A constructive replication of the association between the oxytocin receptor genotype and parenting

Journal of Family Psychology

Volumn 29, Issue 1, 2015, Pages 91-99

  Klahr, Ashlea M ^a   Klump, Kelly ^b   Burt, S Alexandra ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Evocative rGE; Genetic; OXTR; Oxytocin; Parenting

Indexed keywords

OXTR PROTEIN, HUMAN; OXYTOCIN RECEPTOR;

ADULT; CHILD; CHILD PARENT RELATION; FEMALE; GENETICS; GENOTYPE; HUMAN; MALE; MATERNAL BEHAVIOR; PSYCHOLOGY; REGISTER; SEX DIFFERENCE; TWINS;

ADULT; CHILD; FEMALE; GENOTYPE; HUMANS; MALE; MATERNAL BEHAVIOR; PARENTING; RECEPTORS, OXYTOCIN; REGISTRIES; SEX FACTORS;

EID: 84925763550     PISSN: 08933200     EISSN: 19391293     Source Type: Journal    
DOI: 10.1037/fam0000034     Document Type: Article

References (68)

1. Anderson, K. E., Lytton, H.,&Romney, D. M. (1986). Mothers' interactions with normal and conduct-disordered boys: Who affects whom? Developmental Psychology, 22, 604-609. http://dx.doi.org/10.1037/0012-1649.22.5.604
2. Bakermans-Kranenburg, M. J.,&van Ijzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3, 128-134. http://dx.doi.org/10.1093/scan/nsn004
3. Bakermans-Kranenburg, M. J.,&van Ijzendoorn, M. H. (2014). A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. Psychiatric Genetics, 24, 45-51. http://dx.doi.org/10.1097/YPG.0b013e3283643684
4. Belsky, J. (1984). The determinants of parenting: A process model. Child Development, 55, 83-96. Retrieved from http://dx.doi.org/10.2307/1129836
5. Belsky, J. (2011). The determinants of parenting in GxE perspective: A case of differential susceptibility? Biosocial Foundations of Family Processes (61-68). New York: Springer.
6. Bradley, R. H., Corwyn, R. F., McAdoo, H. P.,&García Coll, C. G. (2001). The home environments of children in the United States part I: Variations by age, ethnicity, and poverty status. Child Development, 72, 1844-1867. http://dx.doi.org/10.1111/1467-8624.t01-1-00382
7. Burt, S. A., Klahr, A. M., Neale, M. C.,&Klump, K. L. (2013). Maternal warmth and directiveness jointly moderate the etiology of childhood conduct problems. Journal of Child Psychology and Psychiatry, 54, 1030-1037. http://dx.doi.org/10.1111/jcpp.12095
8. Burt, S. A.,&Klump, K. L. (2013). The Michigan state university twin registry (MSUTR): An update. Twin Research and Human Genetics, 16, 344-350. http://dx.doi.org/10.1017/thg.2012.87
9. Burt, S. A.,&Klump, K. L. (2014). Parent-child conflict as an etiological moderator of childhood conduct problems: An example of a 'bioecological' gene-environment interaction. Psychological Medicine, 44, 1065-1076. http://dx.doi.org/10.1017/S0033291713001190
10. Champagne, F., Diorio, J., Sharma, S.,&Meaney, M. J. (2001). Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proceedings of the National Academy of Sciences of the United States of America, 98, 12736-12741. http://dx.doi.org/10.1073/pnas.221224598
11. Collins, W. A.,&Russell, G. (1991). Mother-child and father-child relationships in middle childhood and adolescence: A developmental analysis. Developmental Review, 11, 99-136. http://dx.doi.org/10.1016/0273-2297(91)90004-8
12. Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., . . . Martini, C. (2009). Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34, 1506-1514. http://dx.doi.org/10.1016/j.psyneuen.2009.05.006
13. Cowan, P. A., Cowan, C. P.,&Kerig, P. K. (1993). Mothers, fathers, sons, and daughters: Gender differences in family formation and parenting style. In P. A. Cowan, D. Field, D. A. Hansen, A. Skolnick,&G. E. Swanson (Eds.), Family, self, and society: Toward a new agenda for family research (pp. 165-195). Hillsdale, NJ, England: Erlbaum, Inc.
14. Craig, L. (2006). Does father care mean fathers share? A comparison of how mothers and fathers in intact families spend time with children. Gender&Society, 20, 259-281. http://dx.doi.org/10.1177/0891243205285212
15. Deater-Deckard, K., Pylas, M.,&Petrill, S. A. (1997). Twin Parent-Child Interaction System. London: Institute of Psychiatry.
16. De Los Reyes, A.,&Kazdin, A. E. (2005). Informant discrepancies in the assessment of childhood psychopathology: A critical review, theoretical framework, and recommendations for further study. Psychological Bulletin, 131, 483-509. http://dx.doi.org/10.1037/0033-2909.131.4.483
17. Donaldson, Z. R.,&Young, L. J. (2008). Oxytocin, vasopressin, and the neurogenetics of sociality. Science, 322, 900-904. http://dx.doi.org/10.1126/science.1158668
18. Fearon, R. P., Bakermans-Kranenburg, M. J., van Ijzendoorn, M. H., Lapsley, A.-M.,&Roisman, G. I. (2010). The significance of insecure attachment and disorganization in the development of children's externalizing behavior: A meta-analytic study. Child Development, 81, 435-456. http://dx.doi.org/10.1111/j.1467-8624.2009.01405.x
19. Feinberg, M. E., Button, T. M. M., Neiderhiser, J. M., Reiss, D., & Hetherington, E. M. (2007). Parenting and adolescent antisocial behavior and depression: Evidence of genotype x parenting environment interaction. Archives of General Psychiatry, 64, 457-465. http://dx.doi.org/10.1001/archpsyc.64.4.457
20. Feldman, R., Gordon, I., Schneiderman, I., Weisman, O.,&Zagoory-Sharon, O. (2010). Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact. Psychoneuroendocrinology, 35, 1133-1141. http://dx.doi.org/10.1016/j.psyneuen.2010.01.013
21. Feldman, R., Gordon, I.,&Zagoory-Sharon, O. (2011). Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: Considering stress and affiliation components of human bonding. Developmental Science, 14, 752-761. http://dx.doi.org/10.1111/j.1467-7687.2010.01021.x
22. Feldman, R., Weller, A., Zagoory-Sharon, O.,&Levine, A. (2007). Evidence for a neuroendocrinological foundation of human affiliation: Plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychological Science, 18, 965-970. http://dx.doi.org/10.1111/j.1467-9280.2007.02010.x
23. Feldman, R., Zagoory-Sharon, O., Weisman, O., Schneiderman, I., Gordon, I., Maoz, R., . . . Ebstein, R. P. (2012). Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biological Psychiatry, 72, 175-181. http://dx.doi.org/10.1016/j.biopsych.2011.12.025
24. Gordon, I., Zagoory-Sharon, O., Leckman, J. F.,&Feldman, R. (2010). Oxytocin and the development of parenting in humans. Biological Psychiatry, 68, 377-382. http://dx.doi.org/10.1016/j.biopsych.2010.02.005
25. Groh, A. M., Roisman, G. I., van Ijzendoorn, M. H., Bakermans-Kranenburg, M. J.,&Fearon, R. P. (2012). The significance of insecure and disorganized attachment for children's internalizing symptoms: A meta-analytic study. Child Development, 83, 591-610.
26. Hoff, E., Laursen, B., Tardif, T.,&Bornstein, M. H. (2002). Socioeconomic status and parenting. In M. H. Bornstein (Ed.), Handbook of parenting: Vol. 2. Biology and ecology of parenting (2nd ed., pp. 231-252). Mahwah, NJ: Erlbaum.
27. IMBCorp. (2011) IBM SPSS Statistics for Windows (version 20.0).
28. Ioannidis, J. P. A., Ntzani, E. E., Trikalinos, T. A.,&Contopoulos-Ioannidis, D. G. (2001). Replication validity of genetic association studies. Nature Genetics, 29, 306-309. http://dx.doi.org/10.1038/ng749
29. Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Riebold, M., Laiba, E., . . . Ebstein, R. P. (2009). The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS ONE, 4, e5535. http://dx.doi.org/10.1371/journal.pone.0005535
30. Kendler, K. S. (1996). Parenting: A genetic-epidemiologic perspective. The American Journal of Psychiatry, 153, 11-20.
31. Kendrick, K. M., Keverne, E. B.,&Baldwin, B. A. (1987). Intracerebroventricular oxytocin stimulates maternal behaviour in the sheep. Neuroendocrinology, 46, 56-61. http://dx.doi.org/10.1159/000124796
32. Kerr, M., Stattin, H.,&Özdemir, M. (2012). Perceived parenting style and adolescent adjustment: Revisiting directions of effects and the role of parental knowledge. Developmental Psychology, 48, 1540-1553. http://dx.doi.org/10.1037/a0027720
33. Klahr, A. M.,&Burt, S. A. (2014). Elucidating the etiology of individual differences in parenting: A meta-analysis of behavioral genetic research. Psychological Bulletin, 140, 544-586. http://dx.doi.org/10.1037/a0034205
34. Klahr, A. M., Klump, K. L.,&Burt, S. A. (2014). The etiology of the association between child antisocial behavior and maternal negativity varies across aggressive and non-aggressive rule-breaking forms of antisocial behavior. [Advance online publication]. Journal of Abnormal Child Psychology, 42, 1299-1311. http://dx.doi.org/10.1007/s10802-014-9886-5
35. Klahr, A. M., Thomas, K. M., Hopwood, C. J., Klump, K. L.,&Burt, S. A. (2013). Evocative gene-environment correlation in the motherchild relationship: A twin study of interpersonal processes. Development and Psychopathology, 25, 105-118. http://dx.doi.org/10.1017/S0954579412000934
36. Klump, K. L.,&Burt, S. A. (2006). The Michigan State University Twin Registry (MSUTR): Genetic, environmental and neurobiological influences on behavior across development. Twin Research and Human Genetics: The Official Journal of the International Society for Twin Studies, 9, 971-977. http://dx.doi.org/10.1375/twin.9.6.971
37. Kochanska, G., Friesenborg, A. E., Lange, L. A.,&Martel, M. M. (2004). Parents' personality and infants' temperament as contributors to their emerging relationship. Journal of Personality and Social Psychology, 86, 744-759. http://dx.doi.org/10.1037/0022-3514.86.5.744
38. Kogan, A., Saslow, L. R., Impett, E. A., Oveis, C., Keltner, D., & Rodrigues Saturn, S. (2011). Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proceedings of the National Academy of Sciences of the United States of America, 108, 19189-19192. http://dx.doi.org/10.1073/pnas.1112658108
39. Kotchick, B. A.,&Forehand, R. (2002). Putting parenting in perspective: A discussion of the contextual factors that shape parenting practices. Journal of Child and Family Studies, 11, 255-269. http://dx.doi.org/10.1023/A:1016863921662
40. Levine, A., Zagoory-Sharon, O., Feldman, R.,&Weller, A. (2007). Oxytocin during pregnancy and early postpartum: Individual patterns and maternal-fetal attachment. Peptides, 28, 1162-1169. http://dx.doi.org/10.1016/j.peptides.2007.04.016
41. Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., . . . Rosskopf, D. (2009). Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Progress in Neuro-Psychopharmacology&Biological Psychiatry, 33, 860-866. http://dx.doi.org/10.1016/j.pnpbp.2009.04.004
42. Lynch, S. K., Turkheimer, E., D'Onofrio, B. M., Mendle, J., Emery, R. E., Slutske, W. S.,&Martin, N. G. (2006). A genetically informed study of the association between harsh punishment and offspring behavioral problems. Journal of Family Psychology, 20, 190-198. http://dx.doi.org/10.1037/0893-3200.20.2.190
43. Maestripieri, D., Hoffman, C. L., Anderson, G. M., Carter, C. S.,&Higley, J. D. (2009). Mother-infant interactions in free-ranging rhesus macaques: Relationships between physiological and behavioral variables. Physiology&Behavior, 96, 613-619. http://dx.doi.org/10.1016/j.physbeh.2008.12.016
44. Manning, M., Hoffman, C. L., Anderson, G. M., Carter, C. S.,&Higley, J. D. (2008). Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: Research tools and potential therapeutic agents. Progress in Brain Research 170, 473-512. http://dx.doi.org/10.1016/S0079-6123(08)00437-8
45. Marceau, K., Horwitz, B. N., Narusyte, J., Ganiban, J. M., Spotts, E. L., Reiss, D.,&Neiderhiser, J. M. (2013). Gene-environment correlation underlying the association between parental negativity and adolescent externalizing problems. Child Development, 84, 2031-2046. http://dx.doi.org/10.1111/cdev.12094
46. Marsh, A. A., Yu, H. H., Pine, D. S., Gorodetsky, E. K., Goldman, D., & Blair, R. J. R. (2012). The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology, 224, 469-476. http://dx.doi.org/10.1007/s00213-012-2775-0
47. McLeod, B. D., Wood, J. J.,&Weisz, J. R. (2007). Examining the association between parenting and childhood anxiety: A meta-analysis. Clinical Psychology Review, 27, 155-172. http://dx.doi.org/10.1016/j.cpr.2006.09.002
48. Michalska, K. J., Decety, J., Liu, C., Chen, Q., Martz, M. E., Jacob, S., . . . Lahey, B. B. (2014). Genetic imaging of the association of oxytocin receptor gene (OXTR) polymorphisms with positive maternal parenting. Frontiers in Behavioral Neuroscience, 8, 21. http://dx.doi.org/10.3389/fnbeh.2014.00021
49. Morsbach, S. K.,&Prinz, R. J. (2006). Understanding and improving the validity of self-report of parenting. Clinical Child and Family Psychology Review, 9, 1-21. http://dx.doi.org/10.1007/s10567-006-0001-5
50. Naber, F. B. A., Poslawsky, I. E., van Ijzendoorn, M. H., van Engeland, H., & Bakermans-Kranenburg, M. J. (2013). Brief report: Oxytocin enhances paternal sensitivity to a child with autism: A double-blind withinsubject experiment with intranasally administered oxytocin. Journal of Autism and Developmental Disorders, 43, 224-229. http://dx.doi.org/10.1007/s10803-012-1536-6
51. Neiderhiser, J. M., Reiss, D., Lichtenstein, P., Spotts, E. L.,&Ganiban, J. (2007). Father-adolescent relationships and the role of genotypeenvironment correlation. Journal of Family Psychology, 21, 560-571. http://dx.doi.org/10.1037/0893-3200.21.4.560
52. Neiderhiser, J. M., Reiss, D., Pedersen, N. L., Lichtenstein, P., Spotts, E. L., Hansson, K., . . . Ellhammer, O. (2004). Genetic and environmental influences on mothering of adolescents: A comparison of two samples. Developmental Psychology, 40, 335-351. http://dx.doi.org/10.1037/0012-1649.40.3.335
53. Paulhus, D. L.,&Vazire, S. (2007). The self-report method. In R. W. Robins, R. C. Fraley,&R. F. Krueger (Eds.), Handbook of research methods in personality psychology (pp. 224-239). New York, NY: Guilford Press.
54. Pedersen, C. A., Ascher, J. A., Monroe, Y. L.,&Prange, A. J., Jr. (1982). Oxytocin induces maternal behavior in virgin female rats. Science, 216, 648-650. http://dx.doi.org/10.1126/science.7071605
55. Plomin, R., DeFries, J. C.,&Loehlin, J. C. (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin, 84, 309-322. http://dx.doi.org/10.1037/0033-2909.84.2.309
56. Ragnauth, A. K., Devidze, N., Moy, V., Finley, K., Goodwillie, A., Kow, L.-M., . . . Pfaff, D. W. (2005). Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior. Genes, Brain and Behavior, 4, 229-239. http://dx.doi.org/10.1111/j.1601-183X.2005.00118.x
57. Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P.,&Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences of the United States of America, 106, 21437-21441. http://dx.doi.org/10.1073/pnas.0909579106
58. Sadler, P., Ethier, N., Gunn, G. R., Duong, D.,&Woody, E. (2009). Are we on the same wavelength? Interpersonal complementarity as shared cyclical patterns during interactions. Journal of Personality and Social Psychology, 97, 1005-1020. http://dx.doi.org/10.1037/a0016232
59. Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K.,&Taylor, S. E. (2011). Oxytocin receptor gene (OXTR) is related to psychological resources. Proceedings of the National Academy of Sciences of the United States of America, 108, 15118-15122. http://dx.doi.org/10.1073/pnas.1113137108
60. Scarr, S.,&McCartney, K. (1983). How people make their own environments: A theory of genotype greater than environment effects. Child Development, 54, 424-435. http://ukpmc.ac.uk/abstract/MED/6683622
61. SNP rs53576. (2014). Retrieved from https://opensnp.org/snps/rs53576
62. Soloff, M. S., Alexandrova, M.,&Fernstrom, M. J. (1979). Oxytocin receptors: Triggers for parturition and lactation? Science, 204, 1313-1315. http://dx.doi.org/10.1126/science.221972
63. Swain, J. E. (2011). The human parental brain: In vivo neuroimaging. Progress in Neuro-Psychopharmacology&Biological Psychiatry, 35, 1242-1254. http://dx.doi.org/10.1016/j.pnpbp.2010.10.017
64. Swain, J. E., Lorberbaum, J. P., Kose, S.,&Strathearn, L. (2007). Brain basis of early parent-infant interactions: Psychology, physiology, and in vivo functional neuroimaging studies. Journal of Child Psychology and Psychiatry, 48, 262-287. http://dx.doi.org/10.1111/j.1469-7610.2007.01731.x
65. Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., & Onaka, T., . . . Nishimori, K. (2005). Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 102, 16096-16101. doi:10.1073/pnas.0505312102
66. Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., & Mattay, V. S., . . . Meyer-Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences of the United States of America, 107, 13936-13941. doi:10.1073/pnas.1003296107
67. Weisman, O., Zagoory-Sharon, O.,&Feldman, R. (2012). Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement. Biological Psychiatry, 72, 982-989. http://dx.doi.org/10.1016/j.biopsych.2012.06.011
68. Wu, P., Robinson, C. C., Yang, C., Hart, C. H., Olsen, S. F., Porter, C. L., . . . Wu, X. (2002). Similarities and differences in mothers' parenting of preschoolers in China and the United States. International Journal of Behavioral Development, 26, 481-491. http://dx.doi.org/10.1080/01650250143000436