Corneal opacity in lumican-null mice: Defects in collagen fibril structure and packing in the posterior stroma

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 11, 2000, Pages 3365-3373

  Chakravarti, S ^a   Petroll, W M ^a   Hassell, J R ^a   Jester, J V ^a   Lass, J H ^a   Paul, J ^a   Birk, D E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN FIBRIL; KERATAN SULFATE; LUMICAN; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA OPACITY; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN STRUCTURE; QUANTITATIVE DIAGNOSIS; TRANSMISSION ELECTRON MICROSCOPY;

ANIMAL; COLLAGEN; CORNEAL OPACITY; CORNEAL STROMA; GENE TARGETING; KERATAN SULFATE; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PROTEOCHONDROITIN SULFATES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033779690     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. The structure and transparency of the cornea
2. Altered corneal stromal matrix organization is associated with mucopolysaccharidosis I, III and VI
3. Scheie's syndrome: The architecture of corneal collagen and distribution of corneal proteoglycans
4. Macular corneal dystrophy: Failure to synthesize a mature keratan sulfate proteoglycan
5. Macular corneal dystrophy: Lack of keratan sulfate in serum and cornea
6. Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate
7. Macular corneal dystrophy: Reduction in both corneal thickness and collagen interfibrillar spacing
8. Lumican regulates collagen fibril assembly: Skin fragility and corneal opacity in the absence of lumican
9. cDNA to chick lumican (corneal keratan sulfate proteoglycan) reveals homology to the small interstitial proteoglycan gene family and expression in muscle and intestine
10. Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22
11. Proteoglycans of the extracellular environment: Clues from the gene and protein side offer novel perspectives in molecular diversity and function
12. The murine decorin gene. Complete cDNA cloning, genomic organization, chromosomal assignment and expression during organogenesis and tissue differentiation
13. Regulation of corneal collagen fibrillogenesis in vitro by corneal keratan sulfate proteoglycan (lumican) and decorin core proteins
14. Decorin-type I collagen interaction
15. Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycans of tendon
16. Characterization of fibril segments from chicken embryo cornea, dermis and tendon
17. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
18. Fibromodulin-null mice have abnormal collagen fibrils, tissue organization and altered lumican deposition in tendon
19. Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF)
20. Quantitative three-dimensional confocal imaging of the cornea in situ and in vivo: System design and calibration
21. Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride
22. Theory of transparency of the eye
23. Confocal microscope characterization of wound repair after photorefractive keratectomy
24. Dense peripheral corneal clouding in Scheie syndrome
25. Role of lumican in the corneal epithelium during wound healing
26. Light and electron microscopy of the cornea in systemic mucopolysaccharidosis type I-S (Scheie's syndrome)
27. Altered organization of collagen in the apex of keratoconus corneas
28. Distribution of hexosamines in bovine cornea
29. Water gradients across bovine cornea
30. Ultrastructure in anterior and posterior stroma of perfused human and rabbit corneas: Relation to transparency
31. Uneven swelling of the corneal stroma
32. A comparative biochemical and ultrastructural study of proteoglycan-collagen interactions in corneal stroma
33. Molecular cloning and tissue distribution of keratocan
34. Distribution of proteoglycans antigenically related to corneal keratan sulfate proteoglycan
35. The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development