Fisetin alleviates early brain injury following experimental subarachnoid hemorrhage in rats possibly by suppressing TLR 4/NF-κB signaling pathway

Brain Research

Volumn 1629, Issue , 2015, Pages 250-259

  Zhou, Chen Hui ^a   Wang, Chun Xi ^a   Xie, Guang Bin ^a   Wu, Ling Yun ^a   Wei, Yong Xiang ^a   Wang, Qiang ^a   Zhang, Hua Sheng ^a   Hang, Chun Hua ^a   Zhou, Meng Liang ^a   Shi, Ji Xin ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Early brain injury; Fisetin; Nuclear factor B; Subarachnoid hemorrhage; Toll like receptor 4

Indexed keywords

FISETIN; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TLR4 PROTEIN, RAT; TOLL LIKE RECEPTOR 4;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN INJURIES; DRUG EFFECTS; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SUBARACHNOID HEMORRHAGE;

ANIMALS; BRAIN INJURIES; FLAVONOIDS; MALE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; TOLL-LIKE RECEPTOR 4;

EID: 84955514289     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.10.016     Document Type: Article

References (50)

1. V.M. Adhami, D.N. Syed, N. Khan, and H. Mukhtar Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management Biochem. Pharmacol. 84 2012 1277 1281
2. Y. Arai, S. Watanabe, M. Kimira, K. Shimoi, R. Mochizuki, and N. Kinae Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration J. Nutr. 130 2000 2243 2250
3. G.M. Barton, and R. Medzhitov Control of adaptive immune responses by toll-like receptors Curr. Opin. Immunol. 14 2002 380 383
4. G.M. Barton, and R. Medzhitov Toll-like receptor signaling pathways Science 300 2003 1524 1525
5. J.P. Broderick, T.G. Brott, J.E. Duldner, T. Tomsick, and A. Leach Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage Stroke 25 1994 1342 1347
6. J. Claassen, J.R. Carhuapoma, K.T. Kreiter, E.Y. Du, E.S. Connolly, and S.A. Mayer Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome Stroke 33 2002 1225 1232
7. J. Duarte, F. Perez-Vizcaino, A. Zarzuelo, J. Jimenez, and J. Tamargo Vasodilator effects of quercetin in isolated rat vascular smooth muscle Eur. J. Pharmacol. 239 1993 1 7
8. M. Fujii, K. Duris, O. Altay, Y. Soejima, P. Sherchan, and J.H. Zhang Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats Neurochem. Int. 60 2012 327 333
9. M. Gelderblom, F. Leypoldt, J. Lewerenz, G. Birkenmayer, D. Orozco, P. Ludewig, J. Thundyil, T.V. Arumugam, C. Gerloff, E. Tolosa, P. Maher, and T. Magnus The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice J. Cereb. Blood Flow Metab. 32 2012 835 843
10. C.H. Hang, J.X. Shi, J. Tian, J.S. Li, W. Wu, and H.X. Yin Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats Brain Res. 1026 2004 23 32
11. R. Helbok, S.B. Ko, J.M. Schmidt, P. Kurtz, L. Fernandez, H.A. Choi, E.S. Connolly, K. Lee, N. Badjatia, S.A. Mayer, and J. Claassen Global cerebral edema and brain metabolism after subarachnoid hemorrhage Stroke 42 2011 1534 1539
12. Y.C. Hu, Q. Sun, W. Li, D.D. Zhang, B. Ma, S. Li, W.D. Li, M.L. Zhou, and C.H. Hang Biphasic activation of nuclear factor kappa B and expression of p65 and c-Rel after traumatic brain injury in rats Inflamm. Res. 63 2014 109 115
13. H.S. Jang, S.H. Kook, Y.O. Son, J.G. Kim, Y.M. Jeon, Y.S. Jang, K.C. Choi, J. Kim, S.K. Han, K.Y. Lee, B.K. Park, N.P. Cho, and J.C. Lee Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells Biochim. Biophys. Acta 1726 2005 309 316
14. H. Jeon, J. Ai, M. Sabri, A. Tariq, and R.L. Macdonald Learning deficits after experimental subarachnoid hemorrhage in rats Neuroscience 169 2010 1805 1814
15. L. Lan, J. Tao, A. Chen, G. Xie, J. Huang, J. Lin, J. Peng, and L. Chen Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-kappaB pathway Int. J. Mol. Med. 31 2013 75 80
16. P.A. Lapchak Drug-like property profiling of novel neuroprotective compounds to treat acute ischemic stroke: guidelines to develop pleiotropic molecules Transl. Stroke Res. 4 2013 328 342
17. D.T. Laskowitz, and B.J. Kolls Neuroprotection in subarachnoid hemorrhage Stroke 41 2010 S79 S84
18. Z. Li, G. Liang, T. Ma, J. Li, P. Wang, L. Liu, B. Yu, Y. Liu, and Y. Xue Blood-brain barrier permeability change and regulation mechanism after subarachnoid hemorrhage Metab. Brain Dis. 30 2015 597 603
19. C.X. Ma, W.N. Yin, B.W. Cai, J. Wu, J.Y. Wang, M. He, H. Sun, J.L. Ding, and C. You Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage Chin. Med. J. 122 2009 1575 1581
20. R.L. Macdonald, R.T. Higashida, E. Keller, S.A. Mayer, A. Molyneux, A. Raabe, P. Vajkoczy, I. Wanke, D. Bach, A. Frey, A. Marr, S. Roux, and N. Kassell Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2) Lancet Neurol. 10 2011 618 625
21. R.L. Macdonald Delayed neurological deterioration after subarachnoid haemorrhage Nat. Rev. Neurol. 10 2014 44 58
22. P. Maher, T. Akaishi, and K. Abe Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory Proc. Natl. Acad. Sci. USA 103 2006 16568 16573
23. P. Maher, K.F. Salgado, J.A. Zivin, and P.A. Lapchak A novel approach to screening for new neuroprotective compounds for the treatment of stroke Brain Res. 1173 2007 117 125
24. P. Maher, R. Dargusch, L. Bodai, P.E. Gerard, J.M. Purcell, and J.L. Marsh ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease Hum. Mol. Genet. 20 2011 261 270
25. I. Murtaza, V.M. Adhami, B.B. Hafeez, M. Saleem, and H. Mukhtar Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB Int. J. Cancer 125 2009 2465 2473
26. M.Y. Patel, H.V. Panchal, O. Ghribi, and K.E. Benzeroual The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease J. Parkinsons Dis. 2 2012 287 302
27. G.F. Prunell, N.A. Svendgaard, K. Alkass, and T. Mathiesen Inflammation in the brain after experimental subarachnoid hemorrhage Neurosurgery 56 2005 1082 1092 Discussion 1082-92
28. C.A. Rice-Evans, N.J. Miller, and G. Paganga Structure-antioxidant activity relationships of flavonoids and phenolic acids Free Radic. Biol. Med. 20 1996 933 956
29. D.A. Ridder, and M. Schwaninger NF-kappaB signaling in cerebral ischemia Neuroscience 158 2009 995 1006
30. F.A. Sehba, J. Hou, R.M. Pluta, and J.H. Zhang The importance of early brain injury after subarachnoid hemorrhage Prog. Neurobiol. 97 2012 14 37
31. Q. Sun, W. Wu, Y.C. Hu, H. Li, D. Zhang, S. Li, W. Li, W.D. Li, B. Ma, J.H. Zhu, M.L. Zhou, and C.H. Hang Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro J. Neuroinflamm. 11 2014 106
32. X. Sun, C. Ji, T. Hu, Z. Wang, and G. Chen Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling J. Neuroinflamm. 10 2013 157
33. B. Sung, M.K. Pandey, and B.B. Aggarwal Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation Mol. Pharmacol. 71 2007 1703 1714
34. H. Suzuki, R. Ayer, T. Sugawara, W. Chen, T. Sozen, Y. Hasegawa, K. Kanamaru, and J.H. Zhang Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats Crit. Care Med. 38 2010 612 618
35. B.C. Topkoru, O. Altay, K. Duris, P.R. Krafft, J. Yan, and J.H. Zhang Nasal administration of recombinant osteopontin attenuates early brain injury after subarachnoid hemorrhage Stroke 44 2013 3189 3194
36. K. Uekawa, Y. Hasegawa, M. Ma, T. Nakagawa, T. Katayama, D. Sueta, K. Toyama, K. Kataoka, N. Koibuchi, T. Kawano, J. Kuratsu, and S. Kim-Mitsuyama Rosuvastatin ameliorates early brain injury after subarachnoid hemorrhage via suppression of superoxide formation and nuclear factor-kappa B activation in rats J. Stroke Cerebrovasc. Dis. 23 2014 1429 1439
37. P. Vajkoczy, B. Meyer, S. Weidauer, A. Raabe, C. Thome, F. Ringel, V. Breu, and P. Schmiedek Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study J. Neurosurg. 103 2005 9 17
38. J. van Gijn, R.S. Kerr, and G.J. Rinkel Subarachnoid haemorrhage Lancet 369 2007 306 318
39. Z. Wang, G. Zuo, X.Y. Shi, J. Zhang, Q. Fang, and G. Chen Progesterone administration modulates cortical TLR4/NF-kappaB signaling pathway after subarachnoid hemorrhage in male rats Mediat. Inflamm. 2011 2011 848309
40. Z. Wang, L. Wu, W. You, C. Ji, and G. Chen Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway J. Pineal Res. 55 2013 399 408
41. M.Y. Wu, S.K. Hung, and S.L. Fu Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-kappaB activity J. Agric. Food Chem. 59 2011 10496 10504
42. M. Yamaguchi, C. Zhou, A. Nanda, and J.H. Zhang Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model Stroke 35 2004 1750 1755
43. W.C. You, W. Li, Z. Zhuang, Y. Tang, H.C. Lu, X.J. Ji, W. Shen, J.X. Shi, and M.L. Zhou Biphasic activation of nuclear factor-kappa B in experimental models of subarachnoid hemorrhage in vivo and in vitro Mediat. Inflamm. 2012 2012 786242
44. W.C. You, C.X. Wang, Y.X. Pan, X. Zhang, X.M. Zhou, X.S. Zhang, J.X. Shi, and M.L. Zhou Activation of nuclear factor-kappaB in the brain after experimental subarachnoid hemorrhage and its potential role in delayed brain injury PLoS One 8 2013 e60290
45. V. Zbarsky, K.P. Datla, S. Parkar, D.K. Rai, O.I. Aruoma, and D.T. Dexter Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease Free Radic. Res. 39 2005 1119 1125
46. X.S. Zhang, X. Zhang, Q. Wu, W. Li, C.X. Wang, G.B. Xie, X.M. Zhou, J.X. Shi, and M.L. Zhou Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage J. Surg. Res. 192 2014 206 213
47. L.T. Zheng, J. Ock, B.M. Kwon, and K. Suk Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity Int. Immunopharmacol. 8 2008 484 494
48. M.L. Zhou, J.X. Shi, C.H. Hang, H.L. Cheng, X.P. Qi, L. Mao, K.F. Chen, and H.X. Yin Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits J. Cereb. Blood Flow Metab. 27 2007 1583 1592
49. M.L. Zhou, J.X. Shi, C.H. Hang, F.F. Zhang, J. Gao, and H.X. Yin Expression of Toll-like receptor 4 in the brain in a rabbit experimental subarachnoid haemorrhage model Inflamm. Res. 56 2007 93 97
50. Z. Zhuang, M.L. Zhou, W.C. You, L. Zhu, C.Y. Ma, X.J. Sun, and J.X. Shi Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits BMC Neurosci. 13 2012 47