Aberrant glycosylation of lumican in aortic valve stenosis revealed by proteomic analysis

International Heart Journal

Volumn 57, Issue 1, 2016, Pages 104-111

  Suzuki, Hirotoshi ^a   Chikada, Masahide ^a   Yokoyama, Michiyo K ^a   Kurokawa, Manae S ^a   Ando, Takashi ^a   Furukawa, Hiroshi ^a   Arito, Mitsumi ^a   Miyairi, Takeshi ^a   Kato, Tomohiro ^a  

^a ST MARIANNA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

2 dimensional gel electrophoresis; Calcification; Mass spectrometry; Peptide:N glycosidase F; Proteoglycan

Indexed keywords

LUMICAN; KERATAN SULFATE; PROTEOCHONDROITIN SULFATE;

ADULT; AGED; AORTA VALVE STENOSIS; ARTICLE; CLINICAL ARTICLE; DYSLIPIDEMIA; FEMALE; GEL ELECTROPHORESIS; GLYCOSYLATION; HUMAN; HYPERTENSION; ISOELECTRIC FOCUSING; MALE; MASS SPECTROMETRY; MIDDLE AGED; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; WESTERN BLOTTING; METABOLISM; PROCEDURES; TWO DIMENSIONAL GEL ELECTROPHORESIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AORTIC VALVE STENOSIS; BLOTTING, WESTERN; CHONDROITIN SULFATE PROTEOGLYCANS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; GLYCOSYLATION; HUMANS; KERATAN SULFATE; MALE; MIDDLE AGED; PROTEOMICS;

EID: 84954497285     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.15-252     Document Type: Article

References (34)

1. Rose AG. Etiology of valvular heart disease. Curr Opin Cardiol 1996; 11: 98-113. (Review)
2. Mohler ER 3rd, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS. Bone formation and inflammation in cardiac valves. Circulation 2001; 103: 1522-8.
3. Newby DE, Cowell SJ, Boon NA. Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both? Heart 2006; 92: 729-34. (Review)
4. Olszowska M. Pathogenesis and pathophysiology of aortic valve stenosis in adults. Pol Arch Med Wewn 2011; 121: 409-13. (Review, English, Polish)
5. Rabuş MB, Kayalar N, Sareyyüpoğlu B, Erkin A, Kirali K, Yakut C. Hypercholesterolemia association with aortic stenosis of various etiologies. J Card Surg 2009; 24: 146-50.
6. O’Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of ‘degenerative’ valvular aortic stenosis. Arterioscler Thromb Vasc Biol 1996; 16: 523-32.
7. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O’Brien KD. Characterization of the early lesion of ‘degenerative’ valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994; 90: 844-53.
8. Miller JD, Weiss RM, Heistad DD. Calcific aortic valve stenosis: methods, models, and mechanisms. Circ Res 2011; 108: 1392-412. (Review)
9. Winchester R, Wiesendanger M, O’Brien W, et al. Circulating activated and effector memory T cells are associated with calcification and clonal expansions in bicuspid and tricuspid valves of calcific aortic stenosis. J Immunol 2011; 187: 1006-14.
10. Ando T, Nagai K, Chikada M, et al. Proteomic analyses of aortic wall in patients with abdominal aortic aneurysm. J Cardiovasc Surg (Torino) 2011; 52: 545-55.
11. Ando T, Iizuka N, Sato T, et al. Autoantigenicity of carbonic anhydrase 1 in patients with abdominal aortic aneurysm, revealed by proteomic surveillance. Hum Immunol 2013; 74: 852-7.
12. Gil-Dones F, Martín-Rojas T, López-Almodovar LF, et al. Development of an optimal protocol for the proteomic analysis of stenotic and healthy aortic valves. Rev Esp Cardiol 2010; 63: 46-53. (English, Spanish)
13. Martín-Rojas T, Gil-Dones F, Lopez-Almodovar LF, Padial LR, Vivanco F, Barderas MG. Proteomic profile of human aortic stenosis: insights into the degenerative process. J Proteome Res 2012; 11: 1537-50.
14. Matsuo K, Xiang Y, Nakamura H, et al. Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach. Arthritis Res Ther 2006; 8: R175.
15. Blochberger TC, Vergnes JP, Hempel J, Hassell JR. cDNA to chick lumican (corneal keratan sulfate proteoglycan) reveals homology to the small interstitial proteoglycan gene family and expression in muscle and intestine. J Biol Chem 1992; 267: 347-52.
16. Svensson L, Närlid I, Oldberg A. Fibromodulin and lumican bind to the same region on collagen type I fibrils. FEBS Lett 2000; 470: 178-82.
17. Chakravarti S, Petroll WM, Hassell JR, et al. Corneal opacity in lumican-null mice: defects in collagen fibril structure and packing in the posterior stroma. Invest Ophthalmol Vis Sci 2000; 41: 3365-73.
18. Embery G, Hall R, Waddington R, Septier D, Goldberg M. Proteoglycans in dentinogenesis. Crit Rev Oral Biol Med 2001; 12: 331-49. (Review)
19. Funderburgh JL, Caterson B, Conrad GW. Keratan sulfate proteoglycan during embryonic development of the chicken cornea. Dev Biol 1986; 116: 267-77.
20. Funderburgh JL, Funderburgh ML, Mann MM, Conrad GW. Arterial lumican. Properties of a corneal-type keratan sulfate proteoglycan from bovine aorta. J Biol Chem 1991; 266: 24773-7.
21. Cheng H, Caterson B, Neame PJ, Lester GE, Yamauchi M. Differential distribution of lumican and fibromodulin in tooth cementum. Connect Tissue Res 1996; 34: 87-96.
22. Qin H, Ishiwata T, Asano G. Effects of the extracellular matrix on lumican expression in rat aortic smooth muscle cells in vitro. J Pathol 2001; 195: 604-8.
23. Perrotta I, Davoli M. Collagen mineralization in human aortic valve stenosis: a field emission scanning electron microscopy and energy dispersive spectroscopy analysis. Ultrastruct Pathol 2014; 38: 281-4.
24. Dweck MR, Boon NA, Newby DE. Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol 2012; 60: 1854-63. (Review)
25. Wypasek E, Natorska J, Grudzień G, Filip G, Sadowski J, Undas A. Mast cells in human stenotic aortic valves are associated with the severity of stenosis. Inflammation 2013; 36: 449-56.
26. Otsuka F, Sakakura K, Yahagi K, Joner M, Virmani R. Has our understanding of calcification in human coronary atherosclerosis progressed? Arterioscler Thromb Vasc Biol 2014; 34: 724-36. (Review)
27. Funderburgh JL, Mitschler RR, Funderburgh ML, Roth MR, Chapes SK, Conrad GW. Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan. Invest Ophthalmol Vis Sci 1997; 38: 1159-67.
28. Hayashi Y, Call MK, Chikama T, et al. Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci 2010; 123: 2987-95.
29. Carlson EC, Sun Y, Auletta J, et al. Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. J Leukoc Biol 2010; 88: 517-22.
30. Chen NX, O’Neill KD, Chen X, Kiattisunthorn K, Gattone VH, Moe SM. Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease. Am J Nephrol
31. Yamamoto T, Matsuda Y, Kawahara K, Ishiwata T, Naito Z. Secreted 70kDa lumican stimulates growth and inhibits invasion of human pancreatic cancer. Cancer Lett 2012; 320: 31-9.
32. Natorska J, Marek G, Hlawaty M, Sadowski J, Tracz W, Undas A. Fibrin presence within aortic valves in patients with aortic stenosis: association with in vivo thrombin generation and fibrin clot properties. Thromb Haemost 2011; 105: 254-60.
33. Martín-Rojas T, Gil-Dones F, Lopez-Almodovar LF, Padial LR, Vivanco F, Barderas MG. Proteomic profile of human aortic stenosis: insights into the degenerative process. J Proteome Res 2012; 11: 1537-50.
34. Natorska J, Wypasek E, Grudzień G, Sadowski J, Undas A. Impaired fibrinolysis is associated with the severity of aortic stenosis in humans. J Thromb Haemost 2013; 11: 733-40.