Can CD44 be a mediator of cell destruction? the challenge of type 1 diabetes

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Assayag Asherie, Nathalie ^a   Sever, Dror ^b   Bogdani, Marika ^c   Johnson, Pamela ^c   Weiss, Talya ^a   Ginzberg, Ariel ^a   Perles, Sharon ^a   Weiss, Lola ^b   Sebban, Lora Eshkar ^a   Turley, Eva A ^d   Okon, Elimelech ^e   Raz, Itamar ^b   Naor, David ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c BENAROYA RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e LEM Labs   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HERMES ANTIGEN; HYALURONIC ACID; INSULIN; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DESTRUCTION; CONTROLLED STUDY; DISEASE RESISTANCE; FEMALE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; TUNEL ASSAY; ANIMAL; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTIGENS, CD44; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL MOVEMENT; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; HYALURONIC ACID; INSULIN-SECRETING CELLS; MICE;

EID: 84955583972     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0143589     Document Type: Article

References (45)

1. Notkins AL (2002) Immunologic and genetic factors in type 1 diabetes. J Biol Chem 277: 43545-43548.
2. Marino E, Silveira PA, Stolp J, Grey ST (2011) B cell-directed therapies in type 1 diabetes. Trends Immunol 32: 287-294. doi: 10.1016/j.it.2011.03.006
3. Lehuen A, Diana J, Zaccone P, Cooke A (2010) Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol 10: 501-513. doi: 10.1038/nri2787
4. Eizirik DL, Colli ML, Ortis F (2009) The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5: 219-226. doi: 10.1038/nrendo.2009.21
5. Dasu MR, Ramirez S, Isseroff RR (2012) Toll-like receptors and diabetes: A therapeutic perspective. Clin Sci (Lond) 122: 203-214.
6. Boerner BP, Sarvetnick NE (2011) Type 1 diabetes: role of intestinal microbiome in humans and mice. Ann N Y Acad Sci 1243: 103-118. doi: 10.1111/j.1749-6632.2011.06340.x
7. Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, et al. (2009) MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization. J Clin Invest 119: 492-503. doi: 10.1172/JCI36541
8. Springer TA (1995) Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 57: 827-872.
9. Savinov AY, Rozanov DV, Strongin AY (2006) Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes. FASEB J 20: 1793-1801.
10. Nandi A, Estess P, Siegelman MH (2000) Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44. J Biol Chem 275: 14939-14948.
11. Nandi A, Estess P, Siegelman M (2004) Bimolecular complex between rolling and firm adhesion receptors required for cell arrest; CD44 association with VLA-4 in T cell extravasation. Immunity 20: 455-465.
12. Yang XD, Michie SA, Tisch R, Karin N, Steinman L, McDevitt HO (1994) A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A 91: 12604-12608.
13. Weiss L, Slavin S, Reich S, Cohen P, Shuster S, Stern R, et al. (2000) Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody. Proc Natl Acad Sci U S A 97: 285-290.
14. Nedvetzki S, Golan I, Assayag N, Gonen E, Caspi D, Gladnikoff M, et al. (2003) A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor. J Clin Invest 111: 1211-1220.
15. Naor D, Nedvetzki S, Golan I, Melnik L, Faitelson Y (2002) CD44 in cancer. Crit Rev Clin Lab Sci 39: 527-579.
16. Nedvetzki S, Gonen E, Assayag N, Reich R, Williams RO, Thurmond RL, et al. (2004) RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: A different interpretation of redundancy. Proc Natl Acad Sci U S A 101: 18081-18086.
17. Pilarski LM, Masellis-Smith A, Belch AR, Yang B, Savani RC, Turley EA (1994) RHAMM, a receptor for hyaluronan-mediated motility, on normal human lymphocytes, thymocytes and malignant B cells: A mediator in B cell malignancy? Leuk Lymphoma 14: 363-374.
18. Maxwell CA, McCarthy J, Turley E (2008) Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions? J Cell Sci 121: 925-932. doi: 10.1242/jcs.022038
19. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, et al. (1997) CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90: 2217-2233.
20. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126: 131-138.
21. Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Meneur C, et al. (2005) Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab 2: 105-117.
22. Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, et al. (2009) LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab 10: 296-308. doi: 10.1016/j.cmet. 2009.08.010
23. Bonner-Weir S (1988) Morphological evidence for pancreatic polarity of beta-cell within islets of Langerhans. Diabetes 37: 616-621.
24. Kurrer MO, Pakala SV, Hanson HL, Katz JD (1997) Beta cell apoptosis in T cell-mediated autoimmune diabetes. Proc Natl Acad Sci U S A 94: 213-218.
25. Eizirik DL, Flodstrom M, Karlsen AE, Welsh N (1996) The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39: 875-890.
26. Kacheva S, Lenzen S, Gurgul-Convey E (2011) Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide. Cytokine 55: 195-201. doi: 10.1016/j.cyto.2011.04.002
27. Hui H, Dotta F, Di Mario U, Perfetti R (2004) Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. J Cell Physiol 200: 177-200.
28. Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL (2005) Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 Suppl 2: S97-107.
29. Sachdeva MM, Stoffers DA (2009) Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol 23: 747-758. doi: 10.1210/me.2008-0400
30. Jiang D, Liang J, Noble PW (2011) Hyaluronan as an immune regulator in human diseases. Physiol Rev 91: 221-264. doi: 10.1152/physrev.00052.2009
31. Sheehan KM, DeLott LB, West RA, Bonnema JD, DeHeer DH (2004) Hyaluronic acid of high molecular weight inhibits proliferation and induces cell death in U937 macrophage cells. Life Sci 75: 3087-3102.
32. Rockey DC, Chung JJ, McKee CM, Noble PW (1998) Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. Hepatology 27: 86-92.
33. Benitez A, Yates TJ, Lopez LE, Cerwinka WH, Bakkar A, Lokeshwar VB (2011) Targeting hyaluronidase for cancer therapy: Antitumor activity of sulfated hyaluronic acid in prostate cancer cells. Cancer Res 71: 4085-4095. doi: 10.1158/0008-5472.CAN-10-4610
34. Liu D, Pavlovic D, Chen MC, Flodstrom M, Sandler S, Eizirik DL (2000) Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). Diabetes 49: 1116-1122.
35. Moore F, Santin I, Nogueira TC, Gurzov EN, Marselli L, Marchetti P, et al. (2012) The transcription factor C/EBP delta has anti-Apoptotic and anti-inflammatory roles in pancreatic beta cells. PLoS One 7: e31062. doi: 10.1371/journal.pone.0031062
36. Du YR, Chen Y, Gao Y, Niu XL, Li YJ, DengWM(2013) Effects and mechanisms of anti-CD44 monoclonal antibody A3D8 on proliferation and apoptosis of sphere-forming cells with stemness from human ovarian cancer. Int J Gynecol Cancer 23: 1367-1375. doi: 10.1097/IGC.0b013e3182a1d023
37. Wang Q, Teder P, Judd NP, Noble PW, Doerschuk CM (2002) CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. Am J Pathol 161: 2219-2228.
38. Golan I, Nedvetzki S, Eshkar-Sebban L, Levartovsky D, Elkayam O, Caspi D, et al. (2007) Expression of extra trinucleotide in CD44 variant of rheumatoid arthritis patients allows generation of disease-specific monoclonal antibody. J Autoimmun 28: 99-113.
39. Vives-Pi M, Somoza N, Fernandez-Alvarez J, Vargas F, Caro P, Alba A, et al. (2003) Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells. Clin Exp Immunol 133: 208-218.
40. Yamasaki K, Muto J, Taylor KR, Cogen AL, Audish D, Bertin J, et al. (2009) NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem 284: 12762-12771. doi: 10.1074/jbc.M806084200
41. Tripathy D, Chavez AO (2010) Defects in insulin secretion and action in the pathogenesis of type 2 diabetes mellitus. Curr Diab Rep 10: 184-191. doi: 10.1007/s11892-010-0115-5
42. De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, et al. (1995) Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96: 2489-2495.
43. Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, et al. (2012) Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells. Cancer Res 72: 1438-1448. doi: 10.1158/0008-5472.CAN-11-3024
44. Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, et al. (2012) Expression-based genomewide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A 109: 7049-7054. doi: 10.1073/pnas.1114513109
45. Kang HS, Liao G, DeGraff LM, Gerrish K, Bortner CD, Garantziotis S, et al. (2013) CD44 plays a critical role in regulating diet-induced adipose inflammation, hepatic steatosis, and insulin resistance. PLoS One 8: e58417. doi: 10.1371/journal.pone.0058417