Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

Molecular Microbiology

Volumn 83, Issue 6, 2012, Pages 1195-1209

  Bottai, Daria ^a   di Luca, Mariagrazia ^a   Majlessi, Laleh ^b,c   Frigui, Wafa ^b   Simeone, Roxane ^b   Sayes, Fadel ^b,c   Bitter, Wilbert ^d   Brennan, Michael J ^e   Leclerc, Claude ^b,c   Batoni, Giovanna ^a   Campa, Mario ^a   Brosch, Roland ^b   Esin, Semih ^a  

^a UNIVERSITY OF PISA   (Italy)

^b INSTITUT PASTEUR   (France)

^c INSERM   (France)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e AERAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; BACITRACIN; DETERGENT; ETHAMBUTOL; ISONIAZID; NORFLOXACIN; OFLOXACIN; PROLYLPROLYLGLUTAMIC ACID; RIFAMPICIN; TRIPEPTIDE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DELETION MUTANT; DRUG EFFECT; GENE INACTIVATION; GENE LOCUS; GENE STRUCTURE; HYDROPHILICITY; MACROPHAGE ACTIVATION; MICROBIAL ATTENUATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TRANSPORT; SCID MOUSE; TYPE V SECRETION SYSTEM;

AMINO ACID MOTIFS; ANIMALS; BACTERIAL PROTEINS; BACTERIAL SECRETION SYSTEMS; CELL WALL; CELLS, CULTURED; HUMANS; MACROPHAGES; MICE; MICE, SCID; MYCOBACTERIUM TUBERCULOSIS; PROTEIN TRANSPORT; TUBERCULOSIS; VIRULENCE;

MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 84858276262     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2012.08001.x     Document Type: Article

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