-
1
-
-
0016724057
-
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vezina C, et al. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975; 28: 721-726.
-
(1975)
J Antibiot (Tokyo)
, vol.28
, pp. 721-726
-
-
Vezina, C.1
-
2
-
-
0017362502
-
Inhibition of the immune response by rapamycin, a new antifungal antibiotic
-
Martel RR, et al. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can J Physiol Pharmacol 1977; 55: 48-51.
-
(1977)
Can J Physiol Pharmacol
, vol.55
, pp. 48-51
-
-
Martel, R.R.1
-
3
-
-
78650457239
-
Individualizing early use of sirolimus in renal transplantation
-
Rial Mdel C, et al. Individualizing early use of sirolimus in renal transplantation. Transplant Proc 2010; 42: 4518-4525.
-
(2010)
Transplant Proc
, vol.42
, pp. 4518-4525
-
-
Rial Mdel, C.1
-
4
-
-
77950624678
-
Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma
-
Toso C, et al. Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma. Hepatology 2010; 51: 1237-1243.
-
(2010)
Hepatology
, vol.51
, pp. 1237-1243
-
-
Toso, C.1
-
5
-
-
67349247929
-
Nanomedicines in renal transplant rejection-focus on sirolimus
-
Shen LJ, Wu FL,. Nanomedicines in renal transplant rejection-focus on sirolimus. Int J Nanomedicine 2007; 2: 25-32.
-
(2007)
Int J Nanomedicine
, vol.2
, pp. 25-32
-
-
Shen, L.J.1
Wu, F.L.2
-
6
-
-
0034145650
-
Sirolimus: A new agent for prevention of renal allograft rejection
-
quiz 449-451
-
Vasquez EM,. Sirolimus: a new agent for prevention of renal allograft rejection. Am J Health Syst Pharm 2000; 57: 437-448, quiz 449-451.
-
(2000)
Am J Health Syst Pharm
, vol.57
, pp. 437-448
-
-
Vasquez, E.M.1
-
7
-
-
0035253757
-
Solubilization of rapamycin
-
Simamora P, et al. Solubilization of rapamycin. Int J Pharm 2001; 213: 25-29.
-
(2001)
Int J Pharm
, vol.213
, pp. 25-29
-
-
Simamora, P.1
-
8
-
-
79955990118
-
Rapamycin-cyclodextrin complexation: Improved solubility and dissolution rate
-
Rouf MA, et al. Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate. J Incl Phenom Macrocycl Chem 2011; 70: 167-175.
-
(2011)
J Incl Phenom Macrocycl Chem
, vol.70
, pp. 167-175
-
-
Rouf, M.A.1
-
9
-
-
84862631967
-
Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process
-
Kim MS, et al. Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process. Int J Nanomedicine 2011; 6: 2997-3009.
-
(2011)
Int J Nanomedicine
, vol.6
, pp. 2997-3009
-
-
Kim, M.S.1
-
10
-
-
84876858469
-
Optimized formulation of solid self-microemulsifying sirolimus delivery systems
-
Cho W, et al. Optimized formulation of solid self-microemulsifying sirolimus delivery systems. Int J Nanomedicine 2013; 8: 1673-1682.
-
(2013)
Int J Nanomedicine
, vol.8
, pp. 1673-1682
-
-
Cho, W.1
-
11
-
-
18944403564
-
The rise and rise of drug delivery
-
Rosen H, Abribat T,. The rise and rise of drug delivery. Nat Rev Drug Discov 2005; 4: 381-385.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 381-385
-
-
Rosen, H.1
Abribat, T.2
-
12
-
-
2442586646
-
Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts
-
Alemdar AY, et al. Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts. Cell Transplant 2004; 13: 263-271.
-
(2004)
Cell Transplant
, vol.13
, pp. 263-271
-
-
Alemdar, A.Y.1
-
13
-
-
4344656740
-
CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. Tacrolimus vs. Sirolimus
-
Lemahieu WP, et al. CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. Am J Transplant 2004; 4: 1514-1522.
-
(2004)
Am J Transplant
, vol.4
, pp. 1514-1522
-
-
Lemahieu, W.P.1
-
14
-
-
33748433791
-
Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction
-
Anglicheau D, et al. Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction. Kidney Int 2006; 70: 1019-1025.
-
(2006)
Kidney Int
, vol.70
, pp. 1019-1025
-
-
Anglicheau, D.1
-
15
-
-
0345866819
-
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: Studies with sirolimus and midazolam
-
Cummins CL, et al. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther 2004; 308: 143-155.
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 143-155
-
-
Cummins, C.L.1
-
16
-
-
0034953105
-
The human ATP-binding cassette (ABC) transporter superfamily
-
Dean M, et al. The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 2001; 42: 1007-1017.
-
(2001)
J Lipid Res
, vol.42
, pp. 1007-1017
-
-
Dean, M.1
-
17
-
-
0025991860
-
Molecular manipulations of the multidrug transporter: A new role for transgenic mice
-
Pastan I, et al. Molecular manipulations of the multidrug transporter: a new role for transgenic mice. FASEB J 1991; 5: 2523-2528.
-
(1991)
FASEB J
, vol.5
, pp. 2523-2528
-
-
Pastan, I.1
-
18
-
-
0030939088
-
Hepatic canalicular membrane 4: Expression of the multidrug resistance genes in the liver
-
Silverman JA, Schrenk D,. Hepatic canalicular membrane 4: expression of the multidrug resistance genes in the liver. FASEB J 1997; 11: 308-313.
-
(1997)
FASEB J
, vol.11
, pp. 308-313
-
-
Silverman, J.A.1
Schrenk, D.2
-
19
-
-
18744432281
-
HIV-1 protease inhibitors and the MDR1 multidrug transporter
-
Lee CG, Gottesman MM,. HIV-1 protease inhibitors and the MDR1 multidrug transporter. J Clin Invest 1998; 101: 287-288.
-
(1998)
J Clin Invest
, vol.101
, pp. 287-288
-
-
Lee, C.G.1
Gottesman, M.M.2
-
20
-
-
0023447098
-
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
-
Thiebaut F, et al. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A 1987; 84: 7735-7738.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
-
21
-
-
30344487254
-
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
-
Breedveld P, et al. Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs. Trends Pharmacol Sci 2006; 27: 17-24.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 17-24
-
-
Breedveld, P.1
-
22
-
-
84872287149
-
A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: Simulation for next generation of P-gp inhibitors
-
Singh DV, et al. A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors. J Mol Model 2013; 19: 227-238.
-
(2013)
J Mol Model
, vol.19
, pp. 227-238
-
-
Singh, D.V.1
-
23
-
-
84918809628
-
Oral bioavailability and intestinal absorption of candesartan cilexetil: Role of naringin as P-glycoprotein inhibitor
-
Gurunath S, et al. Oral bioavailability and intestinal absorption of candesartan cilexetil: role of naringin as P-glycoprotein inhibitor. Drug Dev Ind Pharm 2015; 41: 170-176.
-
(2015)
Drug Dev Ind Pharm
, vol.41
, pp. 170-176
-
-
Gurunath, S.1
-
24
-
-
59549094629
-
Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats
-
Bansal T, et al. Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats. Eur J Pharm Sci 2009; 36: 580-590.
-
(2009)
Eur J Pharm Sci
, vol.36
, pp. 580-590
-
-
Bansal, T.1
-
25
-
-
0036594745
-
Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata
-
Pyo MK, et al. Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata. Arch Pharm Res 2002; 25: 325-328.
-
(2002)
Arch Pharm Res
, vol.25
, pp. 325-328
-
-
Pyo, M.K.1
-
26
-
-
0037285908
-
Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes
-
Park EJ, et al. Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes. Planta Med 2003; 69: 33-37.
-
(2003)
Planta Med
, vol.69
, pp. 33-37
-
-
Park, E.J.1
-
27
-
-
0032977989
-
Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice
-
Kuribara H, et al. Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice. J Pharm Pharmacol 1999; 51: 97-103.
-
(1999)
J Pharm Pharmacol
, vol.51
, pp. 97-103
-
-
Kuribara, H.1
-
28
-
-
3543134309
-
In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp
-
Park J, et al. In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. Eur J Pharmacol 2004; 496: 189-195.
-
(2004)
Eur J Pharmacol
, vol.496
, pp. 189-195
-
-
Park, J.1
-
29
-
-
33749255173
-
Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol
-
Xu D, et al. Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol. Cancer Lett 2006; 243: 274-280.
-
(2006)
Cancer Lett
, vol.243
, pp. 274-280
-
-
Xu, D.1
-
30
-
-
0026887072
-
Preparation of micelle-forming polymer-drug conjugates
-
Yokoyama M, et al. Preparation of micelle-forming polymer-drug conjugates. Bioconjug Chem 1992; 3: 295-301.
-
(1992)
Bioconjug Chem
, vol.3
, pp. 295-301
-
-
Yokoyama, M.1
-
31
-
-
84865271182
-
Ordered-disordered domain coexistence in ternary lipid monolayers activates sphingomyelinase by clearing ceramide from the active phase
-
Ale EC, et al. Ordered-disordered domain coexistence in ternary lipid monolayers activates sphingomyelinase by clearing ceramide from the active phase. Biochim Biophys Acta 2012; 1818: 2767-2776.
-
(2012)
Biochim Biophys Acta
, vol.1818
, pp. 2767-2776
-
-
Ale, E.C.1
-
32
-
-
74449089561
-
The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel
-
Mu CF, et al. The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel. Biomaterials 2010; 31: 2371-2379.
-
(2010)
Biomaterials
, vol.31
, pp. 2371-2379
-
-
Mu, C.F.1
-
33
-
-
77955239415
-
Cyclosporin A-loaded poly(ethylene glycol)-b-poly(d,l-lactic acid) micelles: Preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier
-
Zhang Y, et al. Cyclosporin A-loaded poly(ethylene glycol)-b-poly(d,l-lactic acid) micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Mol Pharm 2010; 7: 1169-1182.
-
(2010)
Mol Pharm
, vol.7
, pp. 1169-1182
-
-
Zhang, Y.1
-
34
-
-
84862731507
-
Enhanced oral bioavailability of paclitaxel in pluronic/LHR mixed polymeric micelles: Preparation, in vitro and in vivo evaluation
-
Dahmani FZ, et al. Enhanced oral bioavailability of paclitaxel in pluronic/LHR mixed polymeric micelles: preparation, in vitro and in vivo evaluation. Eur J Pharm Sci 2012; 47: 179-189.
-
(2012)
Eur J Pharm Sci
, vol.47
, pp. 179-189
-
-
Dahmani, F.Z.1
-
35
-
-
58149125516
-
Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats
-
Yao J, et al. Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats. J Pharm Pharm Sci 2008; 11: 22-29.
-
(2008)
J Pharm Pharm Sci
, vol.11
, pp. 22-29
-
-
Yao, J.1
-
36
-
-
33746217592
-
Intestinal permeability of metformin using single-pass intestinal perfusion in rats
-
Song NN, et al. Intestinal permeability of metformin using single-pass intestinal perfusion in rats. World J Gastroenterol 2006; 12: 4064-4070.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 4064-4070
-
-
Song, N.N.1
-
37
-
-
0031800878
-
Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers
-
Batrakova EV, et al. Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharm Res 1998; 15: 850-855.
-
(1998)
Pharm Res
, vol.15
, pp. 850-855
-
-
Batrakova, E.V.1
-
38
-
-
0036741452
-
Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers
-
Rege BD, et al. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur J Pharm Sci 2002; 16: 237-246.
-
(2002)
Eur J Pharm Sci
, vol.16
, pp. 237-246
-
-
Rege, B.D.1
-
39
-
-
0041402719
-
Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells
-
Troutman MD, Thakker DR,. Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells. Pharm Res 2003; 20: 1192-1199.
-
(2003)
Pharm Res
, vol.20
, pp. 1192-1199
-
-
Troutman, M.D.1
Thakker, D.R.2
-
40
-
-
48649092518
-
Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells
-
Ma Y, Wink M,. Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells. Phytomedicine 2008; 15: 754-758.
-
(2008)
Phytomedicine
, vol.15
, pp. 754-758
-
-
Ma, Y.1
Wink, M.2
-
41
-
-
38049169407
-
Paclitaxel solubility in aqueous dispersions and mixed micellar solutions of lecithin
-
Sznitowska M, et al. Paclitaxel solubility in aqueous dispersions and mixed micellar solutions of lecithin. Chem Pharm Bull (Tokyo) 2008; 56: 70-74.
-
(2008)
Chem Pharm Bull (Tokyo)
, vol.56
, pp. 70-74
-
-
Sznitowska, M.1
-
42
-
-
45849122842
-
Impact of platelet glycoprotein IIb/IIIa receptor inhibitors on outcomes of diabetic patients undergoing percutaneous coronary interventions using sirolimus-eluting stents
-
Nikolsky E, et al. Impact of platelet glycoprotein IIb/IIIa receptor inhibitors on outcomes of diabetic patients undergoing percutaneous coronary interventions using sirolimus-eluting stents. Catheter Cardiovasc Interv 2008; 71: 896-906.
-
(2008)
Catheter Cardiovasc Interv
, vol.71
, pp. 896-906
-
-
Nikolsky, E.1
-
43
-
-
0035865162
-
Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel
-
Malingre MM, et al. Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel. J Clin Oncol 2001; 19: 1160-1166.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1160-1166
-
-
Malingre, M.M.1
-
44
-
-
1242337284
-
Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors
-
Yang S, et al. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharm Res 2004; 21: 261-270.
-
(2004)
Pharm Res
, vol.21
, pp. 261-270
-
-
Yang, S.1
-
45
-
-
0033221068
-
Nano-engineering block copolymer aggregates for drug delivery
-
Allen C, et al. Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf B Biointerfaces 1999; 16: 3-27.
-
(1999)
Colloids Surf B Biointerfaces
, vol.16
, pp. 3-27
-
-
Allen, C.1
-
46
-
-
77955469304
-
Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously
-
Li X, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharm Res 2010; 27: 1498-1511.
-
(2010)
Pharm Res
, vol.27
, pp. 1498-1511
-
-
Li, X.1
-
47
-
-
67649656101
-
Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery
-
Balakrishnan P, et al. Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery. Int J Pharm 2009; 377: 1-8.
-
(2009)
Int J Pharm
, vol.377
, pp. 1-8
-
-
Balakrishnan, P.1
-
48
-
-
84255183734
-
Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol
-
Li X, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Res Lett 2011; 6: 275.
-
(2011)
Nanoscale Res Lett
, vol.6
, pp. 275
-
-
Li, X.1
-
49
-
-
70449705990
-
Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: Synthesis, characterization, and in vivo biodistribution
-
Saravanakumar G, et al. Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: synthesis, characterization, and in vivo biodistribution. J Control Release 2009; 140: 210-217.
-
(2009)
J Control Release
, vol.140
, pp. 210-217
-
-
Saravanakumar, G.1
-
50
-
-
77956414625
-
Quercetin: A potential drug to reverse multidrug resistance
-
Chen C, et al. Quercetin: a potential drug to reverse multidrug resistance. Life Sci 2010; 87: 333-338.
-
(2010)
Life Sci
, vol.87
, pp. 333-338
-
-
Chen, C.1
-
51
-
-
33645294093
-
Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats
-
Shin SC, et al. Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats. Int J Pharm 2006; 313: 144-149.
-
(2006)
Int J Pharm
, vol.313
, pp. 144-149
-
-
Shin, S.C.1
-
52
-
-
0027506202
-
Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs
-
Chaudhary PM, Roninson IB,. Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst 1993; 85: 632-639.
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 632-639
-
-
Chaudhary, P.M.1
Roninson, I.B.2
-
53
-
-
0027500507
-
Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists
-
Herzog CE, et al. Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists. J Biol Chem 1993; 268: 2946-2952.
-
(1993)
J Biol Chem
, vol.268
, pp. 2946-2952
-
-
Herzog, C.E.1
-
54
-
-
70350393672
-
Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation
-
Bansal T, et al. Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation. Drug Discov Today 2009; 14: 1067-1074.
-
(2009)
Drug Discov Today
, vol.14
, pp. 1067-1074
-
-
Bansal, T.1
-
55
-
-
84891777924
-
Inhibition mechanism of P-glycoprotein mediated efflux by mPEG-PLA and influence of PLA chain length on P-glycoprotein inhibition activity
-
Li W, et al. Inhibition mechanism of P-glycoprotein mediated efflux by mPEG-PLA and influence of PLA chain length on P-glycoprotein inhibition activity. Mol Pharm 2013; 11: 71-80.
-
(2013)
Mol Pharm
, vol.11
, pp. 71-80
-
-
Li, W.1
|