Neural activation underlying acute grief in women after the loss of an unborn child

American Journal of Psychiatry

Volumn 166, Issue 12, 2009, Pages 1402-1410

  Kersting, Anette ^a   Ohrmann, Patricia ^a   Pedersen, Anya ^a   Kroker, Kristin ^a   Samberg, Daniela ^a   Bauer, Jochen ^a   Kugel, Harald ^a   Koelkebeck, Katja ^a   Steinhard, Johannes ^a   Heindel, Walter ^a   Arolt, Volker ^a   Suslow, Thomas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN STEM RESPONSE; CELL ACTIVATION; CHILD DEATH; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRIEF; HUMAN; HUMAN EXPERIMENT; MATERNAL STRESS; NERVE CELL; PREGNANCY TERMINATION; PRIORITY JOURNAL;

ABORTION, EUGENIC; ABORTION, INDUCED; ACUTE DISEASE; ADULT; BRAIN; BRAIN STEM; FACIAL EXPRESSION; FEMALE; FRONTAL LOBE; GRIEF; GYRUS CINGULI; HAPPINESS; HUMANS; LIFE CHANGE EVENTS; MAGNETIC RESONANCE IMAGING; MATERNAL BEHAVIOR; NEURAL PATHWAYS; OBJECT ATTACHMENT; PAIN; PREGNANCY; TEMPORAL LOBE; THALAMUS;

EID: 73249123547     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2009.08121875     Document Type: Article

References (43)

1. Salvesen KA, Oyen L, Schmidt N, Malt UF, Eik-Nes SH: Comparison of long-term psychological responses of women after pregnancy termination due to fetal anomalies and after perinatal loss. Ultrasound Obstet Gynecol 1997; 9:80-85
2. Korenromp MJ, Christiaens GC, van den Bout J, Mulder EJ, Hunfeld JA, Bilardo CM, Offermans JP, Visser GH: Long-term psychological consequences of pregnancy termination for fetal abnormality: a cross-sectional study. Prenat Diagn 2005; 25:253-260
3. Kersting A, Dorsch M, Kreulich C, Reutemann M, Ohrmann P, Baez E, Arolt V: Trauma and grief 2-7 years after termination of pregnancy because of fetal anomalies: a pilot study. J Psychosom Obstet Gynaecol 2005; 26:9-14
4. Prigerson HG, Frank E, Kasl SV, Reynolds CF III, Anderson B, Zubenko GS, Houck PR, George CJ, Kupfer DJ: Complicated grief and bereavement-related depression as distinct disorders: preliminary empirical validation in elderly bereaved spouses. Am J Psychiatry 1995; 152:22-30
5. MacDonald G, Leary MR: Why does social exclusion hurt? the relationship between social and physical pain. Psychol Bull 2005; 131:202-223
6. Eisenberger NI: Identifying the neural correlates underlying social pain: implications for developmental processes. Hum Dev 2006; 49:273-293
7. Panksepp J, Nelson E, Bekkedal M: Brain systems for the mediation of separation-distress and social-reward: evolutionary and neuropeptide intermediaters. Ann NY Acad Sci 1997; 807:78-100
8. Apkarian AV, Bushnell MC, Treede RD, Zubieta JK: Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 2005; 9:463-484
9. Gündel H, O'Connor M-F, Littrell L, Fort C, Lane RD: Functional neuroanatomy of grief: an fMRI study. Am J Psychiatry 2003; 160:1946-1953
10. O'Connor MF, Wellisch DK, Stanton AL, Eisenberger NI, Irwin MR, Lieberman MD: Craving love? enduring grief activates brain's reward center. Neuroimage 2008; 42:969-972
11. Najib A, Lorberbaum JP, Kose S, Bohning DE, George MS: Regional brain activity in women grieving a romantic relationship breakup. Am J Psychiatry 2004; 161:2245-2256
12. Lorberbaum JP, Newman JD, Horwitz AR, Dubno JR, Lydiard RB, Hamner MB, Bohning DE, George MS: A potential role for thalamocingulate circuitry in human maternal behaviour. Biol Psychiatry 2002; 51:431-445
13. McLean PD, Newman JD: Role of midline frontolimbic cortex in production of the isolation call of squirrel. Brain Res 1988; 450:111-123
14. Kersting A, Fisch S, Baez E: Psychosocial care of mothers after stillbirth (letter). Lancet 2002; 360:1600
15. Beutel M, Will H, Volkl K, von Rad M, Weiner H: Assessment of grief exemplified by pregnancy loss: development and initial results on the validity of the Munich Grief Scale. Psychother Psychosom Med Psychol 1995; 45:295-302 (German)
16. Kersting A, Kroker K, Steinhard J, Lüdorff K, Wesselmann U, Ohrmann P, Arolt V, Suslow T: Complicated grief after traumatic loss: a 14-month follow up study. Eur Arch Psychiatry Clin Neurosci 2007; 257:437-443
17. Brockington IF, Fraser C, Wilson D: The Postpartum Bonding Questionnaire: a validation. Arch Womens Ment Health 2006; 9:233-242
18. Reck C, Klier CM, Pabst K, Stehle E, Steffenelli U, Struben K, Backenstrass M: The German version of the Postpartum Bonding Instrument: psychometric properties and association with postpartum depression. Arch Womens Ment Health 2006; 9:265-271
19. Beck AT, Ward CH, Mendelson M: An inventory for measuring depression. Arch Gen Psychiatry 1961; 4:561-571
20. Montgomery SA, Åsberg M: A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134:382-389
21. Spielberger CD: State-Trait Anxiety Inventory. Palo Alto, Calif, Consulting Psychologists Press, 1985
22. Hamilton M: The assessment of anxiety states by rating. Br J Med Psychol 1959; 32:50-55
23. Ekman P, Friesen WV: Pictures of Facial Affect. Palo Alto, Calif, Consulting Psychologists Press, 1976
24. Robinson S, Windischberger C, Rauscher A, Moser E: Optimized 3 T EPI of the amygdalae. Neuroimage 2004; 22:203-210
25. Kesler-West ML, Andersen AH, Smith CD, Avison MJ, Davis CE, Kryscio RJ, Blonder LX: Neural substrates of facial emotion processing using fMRI. Brain Res Cogn Brain Res 2001; 11:213-226
26. Rojahn J, Gerhards F, Matlock ST, Kroeger TL: Reliability and validity studies of the facial discrimination task for emotion research. Psychiatry Res 2000; 95:169-181
27. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT: Automated Talairach atlas labels for functional brain mapping. Human Brain Mapp 2000; 10:120-131
28. Eickhoff SB, Stephan KE, Mohlberg H, Grefkes C, Fink GR, Amunts K, Zilles K: A new SPM toolbox for combining probabilistic cytoarchitectonic and functional imaging data. Neuroimage 2005; 25:1325-1335
29. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M: Automated anatomical labelling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002; 15:273-289
30. Brett M, Anton JL, Valabregue R, Poline JB: Region of interest analysis using an SPM toolbox. Neuroimage 2002; 16:abstract 497
31. Maddock RJ, Garrett AS, Buonocore MH: Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Hum Brain Mapp 2003; 18:30-41
32. Fischer H, Wik G, Frederikson M: Functional neuroanatomy of robbery re-experience: affective memories studied with PET. Neuroreport 1996; 7:2081-2086
33. Hariri AR, Bookheimer SY, Mazziotta JC: Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport 2000; 11:43-48
34. Petrovic P, Ingvar M: Imaging cognitive modulation of pain processing. Pain 2002; 95:1-5
35. Ochsner KN, Gross JJ: The cognitive control of emotion. Trends Cogn Sci 2005; 9:242-249
36. Bandler R, Shipley MT: Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci 1994; 17:379-389
37. Dunckley P, Wise RG, Fairhurst M, Hobden P, Aziz Q, Chang I, Tracey I: A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. J Neurosci 2005; 10:7333-7341
38. Lonstein JS, Stern JM: Role of midbrain periaqueductal gray in maternal nurturance and aggression: c-fos and electrolytic lesion studies in lactating rats: J Neurosci 1997; 17:3364-3378
39. MacLean PD: The Triune Brain in Evolution: Role in Paleocerebral Functions. New York, Plenum Press, 1990
40. Slotnick BM, Nigrosh BJ: Maternal behaviour of mice with cingulate cortical, amygdala, or septal lesions. J Comp Physiol Psychol 1975; 88:118-127
41. Schmitz TW, De Rosa E, Anderson K: Opposing influences of affective state valence on visual cortical encoding. J Neurosci 2009; 29:7199-7207
42. Lang PJ, Bradley MM, Fitzsimmons JR, Cuthbert BN, Scott JD, Moulder B, Nangia V: Emotional arousal and activation of the visual cortex: an fMRI analysis. Psychophysiology 1998; 35:199-210
43. Kober H, Barrett FL, Joseph J, Bliss-Moreau E, Lindquist K, Wager TD: Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies. Neuroimage 2008; 42:998-1031