Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors

Experimental Neurology

Volumn 261, Issue , 2014, Pages 354-366

  St Jacques, Bruno ^a   Ma, Weiya ^a,b  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

16,16 dimethyl PGE2; Anterograde axonal transport; COX2; Dorsal root ganglion; EP receptor; Intraplantar injection; Nociceptor; PGE2; Sensitization; Tactile allodynia

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; ENZYME INHIBITOR; GLYCOPROTEIN; ISOLECTIN B4-BINDING GLYCOPROTEIN, RAT; LECTIN; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 4;

ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; HYPERALGESIA; MALE; METABOLISM; NERVE FIBER TRANSPORT; NEURALGIA; PAIN MEASUREMENT; PAIN THRESHOLD; PATHOLOGY; RAT; SENSORY NERVE CELL; SPINAL GANGLION; SPRAGUE DAWLEY RAT; TIME;

16,16-DIMETHYLPROSTAGLANDIN E2; ANIMALS; AXONAL TRANSPORT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GANGLIA, SPINAL; GLYCOPROTEINS; HYPERALGESIA; LECTINS; MALE; NEURALGIA; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; SENSORY RECEPTOR CELLS; TIME FACTORS;

EID: 84905484482     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.05.028     Document Type: Article

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