Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 4, 2016, Pages 966-971

  Kaisari, Sharon ^a   Sitry Shevah, Danielle ^a   Miniowitz Shemtov, Shirly ^a   Hershko, Avram ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Cell cycle; Protein degradation; Ubiquitin

Indexed keywords

ANAPHASE PROMOTING COMPLEX; BUB1 RELATED PROTEIN; CELL CYCLE PROTEIN 20; PROTEIN MAD2; BUB1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

ARTICLE; BINDING SITE; CATALYSIS; ENZYME REGULATION; M PHASE CELL CYCLE CHECKPOINT; PRIORITY JOURNAL; HUMAN; METABOLISM; PHYSIOLOGY;

ANAPHASE-PROMOTING COMPLEX-CYCLOSOME; CATALYSIS; CDC20 PROTEINS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MAD2 PROTEINS; PROTEIN-SERINE-THREONINE KINASES;

EID: 84955462220     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1524551113     Document Type: Article

References (28)

1. Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8(5):379-393.
2. Lara-Gonzalez P, Westhorpe FG, Taylor SS (2012) The spindle assembly checkpoint. Curr Biol 22(22):R966-R980.
3. Jia L, Kim S, Yu H (2013) Tracking spindle checkpoint signals from kinetochores to APC/C. Trends Biochem Sci 38(6):302-311.
4. Primorac I, Musacchio A (2013) Panta rhei: The APC/C at steady state. J Cell Biol 201(2): 177-189.
5. Sudakin V, Chan GK, Yen TJ (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol 154(5):925-936.
6. Miniowitz-Shemtov S, Teichner A, Sitry-Shevah D, Hershko A (2010) ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint. Proc Natl Acad Sci USA 107(12):5351-5356.
7. Teichner A, et al. (2011) p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process. Proc Natl Acad Sci USA 108(8):3187-3192.
8. Miniowitz-Shemtov S, et al. (2012) Role of phosphorylation of Cdc20 in p31(comet)- stimulated disassembly of themitotic checkpoint complex. Proc Natl Acad Sci USA 109(21): 8056-8060.
9. Eytan E, et al. (2014) Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet). Proc Natl Acad Sci USA 111(33):12019-12024.
10. Wang K, et al. (2014) Thyroid hormone receptor interacting protein 13 (TRIP13) AAAATPase is a novelmitotic checkpoint-silencing protein. J Biol Chem289(34):23928-23937.
11. Miniowitz-Shemtov S, Eytan E, Kaisari S, Sitry-Shevah D, Hershko A (2015) Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes. Proc Natl Acad Sci USA 112(37):11536-11540.
12. Ye Q, et al. (2015) TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. eLife 2015(4):e07367.
13. Malureanu LA, et al. (2009) BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Dev Cell 16(1):118-131.
14. Chao WC, Kulkarni K, Zhang Z, Kong EH, Barford D (2012) Structure of the mitotic checkpoint complex. Nature 484(7393):208-213.
15. Davenport J, Harris LD, Goorha R (2006) Spindle checkpoint function requires Mad2- dependent Cdc20 binding to the Mad3 homology domain of BubR1. Exp Cell Res 312(10):1831-1842.
16. Tang Z, Bharadwaj R, Li B, Yu H (2001) Mad2-independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev Cell 1(2):227-237.
17. Diaz-Martinez LA, et al. (2015) The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. J Biol Chem 290(4):2431-2443.
18. Nilsson J, Yekezare M, Minshull J, Pines J (2008) The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol 10(12):1411-1420.
19. Han JS, et al. (2013) Catalytic assembly of the mitotic checkpoint inhibitor BubR1- Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell 51(1):92-104.
20. Izawa D, Pines J (2015) The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C. Nature 517(7536):631-634.
21. Luo X, Tang Z, Rizo J, Yu H (2002) The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell 9(1):59-71.
22. Sironi L, et al. (2002) Crystal structure of the tetrameric Mad1-Mad2 core complex: Implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J 21(10):2496-2506.
23. Fang G (2002) Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol Biol Cell 13(3):755-766.
24. Izawa D, Pines J (2012) Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation. J Cell Biol 199(1):27-37.
25. Lara-Gonzalez P, Scott MI, Diez M, Sen O, Taylor SS (2011) BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. J Cell Sci 124(Pt 24): 4332-4345.
26. Murray AW (1991) Cell cycle extracts. Methods Cell Biol 36:581-605.
27. Braunstein I, Miniowitz S, Moshe Y, Hershko A (2007) Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint. Proc Natl Acad Sci USA 104(12):4870-4875.
28. Uzunova K, et al. (2012) APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol 19(11):1116-1123.