A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjögren's syndrome and systemic lupus erythematosus

Clinical and Experimental Immunology

Volumn 183, Issue 1, 2016, Pages 76-89

  Szabo K ^a   Papp, G ^a   Szanto A ^a   Tarr, T ^a   Zeher, M ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

B cell; Follicular T helper cell; Interleukin 21; Primary Sj gren's syndrome; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 21; LA ANTIBODY; RO ANTIBODY; INTERLEUKIN DERIVATIVE;

ADULT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; FOLLICULAR T HELPER CELL; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPATHOLOGY; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; MIDDLE AGED; PLASMABLAST; PRE B LYMPHOCYTE; PRIORITY JOURNAL; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; AGED; BLOOD; CELL DIFFERENTIATION; CIRCULATION; COMPARATIVE STUDY; GENE REARRANGEMENT; IMMUNOLOGICAL MEMORY; IMMUNOLOGY;

ADULT; AGED; AUTOANTIBODIES; B-LYMPHOCYTES; BLOOD CIRCULATION; CELL DIFFERENTIATION; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOLOGIC MEMORY; INTERLEUKINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; SJOGREN'S SYNDROME; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84955335389     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12703     Document Type: Article

References (45)

1. Yang M, Rui K, Wang S, Lu L. Regulatory B cells in autoimmune diseases. Cell Mol Immunol 2013; 10:122-32.
2. Papp G, Szabó K, Szekanecz Z, Zeher M. Follicular helper T cells in autoimmune diseases. Rheumatology (Oxf) 2014; 53:1159-60.
3. Simpson N, Gatenby P, Wilson A et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010; 62:234-44.
4. Feng X, Wang D, Chen J et al. Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLOS ONE 2012; 7:e51982.
5. Zeher M. Sjögren's syndrome. In: Zeher M, Szodoray P, eds. Sjögren's syndrome and associated disorders. Kerala, India: Transworld Research Network, 2009:1-25.
6. Szabo K, Papp G, Barath S, Gyimesi E, Szanto A, Zeher M. Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome. Clin Immunol 2013; 147:95-104.
7. Maehara T, Moriyama M, Hayashida J et al. Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients. Clin Exp Immunol 2012; 169:89-99.
8. Szabo K, Papp G, Dezso B, Zeher M. The histopathology of labial salivary glands in primary Sjögren's syndrome: focusing on follicular helper T cells in the inflammatory infiltrates. Mediat Inflamm 2014; 2014:631787.
9. Vitali C, Bombardieri S, Jonsson R et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61:554-8.
10. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40:1725.
11. Petri M, Orbai AM, Alarcón GS et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012; 64:2677-86.
12. Rodríguez-Bayona B, Ramos-Amaya A, Pérez-Venegas JJ, Rodríguez C, Brieva JA. Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients. Arthritis Res Ther 2010; 12:R108.
13. Hansen A, Odendahl M, Reiter K et al. Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 2002; 46:2160-71.
14. Bohnhorst J, Bjørgan MB, Thoen JE, Natvig JB, Thompson KM. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome. J Immunol 2001; 167:3610-8.
15. Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M. Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's syndrome. PLOS ONE 2014; 9:e114575.
16. Mietzner B, Tsuiji M, Scheid J et al. Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proc Natl Acad Sci USA 2008; 105:9727-32.
17. Wehr C, Eibel H, Masilamani M et al. A new CD21low B cell population in the peripheral blood of patients with SLE. Clin Immunol 2004; 113:161-71.
18. Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE. Identification and characterization of circulating human transitional B cells. Blood 2005; 105:4390-8.
19. Blair PA, Noreña LY, Flores-Borja F et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010; 32:129-40.
20. Dörner T, Jacobi AM, Lee J, Lipsky PE. Abnormalities of B cell subsets in patients with systemic lupus erythematosus. J Immunol Methods 2011; 363:187-97.
21. Yurasov S, Wardemann H, Hammersen J et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 2005; 201:703-11.
22. Odendahl M, Jacobi AM, Hansen A et al. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol 2000; 165:5970-9.
23. Bohnhorst J, Thoen J, Natvig J, Thompson K. Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjögren's syndrome. Scand J Immunol 2001; 54:421-7.
24. Korganow AS, Knapp AM, Nehme-Schuster H et al. Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: decreased memory B cells and membrane CD19 expression. J Autoimmun 2010; 34:426-34.
25. Hansen A, Reiter K, Ziprian T et al. Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome. Arthritis Rheum 2005; 52:2109-19.
26. Bohnhorst J, Bjørgan M, Thoen J, Jonsson R, Natvig J, Thompson K. Abnormal B cell differentiation in primary Sjögren's syndrome results in a depressed percentage of circulating memory B cells and elevated levels of soluble CD27 that correlate with serum IgG concentration. Clin Immunol 2002; 103:79-88.
27. Jacobi AM, Reiter K, Mackay M et al. Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum 2008; 58:1762-73.
28. Wei C, Anolik J, Cappione A et al. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol 2007; 178:6624-33.
29. Szyszko EA, Brun JG, Skarstein K, Peck AB, Jonsson R, Brokstad KA. Phenotypic diversity of peripheral blood plasma cells in primary Sjögren's syndrome. Scand J Immunol 2011; 73:18-28.
30. Harada Y, Kawano MM, Huang N et al. Identification of early plasma cells in peripheral blood and their clinical significance. Br J Haematol 1996; 92:184-91.
31. Jacobi AM, Odendahl M, Reiter K et al. Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 2003; 48:1332-42.
32. Morita R, Schmitt N, Bentebibel S et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011; 34:108-21.
33. Tsai LM, Yu D. Follicular helper T-cell memory: establishing new frontiers during antibody response. Immunol Cell Biol 2014; 92:57-63.
34. + T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity 2013; 39:770-81.
35. Terrier B, Costedoat-Chalumeau N, Garrido M et al. Interleukin 21 correlates with T cell and B cell subset alterations in systemic lupus erythematosus. J Rheumatol 2012; 39:1819-28.
36. Xu H, Liu J, Cui X et al. Increased frequency of circulating follicular helper T cells in lupus patients is associated with autoantibody production in a CD40L-dependent manner. Cell Immunol 2015; 295:46-51.
37. Zhang X, Lindwall E, Gauthier C et al. Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production. Lupus 2015; 24:909-17.
38. Li X, Wu Z, Ding J et al. Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjögren's syndrome. Biochem Biophys Res Commun 2012; 422:238-44.
39. Wang L, Zhao P, Ma L et al. Increased interleukin 21 and follicular helper T-like cells and reduced interleukin 10+ B cells in patients with new-onset systemic lupus erythematosus. J Rheumatol 2014; 41:1781-92.
40. Choi JY, Ho JH, Pasoto SG et al. Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity. Arthritis Rheumatol 2015; 67:988-99.
41. Le Coz C, Joublin A, Pasquali JL, Korganow AS, Dumortier H, Monneaux F. Circulating TFH subset distribution is strongly affected in lupus patients with an active disease. PLOS ONE 2013; 8:e75319.
42. Szodoray P, Papp G, Horvath I et al. Cells with regulatory function of the innate and adaptive immune system in primary Sjögren's syndrome. Clin Exp Immunol 2009; 157:343-9.
43. Browning JL. B cells move to centre stage: novel opportunities for autoimmune disease treatment. Nat Rev Drug Discov 2006; 5:564-76.
44. Guerrier T, Youinou P, Pers JO, Jamin C. TLR9 drives the development of transitional B cells towards the marginal zone pathway and promotes autoimmunity. J Autoimmun 2012; 39:173-9.
45. Tiller T, Tsuiji M, Yurasov S, Velinzon K, Nussenzweig MC, Wardemann H. Autoreactivity in human IgG+ memory B cells. Immunity 2007; 26:205-13.