Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain

Journal of Dental Research

Volumn 95, Issue 2, 2016, Pages 135-142

  Sun, W H ^a   Chen, C C ^b,c  

^a NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c ACADEMIA SINICA   (Taiwan)

Author keywords

acidosis; ASIC3; hyperalgesic priming; PKC ; TDAG8; TRPV1

Indexed keywords

ACID SENSING ION CHANNEL; AUTACOID; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; LECTIN; PROTEIN KINASE; VANILLOID RECEPTOR;

CHRONIC PAIN; HUMAN; HYPERALGESIA; PAIN; PAIN RECEPTOR; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACID SENSING ION CHANNELS; ACUTE PAIN; CHRONIC PAIN; HUMANS; HYPERALGESIA; INFLAMMATION MEDIATORS; ION CHANNELS; LECTINS; NOCICEPTORS; PROTEIN KINASES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRPV CATION CHANNELS;

EID: 84955328130     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034515618382     Document Type: Review

References (59)

1. Aley KO, Levine JD,. 1999. Role of protein kinase A in the maintenance of inflammatory pain. J Neurosci. 19 (6): 2181-2186.
2. Aley KO, Messing RO, Mochly-Rosen D, Levine JD,. 2000. Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the ε isozyme of protein kinase C. J Neurosci. 20 (12): 4680-4685.
3. Alvarez P, Chen X, Bogen O, Green PG, Levine JD,. 2012. IB4(+) nociceptors mediate persistent muscle pain induced by GDNF. J Neurophysiol. 108 (9): 2545-2553.
4. Alvarez P, Gear RW, Green PG, Levine JD,. 2012. IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat. Exp Neurol. 233 (2): 859-865.
5. Ambalavanar R, Dessem D., 2009. Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies. J Dent Res. 88 (3): 201-211.
6. Ambalavanar R, Moritani M, Haines A, Hilton T, Dessem D., 2003. Chemical phenotypes of muscle and cutaneous afferent neurons in the rat trigeminal ganglion. J Comp Neurol. 26 (2): 167-179.
7. Ambalavanar R, Yallampalli C, Yallampalli U, Dessem D., 2007. Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression. Neuroscience. 149 (3): 650-659.
8. Basbaum AI, Bautista DM, Scherrer G, Julius D., 2009. Cellular and molecular mechanisms of pain. Cell. 139 (2): 267-284.
9. Bogen O, Alessandri-Haber N, Chu C, Gear RW, Levine JD,. 2012. Generation of a pain memory in the primary afferent nociceptor triggered by PKCε activation of CPEB. J Neurosci. 32 (6): 2018-2026.
10. Breese NM, George AC, Pauers LE, Stucky CL,. 2005. Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse. Pain. 115 (1-2): 37-49.
11. Burgess G, Williams D., 2010. The discovery and development of analgesics: new mechanisms, new modalities. J Clin Invest. 120 (11): 3753-3759.
12. Chen CC, Wong CW,. 2013. Neurosensory mechanotransduction through acid-sensing ion channels. J Cell Mol Med. 17 (3): 337-349.
13. Chen WN, Chen CC,. 2014. Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain. Mol Pain. 10: 30.
14. Chen WN, Lee CH, Lin SH, Wong CW, Sun WH, Wood JN, Chen CC,. 2014. Roles of ASIC3, TRPV1, and Nav1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain. 10: 40.
15. Chen YJ, Huang CW, Lin CS, Chang WH, Sun WH,. 2009. Expression and function of proton-sensing G protein-coupled receptors in inflammatory pain. Mol Pain. 5: 39.
16. Denadai-Souza A, Camargo Lde L, Ribela MT, Keeble JE, Costa SK, Muscará MN,. 2009. Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint. Eur J Pain. 13 (8): 812-819.
17. Deval E, Noël J, Lay N, Alloui A, Diochot S, Friend V, Jodar M, Lazdunski M, Lingueglia E., 2008. ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J. 27 (22): 3047-55.
18. Dina OA, Khasar SG, Gear RW, Levine JD,. 2009. Activation of Gi induces mechanical hyperalgesia poststress or inflammation. Neuroscience. 160 (2): 501-507.
19. Ding TT, Xu XX, Cao Y, Liu CR, Gan YH, Xie QF., 2015. Inflammatory pain memory facilitates occlusal interderence-induced masticatory muscle hyperalgesia in rats. Eur J Pain. 2015 26 [Epub ahead of print] in press. doi: 10.1002/ejp.730
20. Ferrari LF, Araldi D, Levine JD,. 2015. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. J Neurosci. 35 (15): 6107-6116.
21. Ferrari LF, Bogen O, Levine JD,. 2010. Nociceptor subpopulations involved in hyperalgesic priming. Neuroscience. 165 (3): 896-901.
22. Ferrari LF, Bogen O, Levine JD,. 2013. Role of nociceptor αCaMKII in transition from acute to chronic pain (hyperalgesic priming) in male and female rats. J Neurosci. 33 (27): 11002-11011.
23. Ferrari LF, Bogen O, Reichling DB, Levine JD,. 2015. Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms. J Neurosci. 35 (2): 495-507.
24. Ferreira J, Trichês KM, Medeiros R, Calixto JB,. 2005. Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice. Pain. 117 (1-2): 171-181.
25. Ferreira SH, Lorenzetti BB, De Campos DI,. 1990. Induction, blockade and restoration of a persistent hypersensitive state. Pain. 42 (3): 365-371.
26. Fong SW, Chen WN, Chen CC,. 2015. Is acid painful or not? Itch Pain. 2 (2): e721.
27. Gold MS, Levine JD, Correa AM,. 1998. Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J Neurosci. 18 (24): 10345-10355.
28. Huang CW, Tzeng JN, Chen YJ, Tsai WF, Chen CC, Sun WH,. 2007. Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors. Mol Cell Neurosci. 36 (2): 195-210.
29. Huang WY, Dai SP, Chang YC, Sun WH,. 2015. Acidosis mediates the switching of Gs-PKA and Gi-PKCε dependence in prolonged hyperalgesia induced by inflammation. PLoS One. 10 (5): e0125022.
30. Hucho TB, Dina OA, Levine JD,. 2005. Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4 (+) neuron-specific mechanism. J Neurosci. 25 (26): 6119-6126.
31. Joseph EK, Bogen O, Alessandri-Haber N, Levine JD,. 2007. PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia. Pain. 132 (1-2): 67-73.
32. Joseph EK, Levine JD,. 2010. Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. Neuroscience. 169 (1): 431-435.
33. Joseph EK, Reichling DB, Levine JD,. 2010. Shared mechanisms for opioid tolerance and a transition to chronic pain. J Neurosci. 30 (13): 4660-4666.
34. Khasar SG, Burkham J, Dina OA, Brown AS, Bogen O, Alessandri-Haber N, Green PG, Reichling DB, Levine JD,. 2008. Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain. J Neurosci. 28 (22): 5721-5730.
35. Khasar SG, McCarter G, Levine JD,. 1999. Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol. 81 (3): 1104-1112.
36. Kress M, Reeh PW, Vyklicky L., 1997. An interaction of inflammatory mediators and protons in small diameter dorsal root ganglion neurons of the rat. Neurosci Lett. 224 (1): 37-40.
37. Lee J, Saloman JL, Weiland G, Auh QS, Chung MK, Ro JY,. 2012. Functional interactions between NMDA receptors and TRPV1 in trigeminal sensory neurons mediate mechanical hyperalgesia in the rat masseter muscle. Pain. 153 (7): 1514-24.
38. Lin CC, Chen WN, Chen CJ, Lin YW, Zimmer A, Chen CC,. 2012. An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci USA. 109 (2): E76-E83.
39. Lin SH, Sun WH, Chen CC,. 2015. Genetic exploration of the roles of acid-sensing ion channels. Neuropharmacology. 94: 99-118.
40. Lin YW, Chen CC,. 2015. Electrophysiological characteristics of IB4-negative TRPV1-expressing muscle afferent DRG neurons. Biophysics. 11 (2015): 9-16.
41. Lund JP, Sadeghi S, Athanassiadis T, Caram Salas N, Auclair F, Thivierge B, Arsenault I, Rompré P, Westberg KG, Kolta A., 2010. Assessment of the potential role of muscle spindle mechanoreceptor afferent in chronic muscle pain in the rat masseter muscle. PLoS One. 5 (6): e11131.
42. Mamet J, Lazdunski M, Voilley N., 2003. How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons. J Biol Chem. 278 (49): 48907-49013.
43. Ohno S, Nishizuka Y., 2002. Protein kinase C isotypes and their specific functions: prologue. J Biochem. 132 (4): 509-511.
44. Parada CA, Reichling DB, Levine JD,. 2005. Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCε second messenger pathways. Pain. 113 (1-2): 185-190.
45. Reeh PW, Steen KH,. 1996. Tissue acidosis in nociception and pain. Prog Brain Res. 113: 143-151.
46. Ro JY, Zhang Y, Nies M., 2005. Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle. Brain Res. 1047 (1): 38-44.
47. Sato H, Castrillon EE, Cairns BE, Bendixen KH, Wang K, Nakagawa T, Wajima K, Svensson P., 2016. Intramuscular pH modulates glutamate-evoked masseter muscle pain magnitude in humans. Eur J Pain. 20 (1): 106-115.
48. Sluka KA, Kalra A, Moore SA,. 2001. Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia. Muscle Nerve. 24 (1): 37-46.
49. Sluka KA, Price MP, Breese NM, Stucky CL, Wemmie JA, Welsh MJ,. 2003. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain. 106 (3): 229-239.
50. Steen KH, Steen AE, Kreysel HW, Reeh PW,. 1996. Inflammatory mediators potentiate pain induced by experimental tissue acidosis. Pain. 66 (2-3): 163-170.
51. Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW,. 2014. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev. 94 (1): 265-301.
52. St-Jacques B, Ma W., 2014. Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors. Exp Neurol. 261: 354-66.
53. Su YS, Sun WH, Chen CC,. 2014. Molecular mechanism of inflammatory pain. World J Anesthesiol. 3 (1): 71-81.
54. Villarreal CF, Funez MI, Figueiredo F, Cunha FQ, Parada CA, Ferreira SH,. 2009. Acute and persistent nociceptive paw sensitization in mice: the involvement of distinct signaling pathways. Life Sci. 85 (23-26): 822-829.
55. Villarreal CF, Sachs D, Cunha FQ, Parada CA, Ferreira SH,. 2005. The role of Na(V)1.8 sodium channel in the maintenance of chronic inflammatory hypernociception. Neurosci Lett. 386 (2): 72-77.
56. Wu WL, Cheng CF, Sun WH, Wong CW, Chen CC,. 2012. Targeting ASIC3 for pain, anxiety, and insulin resistance. Pharmacol Ther. 134 (2): 127-138.
57. Wu YW, Hao T, Kou XX, Gan YH, Ma XC,. 2015. Synovial TRPV1 is upregulated by 17-β-estradiol and involved in allodynia of inflamed temporomandibular joints in female rats. Arch Oral Biol. 60 (9): 1310-1318.
58. Yen YT, Tu PH, Chen CJ, Lin YW, Hsieh ST, Chen CC,. 2009. Role of acid-sensing ion channel 3 in sub-acute-phase inflammation. Mol Pain. 5: 1.
59. Xu XX, Cao Y, Ding TT, Fu KY, Li Y, Xie QF., 2015. Role of TRPV1 and ASIC3 channels in experimental occlusal interference-induced hyperalgesia in rat masseter muscle. Eur J Pain. 2015 22 [Epub ahead of print] in press. doi: 10.1002/ejp.758