Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances

Platelets

Volumn 27, Issue 1, 2016, Pages 86-92

  Södergren, Anna L ^a   Svensson Holm, Ann Charlotte B ^a   Ramström, Sofia ^a   Lindström, Eva G ^a   Grenegård, Magnus ^a,b   Öllinger, Karin ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b ÖREBRO UNIVERSITY   (Sweden)

Author keywords

ADP receptors; endothelium; exocytosis; lysosome; platelet physiology; protease activated receptors (PAR); thrombin

Indexed keywords

ADENOSINE DIPHOSPHATE; CANGRELOR; ICOSANOID; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ENZYME; N ACETYL BETA GLUCOSAMINIDASE; N ACETYL S NITROSOPENICILLAMINE; PADGEM PROTEIN; THROMBIN; THROMBOXANE A2; ACETYLGLUCOSAMINIDASE; ADENOSINE PHOSPHATE; LAMP1 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; PROSTACYCLIN; PROTEINASE ACTIVATED RECEPTOR 1; PURINERGIC P2Y RECEPTOR ANTAGONIST;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM; EXOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; LYSOSOMAL EXOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; LYSOSOME; METABOLISM;

ACETYLGLUCOSAMINIDASE; ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; BLOOD PLATELETS; EPOPROSTENOL; EXOCYTOSIS; HUMANS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RECEPTOR, PAR-1; THROMBIN;

EID: 84955347294     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2015.1042446     Document Type: Article

References (37)

1. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood 2004; 103: 2096-2104
2. Rendu F, Brohard-Bohn B. The platelet release reaction: Granules constituents, secretion and functions. Platelets 2001; 12: 261-273
3. Appelqvist H, Waster P, Kagedal K, Ollinger K. The lysosome: From waste bag to potential therapeutic target. J Mol Cell Biol 2013; 5: 214-226
4. Jackson SP, Schoenwaelder SM. Procoagulant platelets: Are they necrotic? Blood 2010; 116: 2011-2018
5. Repnik U, Stoka V, Turk V, Turk B. Lysosomes and lysosomal cathepsins in cell death. Biochim Biophys Acta 2012; 1824: 22-33
6. Kagedal K, Johansson U, Ollinger K. The lysosomal protease cathepsin d mediates apoptosis induced by oxidative stress. FASEB J 2001; 15: 1592-1594
7. Febbraio M, Silverstein RL. Identification and characterization of lamp-1 as an activation-dependent platelet surface glycoprotein. J Biol Chem 1990; 265: 18531-18537
8. Polasek J. Lysosomal concept of platelet secretion-Revisited. Eur J Haematol Suppl 1989; 50: 3-24
9. Ciferri S, Emiliani C, Guglielmini G, Orlacchio A, Nenci GG, Gresele P. Platelets release their lysosomal content in vivo in humans upon activation. Thromb Haemost 2000; 83: 157-164
10. Jonnalagadda D, Izu LT, Whiteheart SW. Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood 2012; 120: 5209-5216
11. Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW. Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. J Clin Invest 2014; 124: 4517-4528
12. Emiliani C, Ciferri S, Mencarelli S, Mezzasoma AM, Momi S, Orlacchio A, Gresele P. Defective platelet beta- n -acetyl hexosaminidase content and release in chronic myeloproliferative disorders. Platelets 2006; 17: 20-29
13. Lippincott-Schwartz J, Fambrough DM. Lysosomal membrane dynamics: Structure and interorganellar movement of a major lysosomal membrane glycoprotein. J Cell Biol 1986; 102: 1593-1605
14. Reddy A, Caler EV, Andrews NW. Plasma membrane repair is mediated by ca(2+)-regulated exocytosis of lysosomes. Cell 2001; 106: 157-169
15. Coorssen JR, Schmitt H, Almers W. Ca2+ triggers massive exocytosis in chinese hamster ovary cells. EMBO J 1996; 15: 3787-3791
16. Rodriguez A, Webster P, Ortego J, Andrews NW. Lysosomes behave as ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol 1997; 137: 93-104
17. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068
18. Rasmussen UB, Vouret-Craviari V, Jallat S, Schlesinger Y, Pages G, Pavirani A, Lecocq JP, Pouyssegur J, Van Obberghen-Schilling E. CDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett 1991; 288: 123-128
19. Brass LF. Thrombin and platelet activation. Chest 2003; 124: 18S-25S
20. Freedman JE. Molecular regulation of platelet-dependent thrombosis. Circulation 2005; 112: 2725-2734
21. Beaulieu LM, Freedman JE. 2013. Inhibition of platelet function by the endothelium. In: Michelson AD., editor. Platelets, 3rd ed. Place: Elsevier/Academic Press, London, pp 313-342
22. Radomski MW, Palmer RM, Moncada S. The anti-aggregating properties of vascular endothelium: Interactions between prostacyclin and nitric oxide. Br J Pharmacol 1987; 92: 639-646
23. Storrie B, Madden EA. Isolation of subcellular organelles. Methods Enzymol 1990; 182: 203-225
24. Israels SJ, McMillan EM, Robertson C, Singhory S, McNicol A. The lysosomal granule membrane protein, lamp-2, is also present in platelet dense granule membranes. Thromb Haemost 1996; 75: 623-629
25. Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard JM. The protein cd63 is in platelet dense granules, is deficient in a patient with hermansky-pudlak syndrome, and appears identical to granulophysin. J Clin Invest 1993; 91: 1775-1782
26. Holmsen H, Dangelmaier CA, Rongved S. Tight coupling of thrombin-induced acid hydrolase secretion and phosphatidate synthesis to receptor occupancy in human platelets. Biochem J 1984; 222: 157-167
27. Vorland M, Holmsen H. Phospholipase D in human platelets: Presence of isoenzymes and participation of autocrine stimulation during thrombin activation. Platelets 2008; 19: 211-224
28. Kim S, Foster C, Lecchi A, Quinton TM, Prosser DM, Jin J, Cattaneo M, Kunapuli SP. Protease-activated receptors 1 and 4 do not stimulate g(i) signaling pathways in the absence of secreted adp and cause human platelet aggregation independently of g(i) signaling. Blood 2002; 99: 3629-3636
29. Li Z, Delaney MK, OBrien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 2010; 30: 2341-2349
30. Silverstein RL, Febbraio M. Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. Blood 1992; 80: 1470-1475
31. Chronos NA, Wilson DJ, Janes SL, Hutton RA, Buller NP, Goodall AH. Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of alpha-granules or lysosomes from human platelets. Clin Sci (Lond) 1994; 87: 575-580
32. McKenzie ME, Malinin AI, Bell CR, Dzhanashvili A, Horowitz ED, Oshrine BR, Atar D, Serebruany VL. Aspirin inhibits surface glycoprotein iib/iiia, p-selectin, cd63, and cd107a receptor expression on human platelets. Blood Coagul Fibrinolysis 2003; 14: 249-253
33. Ohlmann P, Laugwitz KL, Nurnberg B, Spicher K, Schultz G, Cazenave JP, Gachet C. The human platelet adp receptor activates gi2 proteins. Biochem J 1995; 312(Pt 3): 775-779
34. Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, et al. Identification of the platelet adp receptor targeted by antithrombotic drugs. Nature 2001; 409: 202-207
35. Kajikawa N, Kaibuchi K, Matsubara T, Kikkawa U, Takai Y, Nishizuka Y, Itoh K, Tomioka C. A possible role of protein kinase c in signal-induced lysosomal enzyme release. Biochem Biophys Res Commun 1983; 116: 743-750
36. Kim-Shapiro DB, Schechter AN, Gladwin MT. Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics. Arterioscler Thromb Vasc Biol 2006; 26: 697-705
37. Rao GH, Krishnamurthi S, Raij L, White JG. Influence of nitric oxide on agonist-mediated calcium mobilization in platelets. Biochem Med Metab Biol 1990; 43: 271-275