Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 12, 2014, Pages 2644-2650

  Tourdot, Benjamin E ^a   Conaway, Stanley ^a   Niisuke, Katrin ^a   Edelstein, Leonard C ^a   Bray, Paul F ^a   Holinstat, Michael ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Blood platelet; Continental population groups; Protease activated receptor 4; Thrombin; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DERIVATIVE; CALCIUM; PROSTAGLANDIN SYNTHASE; PROTEINASE ACTIVATED RECEPTOR 4; PURINERGIC P2Y12 RECEPTOR; RAP1 PROTEIN; VERY LATE ACTIVATION ANTIGEN 2; FIBRINOGEN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; P2RY12 PROTEIN, HUMAN; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEASE-ACTIVATED RECEPTOR 4; PROTEIN KINASE C; PURINERGIC P2Y RECEPTOR ANTAGONIST; TELOMERE BINDING PROTEIN; TERF2IP PROTEIN, HUMAN; THROMBIN RECEPTOR;

ARTICLE; BLACK PERSON; CALCIUM TRANSPORT; CAUCASIAN; CELL STIMULATION; CONTROLLED STUDY; EX VIVO STUDY; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PROTEIN EXPRESSION; RACE DIFFERENCE; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; ADULT; BLOOD; CALCIUM SIGNALING; COMPARATIVE STUDY; DRUG EFFECTS; FEMALE; MALE; METABOLISM; PHYSIOLOGY;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; CALCIUM SIGNALING; CYCLOOXYGENASE INHIBITORS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; MALE; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN KINASE C; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2Y12; RECEPTORS, THROMBIN; SIGNAL TRANSDUCTION; TELOMERE-BINDING PROTEINS;

EID: 84918803205     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304249     Document Type: Article

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