Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production

Lupus

Volumn 24, Issue 9, 2015, Pages 909-917

  Zhang, X ^a   Lindwall, E ^b   Gauthier, C ^b   Lyman, J ^b   Spencer, N ^c   Alarakhia, A ^b   Fraser, A ^b   Ing, S ^b   Chen, M ^b   Webb Detiege, T ^b,d   Zakem, J ^b,d   Davis, W ^b   Choi, Y Sung ^a   Quinet, R ^b,d  

^a OCHSNER CLINIC FOUNDATION   (United States)

^b OCHSNER MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

autoantibody production; follicular helper T cells; germinal center; interleukin 21; Systemic lupus erythematosus

Indexed keywords

ANTINUCLEAR ANTIBODY; B AND T LYMPHOCYTE ATTENUATOR; CD57 ANTIGEN; CHEMOKINE RECEPTOR CXCR5; CYTOKINE; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 2; INTERLEUKIN 21; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN; UNCLASSIFIED DRUG; AUTOANTIBODY; CXCR5 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ADULT; AGED; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CELL CLONE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOLLICULAR HELPER T CELL; GERMINAL CENTER; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MALE; PHENOTYPE; PLASMA CELL; PLASMABLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STAINING; SYSTEMIC LUPUS ERYTHEMATOSUS; TONSIL; BLOOD; IMMUNOLOGY; METABOLISM; MIDDLE AGED;

ADULT; AGED; ANTIBODY FORMATION; AUTOANTIBODIES; AUTOIMMUNITY; B-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; GERMINAL CENTER; HUMANS; INTERLEUKINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PHENOTYPE; PLASMA CELLS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CXCR5; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84937851391     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203314567750     Document Type: Article

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