Circulating activated and effector memory T cells are associated with calcification and clonal expansions in bicuspid and tricuspid valves of calcific aortic stenosis

Journal of Immunology

Volumn 187, Issue 2, 2011, Pages 1006-1014

  Winchester, Robert ^a   Wiesendanger, Margrit ^a   O'Brien, Will ^a   Zhang, Hui Zhu ^a   Maurer, Mathew S ^a   Gillam, Linda D ^a   Schwartz, Allan ^a   Marboe, Charles ^a   Stewart, Allan S ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN;

ADULT; AGED; AORTA STENOSIS; ARTICLE; ATHEROSCLEROSIS; CALCIFIC AORTIC STENOSIS; CALCIFICATION; CD28NULL CD8+ T LYMPHOCYTE; CD4+ CD28+ T LYMPHOCYTE; CD4+ CD28NULL T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE CLONE; MEMORY T LYMPHOCYTE; MITRAL VALVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRICUSPID VALVE;

ADULT; AGED; AGED, 80 AND OVER; AGING; AORTIC VALVE STENOSIS; CALCINOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CLONE CELLS; GENES, T-CELL RECEPTOR BETA; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MITRAL VALVE; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTE SUBSETS; TRICUSPID VALVE;

EID: 79960493929     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003521     Document Type: Article

References (33)

1. Ross, J., Jr., and E. Braunwald. 1968. Aortic stenosis. Circulation 38(1, Suppl.) 61-67.
2. Pomerance, A. 1972. Pathogenesis of aortic stenosis and its relation to age. Br. Heart J. 34: 569-574.
3. Otto, C. M., J. Kuusisto, D. D. Reichenbach, A. M. Gown, and K. D. O'Brien. 1994. Characterization of the early lesion of "degenerative" valvular aortic stenosis: histological and immunohistochemical studies. Circulation 90: 844-853.
4. Olsson, M., C. J. Dalsgaard, A. Haegerstrand, M. Rosenqvist, L. Rydén, and J. Nilsson. 1994. Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J. Am. Coll. Cardiol. 23: 1162-1170.
5. Wallby, L., B. Janerot-Sjöberg, T. Steffensen, and M. Broqvist. 2002. T lymphocyte infiltration in non-rheumatic aortic stenosis: a comparative descriptive study between tricuspid and bicuspid aortic valves. Heart 88: 348-351.
6. Soini, Y., T. Salo, and J. Satta. 2003. Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. Hum. Pathol. 34: 756-763.
7. Mazzone, A., M. C. Epistolato, R. De Caterina, S. Storti, S. Vittorini, S. Sbrana, J. Gianetti, S. Bevilacqua, M. Glauber, A. Biagini, and P. Tanganelli. 2004. Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis. J. Am. Coll. Cardiol. 43: 1670-1676.
8. Wu, H. D., M. S. Maurer, R. A. Friedman, C. C. Marboe, E. M. Ruiz-Vazquez, R. Ramakrishnan, A. Schwartz, M. D. Tilson, A. S. Stewart, and R. Winchester. 2007. The lymphocytic infiltration in calcific aortic stenosis predominantly consists of clonally expanded T cells. J. Immunol. 178: 5329-5339. (Pubitemid 46595319)
9. Yu, D. T., R. J. Winchester, S. M. Fu, A. Gibofsky, H. S. Ko, and H. G. Kunkel. 1980. Peripheral blood Ia-positive T cells: increases in certain diseases and after immunization. J. Exp. Med. 151: 91-100.
10. Speiser, D. E., D. Valmori, D. Rimoldi, M. J. Pittet, D. Liénard, V. Cerundolo, H. R. MacDonald, J. C. Cerottini, and P. Romero. 1999. CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients. Eur. J. Immunol. 29: 1990-1999.
11. + T cells. Blood 101: 2711-2720.
12. Sallusto, F., J. Geginat, and A. Lanzavecchia. 2004. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22: 745-763.
13. Hsu, H. C., D. K. Scott, P. Zhang, J. Zhou, P. Yang, Q. Wu, H. W. Schroeder, Jr., L. B. Gerald, E. Ravussin, S. M. Jazwinski, J. D. Mountz; Louisiana Healthy Aging Study. 2006. CD8 T-cell immune phenotype of successful aging. Mech. Ageing Dev. 127: 231-239.
14. + T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol. 29: 601-609.
15. Posnett, D. N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J. Exp. Med. 179: 609-618.
16. + subpopulation. Clin. Immunol. 96: 230-235.
17. Vallejo, A. N. 2006. Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged. Immunol. Res. 36: 221-228.
18. Warren, B. A., and J. L. Yong. 1997. Calcification of the aortic valve: its progression and grading. Pathology 29: 360-368.
19. Curran, S. A., O. M. FitzGerald, P. J. Costello, J. M. Selby, D. J. Kane, B. Bresnihan, and R. Winchester. 2004. Nucleotide sequencing of psoriatic arthritis tissue before and during methotrexate administration reveals a complex inflammatory T cell infiltrate with very few clones exhibiting features that suggest they drive the inflammatory process by recognizing autoantigens. J. Immunol. 172: 1935-1944. (Pubitemid 38116844)
20. Brochet, X., M. P. Lefranc, and V. Giudicelli. 2008. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36(Suppl. 2): W503-W508.
21. Arden, B., S. P. Clark, D. Kabelitz, and T. W. Mak. 1995. Human T-cell receptor variable gene segment families. Immunogenetics 42: 455-500.
22. + repertoire during antiviral therapy. Nat. Med. 4: 215-221.
23. Costello, P. J., R. J. Winchester, S. A. Curran, K. S. Peterson, D. J. Kane, B. Bresnihan, and O. M. FitzGerald. 2001. Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven. J. Immunol. 166: 2878-2886.
24. Venturi, V., K. Kedzierska, S. J. Turner, P. C. Doherty, and M. P. Davenport. 2007. Methods for comparing the diversity of samples of the T cell receptor repertoire. J. Immunol. Methods 321: 182-195.
25. Werwitzke, S., A. Tiede, B. E. Drescher, R. E. Schmidt, and T. Witte. 2003. CD8β/CD28 expression defines functionally distinct populations of peripheral blood T lymphocytes. Clin. Exp. Immunol. 133: 334-343.
26. - T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J. Clin. Invest. 97: 2027-2037.
27. Liuzzo, G., J. J. Goronzy, H. Yang, S. L. Kopecky, D. R. Holmes, R. L. Frye, and C. M. Weyand. 2000. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation 101: 2883-2888.
28. Stemme, S., L. Rymo, and G. K. Hansson. 1991. Polyclonal origin of T lymphocytes in human atherosclerotic plaques. Lab. Invest. 65: 654-660.
29. Oksenberg, J. R., G. T. Stavri, M. C. Jeong, N. Garovoy, J. R. Salisbury, and J. D. Erusalimsky. 1997. Analysis of the T-cell receptor repertoire in human atherosclerosis. Cardiovasc. Res. 36: 256-267.
30. Sansoni, P., R. Vescovini, F. Fagnoni, C. Biasini, F. Zanni, L. Zanlari, A. Telera, G. Lucchini, G. Passeri, D. Monti, et al. 2008. The immune system in extreme longevity. Exp. Gerontol. 43: 61-65.
31. Khan, N., N. Shariff, M. Cobbold, R. Bruton, J. A. Ainsworth, A. J. Sinclair, L. Nayak, and P. A. Moss. 2002. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169: 1984-1992.
32. Boppana, S. B., and K. B. Fowler. 2007. Persistence in the population: epidemiology and transmisson. In Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. A. Arvin, G. Campadelli-Fiume, E. Mocarski, P. S. Moore, B. Roizman, R. Whitley, and K. Yamanishi, eds. Cambridge University Press, New York, p. 795-813.
33. Olsson, M., M. Rosenqvist, and J. Nilsson. 1994. Expression of HLA-DR antigen and smooth muscle cell differentiation markers by valvular fibroblasts in degenerative aortic stenosis. J. Am. Coll. Cardiol. 24: 1664-1671.