Neural correlates of long-term intense romantic love

Social Cognitive and Affective Neuroscience

Volumn 7, Issue 2, 2012, Pages 145-159

  Acevedo, Bianca P ^a   Aron, Arthur ^a   Fisher, Helen E ^b   Brown, Lucy L ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b Rutgers University   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE;

ADULT; AGED; ARTICLE; BRAIN; BRAIN MAPPING; EMOTION; FEMALE; HUMAN; IMAGE PROCESSING; LOVE; MALE; MIDDLE AGED; MOTIVATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSESSION; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REWARD; SEXUAL BEHAVIOR; VENTRAL TEGMENTUM;

ADULT; AGED; BRAIN; BRAIN MAPPING; DOPAMINE; EMOTIONS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LOVE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOTIVATION; OBSESSIVE BEHAVIOR; REWARD; SEXUAL BEHAVIOR; VENTRAL TEGMENTAL AREA;

EID: 84857011879     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nsq092     Document Type: Article

References (96)

1. Acevedo, B.P., Aron, A. (2009). Does a long-term relationship kill romantic love? Review of General Psychology, 13, 59-65.
2. Ainsworth, M.D.S. (1991). Attachments and other affectional bonds across the life cycle. In: Parkes, C.M., Stevenson-Hinde, J., Marris, P., editors. Attachment across the life cycle. New York: Tavistock/Routledge, pp. 33-51.
3. Aragona, B.J., Liu, Y., Curtis, J.T., Stephan, F.K., Wang, Z. (2003). A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles. Journal of Neuroscience, 23(8), 3483-90.
4. Aron, A., Aron, E. (1986). Love and the Expansion of Self: Understanding Attraction and Satisfaction. New York: Hemisphere.
5. Aron, A., Aron, E.N., Smollan, D. (1992). Inclusion of other in the Self Scale and the structure of interpersonal closeness. Journal of Personality and Social Psychology, 63, 596-612.
6. Aron, A., Fisher, H., Mashek, D., Strong, G., Li, H., Brown, L. (2005). Reward, motivation and emotion systems associated with early-stage intense romantic love. Journal of Neurophysiology, 93, 327-37.
7. Aron, A., Henkemeyer, L. (1995). Marital satisfaction and passionate love. Journal of Social and Personal Relationships, 12, 141-9.
8. Aron, A., Norman, C.C., Aron, E., McKenna, C., Heyman, R.E. (2000). Couples' shared participation in novel and arousing activities and experienced relationship quality. Journal of Personality and Social Psychology, 78(2), 273-84.
9. Aron, A., Westbay, L. (1996). Dimensions of the prototype of love. Journal of Personality and Social Psychology, 70, 535-51.
10. Bartels, A., Zeki, S. (2000). The neural basis of romantic love. NeuroReport, 11(17), 3829-34.
11. Bartels, A., Zeki, S. (2004). The neural correlates of maternal and romantic love. NeuroImage, 21(3), 1155-66.
12. Baumeister, R.F., Bratslavsky, E. (1999). Passion, intimacy, and time: Passionate love as a function of change in intimacy. Personality and Social Psychology Review, 3(1), 49-67.
13. Berridge, K.C., Robinson, T.E. (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Research Reviews, 28, 309-69.
14. Berridge, K.C., Ho, C., Richard, J.M., DiFelicieantonio, A.G. (2010). The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Research, 1350, 43-64.
15. Berscheid, E., Hatfield [Walster], E.H. (l969). Interpersonal Attraction. New York: Addison-Wesley.
16. Bittar, R.G., Kar-Purkayastha, I., Owen, S.L., et al. (2005). Deep brain stimulation for pain relief: a meta-analysis. Journal of Clinical Neuroscience, 5, 515-9.
17. Bowlby, J. (1969). Attachment and Loss, Vol. 1, Attachment. London: Hogarth.
18. Bragulat, V., Dzemidzic, M., Bruno, C., et al. (2010). Food-related odor probes of brain reward circuits during hunger: a pilot fMRI study. Obesity, 18, 1566-1571.
19. Buss, D.M. (1989). Sex differences in human mate preferences: Evolutionary hypotheses tested in 37 cultures. Behavioral & Brain Sciences, 12, 1-49.
20. Camara, E., Rodriguez-Fornells, A., Ye, Z., Munte, T.F. (2009). Reward networks in the brain captured by connectivity measures. Frontiers in Neuroscience, 3, 350-62.
21. Carter, C.S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23, 779-818.
22. Carter, C.S., DeVries, A.C., Getz, L.L. (1995). Physiological substrates of mammalian monogamy: the prairie vole model. Neuroscience and Biobehavioral Reviews, 19, 303-14.
23. Carter, R.M., MacInnes, J.J., Huettel, S.A., Adcock, R.A. (2009). Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses. Frontiers in Behavioral Neuroscience, 3(21), 1-15.
24. Coan, J.A., Schaefer, H.S., Davidson, R.J. (2006). Lending a hand: Social regulation of the neural response to threat. Psychological Science, 17(12), 1032-9.
25. Craig, A.D. (2009). How do you feel-now? The anterior insula and human awareness. Nature Review Neuroscience, 10, 59-70.
26. Cromwell, H.C., Berridge, K.C. (1993). Where does damage lead to enhanced food aversion: the ventral pallidum/sunstantia innominata or lateral hypothalamus? Brain Research, 624, 1-10.
27. D'Ardenne, K., McClure, S.M., Nystrom, L.E., Cohen, J.D. (2008). BOLD responses reflecting dopaminergic signals in the human ventral tegmental area. Science, 319, 1264-7.
28. Davidson, T.L., Jarad, L.E. (1993). A role for hippocampus in the utilization of hunger signals. Behavioral and Neural Biology, 59, 161-71.
29. Decker, M.W., Curzon, P., Brioni, J.D. (1995). Influence of separate and combined septal and amygdala lesions on memory, acousticstartle, anxiety, and locomotor activity in rats. Neurobiology of Learning and Memory, 64, 156-68.
30. Degroot, A., Treit, D. (2004). Anxiety is functionally segregated within the septo-hippocampal system. Brain Research, 1001, 60-71.
31. Delgado, M.R., Locke, H.M., Stenger, V.A., Fiez, J.A. (2003). Dorsal striatum responses to reward and punishment: Effects of valence and magnitude manipulations. Cognitive Affective & Behavioral Neuroscience, 3, 27-38.
32. Eastwick, P.W., Finkel, E.J. (2008). The attachment system in fledgling relationships: An activating role for attachment anxiety. Journal of Personality and Social Psychology, 95, 628-47.
33. Enzi, B., Greck, M., Prosch, U., Templemann, C., Northoff, G. (2009). Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality. PLoS ONE, 4, 1-12.
34. Fernandez, G., Kroes, M.C. (2010). Protecting endangered memories. Nature Neuroscience, 13, 408-10.
35. Fromm, Erich. (1956). The Art of Loving. New York: Harper Perennial.
36. Freud, S. (1921). Group Psychology and the Analysis of the Ego. New York: W.W. Norton and Company. SE, XVIII, 90-91.
37. Fisher, H.E. (1992). Anatomy of Love: The Natural History of Monogamy, Adultery, and Divorce. New York: W.W. Norton.
38. Fisher, H. (2004). Why We Love: The Nature and Chemistry of Romantic Love. New York: Henry Holt.
39. Fisher, H.E. (2006). The drive to love. In: Sternberg, R., Weis, K., editors. The New Psychology of Love. New Haven: Yale University Press, pp. 87-115.
40. Fisher, H.E., Brown, L.L., Aron, A., Strong, G., Mashek, D. (2010). Reward, addiction, and emotion regulation systems associated with rejection in love. Journal of Neurophysiology, 104, 51-60.
41. Genovese, C.R., Lazar, N.A., Nichols, T. (2002). Thresholding of statistical maps in functional neuroimaging data using the false discovery rate. NeuroImage, 15, 870-8.
42. Grote, N.K., Frieze, I.H. (1994). The measurement of friendship-based love in intimate relationships. Personal Relationship, 1, 275-300.
43. Guitart-Masip, M., Bunzeck, N., Stephan, K.E., Dolan, R.J., Düzel, E. (2010). Contextual novelty changes reward representations in the striatum. Journal of Neuroscience, 30(5), 1721-6.
44. Hare, T.A., O'Doherty, J., Camerer, C.F., Schultz, W., Rangel, A. (2008). Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors. Journal of Neuroscience, 28, 5623-30.
45. Hatfield, E., Sprecher, S. (1986). Measuring passionate love in intimate relations. Journal of Adolescence, 9, 383-410.
46. Hazan, C., Shaver, P.R. (1987). Romantic love conceptualized as an attachment process. Journal of Personality and Social Psychology, 52, 511-24.
47. Hazan, C., Zeifman, D. (1994). Sex and the psychological tether. In: Bartholomew, K., Perlman, D., editors. Advances in personal relationships: Vol 5. Attachment processes in adulthood. London: Jessica Kingsley, pp. 151-177.
48. Hazan, C., Zeifma, D. (1999). Pair-bonds as attachments: Evaluating the evidence. In: Cassidy, J., Shaver, P.R., editors. Handbook of Attachment: Theory, Research, and Clinical Applications. New York: Guilford Press, pp. 336-354.
49. Heinz, A., Siessmeier, T., Wrase, J., et al. (2004). Correlation between dopamine D2 receptors in the ventral striatum and central processing of alcohol cues and craving. The American Journal of Psychiatry, 161, 1783-9.
50. Hendrick, C., Hendrick, S.S. (1986). A theory and method of love. Journal of Personality and Social Psychology, 50, 392-402.
51. Hendrick, S., Hendrick, C. (1992). Romantic Love. Newbury Park, CA: Sage Publications, Inc.
52. Insel, T.R., Wang, Z.X., Ferris, C.F. (1994). Patterns of brain vasopressin receptor distribution associated with social organization in microtine rodents. Journal of Neuroscience, 14, 5381-92.
53. Jenkins, J.S., Ang, V.T., Hawthorn, J., Rossor, M.N., Iversen, L.L. (1984). Vasopressin, oxytocin and neurophysins in the human brain and spinal cord. Brain Research, 291(1), 111-7.
54. Kampe, K., Frith, C.D., Frith, U. (2003). "Hey John": Signals conveying communicative intention towards the self activate brain regions associated with mentalising regardless of modality. Journal of Neuroscience, 23, 5258-63.
55. Karama, S., Lecours, A.R., Leroux, J.-M., et al. (2002). Areas of brain activation in males and females during viewing of erotic film excerpts. Human Brain Mapping, 16, 1-13.
56. Karney, B.R., Bradbury, T.N. (2005). Contextual influences on marriage: Implications for policy and intervention. Current Directions in Psychological Science, 14, 171-4.
57. Kirouac, G.J., Li, S., Mabrouck, G. (2004). GABAergic projections from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal Raphe nucleus. The Journal of Comparative Neurology, 469, 170-84.
58. Klein, T.A., Endrass, T., Kathmann, N., et al. (2007). Neural correlates of error awareness. Neuroimage, 34, 1774-81.
59. Knutson, B., Greer, S.M. (2008). Anticipatory affect: neural correlates and consequences for choice. Philosophical Transactions of the Royal Society B, 363, 3771-86.
60. Kurth, F., Ziles, K., Fox, P.T., Laird, A.R., Eickhoff, S.B. (2010). A link between the systems: Functional differentiation and integration within the human insula revealed by meta-analysis. Brain Structure and Function, 214, 519-34.
61. LaBar, K.S., Gitelman, D.R., Mesulam, M.M., Parrish, T.B. (2001). Impact of signal-to-noise on functional MRI of the human amygdala. Neuroreport, 12, 3461-4.
62. Lee, John, A. (1977). A typology of styles of loving. Personality & Social Psychology Bulletin, 3, 173-82.
63. Leibenluft, E., Gobbini, M.I., Harrison, T., Haxby, J.V. (2004). Mothers' neural activation in response to pictures of their children and other children. Biological Psychiatry, 56(4), 225-32.
64. Lim, M.M., Young, L.J. (2004). Vasopresson-dependent neural circuits underlying pair-bond formation in the monogamous prairie vole. Neuroscience, 125, 35-45.
65. Loup, F.E., Tribollet, E., Dubois-Dauphin, M., Dreifuss, J.J. (1991). Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Research, 555, 220-32.
66. Loup, F.E., Tribollet, E., Dubois-Dauphin, M., Pizzolato, G., Dreifuss, J.J. (1989). Localization of oxytocin binding sites in the human brainstem and uppoer spinal cord: An auto radiographic study. Brain Research, 500, 223-30.
67. Maddock, R.J., Garrett, A.S., Buonocore, M.H. (2001). Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience, 104(3), 667-76.
68. Mai, J.K., Paxinos, G., Voss, T. (2008). Atlas of the Human Brain, 3rd edn. San Diego: Elsevier Academic Press.
69. Maner, J.K., Rouby, D.A., Gonzaga, G.C. (2008). Automatic inattention to attractive alternatives: the evolved psychology of relationship maintenance. Evolution and Human Behavior, 29, 343-9.
70. Master, S.L., Eisenberger, N.I., Taylor, S.E., Naliboff, B.D., Shirinyan, D., Lieberman, M.D. (2009). A picture's worth. Partner photographs reduce experimentally induced pain. Psychological Science, 20, 1316-8.
71. Menzies, L., Chamberlain, S.R., Laird, A.R., et al. (2008). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofrontal-straitel model revisited. Neuroscience and Behavioral Reviews, 32, 525-49.
72. Mikulincer, M., Shaver, P.R. (2007). Attachment in Adulthood: Structure, Dynamics, and Change. New York: The Guilford Press.
73. Miller, R.S. (1997). Inattentive and contented: Relationship commitment and attention to alternatives. Journal of Personality and Social Psychology, 73, 758-66.
74. Napier, T.C., Mitrovic, I. (1999). Opiod modulation of ventral pallidal inputs. Annals of the New York Academy of Sciences, 877, 176-201.
75. Northoff, G., Heinzel, A., deGreck, M., et al. (2006). Self-referential processing in our brain-a meta-analysis of imaging studies on the self. Neuroimage, 31, 440-57.
76. O'Connor, M.-F., Wellisch, D.K., Stanton, A.L., et al. (2008). Craving love? Enduring grief activates brain's reward center. NeuroImage, 42, 969-72.
77. O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., Dolan, R.J. (2004). Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science, 304, 452-4.
78. Ochsner, K.N., Knierim, K., Ludlow, D.H., et al. (2004). Reflecting upon feelings: An fMRI study of neural systems supporting the attribution of emotion to self and other. Journal of Cognitive Neuroscience, 16, 1746-72.
79. Olive, M.F., Anton, B., Micevych, P., Evans, C.J., Maidment, N.T. (1997). Presynaptic vs. Postsynaptic locoalization of opioid receptors in dorsal and ventral striatopallidal pathways. J Neuroscience, 17, 7471-9.
80. Ortigue, S., Bianchi-Demicheli, F., Hamilton, A.F., Grafton, S.T. (2007). The neural basis of love as a subliminal prime: An event-related fMRI study. Journal of Cognitive Neuroscience, 19, 1218-30.
81. 33P in situ hybridization study. Neuroscience, 88, 1093-135.
82. Pelchat, M.L., Johnson, A., Chan, R., Valdez, J., Ragland, J.D. (2004). Images of desire: food-craving activation during fMRI. Neuroimage, 23, 1486-93.
83. Risinger, R.C., Salmeron, B.J., Ross, T.J., et al. (2005). Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. NeuroImage, 26(4), 1097-108.
84. Rusbult, C.E., Van Lange, P.A.M., Wildschut, T., Yovetich, N.A., Verette, J. (2000). Perceived superiority in close relationships: Why it exists and persists. Journal of Personality and Social Psychology, 79, 521-45.
85. Schultz, W. (2001). Reward signaling by dopamine neurons. The Neuroscientist, 7, 293-302.
86. Smith, K.S., Tindell, A.J., Aldridge, J.W., Berridge, K.C. (2009). Ventral pallidum roles in reward and motivation. Behavioral Brain Research, 196(2), 155-67.
87. Sroufe, L.A., Waters, E. (1977). Attachment as an organizational construct. Child Development, 48, 1184-99.
88. Sternberg, R.J. (1986). A triangular theory of love. Psychological Review, 93, 119-35.
89. Strathearn, L., Li, J., Fonagy, P., Montague, P. (2008). What's in a smile? Maternal brain responses to infant facial cues. Pediatrics, 122(1), 40-51.
90. Tennov, D. (1979). Love and Limerence: The Experience of Being in Love. New York: Stein & Day.
91. Walum, H., Westberg, L., Henningsson, S., et al. (2008). Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proceedings of the National Academy of Sciences, 105, 14153-6.
92. Wang, Z.X, Hulihan, T.J., Insel, T.R. (1997). Sexual and social experience is associated with different patterns of behavior and neural activation in male prairie voles. Brain Research, 767(2), 321-32.
93. Winslow, J., Hastings, N., Carter, C.S., Harbaugh, C., Insel, T.R. (1993). A role of central vasopressin in pair bondings in monogamous prairie voles. Nature, 365, 545-8.
94. Xu, X., Aron, A., Brown, L., Cao, G., Feng, T., Weng, X. (2010). Reward and motivation systems: a brain mapping study of early-stage intense romantic love in Chinese participants. Human Brain Mapping, 32, 249-57.
95. Young, L.J., Lim, M.M., Gingrich, B., Insel, T.R. (2001). Cellular mechanisms of social attachment. Hormones and Behavior, 40(2), 133-8.
96. Young, L.J., Wang, Z. (2004). The neurobiology of pair-bonding. Natural Neurosciences, 7(10), 1048-54.