Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships

Biological Psychiatry

Volumn 79, Issue 3, 2016, Pages 185-193

  Hurlemann, René ^a   Scheele, Dirk ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Attachment; Bond; Grief; Mental illness; Oxytocin; Social relationships

Indexed keywords

ANXIOLYTIC AGENT; OXYTOCIN; OXYTOCIN RECEPTOR; RACLOPRIDE;

CAREGIVER; CHILD PARENT RELATION; CONCEPTUAL FRAMEWORK; DISTRESS SYNDROME; EMOTION; EMOTIONAL DISORDER; HUMAN; MENTAL DISEASE; MENTAL HEALTH; NONHUMAN; PAIR BONDING; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; SOCIAL INTERACTION; SOCIAL SUPPORT; STRESS; TRANSLATIONAL RESEARCH; HUMAN RELATION; PHYSIOLOGY; SOCIAL BEHAVIOR;

EMOTIONS; HUMANS; INTERPERSONAL RELATIONS; OXYTOCIN; SOCIAL BEHAVIOR;

EID: 84955592914     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.05.013     Document Type: Review

References (143)

1. T.R. Insel, and L.J. Young The neurobiology of attachment Nat Rev Neurosci 2 2001 129 136
2. A. Feder, E.J. Nestler, and D.S. Charney Psychobiology and molecular genetics of resilience Nat Rev Neurosci 10 2009 446 457
3. M.L. Boccia, P. Petrusz, K. Suzuki, L. Marson, and C.A. Pedersen Immunohistochemical localization of oxytocin receptors in human brain Neuroscience 253 2013 155 164
4. K.M. Keyes, C. Pratt, S. Galea, K.A. McLaughlin, K.C. Koenen, and M.K. Shear The burden of loss: Unexpected death of a loved one and psychiatric disorders across the life course in a national study Am J Psychiatry 171 2014 864 871
5. Z.R. Donaldson, and L.J. Young Oxytocin, vasopressin, and the neurogenetics of sociality Science 322 2008 900 904
6. J.L. Garrison, E.Z. Macosko, S. Bernstein, N. Pokala, D.R. Albrecht, and C.I. Bargmann Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior Science 338 2012 540 543
7. J.D. Klatt, and J.L. Goodson Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird Proc Biol Sci 280 2013 20122396
8. R.G. Oldfield, and H.A. Hofmann Neuropeptide regulation of social behavior in a monogamous cichlid fish Physiol Behav 102 2011 296 303
9. K.A. Young, K.L. Gobrogge, Y. Liu, and Z. Wang The neurobiology of pair bonding: Insights from a socially monogamous rodent Front Neuroendocrinol 32 2011 53 69
10. L.J. Young, and Z. Wang The neurobiology of pair bonding Nat Neurosci 7 2004 1048 1054
11. Z. Wang, L. Zhou, T.J. Hulihan, and T.R. Insel Immunoreactivity of central vasopressin and oxytocin pathways in microtine rodents: A quantitative comparative study J Comp Neurol 366 1996 726 737
12. L.E. Shapiro, and T.R. Insel Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles Ann N Y Acad Sci 652 1992 448 451
13. L.J. Young, M.M. Lim, B. Gingrich, and T.R. Insel Cellular mechanisms of social attachment Horm Behav 40 2001 133 138
14. B.J. Aragona, Y. Liu, Y.J. Yu, J.T. Curtis, J.M. Detwiler, T.R. Insel, and Z. Wang Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds Nat Neurosci 9 2006 133 139
15. Z.V. Johnson, and L.J. Young Neurobiological mechanisms of social attachment and pair bonding Curr Opin Behav Sci 3 2015 38 44
16. M.M. Lim, Z. Wang, D.E. Olazabal, X. Ren, E.F. Terwilliger, and L.J. Young Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene Nature 429 2004 754 757
17. O.J. Bosch, and I.D. Neumann Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action Horm Behav 61 2012 293 303
18. T.R. Insel, and C.R. Harbaugh Lesions of the hypothalamic paraventricular nucleus disrupt the initiation of maternal behavior Physiol Behav 45 1989 1033 1041
19. T.R. Insel A neurobiological basis of social attachment Am J Psychiatry 154 1997 726 735
20. J.K. Rilling, and L.J. Young The biology of mammalian parenting and its effect on offspring social development Science 345 2014 771 776
21. B.J. Marlin, M. Mitre, J.A. D'Amour, M.V. Chao, and R.C. Froemke Oxytocin enables maternal behaviour by balancing cortical inhibition Nature 520 2015 499 504
22. F. Champagne, J. Diorio, S. Sharma, and M.J. Meaney Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors Proc Natl Acad Sci U S A 98 2001 12736 12741
23. M. Nagasawa, S. Mitsui, S. En, N. Ohtani, M. Ohta, Y. Sakuma, and et al. Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds Science 348 2015 333 336
24. C. Crockford, R.M. Wittig, K. Langergraber, T.E. Ziegler, K. Zuberbuhler, and T. Deschner Urinary oxytocin and social bonding in related and unrelated wild chimpanzees Proc Biol Sci 280 2013 20122765
25. A.J. Grippo, D. Gerena, J. Huang, N. Kumar, M. Shah, R. Ughreja, and C.S. Carter Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles Psychoneuroendocrinology 32 2007 966 980
26. A.J. Grippo, H. Pournajafi-Nazarloo, L. Sanzenbacher, D.M. Trahanas, N. McNeal, D.A. Clarke, and et al. Peripheral oxytocin administration buffers autonomic but not behavioral responses to environmental stressors in isolated prairie voles Stress 15 2012 149 161
27. O.J. Bosch, H.P. Nair, T.H. Ahern, I.D. Neumann, and L.J. Young The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent Neuropsychopharmacology 34 2009 1406 1415
28. R. Feldman, A. Weller, O. Zagoory-Sharon, and A. Levine Evidence for a neuroendocrinological foundation of human affiliation: Plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding Psychol Sci 18 2007 965 970
29. I. Gordon, O. Zagoory-Sharon, J.F. Leckman, and R. Feldman Oxytocin and the development of parenting in humans Biol Psychiatry 68 2010 377 382
30. L. Strathearn, U. Iyengar, P. Fonagy, and S. Kim Maternal oxytocin response during mother-infant interaction: Associations with adult temperament Horm Behav 61 2012 429 435
31. C. Heim, L.J. Young, D.J. Newport, T. Mletzko, A.H. Miller, and C.B. Nemeroff Lower CSF oxytocin concentrations in women with a history of childhood abuse Mol Psychiatry 14 2009 954 958
32. A.B. Wismer Fries, T.E. Ziegler, J.R. Kurian, S. Jacoris, and S.D. Pollak Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior Proc Natl Acad Sci U S A 102 2005 17237 17240
33. S.N. Young, and G.N. Anderson Bioanalytical inaccuracy: A threat to the integrity and efficiency of research J Psychiatry Neurosci 35 2010 3 6
34. J. Bick, and M. Dozier Mothers' and children's concentrations of oxytocin following close, physical interactions with biological and non-biological children Dev Psychobiol 52 2010 100 107
35. R. Feldman, I. Gordon, and O. Zagoory-Sharon Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: Considering stress and affiliation components of human bonding Dev Sci 14 2011 752 761
36. M.J. Bakermans-Kranenburg, and M.H. van Ijzendoorn Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting Soc Cogn Affect Neurosci 3 2008 128 134
37. A.M. Klahr, K. Klump, and S.A. Burt A constructive replication of the association between the oxytocin receptor genotype and parenting J Fam Psychol 29 2014 91 99
38. F.S. Chen, M.E. Barth, S.L. Johnson, I.H. Gotlib, and S.C. Johnson Oxytocin receptor (OXTR) polymorphisms and attachment in human infants Front Psychol 2 2011 200
39. Y. Apter-Levy, M. Feldman, A. Vakart, R.P. Ebstein, and R. Feldman Impact of maternal depression across the first 6 years of life on the child's mental health, social engagement, and empathy: The moderating role of oxytocin Am J Psychiatry 170 2013 1161 1168
40. A.R. Mesquita, I. Soares, G.I. Roisman, M. Ijzendoorn, M. Bakermans-Kranenburg, M. Luijk, and et al. Predicting children's attachment behaviors from the interaction between oxytocin and glucocorticoid receptors polymorphisms Psychiatry Res 210 2013 1322 1323
41. J.J. Connelly, J. Golding, S.P. Gregory, S.M. Ring, J.M. Davis, G. Davey Smith, and et al. Personality, behavior and environmental features associated with OXTR genetic variants in British mothers PloS One 9 2014 e90465
42. K.J. Michalska, J. Decety, C. Liu, Q. Chen, M.E. Martz, S. Jacob, and et al. Genetic imaging of the association of oxytocin receptor gene (OXTR) polymorphisms with positive maternal parenting Front Behav Neurosci 8 2014 21
43. B. Bradley, T.A. Davis, A.P. Wingo, K.B. Mercer, and K.J. Ressler Family environment and adult resilience: Contributions of positive parenting and the oxytocin receptor gene Eur J Psychotraumatol 4 2013
44. B. Bradley, D. Westen, K.B. Mercer, E.B. Binder, T. Jovanovic, D. Crain, and et al. Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene Dev Psychopathol 23 2011 439 452
45. N. Striepens, K.M. Kendrick, V. Hanking, R. Landgraf, U. Wullner, W. Maier, and R. Hurlemann Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans Sci Rep 3 2013 3440
46. A. Buchheim, M. Heinrichs, C. George, D. Pokorny, E. Koops, P. Henningsen, and et al. Oxytocin enhances the experience of attachment security Psychoneuroendocrinology 34 2009 1417 1422
47. F. Naber, M.H. van Ijzendoorn, P. Deschamps, H. van Engeland, and M.J. Bakermans-Kranenburg Intranasal oxytocin increases fathers' observed responsiveness during play with their children: A double-blind within-subject experiment Psychoneuroendocrinology 35 2010 1583 1586
48. O. Weisman, O. Zagoory-Sharon, and R. Feldman Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement Biol Psychiatry 72 2012 982 989
49. O. Weisman, E. Delaherche, M. Rondeau, M. Chetouani, D. Cohen, and R. Feldman Oxytocin shapes parental motion during father-infant interaction Biol Lett 9 2013 20130828
50. D. Wittfoth-Schardt, J. Grunding, M. Wittfoth, H. Lanfermann, M. Heinrichs, G. Domes, and et al. Oxytocin modulates neural reactivity to children's faces as a function of social salience Neuropsychopharmacology 37 2012 1799 1807
51. M.M. Riem, M.J. Bakermans-Kranenburg, S. Pieper, M. Tops, M.A. Boksem, R.R. Vermeiren, and et al. Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: A randomized controlled trial Biol Psychiatry 70 2011 291 297
52. M.M. Riem, M.H. van IJzendoorn, M. Tops, M.A. Boksem, S.A. Rombouts, and M.J. Bakermans-Kranenburg No laughing matter: Intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter Neuropsychopharmacology 37 2012 1257 1266
53. J.A. Bartz, J. Zaki, K.N. Ochsner, N. Bolger, A. Kolevzon, N. Ludwig, and J.E. Lydon Effects of oxytocin on recollections of maternal care and closeness Proc Natl Acad Sci U S A 107 2010 21371 21375
54. M.J. Bakermans-Kranenburg, M.H. van Ijzendoorn, M.M. Riem, M. Tops, and L.R. Alink Oxytocin decreases handgrip force in reaction to infant crying in females without harsh parenting experiences Soc Cogn Affect Neurosci 7 2012 951 957
55. I. Schneiderman, O. Zagoory-Sharon, J.F. Leckman, and R. Feldman Oxytocin during the initial stages of romantic attachment: Relations to couples' interactive reciprocity Psychoneuroendocrinology 37 2012 1277 1285
56. I. Schneiderman, Y. Kanat-Maymon, O. Zagoory-Sharon, and R. Feldman Mutual influences between partners' hormones shape conflict dialog and relationship duration at the initiation of romantic love Soc Neurosci 9 2014 337 351
57. J.P. Gouin, C.S. Carter, H. Pournajafi-Nazarloo, R. Glaser, W.B. Malarkey, T.J. Loving, and et al. Marital behavior, oxytocin, vasopressin, and wound healing Psychoneuroendocrinology 35 2010 1082 1090
58. G.C. Gonzaga, R.A. Turner, D. Keltner, B. Campos, and M. Altemus Romantic love and sexual desire in close relationships Emotion 6 2006 163 179
59. K.M. Grewen, S.S. Girdler, J. Amico, and K.C. Light Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact Psychosom Med 67 2005 531 538
60. K.C. Light, K.M. Grewen, and J.A. Amico More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women Biol Psychol 69 2005 5 21
61. R.A. Turner, M. Altemus, T. Enos, B. Cooper, and T. McGuinness Preliminary research on plasma oxytocin in normal cycling women: Investigating emotion and interpersonal distress Psychiatry 62 1999 97 113
62. S. Wikstrom, T. Gunnarsson, and C. Nordin Tactile stimulus and neurohormonal response: A pilot study Int J Neurosci 113 2003 787 793
63. A. Billhult, C. Lindholm, R. Gunnarsson, and E. Stener-Victorin The effect of massage on cellular immunity, endocrine and psychological factors in women with breast cancer - a randomized controlled clinical trial Auton Neurosci 140 2008 88 95
64. M.H. Rapaport, P. Schettler, and C. Bresee A Preliminary study of the effects of a single session of Swedish massage on hypothalamic-pituitary-adrenal and immune function in normal individuals J Altern Complement Med 16 2010 1079 1088
65. V.B. Morhenn, J.W. Park, E. Piper, and P.J. Zak Monetary sacrifice among strangers is mediated by endogenous oxytocin release after physical contact Evol Hum Behav 29 2008 375 383
66. V. Morhenn, L.E. Beavin, and P.J. Zak Massage increases oxytocin and reduces adrenocorticotropin hormone in humans Altern Ther Health Med 18 2012 11 18
67. S. Ogawa, S. Kudo, Y. Kitsunai, and S. Fukuchi Increase in oxytocin secretion at ejaculation in male Clin Endocrinol (Oxf) 13 1980 95 97
68. M.S. Carmichael, V.L. Warburton, J. Dixen, and J.M. Davidson Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity Arch Sex Behav 23 1994 59 79
69. M.R. Murphy, S.A. Checkley, J.R. Seckl, and S.L. Lightman Naloxone inhibits oxytocin release at orgasm in man J Clin Endocrinol Metab 71 1990 1056 1058
70. W. Blaicher, D. Gruber, C. Bieglmayer, A.M. Blaicher, W. Knogler, and J.C. Huber The role of oxytocin in relation to female sexual arousal Gynecol Obstet Invest 47 1999 125 126
71. T.H. Kruger, B. Schiffer, M. Eikermann, P. Haake, E. Gizewski, and M. Schedlowski Serial neurochemical measurement of cerebrospinal fluid during the human sexual response cycle Eur J Neurosci 24 2006 3445 3452
72. D. Marazziti, B. Dell'Osso, S. Baroni, F. Mungai, M. Catena, P. Rucci, and et al. A relationship between oxytocin and anxiety of romantic attachment Clin Pract Epidemiol Ment Health 2 2006 28
73. S.E. Taylor, G.C. Gonzaga, L.C. Klein, P. Hu, G.A. Greendale, and T.E. Seeman Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women Psychosom Med 68 2006 238 245
74. S.E. Taylor Tend and befriend: Biobehavioral bases of affiliation under stress Curr Dir Psychol Sci 15 2006 273 277
75. B.A. Tabak, M.E. McCullough, A. Szeto, A.J. Mendez, and P.M. McCabe Oxytocin indexes relational distress following interpersonal harms in women Psychoneuroendocrinology 36 2011 115 122
76. M.E. McCullough, P.S. Churchland, and A.J. Mendez Problems with measuring peripheral oxytocin: Can the data on oxytocin and human behavior be trusted? Neurosci Biobehav Rev 37 2013 1485 1492
77. S.M. Kagerbauer, J. Martin, T. Schuster, M. Blobner, E.F. Kochs, and R. Landgraf Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid J Neuroendocrinol 25 2013 668 673
78. H.S. Knobloch, A. Charlet, L.C. Hoffmann, M. Eliava, S. Khrulev, A.H. Cetin, and et al. Evoked axonal oxytocin release in the central amygdala attenuates fear response Neuron 73 2012 553 566
79. G. Gimpl, and F. Fahrenholz The oxytocin receptor system: Structure, function, and regulation Physiol Rev 81 2001 629 683
80. H. Walum, P. Lichtenstein, J.M. Neiderhiser, D. Reiss, J.M. Ganiban, E.L. Spotts, and et al. Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior Biol Psychiatry 71 2012 419 426
81. I. Schneiderman, Y. Kanat-Maymon, R.P. Ebstein, and R. Feldman Cumulative risk on the oxytocin receptor gene (OXTR) underpins empathic communication difficulties at the first stages of romantic love Soc Cogn Affect Neurosci 9 2013 1524 1529
82. B. Ditzen, M. Schaer, B. Gabriel, G. Bodenmann, U. Ehlert, and M. Heinrichs Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict Biol Psychiatry 65 2009 728 731
83. B. Ditzen, U.M. Nater, M. Schaer, R. La Marca, G. Bodenmann, U. Ehlert, and M. Heinrichs Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict Soc Cogn Affect Neurosci 8 2012 897 902
84. C. Unkelbach, A.J. Guastella, and J.P. Forgas Oxytocin selectively facilitates recognition of positive sex and relationship words Psychol Sci 19 2008 1092 1094
85. A. Burri, M. Heinrichs, M. Schedlowski, and T.H. Kruger The acute effects of intranasal oxytocin administration on endocrine and sexual function in males Psychoneuroendocrinology 33 2008 591 600
86. B. Behnia, M. Heinrichs, W. Bergmann, S. Jung, J. Germann, M. Schedlowski, and et al. Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples Horm Behav 65 2014 308 318
87. T. Singer, R. Snozzi, G. Bird, P. Petrovic, G. Silani, M. Heinrichs, and R.J. Dolan Effects of oxytocin and prosocial behavior on brain responses to direct and vicariously experienced pain Emotion 8 2008 781 791
88. J.C. Liu, A.J. Guastella, and M.R. Dadds Exploring the role of intra-nasal oxytocin on the partner preference effect in humans Psychoneuroendocrinology 38 2013 587 591
89. D. Scheele, N. Striepens, O. Güntürkün, S. Deutschlander, W. Maier, K.M. Kendrick, and R. Hurlemann Oxytocin modulates social distance between males and females J Neurosci 32 2012 16074 16079
90. A. Bartels, and S. Zeki The neural correlates of maternal and romantic love Neuroimage 21 2004 1155 1166
91. B.P. Acevedo, A. Aron, H.E. Fisher, and L.L. Brown Neural correlates of long-term intense romantic love Soc Cogn Affect Neurosci 7 2012 145 159
92. D. Scheele, A. Wille, K.M. Kendrick, B. Stoffel-Wagner, B. Becker, O. Güntürkün, and et al. Oxytocin enhances brain reward system responses in men viewing the face of their female partner Proc Natl Acad Sci U S A 110 2013 20308 20313
93. J. Younger, A. Aron, S. Parke, N. Chatterjee, and S. Mackey Viewing pictures of a romantic partner reduces experimental pain: Involvement of neural reward systems PloS One 5 2010 e13309
94. M. Zunhammer, S. Geis, V. Busch, M.W. Greenlee, and P. Eichhammer Effects of intranasal oxytocin on thermal pain in healthy men: A randomized functional magnetic resonance imaging study Psychosom Med 77 2015 156 166
95. K. Preckel, D. Scheele, M. Eckstein, W. Maier, and R. Hurlemann The influence of oxytocin on volitional and emotional ambivalence Soc Cogn Affect Neurosci 10 2015 987 993
96. Y. Liu, and Z.X. Wang Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles Neuroscience 121 2003 537 544
97. N. Striepens, A. Matusch, K.M. Kendrick, Y. Mihov, D. Elmenhorst, B. Becker, and et al. Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system Psychoneuroendocrinology 39 2014 74 87
98. A. Theodoridou, A.C. Rowe, I.S. Penton-Voak, and P.J. Rogers Oxytocin and social perception: Oxytocin increases perceived facial trustworthiness and attractiveness Horm Behav 56 2009 128 132
99. G. Dolen, A. Darvishzadeh, K.W. Huang, and R.C. Malenka Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin Nature 501 2013 179 184
100. R. Mottolese, J. Redoute, N. Costes, D. Le Bars, and A. Sirigu Switching brain serotonin with oxytocin Proc Natl Acad Sci U S A 111 2014 8637 8642
101. H.A. Rupp, T.W. James, E.D. Ketterson, D.R. Sengelaub, B. Ditzen, and J.R. Heiman Lower sexual interest in postpartum women: Relationship to amygdala activation and intranasal oxytocin Horm Behav 63 2013 114 121
102. R. Gregory, H. Cheng, H.A. Rupp, D.R. Sengelaub, and J.R. Heiman Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women Horm Behav 69C 2015 82 88
103. C.N. DeWall, O. Gillath, S.D. Pressman, L.L. Black, J.A. Bartz, J. Moskovitz, and et al. When the love hormone leads to violence: Oxytocin increases intimate partner violence inclinations among high trait aggressive people Soc Psychol Persononal Sci 5 2014 691 697
104. M. Heinrichs, T. Baumgartner, C. Kirschbaum, and U. Ehlert Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress Biol Psychiatry 54 2003 1389 1398
105. M. Eckstein, B. Becker, D. Scheele, C. Scholz, K. Preckel, T. Schlaepfer, and et al. Oxytocin facilitates the extinction of conditioned fear in humans Biol Psychiatry 78 2014 194 202
106. N. Striepens, D. Scheele, K.M. Kendrick, B. Becker, L. Schafer, K. Schwalba, and et al. Oxytocin facilitates protective responses to aversive social stimuli in males Proc Natl Acad Sci U S A 109 2012 18144 18149
107. M. Eckstein, D. Scheele, K. Weber, B. Stoffel-Wagner, W. Maier, and R. Hurlemann Oxytocin facilitates the sensation of social stress Hum Brain Mapp 35 2014 4741 4750
108. P.S. Churchland, and P. Winkielman Modulating social behavior with oxytocin: How does it work? What does it mean? Horm Behav 61 2012 392 399
109. J.A. Bartz, J. Zaki, N. Bolger, and K.N. Ochsner Social effects of oxytocin in humans: Context and person matter Trends Cogn Sci 15 2011 301 309
110. K. Preckel, D. Scheele, K.M. Kendrick, W. Maier, and R. Hurlemann Oxytocin facilitates social approach behavior in women Front Behav Neurosci 8 2014 191
111. D. Scheele, N. Striepens, K.M. Kendrick, C. Schwering, J. Noelle, A. Wille, and et al. Opposing effects of oxytocin on moral judgment in males and females Hum Brain Mapp 35 2014 6067 6076
112. D. Scheele, K.M. Kendrick, C. Khouri, E. Kretzer, T.E. Schlapfer, B. Stoffel-Wagner, and et al. An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits Neuropsychopharmacology 39 2014 2078 2085
113. A.D. Craig How do you feel - now? The anterior insula and human awareness Nat Rev Neurosci 10 2009 59 70
114. H.C. Lou, B. Luber, M. Crupain, J.P. Keenan, M. Nowak, T.W. Kjaer, and et al. Parietal cortex and representation of the mental Self Proc Natl Acad Sci U S A 101 2004 6827 6832
115. A.C. Voos, K.A. Pelphrey, and M.D. Kaiser Autistic traits are associated with diminished neural response to affective touch Soc Cogn Affect Neurosci 8 2013 378 386
116. E. Quattrocki, and K. Friston Autism, oxytocin and interoception Neurosci Biobehav Rev 47 2014 410 430
117. V. Colonnello, F.S. Chen, J. Panksepp, and M. Heinrichs Oxytocin sharpens self-other perceptual boundary Psychoneuroendocrinology 38 2013 2996 3002
118. C. Cardoso, M.A. Ellenbogen, and A.M. Linnen Acute intranasal oxytocin improves positive self-perceptions of personality Psychopharmacology (Berl) 220 2012 741 749
119. V. Colonnello, and M. Heinrichs Intranasal oxytocin enhances positive self-attribution in healthy men J Psychosom Res 77 2014 415 419
120. G. Domes, M. Heinrichs, A. Michel, C. Berger, and S.C. Herpertz Oxytocin improves "mind-reading" in humans Biol Psychiatry 61 2007 731 733
121. R. Hurlemann, A. Patin, O.A. Onur, M.X. Cohen, T. Baumgartner, S. Metzler, and et al. Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans J Neurosci 30 2010 4999 5007
122. J. Ernst, G. Northoff, H. Boker, E. Seifritz, and S. Grimm Interoceptive awareness enhances neural activity during empathy Hum Brain Mapp 34 2013 1615 1624
123. A. Aron, and B. Fraley Relationship closeness as including other in the self: Cognitive underpinnings and measures Soc Cogn 17 1999 140 160
124. F.M. Krienen, P.C. Tu, and R.L. Buckner Clan mentality: Evidence that the medial prefrontal cortex responds to close others J Neurosci 30 2010 13906 13915
125. C.K. De Dreu, L.L. Greer, M.J. Handgraaf, S. Shalvi, G.A. Van Kleef, M. Baas, and et al. The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans Science 328 2010 1408 1411
126. C.K. De Dreu, L.L. Greer, G.A. Van Kleef, S. Shalvi, and M.J. Handgraaf Oxytocin promotes human ethnocentrism Proc Natl Acad Sci U S A 108 2011 1262 1266
127. K. Macdonald, T.M. Macdonald, M. Brune, K. Lamb, M.P. Wilson, S. Golshan, and D. Feifel Oxytocin and psychotherapy: A pilot study of its physiological, behavioral and subjective effects in males with depression Psychoneuroendocrinology 38 2013 2831 2843
128. A. Najib, J.P. Lorberbaum, S. Kose, D.E. Bohning, and M.S. George Regional brain activity in women grieving a romantic relationship breakup Am J Psychiatry 161 2004 2245 2256
129. M.F. O'Connor, D.K. Wellisch, A.L. Stanton, N.I. Eisenberger, M.R. Irwin, and M.D. Lieberman Craving love? Enduring grief activates brain's reward center Neuroimage 42 2008 969 972
130. A. Kersting, P. Ohrmann, A. Pedersen, K. Kroker, D. Samberg, J. Bauer, and et al. Neural activation underlying acute grief in women after the loss of an unborn child Am J Psychiatry 166 2009 1402 1410
131. M.G. Cole, and N. Dendukuri Risk factors for depression among elderly community subjects: A systematic review and meta-analysis Am J Psychiatry 160 2003 1147 1156
132. H.G. Prigerson, E. Frank, S.V. Kasl, C.F. Reynolds 3rd, B. Anderson, G.S. Zubenko, and et al. Complicated grief and bereavement-related depression as distinct disorders: Preliminary empirical validation in elderly bereaved spouses Am J Psychiatry 152 1995 22 30
133. J.P. Burkett, and L.J. Young The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction Psychopharmacology (Berl) 224 2012 1 26
134. A.L. McRae-Clark, N.L. Baker, M.M. Maria, and K.T. Brady Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study Psychopharmacology (Berl) 228 2013 623 631
135. C.A. Pedersen, K.L. Smedley, J. Leserman, L.F. Jarskog, S.W. Rau, A. Kampov-Polevoi, and et al. Intranasal oxytocin blocks alcohol withdrawal in human subjects Alcohol Clin Exp Res 37 2013 484 489
136. S. Shahrestani, A.H. Kemp, and A.J. Guastella The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: A meta-analysis Neuropsychopharmacology 38 2013 1929 1936
137. A. Caria, and S. de Falco Anterior insular cortex regulation in autism spectrum disorders Front Behav Neurosci 9 2015 38
138. M.A. Birkett, N.M. Shinday, E.J. Kessler, J.S. Meyer, S. Ritchie, and J.K. Rowlett Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice Pharmacol Biochem Behav 98 2011 544 551
139. K.L. Bales, A.M. Perkeybile, O.G. Conley, M.H. Lee, C.D. Guoynes, G.M. Downing, and et al. Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles Biol Psychiatry 74 2013 180 188
140. H. Huang, C. Michetti, M. Busnelli, F. Manago, S. Sannino, D. Scheggia, and et al. Chronic and acute intranasal oxytocin produce divergent social effects in mice Neuropsychopharmacology 39 2014 1102 1114
141. J.A. Barraza, N.S. Grewal, S. Ropacki, P. Perez, A. Gonzalez, and P.J. Zak Effects of a 10-day oxytocin trial in older adults on health and well-being Exp Clin Psychopharmacol 21 2013 85 92
142. K.L. Bales, J.A. van Westerhuyzen, A.D. Lewis-Reese, N.D. Grotte, J.A. Lanter, and C.S. Carter Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles Horm Behav 52 2007 274 279
143. C. Cardoso, M.A. Ellenbogen, M.A. Orlando, S.L. Bacon, and R. Joober Intranasal oxytocin attenuates the cortisol response to physical stress: A dose-response study Psychoneuroendocrinology 38 2013 399 407