An interaction of inflammatory mediators and protons in small diameter dorsal root ganglion neurons of the rat

Neuroscience Letters

Volumn 224, Issue 1, 1997, Pages 37-40

  Kress, Michaela ^a   Reeh, Peter W ^a   Vyklicky, Ladislav ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

acidosis; cultured dorsal root ganglion neurons; inflammation; nociception; sensitization; whole cell patch clamp

Indexed keywords

BRADYKININ; HISTAMINE; PROSTAGLANDIN E2; SEROTONIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; INFLAMMATION; ION CURRENT; MALE; NOCICEPTION; NONHUMAN; PATCH CLAMP; PH; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

ACIDS; ANIMALS; CELLS, CULTURED; ELECTRIC CONDUCTIVITY; FEMALE; GANGLIA, SPINAL; HYDROGEN-ION CONCENTRATION; INFLAMMATION MEDIATORS; MALE; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; PROTONS; RATS; RATS, WISTAR;

EID: 0031048957     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)13450-4     Document Type: Article

References (22)

1. Baccaglini, P.I. and Hogan, P.O., Some rat sensory neurons in cultures express characteristics of differential pain sensory cells, Proc. Natl. Acad. Sci. USA, 80 (1983) 594-598.
2. Belmonte, C., Gallar, J., Pozo, M.A. and Rebollo, I., Excitation by irritant chemical substances of sensory afferent units in the cat's cornea, J. Physiol. (Lond.), 437 (1991) 709-725.
3. Bevan, S. and Geppetti, P., Protons: small stimulants of capsaicin-sensitive sensory nerves, Trends Neurosci., 17 (1994) 509-512.
4. Bevan, S. and Yeats, J., Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones, J. Physiol. (Lond.), 433 (1991) 145-161.
5. Burgess, G.M., Mullaney, I., McNeill, M., Dunn, P.M. and Rang, H.P., Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture, J. Neurosci., 9 (1989) 3314-3325.
6. Dray, A., Patel, I.A., Perkins, M.N. and Rueff, A., Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro, Br. J. Pharmacol., 107 (1992) 1129-1134.
7. Handwerker, H.O., Reeh, P.W. and Steen, K.H., Effects of 5HT on nociceptors. In J.-M. Besson (Ed.), Serotonin and Pain, Elsevier, Amsterdam, 1990, pp. 1-15.
8. Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Saxena, P.R. and Humphrey, P.P.A., VIIth International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin), Pharmacol. Rev., 46 (1994) 157-203.
9. Issberner, U., Reeh, P.W. and Steen, K.H., Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia?, Neurosci. Lett., 208 (1996) 191-194.
10. Keele, C.A. and Armstrong, D., Substances Producing Pain and Itch, Edward Arnold, London, 1964.
11. Koltzenburg, M., Kress, M. and Reeh, P.W., The nociceptor sensitization by bradykinin does not depend on sympathetic neurons, Neuroscience, 46 (1992) 465-473.
12. Konnerth, A., Lux, H.D. and Morad, M., Proton-induced transformation of calcium channel in chick dorsal root ganglion cells, J. Physiol. (Lond.), 386 (1987) 603-633.
13. Koppert, W., Reeh, P.W. and Handwerker, H.O., Conditioning of histamine by bradykinin alters responses of rat nociceptor and human itch sensation, Neurosci. Lett., 152 (1993) 117-120.
14. Kress, M., Fetzer, S., Reeh, P.W. and Vyklicky, L., Low pH facilitates capsaicin responses in isolated sensory neurons of the rat, Neurosci. Lett., 211 (1996) 5-8.
15. Kress, M. and Reeh, P.W., Chemical excitation and sensitization in nociceptors. In F. Cervero and C. Belmonte (Eds.), Neurobiology of Nociceptors, Oxford University Press, New York, 1996, pp. 258-297.
16. Krishtal, O.A. and Pidoplichko, V.I., A receptor for protons in the nerve cell membrane, Neuroscience, 5 (1980) 2325-2327.
17. Lang, E., Novak, A., Reeh, P.W. and Handwerker, H.O., Chemosensitivity of fine afferents from rat skin in vitro, J. Neurophysiol., 63 (1990) 887-901.
18. McEachern, A.E., Shelton, E.R., Bhakta, S., Obernolte, R., Bach, C., Zuppan, P., Fujisaki, J., Aldrich, R.W. and Jarnagin, K., Expression cloning of a rat B2 bradykinin receptor, Proc. Natl. Acad. Sci. USA, 88 (1991) 7724-7728.
19. Steen, K.H., Reeh, P.W., Anton, F. and Handwerker, H.O., Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro, J. Neurosci., 12 (1992) 86-95.
20. Steen, K.H., Steen, A.E., Kreysel, H.-W. and Reeh, P.W., Inflammatory mediators potentiate pain induced by experimental tissue acidosis, Pain, 66 (1996) 163-170.
21. Steen, K.H., Steen, A.E. and Reeh, P.W., A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro, J. Neurosci., 15 (1995) 3982-3989.
22. Wood, J.N., Winter, J., James, I.F., Rang, H.P., Yeats, J. and Bevan, S., Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture, J. Neurosci., 8 (1988) 3208-3220.