Development and validation of a high performance liquid chromatographic-mass spectrometry method for the simultaneous quantification of 10 trichothecenes in ultra-high temperature processed cow milk

Journal of Chromatography A

Volumn 1419, Issue , 2015, Pages 37-44

  Flores Flores, Myra E ^a   González Peñas, Elena ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

LC MS MS; Milk; Mycotoxin; Trichothecenes; UHT cow milk

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SODIUM COMPOUNDS;

COW MILK; LC-MS/MS; MILK; MYCOTOXIN; TRICHOTHECENES;

DAIRIES;

15 ACETYLDEOXYNIVALENOL; 3 ACETYLDEOXYNIVALENOL; ACETIC ACID; ACETONITRILE; DEEPOXY DEOXYNIVALENOL; DIACETOXYSCIRPENOL; FORMIC ACID; FUSARENON X; HT 2 TOXIN; NEOSOLANIOL; NIVALENOL; T 2 TOXIN; TRICHOTHECENE DERIVATIVE; UNCLASSIFIED DRUG; VOMITOXIN;

ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MASS SPECTROMETRY; MEASUREMENT PRECISION; MILK; PRIORITY JOURNAL; PURIFICATION; SEPARATION TECHNIQUE; VALIDATION PROCESS; ANIMAL; CHEMISTRY; HEAT; PROCEDURES; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HOT TEMPERATURE; LIMIT OF DETECTION; MILK; TANDEM MASS SPECTROMETRY; TRICHOTHECENES;

EID: 84955662951     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2015.09.069     Document Type: Article

References (40)

1. Binder E.M. Managing the risk of mycotoxins in modern feed production. Anim. Feed Sci. Technol. 2007, 133:149-166. 10.1016/j.anifeedsci.2006.08.008.
2. Joint Research Centre - European Commission European Union Reference Laboratories (EURL)-Mycotoxins 2014, Available at: https://ec.europa.eu/jrc/en/eurl/mycotoxins (Accessed 29.5.15).
3. Wu F., Groopman J.D., Pestka J.J. Public health impacts of foodborne mycotoxins. Annu. Rev. Food Sci. Technol. 2014, 5:351-372. 10.1146/annurev-food-030713-092431.
4. Hussein H.S., Brasel J.M. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 2001, 167:101-134. 10.1016/S0300-483X(01)00471-1.
5. Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 2002, 127:19-28. 10.1016/S0378-4274(01)00479-9.
6. Cavret S., Lecoeur S. Fusariotoxin transfer in animal. Food Chem. Toxicol. 2006, 44:444-453. 10.1016/j.fct.2005.08.021.
7. Broekaert N., Devreese M., De Baere S., De Backer P., Croubels S. Modified Fusarium mycotoxins unmasked: from occurrence in cereals to animal and human excretion. Food Chem. Toxicol. 2015, 80:17-31. 10.1016/j.fct.2015.02.015.
8. Placinta C.M., D'Mello J.P.F., Macdonald A.M.C. A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins. Anim. Feed Sci. Technol. 1999, 78:21-37. 10.1016/S0377-8401(98)00278-8.
9. Sun Y., Zhang G., Zhao H., Zheng J., Hu F., Fang B. Liquid chromatography-tandem mass spectrometry method for toxicokinetics, tissue distribution, and excretion studies of T-2 toxin and its major metabolites in pigs. J. Chromatogr. B 2014, 958:75-82. 10.1016/j.jchromb.2014.03.010.
10. European Food Safety Authority Scientific opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed. EFSA Panel on Contaminants in the Food Chain (CONTAM). Parma, Italy. EFSA J. 2011, 9:2481. Available at: http://www.efsa.europa.eu/en/efsajournal/doc/2481.pdf .
11. Capriotti A.L., Caruso G., Cavaliere C., Foglia P., Samperi R., Lagana A. Multiclass mycotoxin analysis in food, environmental and biological matrices with chromatography/mass spectrometry. Mass Spectrom. Rev. 2012, 31:466-503. 10.1002/mas.20351.
12. Mbandi E., Pestka J.J. Deoxynivalenol and satratoxin G potentiate proinflammatory cytokine and macrophage inhibitory protein 2 induction by Listeria and Salmonella in the macrophage. J. Food Prot. 2006, 69:1334-1339.
13. European Food Safety Authority Scientific opinion on risks for animal and public health related to the presence of nivalenol in food and feed. EFSA J. 2013, 11:3262.
14. Joint FAO/WHO Expert Committee on Food Additives (JECFA) Seventy-second meeting Rome, 16-25 February 2010, Summary and conclusions. Issued 16th March 2010. JECFA/72/SC 2010, Available at: http://www.who.int/foodsafety/chem/summary72_rev.pdf .
15. Food and Agriculture Organization (FAO) Milk and Milk Products 2015, Available at: http://www.fao.org/agriculture/dairy-gateway/milk-and-milk-products/en/#.VW3IBc_tmkp (Accessed 29.5.15).
16. European Commission Milk and Milk Products 2015, Available at: http://ec.europa.eu/agriculture/milk/index_en.htm (Accessed 29.5.15).
17. Fink-Gremmels J. Mycotoxins in cattle feeds and carry-over to dairy milk: a review. Food Addit. Contam. Part A 2008, 25:172-180. 10.1080/02652030701823142.
18. Sørensen L.K., Elbæk T.H. Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 820:183-196. 10.1016/j.jchromb.2005.03.020.
19. European Commission Commission recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochartoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding (2006/576/EC). OJ L 2006, 229:7-9.
20. Côté L.M., Dahlem A.M., Yoshizawa T., Swanson S.P., Buck W.B. Excretion of deoxynivalenol and its metabolite in milk, urine, and feces of lactating dairy cows. J. Dairy Sci. 1986, 69:2416-2423. 10.3168/jds.S0022-0302(86)80681-6.
21. Seeling K., Danicke S., Valenta H., Van Egmond H.P., Schothorst R.C., Jekel A.A., Lebzien P., Schollenberger M., Razzazi-Fazeli E., Flachowsky G. Effects of Fusarium toxin-contaminated wheat and feed intake level on the biotransformation and carry-over of deoxynivalenol in dairy cows. Food Addit. Contam. 2006, 23:1008-1020. 10.1080/02652030600723245.
22. Keese C., Meyer U., Valenta H., Schollenberger M., Starke A., Weber I.A., Rehage J., Breves G., Danicke S. No carry over of unmetabolised deoxynivalenol in milk of dairy cows fed high concentrate proportions. Mol. Nutr. Food Res. 2008, 52:1514-1529. 10.1002/mnfr.200800077.
23. Robison T.S., Mirocha C.J., Kurtz H.J., Behrens J.C., Chi M.S., Weaver G.A., Nystrom S.D. Transmission of T-2 toxin into bovine and porcine milk. J. Dairy Sci. 1979, 62:637-641. 10.3168/jds.S0022-0302(79)83301-9.
24. Yoshizawa T., Mirocha C.J., Behrens J.C., Swanson S.P. Metabolic fate of T-2 toxin in a lactating cow. Food Cosmet. Toxicol. 1981, 19:31-39. 10.1016/0015-6264(81)90300-X.
25. Mirocha C.J., Pathre S.V., Robison T.S. Comparative metabolism of zearalenone and transmission into bovine milk. Food Cosmet. Toxicol. 1981, 19:25-30. 10.1016/0015-6264(81)90299-6.
26. Valimaa A.L., Kivisto A.T., Leskinen P.I., Karp M.T. A novel biosensor for the detection of zearalenone family mycotoxins in milk. J. Microbiol. Methods 2010, 80:44-48. 10.1016/j.mimet.2009.10.017.
27. Flores-Flores M.E., Lizarraga E., López de Cerain A., González-Peñas E. Presence of mycotoxins in animal milk: a review. Food Control 2015, 53:163-176. 10.1016/j.foodcont.2015.01.020.
28. FAO Worldwide regulations for mycotoxins in food and feed in 2003. Food and Agriculture Organization of The United Nations. FAO Food and Nutrition Paper 81 2004.
29. Jia W., Chu X., Ling Y., Huang J., Chang J. Multi-mycotoxin analysis in dairy products by liquid chromatography coupled to quadrupole orbitrap mass spectrometry. J. Chromatogr. A 2014, 1345:107-114. 10.1016/j.chroma.2014.04.021.
30. Beltrán E., Ibáñez M., Portolés T., Ripollés C., Sancho J.V., Yusà V., Marín S., Hernández F. Development of sensitive and rapid analytical methodology for food analysis of 18 mycotoxins included in a total diet study. Anal. Chim. Acta 2013, 783:39-48. 10.1016/j.aca.2013.04.043.
31. Tsiplakou E., Anagnostopoulos C., Liapis K., Haroutounian S.A., Zervas G. Determination of mycotoxins in feedstuffs and ruminant's milk using an easy and simple LC-MS/MS multiresidue method. Talanta 2014, 130:8-19. 10.1016/j.talanta.2014.06.018.
32. European Commission Commission decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (2002/657/EC). OJ L 2002, 221:8-36.
33. Gosetti F., Mazzucco E., Zampieri D., Gennaro M.C. Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry. J. Chromatogr. A 2010, 1217:3929-3937. 10.1016/j.chroma.2009.11.060.
34. Capriotti A.L., Cavaliere C., Foglia P., Samperi R., Stampachiacchiere S., Ventura S., Laganà A. Multiclass analysis of mycotoxins in biscuits by high performance liquid chromatography-tandem mass spectrometry. Comparison of different extraction procedures. J. Chromatogr. A 2014, 1343:69-78. 10.1016/j.chroma.2014.04.009.
35. Koesukwiwat U., Sanguankaew K., Leepipatpiboon N. Evaluation of a modified QuEChERS method for analysis of mycotoxins in rice. Food Chem. 2014, 153:44-51. 10.1016/j.foodchem.2013.12.029.
36. Mol H.G., Plaza-Bolanos P., Zomer P., de Rijk T.C., Stolker A.A., Mulder P.P. Toward a generic extraction method for simultaneous determination of pesticides, mycotoxins, plant toxins, and veterinary drugs in feed and food matrixes. Anal. Chem. 2008, 80:9450-9459. 10.1021/ac801557f.
37. Food and Agriculture Organization (FAO). Mycotoxin prevention and control in foodgrains. Overview of analytical methods for mycotoxin contamination in maize and peanuts. Available at: (Accessed 26.5.15). http://www.fao.org/docrep/x5036e/x5036E0c.htm.
38. Rubert J., Leon N., Saez C., Martins C.P., Godula M., Yusa V., Manes J., Soriano J.M., Soler C. Evaluation of mycotoxins and their metabolites in human breast milk using liquid chromatography coupled to high resolution mass spectrometry. Anal. Chim. Acta 2014, 820:39-46. 10.1016/j.aca.2014.02.009.
39. Van Loco J., Jànosi A., Impens S., Fraselle S., Cornet V., Degroodt J.M. Calculation of the decision limit (CCα) and the detection capability (CCβ) for banned substances: the imperfect marriage between the quantitative and the qualitative criteria. Anal. Chim. Acta 2007, 586:8-12. 10.1016/j.aca.2006.11.058.
40. European Commission Commission Regulation (EC) No 401/2006 of 23 February 2006 laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs. OJ L 2006, 70:12.