Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients

Arthritis Research and Therapy

Volumn 12, Issue 3, 2010, Pages

  Rodríguez Bayona, Beatriz ^a   Ramos Amaya, Ana ^a   Pérez Venegas, José J ^b   Rodríguez, Carmen ^a   Brieva, José A ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DEL MAR   (Spain)

^b HOSPITAL DE JEREZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; B7 ANTIGEN; CD19 ANTIGEN; CD27 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CYCLOPHOSPHAMIDE; FAS ANTIGEN; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN D; IMMUNOGLOBULIN IDIOTYPE; IMMUNOGLOBULIN M; LEFLUNOMIDE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RITUXIMAB;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FLOW CYTOMETRY; GENE FREQUENCY; HUMAN; HUMAN CELL; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; PHENOTYPE; PLASMA CELL; REMISSION; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX;

EID: 77952817885     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3042     Document Type: Article

References (21)

1. Dorner T, Jacobi AM, Lipsky PE. B cells in autoimmunity. Arthritis Res Ther 2009, 11:247. 10.1186/ar2780, 2787254, 19849820.
2. Klein U, Rajewsky K, Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998, 188:1679-1689. 10.1084/jem.188.9.1679, 2212515, 9802980.
3. Odendahl M, Jacobi A, Hansen A, Feist E, Hiepe F, Burmester GR, Lipsky PE, Radbruch A, Dorner T. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol 2000, 165:5970-5979.
4. Wehr C, Eibel H, Masilamani M, Illges H, Schlesier M, Peter HH, Warnatz K. A new CD21 low B cell population in the peripheral blood of patients with SLE. Clin Immunol 2004, 113:161-171. 10.1016/j.clim.2004.05.010, 15451473.
5. Anolik JH, Barnard J, Cappione A, Pugh-Bernard AE, Felgar RE, Looney RJ, Sanz I. Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus. Arthritis Rheum 2004, 50:3580-3590. 10.1002/art.20592, 15529346.
6. Wei C, Anolik J, Cappione A, Zheng B, Pugh-Bernard A, Brooks J, Lee EH, Milner EC, Sanz I. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol 2007, 178:6624-6633.
7. Sanz I, Wei C, Lee FE, Anolik J. Phenotypic and functional heterogeneity of human memory B cells. Semin Immunol 2008, 20:67-82. 10.1016/j.smim.2007.12.006, 2440717, 18258454.
8. Gonzalez-Garcia I, Rodriguez-Bayona B, Mora-Lopez F, Campos-Caro A, Brieva JA. Increased survival is a selective feature of human circulating antigen-induced plasma cells synthesizing high-affinity antibodies. Blood 2008, 111:741-749. 10.1182/blood-2007-08-108118, 17925487.
9. Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D, Tournilhac O, Tchernia G, Steiniger B, Staudt LM, Casanova JL, Reynaud CA, Weill JC. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004, 104:3647-3654. 10.1182/blood-2004-01-0346, 2590648, 15191950.
10. Tangye SG, Good KL. Human IgM+CD27+ B cells: memory B cells or "memory" B cells?. J Immunol 2007, 179:13-19.
11. Jacobi AM, Reiter K, Mackay M, Aranow C, Hiepe F, Radbruch A, Hansen A, Burmester GR, Diamond B, Lipsky PE, Dorner T. Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum 2008, 58:1762-1773. 10.1002/art.23498, 18512812.
12. Chang NH, McKenzie T, Bonventi G, Landolt-Marticorena C, Fortin PR, Gladman D, Urowitz M, Wither JE. Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus. J Immunol 2008, 180:1276-1284.
13. Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, Pascual V, Nussenzweig MC. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 2005, 201:703-711. 10.1084/jem.20042251, 2212839, 15738055.
14. Yurasov S, Tiller T, Tsuiji M, Velinzon K, Pascual V, Wardemann H, Nussenzweig MC. Persistent expression of autoantibodies in SLE patients in remission. J Exp Med 2006, 203:2255-2261. 10.1084/jem.20061446, 2118096, 16966430.
15. Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science 2003, 301:1374-1377. 10.1126/science.1086907, 12920303.
16. Weller S, Faili A, Garcia C, Braun MC, Le Deist FF, de Saint Basile GG, Hermine O, Fischer A, Reynaud CA, Weill JC. CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc Natl Acad Sci USA 2001, 98:1166-1170. 10.1073/pnas.98.3.1166, 14726, 11158612.
17. Weller S, Mamani-Matsuda M, Picard C, Cordier C, Lecoeuche D, Gauthier F, Weill JC, Reynaud CA. Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants. J Exp Med 2008, 205:1331-1342. 10.1084/jem.20071555, 2413031, 18519648.
18. Capolunghi F, Cascioli S, Giorda E, Rosado MM, Plebani A, Auriti C, Seganti G, Zuntini R, Ferrari S, Cagliuso M, Quinti I, Carsetti R. CpG drives human transitional B cells to terminal differentiation and production of natural antibodies. J Immunol 2008, 180:800-808.
19. Tsuiji M, Yurasov S, Velinzon K, Thomas S, Nussenzweig MC, Wardemann H. A checkpoint for autoreactivity in human IgM+ memory B cell development. J Exp Med 2006, 203:393-400. 10.1084/jem.20052033, 2118214, 16446381.
20. Stevenson FK, Longhurst C, Chapman CJ, Ehrenstein M, Spellerberg MB, Hamblin TJ, Ravirajan CT, Latchman D, Isenberg D. Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J Autoimmun 1993, 6:809-825. 10.1006/jaut.1993.1066, 8155258.
21. Cappione A, Anolik JH, Pugh-Bernard A, Barnard J, Dutcher P, Silverman G, Sanz I. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J Clin Invest 2005, 115:3205-3216. 10.1172/JCI24179, 1242189, 16211091.