-
1
-
-
0016317398
-
Coronary thrombosis in myocardial infarction. Report of a workshop on the role of coronary thrombosis in the pathogenesis of acute myocardial infarction
-
Chandler, A.B., et al,. Coronary thrombosis in myocardial infarction. Report of a workshop on the role of coronary thrombosis in the pathogenesis of acute myocardial infarction. Am. J. Cardiol. 34, 823-833 (1974).
-
(1974)
Am. J. Cardiol.
, vol.34
, pp. 823-833
-
-
Chandler, A.B.1
-
2
-
-
0026541706
-
The pathogenesis of coronary artery disease and the acute coronary syndromes (1)
-
Fuster, V., Badimon, L., Badimon, J.J., &, Chesebro, J.H., The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N. Engl. J. Med. 326, 242-250 (1992).
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 242-250
-
-
Fuster, V.1
Badimon, L.2
Badimon, J.J.3
Chesebro, J.H.4
-
3
-
-
0028013622
-
Platelet aggregation, coronary artery disease progression and future coronary events
-
Lam, J.Y., Latour, J.G., Lesperance, J., &, Waters, D., Platelet aggregation, coronary artery disease progression and future coronary events. Am. J. Cardiol. 73, 333-338 (1994).
-
(1994)
Am. J. Cardiol.
, vol.73
, pp. 333-338
-
-
Lam, J.Y.1
Latour, J.G.2
Lesperance, J.3
Waters, D.4
-
4
-
-
0026035523
-
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
-
Vu, T.K.H., Hung, D.T., Wheaton, V.I., &, Coughlin, S.R., Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057-1068 (1991).
-
(1991)
Cell
, vol.64
, pp. 1057-1068
-
-
Vu, T.K.H.1
Hung, D.T.2
Wheaton, V.I.3
Coughlin, S.R.4
-
5
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin, S.R., Thrombin signalling and protease-activated receptors. Nature 407, 258-264 (2000).
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
6
-
-
0035019636
-
Proteinase-activated receptors
-
Macfarlane, S.R., Seatter, M.J., Kanke, T., Hunter, G.D., &, Plevin, R., Proteinase-activated receptors. Pharmacol. Rev. 53, 245-282 (2001).
-
(2001)
Pharmacol. Rev.
, vol.53
, pp. 245-282
-
-
MacFarlane, S.R.1
Seatter, M.J.2
Kanke, T.3
Hunter, G.D.4
Plevin, R.5
-
7
-
-
1642279517
-
Protease-activated receptors: Contribution to physiology and disease
-
Ossovskaya, V.S., &, Bunnett, N.W., Protease-activated receptors: Contribution to physiology and disease. Physiol. Rev. 84, 579-621 (2004).
-
(2004)
Physiol. Rev.
, vol.84
, pp. 579-621
-
-
Ossovskaya, V.S.1
Bunnett, N.W.2
-
8
-
-
62549131608
-
Aspirin for the primary prevention of cardiovascular events: An update of the evidence for the U.S. Preventive services task force
-
Wolff, T., Miller, T., &, Ko, S., Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. Preventive services task force. Ann. Intern. Med. 150, 405-410 (2009).
-
(2009)
Ann. Intern. Med.
, vol.150
, pp. 405-410
-
-
Wolff, T.1
Miller, T.2
Ko, S.3
-
9
-
-
84920811343
-
New approaches to inhibiting platelets and coagulation
-
Depta, J.P., &, Bhatt, D.L., New approaches to inhibiting platelets and coagulation. Annu. Rev. Pharmacol. Toxicol. 55, 373-397 (2015).
-
(2015)
Annu. Rev. Pharmacol. Toxicol.
, vol.55
, pp. 373-397
-
-
Depta, J.P.1
Bhatt, D.L.2
-
10
-
-
0037065502
-
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
-
Antithrombotic Trialists C
-
Antithrombotic Trialists C. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324, 71-86 (2002).
-
(2002)
BMJ
, vol.324
, pp. 71-86
-
-
-
11
-
-
65849268320
-
Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials
-
Antithrombotic Trialists C
-
Antithrombotic Trialists C, Baigent, C., et al,. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373, 1849-1860 (2009).
-
(2009)
Lancet
, vol.373
, pp. 1849-1860
-
-
Baigent, C.1
-
12
-
-
15044340682
-
Protective effect of triflusal and its main metabolite htb in an in vitro model of anoxia-reoxygenation in rat brain slices: Comparison with acetylsalicylic and salicylic acids
-
Gonzalez-Correa, J.A., et al,. Protective effect of triflusal and its main metabolite htb in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids. Naunyn Schmiedebergs Arch. Pharmacol. 371, 81-88 (2005).
-
(2005)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.371
, pp. 81-88
-
-
Gonzalez-Correa, J.A.1
-
13
-
-
0023900087
-
Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients
-
De la Cruz, J.P., Pavia, J., Garcia-Arnes, J., &, Sanchez de la Cuesta, F., Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients. Eur. J. Haematol. 40, 232-236 (1988).
-
(1988)
Eur. J. Haematol.
, vol.40
, pp. 232-236
-
-
De La Cruz, J.P.1
Pavia, J.2
Garcia-Arnes, J.3
Sanchez De La Cuesta, F.4
-
14
-
-
18044385155
-
The p2 receptors in platelet function
-
Hechler, B., Cattaneo, M., &, Gachet C,. The p2 receptors in platelet function. Semin. Thromb. Hemost. 31, 150-161 (2005).
-
(2005)
Semin. Thromb. Hemost.
, vol.31
, pp. 150-161
-
-
Hechler, B.1
Cattaneo, M.2
Gachet, C.3
-
15
-
-
78651515856
-
P2y12 receptor in platelet activation
-
Kim, S., &, Kunapuli, S.P., P2y12 receptor in platelet activation. Platelets 22, 56-60 (2011).
-
(2011)
Platelets
, vol.22
, pp. 56-60
-
-
Kim, S.1
Kunapuli, S.P.2
-
16
-
-
33846533006
-
Platelet p2 receptors: Old and new targets for antithrombotic drugs
-
Cattaneo, M., Platelet p2 receptors: old and new targets for antithrombotic drugs. Expert Rev. Cardiovasc. Ther. 5, 45-55 (2007).
-
(2007)
Expert Rev. Cardiovasc. Ther.
, vol.5
, pp. 45-55
-
-
Cattaneo, M.1
-
17
-
-
84890025521
-
Working Group on On-Treatment Platelet R. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding
-
Tantry, U.S., et al,. Working Group on On-Treatment Platelet R. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J. Am. Coll. Cardiol. 62, 2261-2273 (2013).
-
(2013)
J. Am. Coll. Cardiol.
, vol.62
, pp. 2261-2273
-
-
Tantry, U.S.1
-
18
-
-
0030590746
-
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (caprie)
-
CAPRIE Steering Committee
-
CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (caprie). Lancet 348, 1329-1339 (1996).
-
(1996)
Lancet
, vol.348
, pp. 1329-1339
-
-
-
19
-
-
0035899289
-
Clopidogrel in unstable angina to prevent recurrent events trial I. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without st-segment elevation
-
Yusuf, S., et al,. Clopidogrel in unstable angina to prevent recurrent events trial I. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without st-segment elevation. N. Engl. J. Med. 345, 494-502 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 494-502
-
-
Yusuf, S.1
-
20
-
-
0037145863
-
Observation CICftRoED. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
-
Steinhubl, S.R., et al,. Observation CICftRoED. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 288, 2411-2420 (2002).
-
(2002)
JAMA
, vol.288
, pp. 2411-2420
-
-
Steinhubl, S.R.1
-
21
-
-
0034068625
-
The in vivo pharmacological profile of cs-747, a novel antiplatelet agent with platelet adp receptor antagonist properties
-
Sugidachi, A., Asai, F., Ogawa, T., Inoue, T., &, Koike, H., The in vivo pharmacological profile of cs-747, a novel antiplatelet agent with platelet adp receptor antagonist properties. Br. J. Pharmacol. 129, 1439-1446 (2000).
-
(2000)
Br. J. Pharmacol.
, vol.129
, pp. 1439-1446
-
-
Sugidachi, A.1
Asai, F.2
Ogawa, T.3
Inoue, T.4
Koike, H.5
-
22
-
-
36148983750
-
Prasugrel versus clopidogrel in patients with acute coronary syndromes
-
Wiviott, S.D., et al,. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 357, 2001-2015 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 2001-2015
-
-
Wiviott, S.D.1
-
23
-
-
84882276017
-
Antiplatelet therapy in acute coronary syndromes: Focus on ticagrelor
-
Birkeland, K., Parra, D., &, Rosenstein R,. Antiplatelet therapy in acute coronary syndromes: focus on ticagrelor. J. Blood Med. 1, 197-219 (2010).
-
(2010)
J. Blood Med.
, vol.1
, pp. 197-219
-
-
Birkeland, K.1
Parra, D.2
Rosenstein, R.3
-
24
-
-
73949112820
-
Randomized double-blind assessment of the onset and offset of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The onset/offset study
-
Gurbel, P.A., et al,. Randomized double-blind assessment of the onset and offset of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the onset/offset study. Circulation 120, 2577-2585 (2009).
-
(2009)
Circulation
, vol.120
, pp. 2577-2585
-
-
Gurbel, P.A.1
-
25
-
-
70149101223
-
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
-
Wallentin, L., et al,. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1045-1057
-
-
Wallentin, L.1
-
26
-
-
80052617136
-
Anti-platelet therapy: Phosphodiesterase inhibitors
-
Gresele, P., Momi, S., &, Falcinelli, E., Anti-platelet therapy: phosphodiesterase inhibitors. Br. J. Clin. Pharmacol. 72, 634-646 (2011).
-
(2011)
Br. J. Clin. Pharmacol.
, vol.72
, pp. 634-646
-
-
Gresele, P.1
Momi, S.2
Falcinelli, E.3
-
27
-
-
33646596912
-
Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (esprit): Randomised controlled trial
-
Group, E.S., et al,. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (esprit): randomised controlled trial. Lancet 367, 1665-1673 (2006).
-
(2006)
Lancet
, vol.367
, pp. 1665-1673
-
-
Group, E.S.1
-
28
-
-
51449116270
-
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
-
Sacco, R.L., et al,. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N. Engl. J. Med. 359, 1238-1251 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1238-1251
-
-
Sacco, R.L.1
-
29
-
-
52449085759
-
A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: Results of the OPTIMUS-2 study
-
Angiolillo, D.J., et al,. A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study. Eur. Heart J. 29, 2202-2211 (2008).
-
(2008)
Eur. Heart J.
, vol.29
, pp. 2202-2211
-
-
Angiolillo, D.J.1
-
30
-
-
84933679982
-
Bivalirudin in stable angina and acute coronary syndromes
-
Mavrakanas, T.A., &, Chatzizisis, Y.S., Bivalirudin in stable angina and acute coronary syndromes. Pharmacol. Ther. 152, 1-10 (2015).
-
(2015)
Pharmacol. Ther.
, vol.152
, pp. 1-10
-
-
Mavrakanas, T.A.1
Chatzizisis, Y.S.2
-
31
-
-
23644443663
-
Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: Meta-analysis with estimates of risk and benefit
-
Rothberg, M.B., Celestin, C., Fiore, L.D., Lawler, E., &, Cook J.R., Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann. Intern. Med. 143, 241-250 (2005).
-
(2005)
Ann. Intern. Med.
, vol.143
, pp. 241-250
-
-
Rothberg, M.B.1
Celestin, C.2
Fiore, L.D.3
Lawler, E.4
Cook, J.R.5
-
32
-
-
84855723464
-
A new era in secondary prevention after acute coronary syndrome
-
Roe, M.T., &, Ohman, E.M., A new era in secondary prevention after acute coronary syndrome. N. Engl. J. Med. 366, 85-87 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 85-87
-
-
Roe, M.T.1
Ohman, E.M.2
-
33
-
-
84862907587
-
Rivaroxaban in patients with a recent acute coronary syndrome
-
Mega, J.L., et al,. Rivaroxaban in patients with a recent acute coronary syndrome. N. Engl. J. Med. 366, 9-19 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 9-19
-
-
Mega, J.L.1
-
34
-
-
0027933068
-
Molecular cloning of a potential proteinase activated receptor
-
Nystedt, S., Emilsson, K., Wahlestedt, C., &, Sundelin, J., Molecular cloning of a potential proteinase activated receptor. Proc. Natl. Acad. Sci. U. S. A. 91, 9208-9212 (1994).
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 9208-9212
-
-
Nystedt, S.1
Emilsson, K.2
Wahlestedt, C.3
Sundelin, J.4
-
35
-
-
0030979972
-
Protease-activated receptor 3 is a second thrombin receptor in humans
-
Ishihara, H., et al,. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386, 502-506 (1997).
-
(1997)
Nature
, vol.386
, pp. 502-506
-
-
Ishihara, H.1
-
36
-
-
0032499696
-
Cloning and characterization of human protease-activated receptor 4
-
Xu, W.F., et al,. Cloning and characterization of human protease-activated receptor 4. Proc. Natl. Acad. Sci. U. S. A. 95, 6642-6646 (1998).
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 6642-6646
-
-
Xu, W.F.1
-
37
-
-
84920116737
-
Corrigendum: Biased signaling of protease-activated receptors
-
Zhao, P., Metcalf, M., &, Bunnett, N.W,. Corrigendum: biased signaling of protease-activated receptors. Front. Endocrinol. 5, 228 (2014).
-
(2014)
Front. Endocrinol.
, vol.5
, pp. 228
-
-
Zhao, P.1
Metcalf, M.2
Bunnett, N.W.3
-
38
-
-
0030843881
-
Pathophysiology of platelet thrombin receptors
-
Jamieson, G.A., Pathophysiology of platelet thrombin receptors. Thromb. Haemost. 78, 242-246 (1997).
-
(1997)
Thromb. Haemost.
, vol.78
, pp. 242-246
-
-
Jamieson, G.A.1
-
39
-
-
0032541084
-
G protein-coupled receptors. II. Mechanism of agonist activation
-
Gether, U., &, Kobilka, B.K., G protein-coupled receptors. II. Mechanism of agonist activation. J. Biol. Chem. 273, 17979-17982 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 17979-17982
-
-
Gether, U.1
Kobilka, B.K.2
-
40
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski, K., et al,. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745 (2000).
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
-
41
-
-
3142665410
-
Clusters of transmembrane residues are critical for human prostacyclin receptor activation
-
Stitham, J., Stojanovic, A., Ross, L.A., Blount, A.C., Jr., &, Hwa, J., Clusters of transmembrane residues are critical for human prostacyclin receptor activation. Biochemistry 43, 8974-8986 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 8974-8986
-
-
Stitham, J.1
Stojanovic, A.2
Ross, L.A.3
Blount, A.C.4
Hwa, J.5
-
42
-
-
0013118587
-
Platelet signal transduction
-
In (ed. Coleman, R.W. et al.) (Lippincott Williams & Wilkins: Philadelphia, PA)
-
Abrams, C.S., &, Brass, L.F., Platelet signal transduction. In Hemostasis and Thrombosis (ed., Coleman, R.W., et al.) 617-629 (Lippincott Williams & Wilkins: Philadelphia, PA, 2006).
-
(2006)
Hemostasis and Thrombosis
, pp. 617-629
-
-
Abrams, C.S.1
Brass, L.F.2
-
43
-
-
33748745670
-
Par4, but not par1, signals human platelet aggregation via ca2+ mobilization and synergistic p2y12 receptor activation
-
Holinstat, M., et al,. Par4, but not par1, signals human platelet aggregation via ca2+ mobilization and synergistic p2y12 receptor activation. J. Biol. Chem. 281, 26665-26674 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26665-26674
-
-
Holinstat, M.1
-
44
-
-
0035019636
-
Proteinase-activated receptors
-
Macfarlane, S.R., Seatter, M.J., Kanke, T., Hunter, G.D., &, Plevin, R., Proteinase-activated receptors. Pharmacol. Rev. 53, 245-282 (2001).
-
(2001)
Pharmacol. Rev.
, vol.53
, pp. 245-282
-
-
MacFarlane, S.R.1
Seatter, M.J.2
Kanke, T.3
Hunter, G.D.4
Plevin, R.5
-
45
-
-
0034625055
-
Biphasic kinetics of activation and signaling for par1 and par4 thrombin receptors in platelets
-
Covic, L., Gresser, A.L., &, Kuliopulos, A., Biphasic kinetics of activation and signaling for par1 and par4 thrombin receptors in platelets. Biochemistry 39, 5458-5467 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 5458-5467
-
-
Covic, L.1
Gresser, A.L.2
Kuliopulos, A.3
-
46
-
-
84898012855
-
Unmet needs in the management of acute myocardial infarction: Role of novel protease-activated receptor-1 antagonist vorapaxar
-
Cho, J.R., Rollini, F., Franchi, F., Ferrante, E., &, Angiolillo, D.J., Unmet needs in the management of acute myocardial infarction: role of novel protease-activated receptor-1 antagonist vorapaxar. Vasc. Health Risk Manag. 10, 177-188 (2014).
-
(2014)
Vasc. Health Risk Manag.
, vol.10
, pp. 177-188
-
-
Cho, J.R.1
Rollini, F.2
Franchi, F.3
Ferrante, E.4
Angiolillo, D.J.5
-
47
-
-
61849180442
-
Safety and tolerability of sch 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study
-
Becker, R.C., et al,. Safety and tolerability of sch 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study. Lancet 373, 919-928 (2009).
-
(2009)
Lancet
, vol.373
, pp. 919-928
-
-
Becker, R.C.1
-
48
-
-
83655177669
-
Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
-
Tricoci, P., et al,. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N. Engl. J. Med. 366, 20-33 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 20-33
-
-
Tricoci, P.1
-
49
-
-
84859555815
-
Vorapaxar in the secondary prevention of atherothrombotic events
-
Morrow, D.A., et al,. Vorapaxar in the secondary prevention of atherothrombotic events. N. Engl. J. Med. 366, 1404-1413 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1404-1413
-
-
Morrow, D.A.1
-
50
-
-
0037154270
-
Activation and inhibition of g protein-coupled receptors by cell-penetrating membrane-tethered peptides
-
Covic, L., Gresser, A.L., Talavera, J., Swift, S., &, Kuliopulos, A., Activation and inhibition of g protein-coupled receptors by cell-penetrating membrane-tethered peptides. Proc. Natl. Acad. Sci. U. S. A. 99, 643-648 (2002).
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 643-648
-
-
Covic, L.1
Gresser, A.L.2
Talavera, J.3
Swift, S.4
Kuliopulos, A.5
-
51
-
-
0036797590
-
Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
-
Covic, L., Misra, M., Badar, J., Singh, C., &, Kuliopulos, A., Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation. Nat. Med. 8, 1161-1165 (2002).
-
(2002)
Nat. Med.
, vol.8
, pp. 1161-1165
-
-
Covic, L.1
Misra, M.2
Badar, J.3
Singh, C.4
Kuliopulos, A.5
-
52
-
-
33748495552
-
Protease-activated receptors in cardiovascular diseases
-
Leger, A.J., Covic, L., &, Kuliopulos, A., Protease-activated receptors in cardiovascular diseases. Circulation 114, 1070-1077 (2006).
-
(2006)
Circulation
, vol.114
, pp. 1070-1077
-
-
Leger, A.J.1
Covic, L.2
Kuliopulos, A.3
-
53
-
-
84925359034
-
Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
-
Aisiku, O., et al,. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood 125, 1976-1985 (2015).
-
(2015)
Blood
, vol.125
, pp. 1976-1985
-
-
Aisiku, O.1
-
54
-
-
0036285450
-
Selective inhibition of protease-activated receptor 4-dependent platelet activation by yd-3
-
Wu, C.C., et al,. Selective inhibition of protease-activated receptor 4-dependent platelet activation by yd-3. Thromb. Haemost. 87, 1026-1033 (2002).
-
(2002)
Thromb. Haemost.
, vol.87
, pp. 1026-1033
-
-
Wu, C.C.1
-
55
-
-
33748307543
-
Comparison of the effects of par1 antagonists, par4 antagonists, and their combinations on thrombin-induced human platelet activation
-
Wu, C.C., &, Teng, C.M., Comparison of the effects of par1 antagonists, par4 antagonists, and their combinations on thrombin-induced human platelet activation. Eur. J. Pharmacol. 546, 142-147 (2006).
-
(2006)
Eur. J. Pharmacol.
, vol.546
, pp. 142-147
-
-
Wu, C.C.1
Teng, C.M.2
-
56
-
-
84907189440
-
Substituted indoles as selective protease activated receptor 4 (par-4) antagonists: Discovery and SAR of ml354
-
Wen, W., et al,. Substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and SAR of ml354. Bioorg. Med. Chem. Lett. 24, 4708-4713 (2014).
-
(2014)
Bioorg. Med. Chem. Lett.
, vol.24
, pp. 4708-4713
-
-
Wen, W.1
-
57
-
-
81755184108
-
Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia
-
Sevigny, L.M., et al,. Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia. Arterioscler. Thromb. Vasc. Biol. 31, e100-106 (2011).
-
(2011)
Arterioscler. Thromb. Vasc. Biol.
, vol.31
, pp. e100-e106
-
-
Sevigny, L.M.1
-
58
-
-
34249319813
-
Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis
-
Uusitalo-Jarvinen, H., et al,. Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis. Arterioscler. Thromb. Vasc. Biol. 27, 1456-1462 (2007).
-
(2007)
Arterioscler. Thromb. Vasc. Biol.
, vol.27
, pp. 1456-1462
-
-
Uusitalo-Jarvinen, H.1
-
59
-
-
33645507738
-
Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis
-
Leger, A.J., et al,. Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis. Circulation 113, 1244-1254 (2006).
-
(2006)
Circulation
, vol.113
, pp. 1244-1254
-
-
Leger, A.J.1
-
60
-
-
84888178878
-
Cofactoring and dimerization of proteinase-activated receptors
-
Lin, H., Liu, A.P., Smith, T.H., &, Trejo, J., Cofactoring and dimerization of proteinase-activated receptors. Pharmacol. Rev. 65, 1198-1213 (2013).
-
(2013)
Pharmacol. Rev.
, vol.65
, pp. 1198-1213
-
-
Lin, H.1
Liu, A.P.2
Smith, T.H.3
Trejo, J.4
-
61
-
-
84887491969
-
Protease-activated receptor 1 (par1) and par4 heterodimers are required for par1-enhanced cleavage of par4 by alpha-thrombin
-
Arachiche, A., Mumaw, M.M., de la Fuente, M., &, Nieman, M.T., Protease-activated receptor 1 (par1) and par4 heterodimers are required for par1-enhanced cleavage of par4 by alpha-thrombin. J. Biol. Chem. 288, 32553-32562 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 32553-32562
-
-
Arachiche, A.1
Mumaw, M.M.2
De La Fuente, M.3
Nieman, M.T.4
-
62
-
-
84858986564
-
Mapping human protease-activated receptor 4 (par4) homodimer interface to transmembrane helix 4
-
de la Fuente, M., Noble, D.N., Verma, S., &, Nieman, M.T., Mapping human protease-activated receptor 4 (par4) homodimer interface to transmembrane helix 4. J. Biol. Chem. 287, 10414-10423 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 10414-10423
-
-
De La Fuente, M.1
Noble, D.N.2
Verma, S.3
Nieman, M.T.4
-
63
-
-
84901455907
-
The physical association of the p2y12 receptor with par4 regulates arrestin-mediated akt activation
-
Khan, A., Li, D., Ibrahim, S., Smyth, E., &, Woulfe, D.S., The physical association of the p2y12 receptor with par4 regulates arrestin-mediated akt activation. Mol. Pharmacol. 86, 1-11 (2014).
-
(2014)
Mol. Pharmacol.
, vol.86
, pp. 1-11
-
-
Khan, A.1
Li, D.2
Ibrahim, S.3
Smyth, E.4
Woulfe, D.S.5
-
64
-
-
33947195552
-
Summary health statistics for U.S. Adults: National health interview survey, 2006
-
Pleis, J.R., &, Lethbridge-Cejku, M., Summary health statistics for U.S. adults: national health interview survey, 2006. Vital Health Stat. 10, 1-153 (2007).
-
(2007)
Vital Health Stat
, vol.10
, pp. 1-153
-
-
Pleis, J.R.1
Lethbridge-Cejku, M.2
-
65
-
-
77957841890
-
Racial differences in long-term survival among patients with coronary artery disease
-
Thomas, K.L., Honeycutt, E., Shaw, L.K., &, Peterson, E.D., Racial differences in long-term survival among patients with coronary artery disease. Am. Heart J. 160, 744-751 (2010).
-
(2010)
Am. Heart J.
, vol.160
, pp. 744-751
-
-
Thomas, K.L.1
Honeycutt, E.2
Shaw, L.K.3
Peterson, E.D.4
-
66
-
-
84856245226
-
Lifetime risks of cardiovascular disease
-
Berry, J.D., et al,. Lifetime risks of cardiovascular disease. N. Engl. J. Med. 366, 321-329 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 321-329
-
-
Berry, J.D.1
-
67
-
-
77950270390
-
Identifying patients at high risk of a cardiovascular event in the near future: Current status and future directions: Report of a national heart, lung, and blood institute working group
-
Eagle, K.A., et al,. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation 121, 1447-1454 (2010).
-
(2010)
Circulation
, vol.121
, pp. 1447-1454
-
-
Eagle, K.A.1
-
68
-
-
34447636770
-
Heritability of platelet function in families with premature coronary artery disease
-
Bray, P.F., et al,. Heritability of platelet function in families with premature coronary artery disease. J. Thromb. Haemost. 5, 1617-1623 (2007).
-
(2007)
J. Thromb. Haemost.
, vol.5
, pp. 1617-1623
-
-
Bray, P.F.1
-
69
-
-
84889878234
-
Racial differences in human platelet par4 reactivity reflect expression of pctp and mir-376c
-
Edelstein, L.C., Racial differences in human platelet par4 reactivity reflect expression of pctp and mir-376c. Nat. Med. 19, 1609-1616 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 1609-1616
-
-
Edelstein, L.C.1
-
70
-
-
84914680239
-
Common variants in the human platelet par4 thrombin receptor alter platelet function and differ by race
-
Edelstein, L.C., et al,. Common variants in the human platelet par4 thrombin receptor alter platelet function and differ by race. Blood 124, 3450-3458 (2014).
-
(2014)
Blood
, vol.124
, pp. 3450-3458
-
-
Edelstein, L.C.1
-
71
-
-
84918803205
-
Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and gq signaling axis
-
Tourdot, B.E., et al,. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and gq signaling axis. Arterioscler. Thromb. Vasc. Biol. 34, 2644-2650 (2014).
-
(2014)
Arterioscler. Thromb. Vasc. Biol.
, vol.34
, pp. 2644-2650
-
-
Tourdot, B.E.1
-
72
-
-
85027958733
-
Novel antiplatelet drug revacept (dimeric glycoprotein VI-fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans
-
Ungerer, M., et al,. Novel antiplatelet drug revacept (dimeric glycoprotein vi-fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans. Circulation 123, 1891-1899 (2011).
-
(2011)
Circulation
, vol.123
, pp. 1891-1899
-
-
Ungerer, M.1
-
73
-
-
54049128201
-
Targeting a metalloprotease-par1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer
-
Agarwal, A., et al,. Targeting a metalloprotease-par1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer. Mol. Cancer Ther. 7, 2746-2757 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2746-2757
-
-
Agarwal, A.1
-
74
-
-
68049143326
-
Blockade of par1 signaling with cell-penetrating pepducins inhibits akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis
-
Yang, E., et al,. Blockade of par1 signaling with cell-penetrating pepducins inhibits akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis. Cancer Res. 69, 6223-6231 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 6223-6231
-
-
Yang, E.1
-
75
-
-
80052443569
-
Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer
-
Cisowski, J., et al,. Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer. Am. J. Pathol. 179, 513-523 (2011).
-
(2011)
Am. J. Pathol.
, vol.179
, pp. 513-523
-
-
Cisowski, J.1
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