, vol.268
, pp. 19650-19655
-
-
Goke, R.1
Fehmann, H.C.2
Linn, T.3
-
38
-
-
0028883257
-
Reduction of the incretin effect in rats by the glucagon-like peptide-1 receptor antagonist exendin(9–39) amide
-
COI: 1:CAS:528:DyaK2MXivVyitLg%3D, PID: 7813808
-
Kolligs F, Fehmann HC, Goke R, Goke B (1995) Reduction of the incretin effect in rats by the glucagon-like peptide-1 receptor antagonist exendin(9–39) amide. Diabetes 44:16–19
-
(1995)
Diabetes
, vol.44
, pp. 16-19
-
-
Kolligs, F.1
Fehmann, H.C.2
Goke, R.3
Goke, B.4
-
39
-
-
0036232690
-
Use of the incretin hormone glucagon-like peptide-1 (GLP-1) for the detection of insulinomas: initial experimental results
-
COI: 1:CAS:528:DC%2BD38XkvFSns74%3D, PID: 11976797
-
Gotthardt M, Fischer M, Naeher I et al (2002) Use of the incretin hormone glucagon-like peptide-1 (GLP-1) for the detection of insulinomas: initial experimental results. Eur J Nucl Med Mol Imaging 29:597–606
-
(2002)
Eur J Nucl Med Mol Imaging
, vol.29
, pp. 597-606
-
-
Gotthardt, M.1
Fischer, M.2
Naeher, I.3
-
40
-
-
34250722229
-
[Lys(40)(Ahx-DTPA-In-111)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma
-
COI: 1:CAS:528:DC%2BD2sXmsFCqu70%3D, PID: 17575235
-
Wicki A, Wild D, Storch D et al (2007) [Lys(40)(Ahx-DTPA-In-111)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma. Clin Cancer Res 13:3696–3705
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3696-3705
-
-
Wicki, A.1
Wild, D.2
Storch, D.3
-
41
-
-
84896395302
-
64Cu- and 68Ga-labelled [Nle(14), Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats
-
PID: 24101374
-
Mikkola K, Yim CB, Fagerholm V et al (2014) 64Cu- and 68Ga-labelled [Nle(14), Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats. Mol Imaging Biol 16:255–263
-
(2014)
Mol Imaging Biol
, vol.16
, pp. 255-263
-
-
Mikkola, K.1
Yim, C.B.2
Fagerholm, V.3
-
42
-
-
77954986457
-
Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT
-
COI: 1:CAS:528:DC%2BC3cXhtVWmu73F, PID: 20595511
-
Wild D, Wicki A, Mansi R et al (2010) Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT. J Nucl Med 51:1059–1067
-
(2010)
J Nucl Med
, vol.51
, pp. 1059-1067
-
-
Wild, D.1
Wicki, A.2
Mansi, R.3
-
43
-
-
84923230371
-
Dual-purpose linker for alpha helix stabilization and imaging agent conjugation to glucagon-like peptide-1 receptor ligands
-
COI: 1:CAS:528:DC%2BC2MXovFGnsw%3D%3D, PID: 25594741
-
Zhang L, Navaratna T, Liao JS, Thurber GM (2015) Dual-purpose linker for alpha helix stabilization and imaging agent conjugation to glucagon-like peptide-1 receptor ligands. Bioconjug Chem 26:329–337
-
(2015)
Bioconjug Chem
, vol.26
, pp. 329-337
-
-
Zhang, L.1
Navaratna, T.2
Liao, J.S.3
Thurber, G.M.4
-
44
-
-
80053493999
-
PET of insulinoma using F-18-FBEM-EM3106B, a new GLP-1 analogue
-
COI: 1:CAS:528:DC%2BC3MXhtVemu73F, PID: 21800885
-
Gao HK, Niu G, Yang M et al (2011) PET of insulinoma using F-18-FBEM-EM3106B, a new GLP-1 analogue. Mol Pharm 8:1775–1782
-
(2011)
Mol Pharm
, vol.8
, pp. 1775-1782
-
-
Gao, H.K.1
Niu, G.2
Yang, M.3
-
46
-
-
79955014687
-
Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics
-
COI: 1:CAS:528:DC%2BC3MXjtV2mu74%3D, PID: 21401109
-
Kim TH, Jiang HH, Lee S et al (2011) Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics. Bioconjug Chem 22:625–632
-
(2011)
Bioconjug Chem
, vol.22
, pp. 625-632
-
-
Kim, T.H.1
Jiang, H.H.2
Lee, S.3
-
47
-
-
84869748023
-
Site-specific PEGylated exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects
-
COI: 1:CAS:528:DC%2BC38Xhs1Wjt7bM, PID: 23116483
-
Kim TH, Jiang HH, Lim SM et al (2012) Site-specific PEGylated exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects. Bioconjug Chem 23:2214–2220
-
(2012)
Bioconjug Chem
, vol.23
, pp. 2214-2220
-
-
Kim, T.H.1
Jiang, H.H.2
Lim, S.M.3
-
48
-
-
0029117847
-
Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas
-
COI: 1:CAS:528:DyaK2MXnsVyju7s%3D, PID: 7646446
-
Widmann C, Dolci W, Thorens B (1995) Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas. Biochem J 310(Pt 1):203–214
-
(1995)
Biochem J
, vol.310
, pp. 203-214
-
-
Widmann, C.1
Dolci, W.2
Thorens, B.3
-
49
-
-
52549121490
-
Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability
-
COI: 1:CAS:528:DC%2BD1cXhtFCgu7jI, PID: 18408925
-
Schmidt MM, Thurber GM, Wittrup KD (2008) Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability. Cancer Immunol Immunother 57:1879–1890
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 1879-1890
-
-
Schmidt, M.M.1
Thurber, G.M.2
Wittrup, K.D.3
-
50
-
-
84871717195
-
A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies
-
PID: 23009555
-
Oliveira S, Cohen R, Walsum MS et al (2012) A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies. EJNMMI Res 2:50
-
(2012)
EJNMMI Res
, vol.2
, pp. 50
-
-
Oliveira, S.1
Cohen, R.2
Walsum, M.S.3
-
51
-
-
45549086826
-
Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
-
COI: 1:CAS:528:DC%2BD1cXkvVSgtr4%3D, PID: 18287102
-
Runge S, Thogersen H, Madsen K et al (2008) Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem 283:11340–11347
-
(2008)
J Biol Chem
, vol.283
, pp. 11340-11347
-
-
Runge, S.1
Thogersen, H.2
Madsen, K.3
-
52
-
-
79953219749
-
Rational approach to select small peptide molecular probes labeled with fluorescent cyanine dyes for in vivo optical imaging
-
COI: 1:CAS:528:DC%2BC3MXivVChur4%3D, PID: 21329363
-
Berezin MY, Guo K, Akers W et al (2011) Rational approach to select small peptide molecular probes labeled with fluorescent cyanine dyes for in vivo optical imaging. Biochemistry 50:2691–2700
-
(2011)
Biochemistry
, vol.50
, pp. 2691-2700
-
-
Berezin, M.Y.1
Guo, K.2
Akers, W.3
-
53
-
-
80052841941
-
A systems approach for tumor pharmacokinetics
-
Thurber GM, Weissleder R (2011) A systems approach for tumor pharmacokinetics. PLoS ONE 6
-
(2011)
PLoS ONE
, pp. 6
-
-
Thurber, G.M.1
Weissleder, R.2
-
54
-
-
84930171216
-
Multichannel imaging to quantify four classes of pharmacokinetic distribution in tumors
-
COI: 1:CAS:528:DC%2BC2cXhtFygtrbI, PID: 25048378
-
Bhatnagar S, Deschenes E, Liao JS et al (2014) Multichannel imaging to quantify four classes of pharmacokinetic distribution in tumors. J Pharm Sci 103:3276–3286
-
(2014)
J Pharm Sci
, vol.103
, pp. 3276-3286
-
-
Bhatnagar, S.1
Deschenes, E.2
Liao, J.S.3
-
55
-
-
84895190840
-
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential
-
COI: 1:CAS:528:DC%2BC3sXhs1ykt73E, PID: 24152968
-
Fujita H, Morii T, Fujishima H et al (2014) The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential. Kidney Int 85:579–589
-
(2014)
Kidney Int
, vol.85
, pp. 579-589
-
-
Fujita, H.1
Morii, T.2
Fujishima, H.3
-
56
-
-
84862944057
-
Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats
-
COI: 1:CAS:528:DC%2BC38XjtVSltL0%3D, PID: 22025647
-
Liu WJ, Xie SH, Liu YN et al (2012) Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 340:248–255
-
(2012)
J Pharmacol Exp Ther
, vol.340
, pp. 248-255
-
-
Liu, W.J.1
Xie, S.H.2
Liu, Y.N.3
-
57
-
-
84897852105
-
GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody
-
PID: 24467746
-
Pyke C, Heller RS, Kirk RK et al (2014) GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody. Endocrinology 155:1280–1290
-
(2014)
Endocrinology
, vol.155
, pp. 1280-1290
-
-
Pyke, C.1
Heller, R.S.2
Kirk, R.K.3
-
58
-
-
84938414413
-
Glucagon-like-peptide-1 receptor expression in normal and diseased human thyroid and pancreas
-
PID: 25216224
-
Waser B, Blank A, Karamitopoulou E et al (2015) Glucagon-like-peptide-1 receptor expression in normal and diseased human thyroid and pancreas. Mod Pathol 28:391–402
-
(2015)
Mod Pathol
, vol.28
, pp. 391-402
-
-
Waser, B.1
Blank, A.2
Karamitopoulou, E.3
-
59
-
-
77958603882
-
Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist
-
Wang QH, Chen K, Liu R et al (2010) Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. PLoS One 5:9
-
(2010)
PLoS One
, vol.5
, pp. 9
-
-
Wang, Q.H.1
Chen, K.2
Liu, R.3
-
60
-
-
84895198774
-
Novel exenatide analogs with peptidic albumin binding domains: potent anti-diabetic agents with extended duration of action
-
PID: 24503632
-
Levy OE, Jodka CM, Ren SS et al (2014) Novel exenatide analogs with peptidic albumin binding domains: potent anti-diabetic agents with extended duration of action. PLoS One 9:e87704
-
(2014)
PLoS One
, vol.9
, pp. 87704
-
-
Levy, O.E.1
Jodka, C.M.2
Ren, S.S.3
-
61
-
-
77952756104
-
Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein
-
COI: 1:CAS:528:DC%2BC3cXoslyltbc%3D, PID: 20503261
-
Glaesner W, Vick AM, Millican R et al (2010) Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein. Diabetes Metab Res Rev 26:287–296
-
(2010)
Diabetes Metab Res Rev
, vol.26
, pp. 287-296
-
-
Glaesner, W.1
Vick, A.M.2
Millican, R.3
-
62
-
-
38749139878
-
Factors determining antibody distribution in tumors
-
COI: 1:CAS:528:DC%2BD1cXhslOjsLw%3D, PID: 18179828
-
Thurber GM, Schmidt MM, Wittrup KD (2008) Factors determining antibody distribution in tumors. Trends Pharmacol Sci 29:57–61
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 57-61
-
-
Thurber, G.M.1
Schmidt, M.M.2
Wittrup, K.D.3
-
63
-
-
84855322440
-
Techniques for molecular imaging probe design
-
COI: 1:CAS:528:DC%2BC38XitlGgu7c%3D, PID: 22201532
-
Reynolds F, Kelly KA (2011) Techniques for molecular imaging probe design. Mol Imaging 10:407–419
-
(2011)
Mol Imaging
, vol.10
, pp. 407-419
-
-
Reynolds, F.1
Kelly, K.A.2
-
64
-
-
0028117154
-
Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells
-
COI: 1:CAS:528:DyaK2cXltVeiurc%3D, PID: 8306261
-
Mattes MJ, Griffiths G, Diril H et al (1994) Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells. Cancer 73:787–793
-
(1994)
Cancer
, vol.73
, pp. 787-793
-
-
Mattes, M.J.1
Griffiths, G.2
Diril, H.3
-
65
-
-
34250732525
-
[Lys(40) (Ahx-DTPA-In-111)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting
-
COI: 1:CAS:528:DC%2BD2sXksFKntw%3D%3D, PID: 17138746
-
Wild D, Behe M, Wicki A et al (2006) [Lys(40) (Ahx-DTPA-In-111)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting. J Nucl Med 47:2025–2033
-
(2006)
J Nucl Med
, vol.47
, pp. 2025-2033
-
-
Wild, D.1
Behe, M.2
Wicki, A.3
-
66
-
-
84890087174
-
Real-time trafficking and signaling of the glucagon-like peptide-1 receptor
-
COI: 1:CAS:528:DC%2BC2cXlt1ajtQ%3D%3D, PID: 24275181
-
Roed SN, Wismann P, Underwood CR et al (2014) Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. Mol Cell Endocrinol 382:938–949
-
(2014)
Mol Cell Endocrinol
, vol.382
, pp. 938-949
-
-
Roed, S.N.1
Wismann, P.2
Underwood, C.R.3
-
67
-
-
71149111180
-
Functional characterization of N-terminally GFP-tagged GLP-1 receptor
-
Bavec A, Licar A (2009) Functional characterization of N-terminally GFP-tagged GLP-1 receptor. J Biomed Biotechnol
-
(2009)
J Biomed Biotechnol
-
-
Bavec, A.1
Licar, A.2
-
68
-
-
70350234894
-
A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
-
COI: 1:CAS:528:DC%2BD1MXht1Cqur7K, PID: 19825804
-
Schmidt MM, Wittrup KD (2009) A modeling analysis of the effects of molecular size and binding affinity on tumor targeting. Mol Cancer Ther 8:2861
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2861
-
-
Schmidt, M.M.1
Wittrup, K.D.2
-
69
-
-
79953708503
-
Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
-
COI: 1:CAS:528:DC%2BC3MXivFyksL0%3D, PID: 21170526
-
Vegt E, Melis M, Eek A et al (2011) Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice. Eur J Nucl Med Mol Imaging 38:623–632
-
(2011)
Eur J Nucl Med Mol Imaging
, vol.38
, pp. 623-632
-
-
Vegt, E.1
Melis, M.2
Eek, A.3
-
70
-
-
34447336118
-
64Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression
-
COI: 1:CAS:528:DC%2BD2sXhtVertL7F, PID: 17574975
-
Li ZB, Cai WB, Cao QZ et al (2007) 64Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med 48:1162–1171
-
(2007)
J Nucl Med
, vol.48
, pp. 1162-1171
-
-
Li, Z.B.1
Cai, W.B.2
Cao, Q.Z.3
-
71
-
-
27944452698
-
Near-infrared fluorescent RGD peptides for optical imaging of integrin alpha(v)beta 3 expression in living mice
-
COI: 1:CAS:528:DC%2BD2MXhtFGmtLjL, PID: 16287239
-
Cheng Z, Wu Y, Xiong ZM et al (2005) Near-infrared fluorescent RGD peptides for optical imaging of integrin alpha(v)beta 3 expression in living mice. Bioconjug Chem 16:1433–1441
-
(2005)
Bioconjug Chem
, vol.16
, pp. 1433-1441
-
-
Cheng, Z.1
Wu, Y.2
Xiong, Z.M.3
-
72
-
-
84899980586
-
Alternative non-antibody protein scaffolds for molecular imaging of cancer
-
Stern LA, Case BA, Hackel BJ (2013) Alternative non-antibody protein scaffolds for molecular imaging of cancer. Curr Opin Chem Eng 2
-
(2013)
Curr Opin Chem Eng
, pp. 2
-
-
Stern, L.A.1
Case, B.A.2
Hackel, B.J.3
-
73
-
-
84883442008
-
Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma
-
COI: 1:CAS:528:DC%2BC3sXhsVKks7bF, PID: 23950221
-
Moore SJ, Gephart MGH, Bergen JM et al (2013) Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma. Proc Natl Acad Sci U S A 110:14598–14603
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 14598-14603
-
-
Moore, S.J.1
Gephart, M.G.H.2
Bergen, J.M.3
-
74
-
-
84946569926
-
-
Residualization rates of near-infrared dyes for the rational design of molecular imaging agents, Mol Imaging Biol
-
Cilliers C, Liao J, Atangcho L, Thurber GM (2015) Residualization rates of near-infrared dyes for the rational design of molecular imaging agents. Mol Imaging Biol
-
(2015)
Thurber GM
-
-
Cilliers, C.1
Liao, J.2
Atangcho, L.3
-
75
-
-
84901356899
-
Optimizing the bioavailability of small molecular optical imaging probes by conjugation to an albumin affinity tag
-
COI: 1:CAS:528:DC%2BC2cXpvFKis74%3D, PID: 24815420
-
Hahnenkamp A, Alsibai W, Bremer C, Holtke C (2014) Optimizing the bioavailability of small molecular optical imaging probes by conjugation to an albumin affinity tag. J Control Release 186:32–40
-
(2014)
J Control Release
, vol.186
, pp. 32-40
-
-
Hahnenkamp, A.1
Alsibai, W.2
Bremer, C.3
Holtke, C.4
-
76
-
-
84964285745
-
Bicyclic peptides conjugated to an albumin-binding tag diffuse efficiently into solid tumors
-
COI: 1:CAS:528:DC%2BC2MXnslWnsg%3D%3D, PID: 25381263
-
Pollaro L, Raghunathan S, Morales-Sanfrutos J et al (2015) Bicyclic peptides conjugated to an albumin-binding tag diffuse efficiently into solid tumors. Mol Cancer Ther 14:151–161
-
(2015)
Mol Cancer Ther
, vol.14
, pp. 151-161
-
-
Pollaro, L.1
Raghunathan, S.2
Morales-Sanfrutos, J.3
-
77
-
-
84914819810
-
Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions
-
COI: 1:CAS:528:DC%2BC2cXhsFWitrbO, PID: 25209466
-
Geng SB, Cheung JK, Narasimhan C et al (2014) Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions. J Pharm Sci 103:3356–3363
-
(2014)
J Pharm Sci
, vol.103
, pp. 3356-3363
-
-
Geng, S.B.1
Cheung, J.K.2
Narasimhan, C.3
-
78
-
-
84869840045
-
A strategy for risk mitigation of antibodies with fast clearance
-
PID: 23778268
-
Hotzel I, Theil FP, Bernstein LJ et al (2012) A strategy for risk mitigation of antibodies with fast clearance. MAbs 4:753–760
-
(2012)
MAbs
, vol.4
, pp. 753-760
-
-
Hotzel, I.1
Theil, F.P.2
Bernstein, L.J.3
-
79
-
-
84861861669
-
Tumor targeting using affibody molecules: interplay of affinity, target expression level, and binding site composition
-
COI: 1:CAS:528:DC%2BC38XhtVyntL3L, PID: 22586147
-
Tolmachev V, Tran TA, Rosik D et al (2012) Tumor targeting using affibody molecules: interplay of affinity, target expression level, and binding site composition. J Nucl Med 53:953–960
-
(2012)
J Nucl Med
, vol.53
, pp. 953-960
-
-
Tolmachev, V.1
Tran, T.A.2
Rosik, D.3
-
80
-
-
84918566063
-
Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach
-
COI: 1:CAS:528:DC%2BC2cXitVOht7zN, PID: 25344226
-
Samkoe KS, Tichauer KM, Gunn JR et al (2014) Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach. Cancer Res 74:7465–7474
-
(2014)
Cancer Res
, vol.74
, pp. 7465-7474
-
-
Samkoe, K.S.1
Tichauer, K.M.2
Gunn, J.R.3
-
81
-
-
23044438069
-
Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass
-
COI: 1:CAS:528:DC%2BD2MXmslCmsLc%3D, PID: 16025399
-
Hampe CS, Wallen AR, Schlosser M et al (2005) Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass. Exp Clin Endocrinol Diabetes 113:381–387
-
(2005)
Exp Clin Endocrinol Diabetes
, vol.113
, pp. 381-387
-
-
Hampe, C.S.1
Wallen, A.R.2
Schlosser, M.3
-
82
-
-
84888376674
-
Sphingomyelin patches on pancreatic beta-cells are indicative of insulin secretory capacity
-
COI: 1:CAS:528:DC%2BC2cXhslOhtA%3D%3D, PID: 23920110
-
Kavishwar A, Moore A (2013) Sphingomyelin patches on pancreatic beta-cells are indicative of insulin secretory capacity. J Histochem Cytochem 61:910–919
-
(2013)
J Histochem Cytochem
, vol.61
, pp. 910-919
-
-
Kavishwar, A.1
Moore, A.2
|