Robotic gait rehabilitation and substitution devices in neurological disorders: where are we now?

Neurological Sciences

Volumn 37, Issue 4, 2016, Pages 503-514

  Calabrò, Rocco Salvatore ^a   Cacciola, Alberto ^a,b   Bertè, Francesco ^a   Manuli, Alfredo ^a   Leo, Antonino ^a   Bramanti, Alessia ^a   Naro, Antonino ^a   Milardi, Demetrio ^a,b   Bramanti, Placido ^a  

^a IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Lokomat; Robotic rehabilitation; Severe acquired brain injury; Spinal cord injury; Stroke

Indexed keywords

ABDUCTION; ACQUIRED BRAIN INJURY; ADDUCTION; ANKLE; CEREBRAL PALSY; DIRECT CURRENT; GAIT; GAIT DISORDER; GAIT ORTHOSIS; HUMAN; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEUROREHABILITATION; PARKINSON DISEASE; PHYSIOTHERAPY; REVIEW; ROBOTIC EXOSKELETON; SPINAL CORD INJURY; VIRTUAL REALITY; BRAIN INJURIES; DEVICES; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); ROBOTICS; SPINAL CORD INJURIES;

BRAIN INJURIES; GAIT; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; ROBOTICS; SPINAL CORD INJURIES;

EID: 84954552392     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-016-2474-4     Document Type: Review

References (101)

1. Xie Ming (2004) Fundamentals of robotics: linking perception to action. Singapore-MIT Alliance & Nanyang Technological University, Singapore
2. Van Peppen RP, Kwakkel G, Wood-Dauphinee S, Hendriks HJ, Van der Wees PJ, Dekker J (2004) The impact of physical therapy on functional outcomes after stroke: what’s the evidence? Clin Rehabil 18(8):833–862
3. Cramer SC, Riley JD (2008) Neuroplasticity and brain repair after stroke. Curr Opin Neurol 21(1):76–82
4. French B, Thomas LH, Leathley MJ, Sutton CJ, McAdam J, Forster A, Langhorne P,Price CI, Walker A, Watkins CL (2007) Repetitive task training for improving functional ability after stroke. Cochrane Database Syst Rev 4:CD006073
5. Kraus JF, McArthur DL (1996) Epidemiologic aspects of brain injury. Neurol Clin 14(2):435–450
6. Kolominsky-Rabas PL, Heuschmann PU (2002) Incidence, etiology and long-term prognosis of stroke. Fortschr Neurol Psychiatr 70:657–662
7. Dobkin BH (2005) Clinical practice. Rehabilitation after stroke. N Engl J Med 352:1677–1684
8. Colombo G, Joer M, Schreier R, Dietz V (2000) Treadmill training of paraplegic patients using a robotic orthosis. J Rehabil Res Dev 37:693–700
9. Lotze M, Braun C, Birbaumer N, Anders S, Cohen LG (2003) Motor learning elicited by voluntary drive. Brain 126(Pt 4):866–872
10. Nudo RJ (2003) Functional and structural plasticity in motor cortex: implications for stroke recovery. Phys Med Rehabil Clin N Am 14(1 Suppl):S57–S76
11. Masiero S, Poli P, Rosati G, Zanotto D, Iosa M, Paolucci S, Morone G (2014) The value of robotic systems in stroke rehabilitation. Expert Rev Med Devices 11(2):187–198
12. Hesse S, Bertelt C, Schaffrin A, Malezic A, Mauritz KH (1994) Restoration of gait in nonambulatory hemiparetic patients by treadmill training with partial body-weight support. Arch Phys Med Rehabil 75(10):1087–1093
13. Nilsson L, Carlsson J, Danielsson A, Fugl-Meyer A, Hellström K, Kristensen L, Sjölund B, Sunnerhagen KS, Grimby G (2001) Walking training of patients with hemiparesis at an early stage after stroke: a comparison of walking training on a treadmill with body weight support and walking training on the ground. Clin Rehabil 15(5):515–527
14. Iosa M, Morone G, Fusco A, Bragoni M, Coiro P, Multari M, Venturiero V, De Angelis D, Pratesi L, Paolucci S (2012) Seven capital devices for the future of stroke rehabilitation. Stroke Res Treat 2012:187965
15. Mehrholz J, Pohl M (2012) Electromechanical-assisted gait training after stroke: a systematic review comparing end-effector and exoscelton devices. J Rehabil Med 44:193–199
16. Da Cunha-Filho TI, Lim PA, Qureshy H, Henson H, Monga T, Protas EJ (2002) Gait outcomes after acute stroke rehabilitation with supported treadmill ambulation training: a randomized controlled pilot study. Arch Phys Med Rehabil 83:1258–1265
17. Mulroy SJ, Klassen T, Gronley JK, Eberly VJ, Brown DA, Sullivan KJ (2010) Gait parameters associated with responsiveness to treadmill training with body-weight support after stroke: an exploratory study. Phys Ther 90(2):209–223
18. Calabrò RS, De Cola MC, Leo A, Reitano S, Balletta T, Trombetta G, Naro A, Russo M, Bertè F, De Luca R, Bramanti P (2015) Robotic neurorehabilitation in patients with chronic stroke: psychological well-being beyond motor improvement. Int J Rehabil Res 38(3):219–225
19. Hidler J, Wisman W, Neckel N (2008) Kinematic trajectories while walking within the Lokomat robotic gait-orthosis. Clin Biomechanics 23(10):1251–1259
20. Jezernik S, Colombo G, Keller T, Frueh H, Morari M (2003) Robotic orthosis lokomat: a rehabilitation and research tool. Neuromodulation 6(2):108–115
21. Veneman J, Menger J, van Asseldonk E, van der Helm F, van der Kooij H (2008) Fixating the pelvis in the horizontal plane affects gait characteristics. Gait Posture 28:157–163
22. Hidler JM, Wall AE (2005) Alterations in muscle activation patterns during robotic-assisted walking. Clin Biomech (Bristol, Avon) 20(2):184–193
23. Veneman JF, Kruidhof R, Hekman EEG, Ekkelenkamp R, Van Asseldonk EH, van der Kooij H (2007) Design and evaluation of the Lopes exoskeleton robot for interactive gait rehabilitation. IEEE Trans Neural Syst Rehabil Eng 15(3):379–386
24. Hesse S, Uhlenbrock D (2000) A mechanized gait trainer for restoration of gait. J Rehabil Res Dev 37(6):701–708
25. Freivogel S, Mehrholz J, Husak-Sotomayor T, Schmalohr D (2008) Gait training with the newly developed ‘LokoHelp’-system is feasible for non-ambulatory patients after stroke, spinal cord and brain injury. A feasibility study. Brain Inj 22:625–632
26. Wall A, Borg J, Palmcrantz S (2015) Clinical application of the hybrid assistive limb (HAL) for gait training—a systematic review. Front Syst Neurosci. 25(9):48
27. Hussain S, Xie SQ, Jamwal PK, Parsons J (2012) An intrinsically compliant robotic orthosis for treadmill training. Med Eng Phys 34:1448–1453
28. Stegall P, Winfree K, Zanotto D, Agrawal SK (2013) Rehabilitation exoskeleton design: exploring the effect of the anterior lunge degree of freedom. IEEE T Robot 29(4):838–846
29. Duschau-Wicke A, Caprez A, Riener R (2010) Patient-cooperative control increases active participation of individuals with SCI during robot-aided gait training. J Neuroeng Rehabil 7(1)
30. Morone G, Iosa M, Bragoni M, De Angelis D, Venturiero V, Coiro P, Riso R, Pratesi L, Paolucci S (2012) Who may have durable benefit from robotic gait training?: a 2-year follow-up randomized controlled trial in patients with subacute stroke. Stroke 43(4):1140–1142
31. van Nunen MP, Gerrits KH, Konijnenbelt M, Janssen TW, de Haan A (2015) Recovery of walking ability using a robotic device in subacute stroke patients: a randomized controlled study. Disabil Rehabil Assist Technol 10(2):141–148
32. Hidler JM, Carroll M, Federovich EH (2007) Strength and coordination in the paretic leg of individuals following acute stroke. IEEE Trans Neural Syst Rehabil Eng 15(4):526–534
33. Husemann B, Müller F, Krewer C, Heller S, Koenig E (2007) Effects of locomotion training with assistance of a driven gait orthosis in hemiparetic patients after stroke. Stroke 38(2):349–354
34. Swinnen E, Beckwée D, Meeusen R, Baeyens JP, Kerckhofs E (2014) Does robot-assisted gait rehabilitation improve balance in stroke patients? A systematic review. Top Stroke Rehabil 21(2):87–100
35. Mehrholz J, Pohl M, Elsner B (2014) Treadmill training and body weight support for walking after stroke. Cochrane Database Syst Rev 1:CD002840
36. Uçar DE, Paker N, Buğdaycı D (2014) Lokomat: a therapeutic chance for patients with chronic hemiplegia. NeuroRehabilitation 34:447–453
37. Calabrò RS, Reitano S, Leo A, De Luca R, Melegari C, Bramanti P (2014) Can robot-assisted movement training (Lokomat) improve functional recovery and psychological well-being in chronic stroke? Promising findings from a case study. Funct Neurol 29(2):139–141
38. Hidler J, Nichols D, Pelliccio M, Brady K, Campbell DD, Kahn JH, Hornby TG (2009) Multicenter randomized clinical trial evaluating the effectiveness of the Lokomat in subacute stroke. Neurorehabil Neural Repair 23(1):5–13
39. Hornby TG, Campbell DD, Kahn JH, Demott T, Moore JL, Roth HR (2008) Enhanced gait-related improvements after therapist- versus robotic-assisted locomotor training in subjects with chronic stroke: a randomized controlled study. Stroke 39(6):1786–1792
40. Kelley CP, Childress J, Boake C, Noser EA (2013) Over-ground and robotic-assisted locomotor training in adults with chronic stroke: a blinded randomized clinical trial. Disabil Rehabil Assist Technol 8(2):161–168
41. Moreh E, Meiner Z, Neeb M, Hiller N, Schwartz I (2009) Spinal decompression sickness presenting as partial Brown-Sequard syndrome and treated with robotic-assisted body-weight support treadmill training. J Rehabil Med 41(1):88–89
42. Ustinova K, Chernikova L, Bilimenko A, Telenkov A, Epstein N (2011) Effect of robotic locomotor training in an individual with Parkinson’s disease: a case report. Disabil Rehabil Assist Technol 6(1):77–85
43. Calabrò RS, De Luca R, Leo A, Balletta T, Marra A, Bramanti P (2015) Lokomat training in vascular dementia: motor improvement and beyond! Aging Clin Exp Res. doi:10.1007/40520-015-0343-2
44. Borggraefe I, Schaefer JS, Klaiber M, Dabrowski E, Ammann-Reiffer C, Knecht B, Berweck S, Heinen F, Meyer-Heim A (2010) Robotic-assisted treadmill therapy improves walking and standing performance in children and adolescents with cerebral palsy. Eur J Paediatr Neurol 14(6):496–502
45. Lo AC, Chang VC, Gianfrancesco MA, Friedman JH, Patterson TS, Benedicto DF (2010) Reduction of freezing of gait in Parkinson’s disease by repetitive robot-assisted treadmill training: a pilot study. J Neuroeng Rehabil 7:51
46. Carda S, Invernizzi M, Baricich A, Comi C, Croquelois A, Cisari C (2012) Robotic gait training is not superior to conventional treadmill training in parkinson disease: a single-blind randomized controlled trial. Neurorehabil Neural Repair 26(9):1027–1034
47. Nardo A, Anasetti F, Servello D, Porta M (2014) Quantitative gait analysis in patients with Parkinson treated with deep brain stimulation: the effects of a robotic gait training. Neuro Rehabil 35(4):779–788
48. Schwartz I, Sajin A, Moreh E, Fisher I, Neeb M, Forest A, Vaknin-Dembinsky A, Karusis D, Meiner Z (2012) Robot-assisted gait training in multiple sclerosis patients: a randomized trial. Mult Scler 18(6):881–890
49. Straudi S, Benedetti MG, Venturini E, Manca M, Foti C, Basaglia N (2013) Does robot-assisted gait training ameliorate gait abnormalities in multiple sclerosis? A pilot randomized-control trial. Neuro Rehabil 33:555–563
50. Gandolfi M, Geroin C, Picelli A, Munari D, Waldner A, Tamburin S, Marchioretto F, Smania N (2008) Robot-assisted vs. sensory integration training in treating gait and balance dysfunctions in patients with multiple sclerosis: a randomized controlled trial. Front Hum Neurosci 8:318
51. Lo AC, Triche EW (2008) Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil Neural Repair 22:661–671
52. Vaney C, Gattlen B, Lugon-Moulin V, Meichtry A, Hausammann R, Foinant D, Anchisi-Bellwald AM, Palaci C, Hilfiker R (2012) Robotic-assisted step training (lokomat) not superior to equal intensity of overground rehabilitation in patients with multiple sclerosis. Neurorehabil Neural Repair 26:212–221
53. Domingo A, Lam T (2014) Reliability and validity of using the Lokomat to assess lower limb joint position sense in people with incomplete spinal cord injury. J Neuroeng Rehabil 11:167
54. Van Kammen K, Boonstra A, Reinders-Messelink H, den Otter R (2014) The combined effects of body weight support and gait speed on gait related muscle activity: a comparison between walking in the Lokomat exoskeleton and regular treadmill walking. PLoS ONE 9(9):e107323
55. Krewer C, Müller F, Husemann B, Heller S, Quintern J, Koenig E (2007) The influence of different Lokomat walking conditions on the energy expenditure of hemiparetic patients and healthy subjects. Gait Posture 26(3):372–377
56. Lewek MD, Cruz TH, Moore JL, Roth HR, Dhaher YY, Hornby TG (2009) Allowing intralimb kinematic variability during locomotor training poststroke improves kinematic consistency: a subgroup analysis from a randomized clinical trial. Phys Ther 89(8):829–839
57. Mat Dzahir MA, Yamamoto SI (2014) Recent Trends in Lower-Limb Robotic Rehabilitation Orthosis: control Scheme and Strategy for Pneumatic Muscle Actuated Gait Trainers. Robotics 3:120–148
58. Fisher S (2008) Use of autoambulator for mobility improvement in patients with central nervous system (CNS) injury or disease. Neurorehabil Neural Repair 22:556
59. Fisher S, Lucas L, Thrasher TA (2011) Robot-assisted gait training for patients with hemiparesis due to stroke. Top Stroke Rehabil 18(3):269–276
60. Mantone J (2006) Getting a leg up? Rehab patients get an assist from devices such as HealthSouth’s AutoAmbulator, but the robots’ clinical benefits are still in doubt. Mod Healthc 36(7):58–60
61. https://www.utwente.nl/ctw/bw/research/projects/MINDWALKER. Accessed 4 January 2016
62. https://www.symbitron.eu/. Accessed 4 January 2016
63. Tufekciler N, van Asseldonk EH, van der Kooij H (2011) Velocity-dependent reference trajectory generation for the LOPES gait training robot. IEEE Int Conf Rehabil Robot 2011:5975414
64. Koopman B, van Asseldonk EH, van der Kooij H (2013) Selective control of gait subtasks in robotic gait training: foot clearance support in stroke survivors with a powered exoskeleton. J Neuroeng Rehabil 10:3
65. Fleerkotte BM, Koopman B, Buurke JH, van Asseldonk EH, van der Kooij H, Rietman JS (2014) The effect of impedance-controlled robotic gait training on walking ability and quality in individuals with chronic incomplete spinal cord injury: an explorative study. J Neuroeng Rehabil 11:26
66. Khanna I, Roy A, Rodgers MM, Krebs HI, Macko RM, Forrester LW (2010) Effects of unilateral robotic limb loading on gait characteristics in subjects with chronic stroke. J Neuroeng Rehabil 7:23
67. Agrawal SK, Banala SK, Fattah A, Sangwan V, Krishnamoorthy V, Scholz JP, Hsu WL (2007) Assessment of motion of a swing leg and gait rehabilitation with a gravity balancing exoskeleton. IEEE Trans Neural Syst Rehabil Eng 15(3):410–20
68. Banala SK, Agrawal SK, Kim SH, Scholz JP (2010) Novel gait adaptation and neuromotor training results using an active leg exoskeleton. IEEE/ASME Trans Mechatron 15(2):216–225
69. Banala SK, Kim SH, Agrawal SK, Scholz JP (2009) Robot assisted gait training with active leg exoskeleton (ALEX). IEEE Trans Neural Syst Rehabil Eng 17(1):2–8
70. Hussain S (2014) State-of-the-art robotic gait rehabilitation orthoses: design and control aspects. Neuro Rehabil 35:701–709
71. Hesse S, Sarkodie-Gyan T, Uhlenbrock D (1999) Development of an advanced mechanized gait trainer, controlling the movement of the center of mass, for restoring gait in non-ambulant subjects. Biomed Tech 44:194–201
72. Dias D, Laíns J, Pereira A, Nunes R, Caldas J, Amaral C, Pires S, Costa A, Alves P, Moreira M, Garrido N, Loureiro L (2007) Can we improve gait skills in chronic hemiplegics? A randomised control trial with gait trainer. Eura Medicophys 43(4):499–504
73. Peurala SH, Tarkka IM, Pitkänen K, Sivenius J (2005) The effectiveness of body weight-supported gait training and floor walking in patients with chronic stroke. Arch Phys Med Rehabil 86(8):1557–1564
74. Hesse S, Werner C, Uhlenbrock D, von Frankenberg S, Bardeleben A, Brandl-Hesse B (2001) An electromechanical gait trainer for restoration of gait in hemiparetic stroke patients: preliminary results. Neurorehabil Neural Repair 15(1):39–50
75. Hesse S, Werner C, Bardeleben A (2004) Electromechanical gait training with functional electrical stimulation: case studies in spinal cord injury. Spinal Cord 42(6):346–352
76. Manella KJ, Torres J, Field-Fote EC (2010) Restoration of walking function in an individual with chronic complete (AIS A) spinal cord injury. J Rehabil Med 42(8):795–798
77. Iosa M, Morone G, Bragoni M, De Angelis D, Venturiero V, Coiro P, Pratesi L, Paolucc S (2011) Driving electromechanically assisted Gait Trainer for people with stroke. J Rehabil Res Dev 48(2):135–146
78. Paleg G, Livingstone R (2015) Outcomes of gait trainer use in home and school settings for children with motor impairments: a systematic review. Clin Rehabil. doi:10.1177/0269215514565947
79. Picelli A, Melotti C, Origano F, Neri R, Waldner A, Smania N (2013) Robot-assisted gait training versus equal intensity treadmill training in patients with mild to moderate Parkinson’s disease: a randomized controlled trial. Parkinsonism Relat Disor 19(6):605–610
80. Picelli A, Melotti C, Origano F, Waldner A, Fiaschi A, Santilli V, Smania N (2012) Robot-assisted gait training in patients with Parkinson disease: a randomized controlled trial. Neurorehabil Neural Repair 26(4):353–361
81. Picelli A, Melotti C, Origano F, Waldner A, Gimigliano R, Smania N (2012) Does robotic gait training improve balance in Parkinson’s disease? A randomized controlled trial. Parkinsonism Relat Disord 18(8):990–993
82. Hesse S, Waldner A, Tomelleri C (2010) Innovative gait robot for the repetitive practice of floor walking and stair climbing up and down in stroke patients. J Neuroeng Rehabil 7:30
83. Stoller O, Schindelholz M, Bichsel L, Hunt KJ (2014) Cardiopulmonary responses to robotic end-effector-based walking and stair climbing. Med Eng Phys 36(4):425–431
84. Sale P, Franceschini M, Waldner A, Hesse S (2012) Use of the robot assisted gait therapy in rehabilitation of patients with stroke and spinal cord injury. Eur J Phys Rehabil Med 48(1):111–121
85. Fineberg DB, Asselin P, Harel NY, Agranova-Breyter I, Kornfeld SD, Bauman WA, Spungen AM (2013) Vertical ground reaction force-based analysis of powered exoskeleton-assisted walking in persons with motor-complete paraplegia. J Spinal Cord Med 36(4):313–321
86. Esquenazi A, Talaty M, Packel A, Saulino M (2012) The ReWalk powered exoskeleton to restore ambulatory function to individuals with thoracic-level motor-complete spinal cord injury. Am J Phys Med Rehabil 91(11):911–921
87. Nooijen CF, Ter Hoeve N, Field-Fote EC (2009) Gait quality is improved by locomotor training in individuals with SCI regardless of training approach. J Neuroeng Rehabi 6(6):36
88. ClinicalTrials.gov [Internet]. Bethesda, MD: National Library of Medicine (US); 2000. Available from: http://clinicaltrials.gov/. Accessed 4 January 2016
89. ® exoskeleton training improves walking parameters and normalizes cortical excitability in primary somatosensory cortex in spinal cord injury patients. J Neuroeng Rehabil 12:68
90. Weiss PL, Tirosh E, Fehlings D (2014) Role of virtual reality for cerebral palsy management. J Child Neurol 29(8):1119–1124
91. Imam B, Jarus T (2014) Virtual reality rehabilitation from social cognitive and motor learning theoretical perspectives in stroke population. Rehab Res Pract 2014:594
92. Gamito P, Oliveira J, Coelho C, Morais D, Lopes P, Pacheco J, Brito R, Soares F, Santos N, Barata AF (2015) Cognitive training on stroke patients via virtual reality-based serious games. Disabil Rehabil 5:1–4
93. Laver KE, George S, Thomas S, Deutsch JE, Crotty M (2015) Virtual reality for stroke rehabilitation. Cochrane Database Syst Rev 12:2
94. Mirelman A, Patritti BL, Bonato P, Deutsch JE (2010) Effects of virtual reality training on gait biomechanics of individuals post-stroke. Gait Posture. 31(4):433–437
95. Putrino D (2014) Telerehabilitation and emerging virtual reality approaches to stroke rehabilitation. Curr Opin Neurol 27(6):631–636
96. Isaacson BM, Swanson TM, Pasquina PF (2013) The use of a computer-assisted rehabilitation environment (CAREN) for enhancing wounded warrior rehabilitation regimens. J Spinal Cord Med 36:296–299
97. Hak L, Houdijk H, van der Wurff P, Prins MR, Beek PJ, van Dieën JH (2015) Stride frequency and length adjustment in post-stroke individuals: influence on the margins of stability. J Rehabil Med 47:126–132
98. Sessoms PH, Gottshall KR, Collins JD, Markham AE, Service KA, Reini SA (2015) Improvements in gait speed and weight shift of persons with traumatic brain injury and vestibular dysfunction using a virtual reality computer-assisted rehabilitation environment. Mil Med 180:143–149
99. Villamar MF, Santos Portilla A, Fregni F, Zafonte R (2012) Noninvasive brain stimulation to modulate neuroplasticity in traumatic brain injury. Neuromodulation 15(4):326–338
100. Picelli A, Chemello E, Castellazzi P, Roncari L, Waldner A, Saltuari L, Smania N (2015) Combined effects of transcranial direct current stimulation (tDCS) and transcutaneous spinal direct current stimulation (tsDCS) on robot-assisted gait training in patients with chronic stroke: a pilot, double blind, randomized controlled trial. Restor Neurol Neurosci 33(3):357–368
101. Danzl MM, Chelette KC, Lee K, Lykins D, Sawaki L (2013) Brain stimulation paired with novel locomotor training with robotic gait orthosis in chronic stroke: a feasibility study. NeuroRehabilitation 33(1):67–76