Growth selection in mice reveals conserved and redundant expression patterns of the insulin-like growth factor system

General and Comparative Endocrinology

Volumn 136, Issue 2, 2004, Pages 248-259

  Hoeflich, Andreas ^a   Bünger, Lutz ^b,c   Nedbal, Sabine ^a   Renne, Ulla ^d   Elmlinger, Martin W ^e   Blum, Werner F ^f   Bruley, Charlotte ^b   Kolb, Helmut J ^g   Wolf, Eckhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c SCOTTISH AGRICULTURAL COLLEGE   (United Kingdom)

^d LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^f LILLY DEUTSCHLAND GMBH   (Germany)

^g Institut für Klinische Chemie   (Germany)

Author keywords

Body weight; Gene expression; GH; Growth selection; IGF I; IGFBPs; Muscle

Indexed keywords

GROWTH FACTOR; SOMATOMEDIN;

ARTICLE; BODY WEIGHT; CARCASS; CIRCULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; KNOCKOUT MOUSE; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; POSTNATAL GROWTH; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; TISSUE SPECIFICITY;

EID: 1542509346     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2003.12.019     Document Type: Article

References (47)

1. Adams T.E., Hansen J.A., Starr R., Nicola N.A., Hilton D.J., Billestrup N. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273:1998;1285-1287.
2. Awede B., Thissen J., Gailly P., Lebacq J. Regulation of IGF-I, IGFBP-4 and IGFBP-5 gene expression by loading in mouse skeletal muscle. FEBS Lett. 461:1999;263-267.
3. Bach L.A., Hsieh S., Brown A.L., Rechler M.M. Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts. Endocrinology. 135:1994;2168-2176.
4. Baker J., Liu J.P., Robertson E.J., Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell. 75:1993;73-82.
5. Bang, P., Baxter, R.C., Blum, W.F., Breier, B.H., Clemmons, D.R., Hall, K., Hintz, R.L., Holly, J.M., Rosenfeld, R.G., Zapf, J., 1994. Valid measurements of total IGF concentrations in biological fluids. Recommendations from the third International Symposium on Insulin-like Growth Factors. J. Endocrinol. 143, C1-2.
6. Baserga R., Resnicoff M., Dews M. The IGF-I receptor and cancer. Endocrine. 7:1997;99-102.
7. Blum W.F., Breier B.H. Radioimmunoassays for IGFs and IGFBPs. Growth Regul. 4(Suppl 1):1994;11-19.
8. Brockmann G.A., Haley C.S., Wolf E., Kratzsch J., Renne U., Schwerin M., Hoeflich A. Genome-wide search for loci controlling serum IGF binding protein levels of mice. FASEB J. 14:2001.
9. Bünger L., Laidlaw A., Bulfield G., Eisen E.J., Medrano J.F., Bradford G.E., Pirchner F., Renne U., Schlote W., Hill W.G. Inbred lines of mice derived from long-term growth selected lines: unique resources for mapping growth genes. Mamm. Genome. 12:2001;678-686.
10. DeChiara T.M., Efstratiadis A., Robertson E.J. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature. 345:1990;78-80.
11. Dey B.R., Spence S.L., Nissley P., Furlanetto R.W. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J. Biol. Chem. 273:1998;24095-24101.
12. Efstratiadis A. Genetics of mouse growth. Int. J. Dev. Biol. 42:1998;955-976.
13. Ewton D.Z., Coolican S.A., Mohan S., Chernausek S.D., Florini J.R. Modulation of insulin-like growth factor actions in L6A1 myoblasts by insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5: a dual role for IGFBP-5. J. Cell. Physiol. 177:1998;47-57.
14. Firth S.M., Baxter R.C. Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 23:2002;824-854.
15. Florini J.R., Ewton D.Z., Magri K.A., Mangiacapra F.J. IGFs and muscle differentiation. Adv. Exp. Med. Biol. 343:1993;319-326.
16. Hoeflich A., Nedbal S., Blum W.F., Erhard M., Lahm H., Brem G., Kolb H., Wanke R., Wolf E. Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2. Endocrinology. 142:2001;1889-1898.
17. Hoeflich A., Schmidt P., Foll J., Rottmann O., Weber M.M., Kolb H.J., Pirchner F., Wolf E. Altered growth of mice divergently selected for body weight is associated with complex changes in the growth hormone/insulin-like growth factor system. Growth Horm. IGF Res. 8:1998;113-123.
18. Hoeflich A., Weber M.M., Fisch T., Nedbal S., Fottner C., Elmlinger M.W., Wanke R., Wolf E. Insulin-like growth factor binding protein 2 (IGFBP-2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF-I excess on adrenocortical cell in vivo. FASEB J. 16:2002.
19. Hoeflich A., Wu M., Mohan S., Föll J., Wanke R., Froehlich T., Arnold G., Lahm H., Kolb H.J., Wolf E. Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain. Endocrinology. 140:1999;5488-5496.
20. Horst P., Major F., Tawfik E.S., Wolf M., Weniger J.H., Steinhauf D. Model experiments on selection for endurance and its relation to growth. Part II. Selection results up to the 10th generation. J. Anim. Breed. Genet. 92:1975;260-266.
21. Hossenlopp P., Seurin D., Segovia Quinson B., Hardouin S., Binoux M. Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding studies. Anal. Biochem. 154:1986;138-143.
22. Keightley P.D., Bulfield G. Detection of quantitative trait loci from frequency changes of marker alleles under selection. Genet. Res. 62:1993;195-203.
23. Krebs D.L., Hilton D.J. SOCS proteins: negative regulators of cytokine signaling. Stem Cells. 19:2001;378-387.
24. Kuemmerle J.F., Zhou H. Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates growth and IGF-I secretion in human intestinal smooth muscle by Ras-dependent activation of p38 MAP kinase and Erk1/2 pathways. J. Biol. Chem. 277:2002;20563-20571.
25. Le Roith D., Bondy C., Yakar S., Liu J.L., Butler A. The somatomedin hypothesis: 2001. Endocr. Rev. 22:2001;53-74.
26. Liu J.P., Baker J., Perkins A.S., Robertson E.J., Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 75:1993;59-72.
27. Lupu F., Terwilliger J.D., Lee K., Segre G.V., Efstratiadis A. Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev. Biol. 229:2001;141-162.
28. Mathews L.S., Hammer R.E., Behringer R.R., D'Ercole A.J., Bell G.I., Brinster R.L., Palmiter R.D. Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology. 123:1988;2827-2833.
29. McPherron A.C., Lawler A.M., Lee S.J. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 387:1997;83-90.
30. Modric T., Silha J.V., Shi Z., Gui Y., Suwanichkul A., Durham S.K., Powell D.R., Murphy L.J. Phenotypic manifestations of insulin-like growth factor-binding protein- 3 overexpression in transgenic mice. Endocrinology. 142:2001;1958-1967.
31. Motani A., Rutherford C., Anggard E.E., Ferns G.A. Insulin-like growth factor binding protein-1 inhibits arterial smooth muscle cell proliferation in vitro but does not reduce the neointimal response to balloon catheter injury. Atherosclerosis. 118:1995;57-66.
32. Murphy L.J., Rajkumar K., Molnar P. Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice. Prog. Growth Factor Res. 6:1995;425-432.
33. Pampusch M.S., Kamanga-Sollo E., White M.E., Hathaway M.R., Dayton W.R. Effect of recombinant porcine IGF-binding protein-3 on proliferation of embryonic porcine myogenic cell cultures in the presence and absence of IGF-I. J. Endocrinol. 176:2003;227-235.
34. Ram P.A., Waxman D.J. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J. Biol. Chem. 274:1999;35553-35561.
35. Rosenthal S.M. IGFs and skeletal muscle. Rosenfeld R.G., Roberts C.T. Jr. In The IGF System. 1999;497-516 Humana Press, Totowa, NJ.
36. Schneider M.R., Lahm H., Wu M., Hoeflich A., Wolf E. Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins. FASEB J. 14:2000;629-640.
37. Sharp G.L., Hill W.G., Robertson A. Effects of selection on growth, body composition and food intake in mice. I. Responses in selected traits. Genet. Res. 43:1984;75-92.
38. Sjogren K., Liu J.L., Blad K., Skrtic S., Vidal O., Wallenius V., LeRoith D., Tornell J., Isaksson O.G., Jansson J.O., Ohlsson C. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc. Natl. Acad. Sci. USA. 96:1999;7088-7092.
39. Szabo G., Dallmann G., Muller G., Patthy L., Soller M., Varga L. A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice. Mamm. Genome. 9:1998;671-672.
40. Varga L., Szabo G., Darvasi A., Muller G., Sass M., Soller M. Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice. Genetics. 147:1997;755-764.
41. von Butler I., Willeke H., Pirchner F. Two-way within-family and mass selection for 8-week body weight in different mouse populations. Genet. Res. 43:1984;191-200.
42. Wang J., Niu W., Witte D.P., Chernausek S.D., Nikiforov Y.E., Clemens T.L., Sharifi B., Strauch A.R., Fagin J.A. Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139:1998;2605-2614.
43. Weniger J.H., Horst P., Steinhauf D., Major F., Wolf M., Tawfik E.S. Model experiments on selection for endurance and its relation to growth. Part I. Introduction, methods, and preliminary investigations on the basic population (G). J. Anim. Breed. Genet. 91:1974;265-270.
44. Wolf E., Kramer R., Blum W.F., Foll J., Brem G. Consequences of postnatally elevated insulin-like growth factor- II in transgenic mice: endocrine changes and effects on body and organ growth. Endocrinology. 135:1994;1877-1886.
45. Yakar S., Liu J.L., Stannard B., Butler A., Accili D., Sauer B., LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc. Natl. Acad. Sci. USA. 96:1999;7324-7329.
46. Yakar S., Rosen C.J., Beamer W.G., Ackert-Bicknell C.L., Wu Y., Liu J.L., Ooi G.T., Setser J., Frystyk J., Boisclair Y.R., LeRoith D. Circulating levels of IGF-1 directly regulate bone growth and density. J. Clin. Invest. 110:2002;771-781.
47. Zaina S., Pettersson L., Thomsen A.B., Chai C.M., Qi Z., Thyberg J., Nilsson J. Shortened life span, bradycardia, and hypotension in mice with targeted expression of an igf2 transgene in smooth muscle cells. Endocrinology. 144:2003;2695-2703.