Does robot-assisted gait training ameliorate gait abnormalities in multiple sclerosis? A pilot randomized-control trial

NeuroRehabilitation

Volumn 33, Issue 4, 2013, Pages 555-563

  Straudi, S ^a,b   Benedetti, M G ^c   Venturini, E ^a   Manca, M ^a   Foti, C ^b   Basaglia, N ^a  

^a UNIVERSITY HOSPITAL OF FERRARA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

gait analysis; multiple sclerosis; Rehabilitation; robot driven gait orthosis

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDURANCE; EXERCISE TEST; EXPANDED DISABILITY STATUS SCALE; FEMALE; GAIT; GAIT DISORDER; HIP EXTENSION; HUMAN; KINEMATICS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MUSCULOSKELETAL FUNCTION; OUTCOME ASSESSMENT; PELVIC ANTIVERSION; PHYSICAL MOBILITY; PHYSIOTHERAPY; PILOT STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; ROBOTICS; SPATIOTEMPORAL ANALYSIS; STRETCHING EXERCISE; WALKING;

GAIT ANALYSIS; MULTIPLE SCLEROSIS; REHABILITATION; ROBOT-DRIVEN GAIT ORTHOSIS;

ADULT; AGED; BIOMECHANICAL PHENOMENA; DISABILITY EVALUATION; EXERCISE TEST; EXERCISE THERAPY; FEMALE; FOLLOW-UP STUDIES; GAIT; GAIT DISORDERS, NEUROLOGIC; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PHYSICAL THERAPY MODALITIES; PILOT PROJECTS; ROBOTICS; TREATMENT OUTCOME; WALKING;

EID: 84892745127     PISSN: 10538135     EISSN: 18786448     Source Type: Journal    
DOI: 10.3233/NRE-130990     Document Type: Article

References (41)

1. Beer, S., Aschbacher, B., Manoglou, D., Gamper, E., Kool, J., & Kesselring, J. (2008). Robot-assisted gait training in multiple sclerosis: A pilot randomized trial. Mult Scler, 1(2), 231-236.
2. Benedetti, M. G., Catani, F., Leardini, A., Pignotti, E., & Giannini, S. (1998). Data Management in gait analysis for clinical applications. Clinical Biomechanics, 13, 204-215.
3. Benedetti, M. G., Piperno, R., Simoncini, L., Bonato, P., Tonini, A., & Giannini, S. (1999). Gait abnormalities in minimally impaired multiple sclerosis patients. Mult Scler, 5(5), 363-368.
4. Benedetti, M. G., Gasparroni, V., Stecchi, S., Zilioli, R., Straudi, S., & Piperno, R. (2009). Treadmill exercise in early mutiple sclerosis: A case series study. Eur J Phys Rehabil Med, 45(1), 53-59.
5. Bosma, L., Kragt, J. J., Polman, C. H., & Uitdehaag, B. M. (2013). Walking speed, rather than Expanded Disability Status Scale, relates to long-term patient-reported impact in progressive MS. Mult Scler, 19(3), 326-333.
6. Bruck, W. (2005). The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. J Neurol, 252(suppl 5), v3-v9.
7. Cattaneo, D., De Nuzzo, C., Fascia, T., Macalli, M., Pisoni, I., & Cardini, R.(2002). Risk of falls insubjects with multiple sclerosis. Arch Phys Med Rehabil, 83, 864-867.
8. Colombo, G., Joerg, M., Schreier, R., & Dietz, V. (2000). Treadmill training of paraplegic patients with a robotic orthosis. J Reha bil Res Dev, 37, 693-700.
9. Colombo, G., Wirz, M., & Dietz, V. (2001). Driven gait orthosis for improvement of locomotor training in paraplegic patients. Spinal Cord, 39, 252-255.
10. Confavreux, C., Vukusic, S., Moreau, T., & Adeleine, P. (2000). Relapses and progression of disability in multiple sclerosis. N Eng J Med, 343, 1430-1438.
11. Crenshaw, S. J., Royer, T. D., Richards, J. G., & Hudson, D. J. (2006). Gait variability in people with multiple sclerosis. Mult Scler, 12(5), 613-619.
12. Franz, J. R., Paylo, K. W., Dicharry, J., Riley, P. O., & Kerrigan, D. C. (2009). Changes in the coordination of hip and pelvis kinematics with mode of locomotion. Gait Posture, 29(3), 494-498.
13. Freal, J.E., Kraft, G.H., & Coryell, J.K. (1984). Symptomatic fatigue in multiple sclerosis. Arch Phys Med Rehabil, 65, 135-138.
14. Gardner, M. B., Holden, M. K., Leikauskas, J. M., & Richard, R. L. (1998). Partial body weight support with treadmill locomotion to improve gait after incomplete spinal cord injury: A single-subject experimental design. Phys Ther, 78, 361-374.
15. Giesser, B., Beres-Jones, J., Budovitch, A., Herlihy, E., & Harkema, S. (2007). Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: A pilot study. Mult Scler, 13(2), 224-231.
16. Givon, U., Zeilig, G., & Achiron, A. (2009). Gait analysis in multiple sclerosis: Characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait Posture, 29(1), 138-142.
17. Goldman, M. D., Marrie, R. A., & Cohen, J. A. (2008). Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls. Mult Scler, 14(3), 383-9014.
18. Gutierrez, G. M., Chow, J. W., Tillman, M. D., McCoy, S. C, Castel-lano, V., & White, L. J. (2005). Resistance training improves gait kinematics in persons with multiple sclerosis. Arch Phys Med Rehabil, 86, 1824-1829.
19. Hesse, S., Konrad, M., & Uhlenbrock, D. (1999). Treadmill walking with partial body weight support versus floor walking in hemiparetic subjcts. Arch Phys Med Rehabil, 80, 421-427.
20. Hidler, J., Wisman, W., & Neckel, N. (2008). Kinematic trajectories while walking within the Lokomat robotic gait-orthosis. Clin Biomech (Bristol, Avon), 23(10), 1251-1259.
21. Kelleher, K. J., Spence, W., Solomonidis, S., & Apatsidis, D. (2010). The characterisation of gait patterns of people with multiple sclerosis. Disabil Rehabil, 32(15), 1242-1250.
22. Kerrigan, D. C, Lee, L. W., Collins, J. J., Riley, P. O, & Lipsiz, L. A. (2001). Reduced Hip Extension During Walking: Healthy Elderly andFallers Versus Young Adults. Arch Phys Med Rehabil, 82(1), 26-30.
23. Kleim, J. A., Barbay, S., & Nudo, R. J. (1998). Functional reorganization of the rat motor cortex following motor skill learning. J Neurophysiol, 80(6), 3321-3325.
24. Krupp, L. B., Alvarez, L. A., LaRocca, N. G., & Scheinberg, L. C. (1988). Fatigue in multiple sclerosis. Arch Neurol, 45, 435-437.
25. Krupp, L. B., LaRocca, N. G., Muir-Nash, J., & Steinberg, A. D. (1989). The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol, 46, 1121-1123.
26. Kurtze, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33, 1444-1452.
27. Lo, A. C, & Triche, E. W (2008). Improving gaitin multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil Neural Repair, 22(6), 661-671.
28. Lord, S. E., Wade, D. T, & Halligan, P. W (1998). A comparison of two physiotherapy treatment approaches to improve walking in multiple sclerosis: A pilot randomized controlled study. Clin Rehabil, 12, 477-486.
29. Matsuda, P. N., Shumway-Cook, A., Bamer, A. M., Johnson, S. L., Amtmann, D., & Kraft, G. H. (2011). Falls in multiple sclerosis. PMR, 3, 624-632.
30. Newman, M. A., Dawes, H., Van den Berg, M., Wade, D. T, Burridge, J., & Izadi, H. (2007). Can aerobic treadmill training reduce the effort of walking and fatigue in people with multiple sclerosis: A pilot study. Mult Scler, 13(1), 113-119.
31. Nudo, R. J., Milliken, G. W, Jenkins, W M., & Merzenich, M. M. (1996). Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J Neurosci, 16(2), 785-807.
32. Perera, S., Mody, S. H., Woodman, R. C., & Studenski, S. A. (2006). Meaningful Change and Responsiveness in Common Physical Performance Measures in Older Adults. J Am Geriatr Soc, 54(5), 743-749.
33. Podsiadlo, D., & Richardson, S. (1991). The Time "Up & Go": A Test of Basic Functional Mobility for Frail Elderly Persons. Journal of the American Geriatrics Society, 39(2), 142-148.
34. Reinkensmeyer, D. J., Emken, J. L., & Cramer, S. C. (2004). Robotic, motor learning, and neurologic recovery. Annu Rev Biomed Eng, 6, 497-525.
35. Remelius, J. G., Jones, S. L., House, J. D., Busa, M. A., Averill, J. L., Sugumaran, K., Kent-Braun, J. A., & Van Emmerik, R. E. (2012). Gait Impairments in Persons With Multiple Sclerosis Across Preferred and Fixed Walking Speeds. Arch Phys Med Rehabil, 93(9), 1637-1642.
36. Schwartz, I., Sajin, A., Moreh, E., Fisher, I., Neeb, M., Forest, A., Vaknin-Dembinsky, A., Karusis, D., & Meiner, Z. (2012). Robot-assisted gait training in multiple sclerosis patients: A randomized trial. Mult Scler, 18(6), 881-890.
37. Schwid, S. R., Goodman, A. D., McDermott, M. P., Bever, C. F., & Cook, S.D. (2002). Quantitative functional measures in MS: what is a reliable change? Neurology, 58, 1294-1296.
38. Solari, A., Filippini, G., Gasco, P., Colla, L., Salmaggi, A., & La Mantia, L. (1999). Physical rehabilitation has a positive effect on disability in multiple sclerosis patients. Neurology, 52, 57-62.
39. Van Den Berg, M., Dawes, H., Wade, D. T., Newman, M., Burridge, J., & Izadi, H. (2006). Treadmill training for individuals with multiple sclerosis: A pilot randomized trial. J Neurol Neurosurg Psychiatry, 77, 531-533.
40. Vaney, C., Gattlen, B., Lugon-Moulin, V., Meichtry, A., Hausam-mann, R., Foinant, D., Anchisi-Bellwald, A. M., Palaci, C., & Hilfiker, R. (2012). Robotic-assisted step training (lokomat) not superior to equal intensity of over-ground rehabilitation in patients with multiple sclerosis. Neurorehabil Neural Repair, 26(3), 212-221.
41. Wiles, C. M., Newcombe, R. G., Fuller, K. J., Shaw, S., Furnival-Doran, J., Pickersgill, T. P., & Morgan, A. (2001). Controlled randomised crossover trial of the effects of physiotherapy on mobility in chronic multiple sclerosis. J Neurol Neurosurg Psychiatry, 70(2), 174-179.