메뉴 건너뛰기




Volumn 30, Issue 13, 2010, Pages 4660-4666

Shared mechanisms for opioid tolerance and a transition to chronic pain

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; EMULSIFYING AGENT; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; INFLAMMOGEN; MU OPIATE RECEPTOR ANTAGONIST; OPIATE; PROSTAGLANDIN E2; PROTEIN KINASE C EPSILON; UNCLASSIFIED DRUG;

EID: 77950657123     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5530-09.2010     Document Type: Article
Times cited : (79)

References (62)
  • 1
    • 0034195205 scopus 로고    scopus 로고
    • μ-Opioid receptors often colocalize with the substance P receptor (NK1) in the trigeminal dorsal horn
    • Aicher SA, Punnoose A, Goldberg A (2000) μ-Opioid receptors often colocalize with the substance P receptor (NK1) in the trigeminal dorsal horn. J Neurosci 20:4345-4354. (Pubitemid 30365705)
    • (2000) Journal of Neuroscience , vol.20 , Issue.11 , pp. 4345-4354
    • Aicher, S.A.1    Punnoose, A.2    Goldberg, A.3
  • 2
    • 0031029783 scopus 로고    scopus 로고
    • Multiple receptors involved in peripheral alpha 2, mu, and Al antinociception, tolerance, and withdrawal
    • Aley KO, Levine JD (1997) Multiple receptors involved in peripheral alpha 2, mu, and Al antinociception, tolerance, and withdrawal. J Neurosci 17:735-744.
    • (1997) J Neurosci , vol.17 , pp. 735-744
    • Aley, K.O.1    Levine, J.D.2
  • 3
    • 0029590279 scopus 로고
    • Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal
    • Aley KO, Green PG, Levine JD (1995) Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal. J Neurosci 15:8031-8038. (Pubitemid 26006909)
    • (1995) Journal of Neuroscience , vol.15 , Issue.12 , pp. 8031-8038
    • Aley, K.O.1    Green, P.G.2    Levine, J.D.3
  • 4
    • 0034659718 scopus 로고    scopus 로고
    • Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the ε isozyme of protein kinase C
    • Aley KO, Messing RO, Mochly-Rosen D, Levine JD (2000) Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci 20:4680-4685. (Pubitemid 30396633)
    • (2000) Journal of Neuroscience , vol.20 , Issue.12 , pp. 4680-4685
    • Aley, K.O.1    Messing, R.O.2    Mochly-Rosen, D.3    Levine, J.D.4
  • 5
    • 9444274109 scopus 로고    scopus 로고
    • Protein kinase C activation enhances morphine-induced rapid desensitization of μ-opioid receptors in mature rat locus ceruleus neurons
    • DOI 10.1124/mol.104.004747
    • Bailey CP, Kelly E, Henderson G (2004) Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons. Mol Pharmacol 66:1592-1598. (Pubitemid 39564786)
    • (2004) Molecular Pharmacology , vol.66 , Issue.6 , pp. 1592-1598
    • Bailey, C.P.1    Kelly, E.2    Henderson, G.3
  • 6
    • 77952995346 scopus 로고    scopus 로고
    • Involvement of PLC-{beta}3 in the effect of morphine on memory retrieval in passive avoidance task
    • Advance online publication15, 2009. doi:10.1177/0269881108102013
    • Bianchi E, Lehmann D, Vivoli E, Norcini M, Ghelardini C (2009) Involvement of PLC-{beta}3 in the effect of morphine on memory retrieval in passive avoidance task. J Psychopharmacol. Advance online publication. Retrieved May 15, 2009. doi:10.1177/0269881108102013.
    • (2009) J Psychopharmacol
    • Bianchi, E.1    Lehmann, D.2    Vivoli, E.3    Norcini, M.4    Ghelardini, C.5
  • 7
    • 67651111652 scopus 로고    scopus 로고
    • Overuse of acute migraine medications and migraine chronifcation
    • Bigal ME, Lipton RB (2009) Overuse of acute migraine medications and migraine chronifcation. Curr Pain Headache Rep 13:301-307.
    • (2009) Curr Pain Headache Rep , vol.13 , pp. 301-307
    • Bigal, M.E.1    Lipton, R.B.2
  • 8
    • 0037318163 scopus 로고    scopus 로고
    • Opioid resistance in chronic daily headache: A synthesis of ideas from the bench and bedside
    • Biondi DM (2003) Opioid resistance in chronic daily headache: a synthesis of ideas from the bench and bedside. Curr Pain Headache Rep 7:67-75.
    • (2003) Curr Pain Headache Rep , vol.7 , pp. 67-75
    • Biondi, D.M.1
  • 9
    • 2642536906 scopus 로고    scopus 로고
    • Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: Characterization of a tool for inverse agonist screening
    • DOI 10.1186/1471-2210-3-14
    • Brillet K, Kieffer BL, Massotte D (2003) Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening. BMC Pharmacol 3:14. (Pubitemid 38729264)
    • (2003) BMC Pharmacology , vol.3 , pp. 14
    • Brillet, K.1    Kieffer, B.L.2    Massotte, D.3
  • 10
    • 18044387415 scopus 로고    scopus 로고
    • Biochemical demonstration of mu-opioid receptor association with Gsα: Enhancement following morphine exposure
    • DOI 10.1016/j.molbrainres.2004.12.016
    • Chakrabarti S, Regec A, Gintzler AR (2005) Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure. Brain Res Mol Brain Res 135:217-224. (Pubitemid 40602413)
    • (2005) Molecular Brain Research , vol.135 , Issue.1-2 , pp. 217-224
    • Chakrabarti, S.1    Regec, A.2    Gintzler, A.R.3
  • 11
    • 63649130832 scopus 로고    scopus 로고
    • Altered quantitative sensory testing outcome in subjects with opioid therapy
    • Chen L, Malarick C, Seefeld L,Wang S, Houghton M, Mao J (2009) Altered quantitative sensory testing outcome in subjects with opioid therapy. Pain 143:65-70.
    • (2009) Pain , vol.143 , pp. 65-70
    • Chen, L.1    Malarick, C.2    Seefeld, L.3    Wang, S.4    Houghton, M.5    Mao, J.6
  • 12
    • 49649102696 scopus 로고    scopus 로고
    • Opioid-induced hyperalgesia in humans: Molecular mechanisms and clinical considerations
    • Chu LF, Angst MS, Clark D (2008) Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain 24:479-496.
    • (2008) Clin J Pain , vol.24 , pp. 479-496
    • Chu, L.F.1    Angst, M.S.2    Clark, D.3
  • 13
    • 0028113829 scopus 로고
    • Cold-pressor pain tolerance in opiate and cocaine abusers: Correlates of drug type and use status
    • Compton MA (1994) Cold-pressor pain tolerance in opiate and cocaine abusers: correlates of drug type and use status. J Pain Symptom Manage 9:462-473.
    • (1994) J Pain Symptom Manage , vol.9 , pp. 462-473
    • Compton, M.A.1
  • 15
    • 33745891537 scopus 로고    scopus 로고
    • Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon
    • Dina OA, Messing RO, Levine JD (2006) Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon. Eur J Neurosci 24:197-204.
    • (2006) Eur J Neurosci , vol.24 , pp. 197-204
    • Dina, O.A.1    Messing, R.O.2    Levine, J.D.3
  • 16
    • 64049103388 scopus 로고    scopus 로고
    • Activation of Gi induces mechanical hyperalgesia poststress or inflammation
    • Dina OA, Khasar SG, Gear RW, Levine JD (2009) Activation of Gi induces mechanical hyperalgesia poststress or inflammation. Neuroscience 160:501-507.
    • (2009) Neuroscience , vol.160 , pp. 501-507
    • Dina, O.A.1    Khasar, S.G.2    Gear, R.W.3    Levine, J.D.4
  • 18
    • 38149119083 scopus 로고    scopus 로고
    • Early opioid prescription and subsequent disability among workers with back injuries: The Disability Risk Identification Study Cohort
    • Franklin GM, Stover BD, Turner JA, Fulton-Kehoe D, Wickizer TM (2008) Early opioid prescription and subsequent disability among workers with back injuries: the Disability Risk Identification Study Cohort. Spine (Phila Pa 1976) 33:199-204.
    • (2008) Spine (Phila Pa 1976) , vol.33 , pp. 199-204
    • Franklin, G.M.1    Stover, B.D.2    Turner, J.A.3    Fulton-Kehoe, D.4    Wickizer, T.M.5
  • 19
    • 33745700151 scopus 로고    scopus 로고
    • Signaling pathway of morphine induced acute thermal hyperalgesia in mice
    • Galeotti N, Stefano GB, Guarna M, Bianchi E, Ghelardini C (2006) Signaling pathway of morphine induced acute thermal hyperalgesia in mice. Pain 123:294-305.
    • (2006) Pain , vol.123 , pp. 294-305
    • Galeotti, N.1    Stefano, G.B.2    Guarna, M.3    Bianchi, E.4    Ghelardini, C.5
  • 20
    • 0021362536 scopus 로고
    • Intermittent cold water stress-analgesia in rats: Cross-tolerance to morphine
    • Girardot MN, Holloway FA ( 1984) Intermittent cold water stress-analgesia in rats: cross-tolerance to morphine. Pharmacol Biochem Behav 20: 631-633.
    • (1984) Pharmacol Biochem Behav , vol.20 , pp. 631-633
    • Girardot, M.N.1    Holloway, F.A.2
  • 21
    • 33751229313 scopus 로고    scopus 로고
    • Phospholipase Cβ 3 mediates the scratching response activated by the histamine h1 receptor on C-fiber nociceptive neurons
    • DOI 10.1016/j.neuron.2006.09.036, PII S0896627306007744
    • Han SK, Mancino V, Simon MI (2006) Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons. Neuron 52:691-703. (Pubitemid 44781169)
    • (2006) Neuron , vol.52 , Issue.4 , pp. 691-703
    • Han, S.-K.1    Mancino, V.2    Simon, M.I.3
  • 23
    • 21544452743 scopus 로고    scopus 로고
    • Epac mediates a cAMP-to-PKC signaling in inflammatory pain: An isolectin B4(+) neuron-specific mechanism
    • Hucho TB, Dina OA, Levine JD (2005) Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. J Neurosci 25:6119-6126.
    • (2005) J Neurosci , vol.25 , pp. 6119-6126
    • Hucho, T.B.1    Dina, O.A.2    Levine, J.D.3
  • 24
    • 10844229048 scopus 로고    scopus 로고
    • Caspase signalling in neuropathic and inflammatory pain in the rat
    • DOI 10.1111/j.1460-9568.2004.03750.x
    • Joseph EK, Levine JD (2004) Caspase signalling in neuropathic and inflammatory pain in the rat. Eur J Neurosci 20:2896-2902. (Pubitemid 40007283)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.11 , pp. 2896-2902
    • Joseph, E.K.1    Levine, J.D.2
  • 25
    • 0346724920 scopus 로고    scopus 로고
    • Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat
    • DOI 10.1016/j.pain.2003.10.010
    • Joseph EK, Chen X, Khasar SG, Levine JD (2004) Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. Pain 107:147-158. (Pubitemid 38058710)
    • (2004) Pain , vol.107 , Issue.1-2 , pp. 147-158
    • Joseph, E.K.1    Chen, X.2    Khasar, S.G.3    Levine, J.D.4
  • 26
    • 34848814724 scopus 로고    scopus 로고
    • PLC-β3 signals upstream of PKCε in acute and chronic inflammatory hyperalgesia
    • DOI 10.1016/j.pain.2007.01.027, PII S030439590700053X
    • Joseph EK, Bogen O, Alessandri-Haber N, Levine JD (2007) PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia. Pain 132:67-73. (Pubitemid 47494562)
    • (2007) Pain , vol.132 , Issue.1-2 , pp. 67-73
    • Joseph, E.K.1    Bogen, O.2    Alessandri-Haber, N.3    Levine, J.D.4
  • 27
    • 42749090550 scopus 로고    scopus 로고
    • Oxaliplatin acts on IB4positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathy
    • Joseph EK, Chen X, Bogen O, Levine JD (2008) Oxaliplatin acts on IB4positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathy. J Pain 9:463-472.
    • (2008) J Pain , vol.9 , pp. 463-472
    • Joseph, E.K.1    Chen, X.2    Bogen, O.3    Levine, J.D.4
  • 28
    • 9244233833 scopus 로고    scopus 로고
    • Opioids in chronic non-cancer pain: Systematic review of efficacy and safety
    • DOI 10.1016/j.pain.2004.09.019, PII S0304395904004476
    • Kalso E, Edwards JE, Moore RA, McQuay HJ (2004) Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain 112: 372-380. (Pubitemid 39550738)
    • (2004) Pain , vol.112 , Issue.3 , pp. 372-380
    • Kalso, E.1    Edwards, J.E.2    Moore, R.A.3    McQuay, H.J.4
  • 29
    • 40349114499 scopus 로고    scopus 로고
    • Agonist-selective mechanisms of GPCR desensitization
    • Kelly E, Bailey CP, Henderson G (2008) Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol 153 [Suppl 1]:S379-S388.
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1
    • Kelly, E.1    Bailey, C.P.2    Henderson, G.3
  • 30
    • 0028169345 scopus 로고
    • Comparison of prostaglandin E1- And prostaglandin E2-induced hyperalgesia in the rat
    • DOI 10.1016/0306-4522(94)90369-7
    • Khasar SG, Ho T, Green PG, Levine JD (1994) Comparison of prostaglandin El- and prostaglandin E2-induced hyperalgesia in the rat. Neuroscience 62:345-350. (Pubitemid 2141899)
    • (1994) Neuroscience , vol.62 , Issue.2 , pp. 345-350
    • Khasar, S.G.1    Ho, T.2    Green, P.G.3    Levine, J.D.4
  • 32
    • 0032892815 scopus 로고    scopus 로고
    • Kappa-and mu-Opioid inhibition of N-type calcium currents is attenuated by 4beta-phorbol 12-myristate 13-acetate and protein kinase C in rat dorsal root ganglion neurons
    • King AP, Hall KE, Macdonald RL (1999) kappa-and mu-Opioid inhibition of N-type calcium currents is attenuated by 4beta-phorbol 12-myristate 13-acetate and protein kinase C in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 289:312-320.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 312-320
    • King, A.P.1    Hall, K.E.2    Macdonald, R.L.3
  • 33
    • 38549176643 scopus 로고    scopus 로고
    • Spinal mu-opioid receptor-expressing dorsal horn neurons: Role in nociception and morphine antinociception
    • Kline RH 4th, Wiley RG (2008) Spinal mu-opioid receptor-expressing dorsal horn neurons: role in nociception and morphine antinociception. J Neurosci 28:904-913.
    • (2008) J Neurosci , vol.28 , pp. 904-913
    • Kline IV, R.H.1    Wiley, R.G.2
  • 34
    • 28844493645 scopus 로고    scopus 로고
    • Peripheral axonal injury results in reduced μ opioid receptor pre- And post-synaptic action in the spinal cord
    • DOI 10.1016/j.pain.2005.05.035, PII S030439590500254X
    • Kohno T, Ji RR, Ito N, Allchrone AJ, Befort K, Karchewski LA, Woolf CJ (2005) Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. Pain 117:77-87. (Pubitemid 41764774)
    • (2005) Pain , vol.117 , Issue.1-2 , pp. 77-87
    • Kohno, T.1    Ji, R.-R.2    Ito, N.3    Allchorne, A.J.4    Befort, K.5    Karchewski, L.A.6    Woolf, C.J.7
  • 35
    • 0019796937 scopus 로고
    • Opioid and non-opioid stress analgesia: Assessment of tolerance and cross-tolerance with morphine
    • Lewis JW, Sherman JE, Liebeskind JC (1981) Opioid and non-opioid stress analgesia: assessment of tolerance and cross-tolerance with morphine. J Neurosci 1:358-363.
    • (1981) J Neurosci , vol.1 , pp. 358-363
    • Lewis, J.W.1    Sherman, J.E.2    Liebeskind, J.C.3
  • 36
    • 0035696235 scopus 로고    scopus 로고
    • Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence
    • Liu JG, Anand KJ (2001) Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence. Brain Res Brain Res Rev 38:1-19.
    • (2001) Brain Res Brain Res Rev , vol.38 , pp. 1-19
    • Liu, J.G.1    Anand, K.J.2
  • 37
    • 0034955327 scopus 로고    scopus 로고
    • Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment
    • Liu JG, Prather PL (2001) Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol Pharmacol 60:53-62.
    • (2001) Mol Pharmacol , vol.60 , pp. 53-62
    • Liu, J.G.1    Prather, P.L.2
  • 38
    • 0029162234 scopus 로고
    • Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions
    • Mao J, Price DD, Mayer DJ (1995) Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 62:259-274.
    • (1995) Pain , vol.62 , pp. 259-274
    • Mao, J.1    Price, D.D.2    Mayer, D.J.3
  • 39
    • 0020082059 scopus 로고
    • Transformation of episodic migraine into daily headache: Analysis of factors
    • Mathew NT, Stubits E, Nigam MP (1982) Transformation of episodic migraine into daily headache: analysis of factors. Headache 22:66-68. (Pubitemid 12190412)
    • (1982) Headache , vol.22 , Issue.2 , pp. 66-68
    • Mathew, N.T.1    Stubits, E.2    Nigam, M.P.3
  • 40
    • 58149400019 scopus 로고    scopus 로고
    • A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence
    • Mathews JL, Smrcka AV, Bidlack JM (2008) A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence. J Neurosci 28:12183-12189.
    • (2008) J Neurosci , vol.28 , pp. 12183-12189
    • Mathews, J.L.1    Smrcka, A.V.2    Bidlack, J.M.3
  • 41
    • 36549038723 scopus 로고    scopus 로고
    • Opioids for persistent noncancer pain
    • McCleane G, Smith HS (2007) Opioids for persistent noncancer pain. Anesthesiol Clin 25:787-807.
    • (2007) Anesthesiol Clin , vol.25 , pp. 787-807
    • McCleane, G.1    Smith, H.S.2
  • 43
    • 0028952242 scopus 로고
    • The human mu opioid receptor: Modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C
    • Mestek A, Hurley JH, Bye LS, Campbell AD, Chen Y, Tian M, Liu J, Schulman H, Yu L (1995) The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C. J Neurosci 15:2396-2406.
    • (1995) J Neurosci , vol.15 , pp. 2396-2406
    • Mestek, A.1    Hurley, J.H.2    Bye, L.S.3    Campbell, A.D.4    Chen, Y.5    Tian, M.6    Liu, J.7    Schulman, H.8    Yu, L.9
  • 44
    • 0029860103 scopus 로고    scopus 로고
    • Opioid mu, delta, and kappa receptorinduced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle
    • Murthy KS, Makhlouf GM (1996) Opioid mu, delta, and kappa receptorinduced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle. Mol Pharmacol 50:870-877.
    • (1996) Mol Pharmacol , vol.50 , pp. 870-877
    • Murthy, K.S.1    Makhlouf, G.M.2
  • 46
    • 0036883619 scopus 로고    scopus 로고
    • Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism
    • DOI 10.1016/S0197-0186(02)00047-5, PII S0197018602000475
    • Ono T, Inoue M, Rashid MH, Sumikawa K, Ueda H (2002) Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism. Neurochem lnt 41:399-407. (Pubitemid 35232325)
    • (2002) Neurochemistry International , vol.41 , Issue.6 , pp. 399-407
    • Ono, T.1    Inoue, M.2    Rashid, M.H.3    Sumikawa, K.4    Ueda, H.5
  • 47
    • 0037716476 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat
    • Parada CA, Yeh JJ, Joseph EK, Levine JD (2003) Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Eur J Neurosci 17:1847-1852.
    • (2003) Eur J Neurosci , vol.17 , pp. 1847-1852
    • Parada, C.A.1    Yeh, J.J.2    Joseph, E.K.3    Levine, J.D.4
  • 48
    • 11144271468 scopus 로고    scopus 로고
    • Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways
    • Parada CA, Reichling DB, Levine JD (2005) Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways. Pain 113:185-190.
    • (2005) Pain , vol.113 , pp. 185-190
    • Parada, C.A.1    Reichling, D.B.2    Levine, J.D.3
  • 49
    • 70449633251 scopus 로고    scopus 로고
    • Critical role of nociceptor plasticity in chronic pain
    • Reichling DB, Levine JD (2009) Critical role of nociceptor plasticity in chronic pain. Trends Neurosci 32:611-618.
    • (2009) Trends Neurosci , vol.32 , pp. 611-618
    • Reichling, D.B.1    Levine, J.D.2
  • 50
    • 54049132600 scopus 로고    scopus 로고
    • Opioids and the treatment of chronic pain: Controversies, current status, and future directions
    • Rosenblum A, Marsch LA, Joseph H, Portenoy RK (2008) Opioids and the treatment of chronic pain: controversies, current status, and future directions. Exp Clin Psychopharmacol 16:405-416.
    • (2008) Exp Clin Psychopharmacol , vol.16 , pp. 405-416
    • Rosenblum, A.1    Marsch, L.A.2    Joseph, H.3    Portenoy, R.K.4
  • 51
    • 0035862538 scopus 로고    scopus 로고
    • Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia
    • Sánchez-Blázquez P, Gómez-Serranillos P, Garzón J (2001) Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia. Brain Res Bull 54:229-235.
    • (2001) Brain Res Bull , vol.54 , pp. 229-235
    • Sánchez-Blázquez, P.1    Gómez-Serranillos, P.2    Garzón, J.3
  • 52
    • 0029920390 scopus 로고    scopus 로고
    • Long-term opioid therapy: Assessment of consequences and risks
    • DOI 10.1016/0885-3924(95)00202-2
    • Savage SR (1996) Long-term opioid therapy: assessment of consequences and risks. J Pain Symptom Manage 11:274-286. (Pubitemid 26129963)
    • (1996) Journal of Pain and Symptom Management , vol.11 , Issue.5 , pp. 274-286
    • Savage, S.R.1
  • 53
    • 58149399329 scopus 로고    scopus 로고
    • Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain
    • Shi TJ, Liu SX, Hammarberg H, Watanabe M, Xu ZQ, Hökfelt T (2008) Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc Natl Acad Sci U S A 105:20004-20008.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20004-20008
    • Shi, T.J.1    Liu, S.X.2    Hammarberg, H.3    Watanabe, M.4    Xu, Z.Q.5    Hökfelt, T.6
  • 54
    • 0032859753 scopus 로고    scopus 로고
    • Involvement of phospholipid signal transduction pathways in morphine tolerance in mice
    • DOI 10.1038/sj.bjp.0702771
    • Smith FL, Lohmann AB, Dewey WL (1999) Involvement of phospholipid signal transduction pathways in morphine tolerance in mice. Br J Pharmacol 128:220-226. (Pubitemid 29425288)
    • (1999) British Journal of Pharmacology , vol.128 , Issue.1 , pp. 220-226
    • Smith, F.L.1    Lohmann, A.B.2    Dewey, W.L.3
  • 55
    • 0024833492 scopus 로고
    • Tolerance to morphine induced by chronic mild environmental stressors
    • Szikszay M, Benedek G (1989) Tolerance to morphine induced by chronic mild environmental stressors. Acta Physiol Hung 73:447-453. (Pubitemid 20068817)
    • (1989) Acta Physiologica Hungarica , vol.73 , Issue.4 , pp. 447-453
    • Szikszay, M.1    Benedek, G.2
  • 57
    • 33750807737 scopus 로고    scopus 로고
    • Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein
    • Wang HY, Burns LH (2006) Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. J Neurobiol 66:1302-1310.
    • (2006) J Neurobiol , vol.66 , pp. 1302-1310
    • Wang, H.Y.1    Burns, L.H.2
  • 58
    • 70350334263 scopus 로고    scopus 로고
    • The "toll" of opioid-induced glial activation: Improving the clinical efficacy of opioids by targeting glia
    • Watkins LR, Hutchinson MR, Rice KC, Maier SF (2009) The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci 30:581-591.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 581-591
    • Watkins, L.R.1    Hutchinson, M.R.2    Rice, K.C.3    Maier, S.F.4
  • 59
    • 34548390965 scopus 로고    scopus 로고
    • Relationship between early opioid prescribing for acute occupational low back pain and disability duration, medical costs, subsequent surgery and late opioid use
    • Webster BS, Verma SK, Gatchel RJ (2007) Relationship between early opioid prescribing for acute occupational low back pain and disability duration, medical costs, subsequent surgery and late opioid use. Spine (Phila Pa 1976) 32:2127-2132.
    • (2007) Spine (Phila Pa 1976) , vol.32 , pp. 2127-2132
    • Webster, B.S.1    Verma, S.K.2    Gatchel, R.J.3
  • 60
    • 0036967449 scopus 로고    scopus 로고
    • The role of spinal cholecystokinin in chronic pain states
    • DOI 10.1034/j.1600-0773.2002.910619.x
    • Wiesenfeld-Hallin Z, Xu XJ, Hökfelt T (2002) The role of spinal cholecystokinin in chronic pain states. Pharmacol Toxicol 91:398-403. (Pubitemid 36138721)
    • (2002) Pharmacology and Toxicology , vol.91 , Issue.6 , pp. 398-403
    • Wiesenfeld-Hallin, Z.1    Xu, X.-J.2    Hokfelt, T.3
  • 61
    • 0035078742 scopus 로고    scopus 로고
    • Opiate use to control bowel motility may induce chronic daily headache in patients with migraine
    • Wilkinson SM, Becker WJ, Heine JA (2001) Opiate use to control bowel motility may induce chronic daily headache in patients with migraine. Headache 41:303-309.
    • (2001) Headache , vol.41 , pp. 303-309
    • Wilkinson, S.M.1    Becker, W.J.2    Heine, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.