Platelets release their lysosomal content in vivo in humans upon activation

Thrombosis and Haemostasis

Volumn 83, Issue 1, 2000, Pages 157-164

  Ciferri, Silvia ^b   Emiliani, Carla ^b   Guglielmini, Giuseppe ^b   Orlacchio, Antonio ^b   Nenci, Giuseppe G ^b   Gresele, Paolo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b NONE

Author keywords

Bleeding time; Flow cytometry; LIMP and LAMP2; Platelet secretion; Platelet vessel wall interaction

Indexed keywords

BETA GALACTOSIDASE; BETA N ACETYLHEXOSAMINIDASE; GLYCOLIPID; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; GLYCOSIDASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME ENZYME; PROTEIN; PROTEIN LIMP; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLEEDING TIME; BLOOD; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN EXPERIMENT; HUMAN TISSUE; IN VIVO STUDY; LYSOSOME; MALE; NONHUMAN; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN INJURY; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE RELEASE REACTION;

EID: 0033964465     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613772     Document Type: Article

References (50)

1. White JG. Platelet secretory granules and associated proteins. Lab Invest 1993; 68: 497-8.
2. Holmsen H. Platelet secretion and energy metabolism. In: Hemostasis and Thrombosis. Basic Principles and Clinical Practice. Colman RW, Hirsh J, Marder VJ. Salzman EW, eds. Philadelphia: JB Lippincott 1994; 524-45.
3. Holmsen H, Day HJ. The selectivity of the thrombin-induced platelet release reaction: sub-cellular localization of released and retained constituents. J Lab Clin Med 1970; 75: 841-55.
4. Metzelaar M, Clevers HC. Lysosomal membrane glycoproteins in platelets. Thromh Haemost 1992; 68: 378-82.
5. Gresele P, Arnout J, Deckmyn H, Huybrechts E, Pieters GP, Vermylen J. Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. J Clin Invest 1987; 80: 1435-45.
6. Weiss HJ, Lages B. Evidence for tissue factor dependent activation of the classic extrinsic coagulation mechanism in blood obtained from bleeding time wounds. Blood 1988; 71: 629-35.
7. Kyrle PA, Stockenhuber F, Brenner B, Gossinger H, Korninger C, Pabinger I, Sunder-Plassman G, Balcke P, Lechner K. Evidence for an increased generation of prostacyclin in microvasculature and an impairment of the platelet α-granule release in chronic renal failure. Thromb Haemost 1988; 60: 205-8.
8. Abrams CS, Ellison N, Budzynski AZ, Shattil SJ. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood 1990; 75: 128-38.
9. Michelson AD, Ellis PA, Barnard MR, Matic GB, Viles AF, Kestin AS. Downregulation of platelet surface glycoprotein Ib-IX in whole blood stimulated by thrombin, adenosine diphosphate, or an in vivo wound. Blood 1991; 77: 770-9.
10. Holtzman E. Lysosomes. New York: Plenum 1989.
11. Barret AJ. Proteolytic and other metabolic pathways in lysosomes. Biochem Soc Transact 1984; 12: 899-902.
12. Mahuran DJ, Novak A, Lowden JA. The lysosomal hexosaminidase isoenzymes. In: Isoenzymes, Current Topics in Biological and Medical Research. New York: Alan Liss Inc 1985; 229-88.
13. Thompson NJ, Stoolmiller AC, Matalon R, Dorfman A. N-Acetyl β-hexosaminidase: role in the degradation of glycosaminoglycans. Science 1973; 181: 866-7.
14. Koike K, Holmsen H. Requirement for thrombin receptor occupancy during platelet secretion under aggregating and non-aggregating conditions. Thromb Haemost 1987; 58: 1053-9.
15. Gresele P, Dottorini M, Selli ML, Iannacci L, Canino S, Todisco T, Romano S, Crook P, Page CP, Nenci GG. Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma. J Allergy Clin Immunol 1993; 91: 894-902.
16. Nieuwenhuis HK, van Oosterhout JJG, Rozemuller E, van Iwaarden F, Sixma JJ. Studies with a monoclonal antibody against activated platelets: evidence that secreted 53,000-molecular weight lysosome-like granule protein is exposed on surface of activated platelets in the circulation. Blood 1987; 70: 838-45.
17. Mc Ever RP. Properties of GMP-140, an inducible granule membrane protein of platelets and endothelium. Blood Cells 1990; 16: 73-83.
18. Israels SJ, McMillan EM, Robertson C, Singhroy S, McNicol A. The lysosomal granule membrane protein, LAMP-2 is also present in platelet dense granule membrane. Thromb Haemost 1996; 4: 623-9.
19. McGregor JL, Brochier J, Wild F, Follea G, Trzeciak MC, James E, Dechavanne M, McGregor L, Clemetson K. Monoclonal antibodies against platelet membrane glycoproteins. Eur J Biochem 1983; 131: 427-36.
20. Emiliani C, Martino S, Orlacchio A, Vezza R, Nenci GG, Gresele P. Platelet glycohydrolase activities: characterization and release. Cell Biochem Funct 1995; 13: 31-9.
21. Emiliani C, Beccari T, Stirling JL, Sciarra R, Orlacchio A. New biospecific chromatographies for β-Hexosaminidase. In: Macromolecular Biorecognition. Chaiken I, Chicone E, Fontana A, Neri P, eds. Clifton: The Humana Press 1988; 309-19.
22. Kaplan KL, Owen J. Plasma levels of β-thromboglobulin and platelet factor 4 as indices of platelet activation "in vivo". Blood 1981; 57: 199-202.
23. Laudano AP, Doolittle RF. Synthetic peptide derivatives that bind fibrinogen and prevent the polymerization of fibrin monomers. Proc Natl Acad Sci USA 1978; 75: 3085-9.
24. Knöfler R, Weissbach G, Khlisc E. Critical evaluation of ATP release reaction in whole blood. Thromb Res 1996; 84: 157-65.
25. 2 potentiates platelet aggregation by priming protein kinase C. Blood 1993; 82: 2704-13.
26. 4 production by stimulated whole blood: comparative studies with isolated polymorphonuclear cells. Biochem Biophys Res Commun 1986; 137: 334-42.
27. Gresele P, Ribaldi E, Mezzasoma AM, Quero E, Stasi M, Prosdocimi M, Goracci G, Nenci GG. Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids. Biochem Pharmacol 1993; 45: 123-30.
28. Martino S, Emiliani C, Tabilio A, Falzetti F, Stirling JL, Orlacchio A. Distribution of active alpha-and beta-subunits of beta-N-acetylhexosaminidase as function of leukaemic cell type. Biochim Biophys Acta 1997; 1335: 5-15.
29. Gerli R, Paolucci C, Gresele P, Bistoni O, Fiorucci S, Muscat C, Belia S, Bertotto A, Costantini V. Salicylates inhibit adhesion and transmigration of T lymphocytes by preventing integrin activation induced by contact with endothelial cells. Blood 1998; 92: 2389-98.
30. Beccari T, Emiliani C, Hosseini R, Orlacchio A, Stirling JL. Intermediate forms of beta-N-acetylhexosaminidase lack activity towards 4-methylumbelliferyl beta-N-acetylglucosaminide 6-sulphate. Biochem J 1987; 244: 801-4.
31. Murphy S. The oxidation of exogenously added organic anions by platelets facilitates maintainance of pH during their storage for transfusion at 22 degrees C. Blood 1995; 85: 1929-35.
32. Leoncini G, Balestrero F, Maresca M. Lysosomal enzymes in human platelets. Cell Biochem Funct 1985; 3: 121-5.
33. Holmsen H, Setkowsky CA, Lages B, Day HJ, Weiss HJ, Scrutton MC. Content and thrombin-induced release of acid hydrolases in gel-filtered platelets from patients with storage pool disease. Blood 1975; 46: 131-42.
34. Gresele P, Catalano M, Giammarresi C, Volpato R, Termini R, Ciabattoni G, Nenci GG, Davì G. Platelet activation markers in patients with peripheral arterial disease. A prospective comparison of different platelet function tests. Thromb Haemost 1997; 78: 1434-7.
35. Nguyen A, Gemmell CH, Yeo EL, Packham MA, Rand ML. Ethanol inhibits thrombin-induced secretion of content of human platelet dense and α-granules and lysosomes. Thromb Haemost 1998; 80: 662-7.
36. Macey MG. The protease-activated receptors and their cellular expression and function in blood-related cells. Br J Haematol 1998; 101: 1-9.
37. Senior RM, Hinek A, Griffin GL, Pipoly DJ, Crouch EC, Mecham RP. Neutrophils show chemotaxis to type IV collagen and its 7s domain and contain a 67 KD type IV collagen binding protein with lectin properties. Am J Cell Mol Biol 1989; 1: 479-87.
38. Senger DR, Claffey KP, Detmar M. Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci Usa 1997; 94: 13612-7.
39. Silverstein RL, Febbraio M. Identification of lysosomal-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. Blood 1992; 80: 1470-5.
40. Kannan K, Divers SG, Lurie AA, Chervenak R, Fukuda M, Holcombe RF. Cell surface expression of lysosome-associated membrane protein-2 (LAMP-2 ) and CD 63 as markers of "in vivo" platelet activation in malignancy. Eur J Haematol 1995; 55: 145-51.
41. Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard JM. The protein CD63 is in platelet dense granules, is deficient in patients with Hermansky-Pudlak syndrome, and appears identical to granulophysin. J Clin Invest 1993; 91: 1775-82.
42. Janes SJ, Wilson DJ, Cox AD, Chronos NAF, Goodall AH. ADP causes partial degranulation of platelets in the absence of aggregation. Brit J Haematol 1994; 86: 568-73.
43. Doebber TW, Wu MS, Shen TY. Platelet activating factor intravenous infusion in rats stimulates lysosomal hydrolase secretion independent of blood neutrophils. Biochem Biophys Res Commun 1984; 125: 980-7.
44. Baron R, Neff L, Louvard D. Courtoy PJ. Cell-mediated extracellular acidification and bone resorption: evidence for low pH in resorbing lacunae and localization of a 100-KD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 1985; 10: 2210-22.
45. Montcourrier P, Mangeat PH, Salarar G, Morriset M, Sahuquet A, Rochefort H. Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles. Cancer Res 1990, 50: 6045-54.
46. Miller D, Gong X, Decker G, Shur BD. Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy. J Cell Biol 1993; 123: 1431-40.
47. Movat H, Wasi S. Severe microvascular injury induced by lysosomal releasates of human polymorphonuclear leukocytes. Increase in vasopermeability, hemorrhage, and microthrombosis due to degradation of subendothelial and perivascular matrices. Am J Pathol 1985; 12: 404-17.
48. Muir EM, Bowyer DE. Inhibition of pinocytosis and induction of release of lysosomal contents by lysosomal overload of arterial smooth muscle cells "in vitro". Atherosclerosis 1984; 50: 85-92.
49. Sasahara M, Hazamana F, Amano S, Hayase Y, Yukioka N, Kawai J, Kataoka H. Effects of hypertension on lysosomal enzymes activities in aortic endothelial cells. Atherosclerosis 1988; 24: 433-6.
50. Hultberg B, Isaksson A, Nilsson JA, Lindgarde F. Serum beta-hexosaminidase isoenzymes are related to risk factors for atherosclerosis in a large population of postmenopausal women. Clin Chim Acta 1994; 227: 59-68.