Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice

Aging Cell

Volumn 15, Issue 1, 2016, Pages 111-117

  Hoeflich, Andreas ^a   Reyer, Anja ^a   Ohde, Daniela ^a   Schindler, Nancy ^a   Brenmoehl, Julia ^a   Spitschak, Marion ^a   Langhammer, Martina ^a   Tuchscherer, Armin ^a   Wirthgen, Elisa ^a,b   Renner Müller, Ingrid ^c   Wanke, Rüdiger ^c   Metzger, Friedrich ^d   Bielohuby, Maximilian ^e   Wolf, Eckhard ^c,f  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b Ligandis GbR   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^f GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

Author keywords

Aging; AKT; Cell signaling; Growth; IGFBP 2; Reproductive development

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; SOMATOMEDIN BINDING PROTEIN 2;

ANIMAL EXPERIMENT; ARTICLE; BODY GROWTH; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GROWTH INHIBITION; GROWTH RATE; LIFE EXPECTANCY; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN MOTIF; SEXUAL MATURITY; ANIMAL; BODY WEIGHT; C57BL MOUSE; GENETICS; LIPID METABOLISM; METABOLISM; ORGAN SIZE; PHYSIOLOGY; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; BODY WEIGHT; FEMALE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; LIFE EXPECTANCY; LIPID METABOLISM; MICE, INBRED C57BL; MICE, TRANSGENIC; ORGAN SIZE; TIME FACTORS;

EID: 84955213224     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12413     Document Type: Article

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