Ion mobility in clinical analysis: Current progress and future perspectives

Clinical Chemistry

Volumn 62, Issue 1, 2016, Pages 124-133

  Chouinard, Christopher D ^a   Wei, Michael S ^a   Beekman, Christopher R ^a   Kemperman, Robin H J ^a   Yost, Richard A ^a,b  

^a University of Florida ^*  (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTANONE; ACETONE; AMMONIA; CHEMICAL WARFARE AGENT; ILLICIT DRUG; LIPOPROTEIN; VOLATILE AGENT; ION;

ALZHEIMER DISEASE; ASPERGILLUS; ASTHMA; BACILLUS CEREUS; BACTERIUM IDENTIFICATION; BREATH ANALYSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; ELECTRIC POTENTIAL; ESCHERICHIA COLI; GAS; HUMAN; ION MOBILITY SPECTROMETRY; LUNG CANCER; LUNG INFECTION; MACROMOLECULE; MASS SPECTROMETRY; METABOLOMICS; MYCOBACTERIUM; NEUTROPENIA; NONHUMAN; PARKINSON DISEASE; PHASE SEPARATION; POINT OF CARE TESTING; POLYCHONDRITIS; PROTEIN ANALYSIS; PROTEOMICS; RESPIRATORY TRACT INFECTION; RESPIRATORY TRACT INFLAMMATION; REVIEW; SARCOIDOSIS; SCREENING; SEPARATION TECHNIQUE; LABORATORY TEST;

CLINICAL LABORATORY TECHNIQUES; HUMANS; IONS; MASS SPECTROMETRY; METABOLOMICS;

EID: 84954479371     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2015.238840     Document Type: Review

References (76)

1. Cohen MJ, Karasek FW. Plasma ChromatographyTM-a new dimension for gas chromatography and mass spectrometry. J Chrom Sci 1970;8:330-7.
2. Revercomb HE, Mason EA. Theory of plasma chromatography/gaseous electrophoresis. Review. Anal Chem 1975;47:970-83.
3. Mason EA, McDaniel EW. Transport properties of ions in gases. New York: Wiley; 1988.
4. Eiceman GA, Karpas Z. Ion Mobility Spectrometry. 2nd ed. New York: Taylor & Francis; 2005.
5. Kliman M, May JC, McLean JA. Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry. Biochim Biophys Acta 2011;1811:935-45.
6. Fernandez-Lima F, Kaplan DA, Suetering J, Park MA. Gas-phase separation using a trapped ion mobility spectrometer. Int J Ion Mobil Spectrom 2011;14:93-8.
7. Adams NG, Smith D. The selected ion flow tube (SIFT); a technique for studying ion-neutral reactions. Int J Mass Spectrom Ion Phys 1976;21:349-59.
8. Pringle SD, Giles K, Wildgoose JL, Williams JP, Slade SE, Thalassinos K, et al. An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument. Int J Mass Spectrom 2007;261:1-12.
9. Buryakov IA, Krylov EV, Nazarov EG, Rasulev UK. A new method of separation of multi-atomic ions by mobility at atmospheric pressure using a high-frequency amplitude-asymmetric strong electric field. Int J Mass Spectrom Ion Process 1993;128:143-8.
10. Knutson E, Whitby, K. Aerosol classification by electric mobility: apparatus, theory, and applications. Aerosol Sci 1975;6:443-51.
11. Mora JDL, Juan TD, Eichler T, Rosell J. Differential mobility analysis of molecular ions and nanometer particles. Trends Anal Chem 1998;17:328-39.
12. Karasek FW, Keller RA. Gas chromatograph/plasma chromatograph interface and its performance in the detection of musk ambrette. J Chrom Sci 1972;10:626-8.
13. Shumate CB, Hill HH. Coronaspray nebulization and ionization of liquid samples for ion mobility spectrometry. Anal Chem 1989;61:601-6.
14. Ruzsanyi V, Baumbach JI, Sielemann S, Litterst P, Westhoff M, Freitag L. Detection of human metabolites using multi-capillary columns coupled to ion mobility spectrometers. J Chromatogr A 2005;1084:145-51.
15. Ruzsanyi V, Baumbach JI. Analysis of human breath using IMS. Int J Ion Mobil Spectrom 2005;8:5-7.
16. Karasek FW, Cohen MJ, Carroll DI. Trace studies of alcohols in the plasma chromatograph-mass spectrometer. J Chrom Sci 1971;9:390-2.
17. Von Helden G, Wyttenbach T, Bowers MT. Conformation of macromolecules in the gas phase: use of matrixassisted laser desorption methods in ion chromatography. Science 1995;267:1483-5.
18. Clemmer DE, Hudgins RR, Jarrold MF. Naked protein conformations: cytochrome C in the gas phase. J Am Chem Soc 1995;117:10141-2.
19. Shelimov KB, Jarrold MF. Conformations, unfolding, and refolding of apomyoglobin in vacuum: an activation barrier for gas-phase protein folding. J Am Chem Soc 1997;119:2987-94.
20. Teranishi R, Mon TR, Robinson AB, Cary P, Pauling L. Gas chromatography of volatiles from breath and urine. Anal Chem 1972;44:18-20.
21. Eiceman GA, Shoff DB, Harden CS, Snyder AP, Martinez PM, Fleischer ME, et al. Ion mobility spectrometry of halothane, enflurane, and isoflurane anesthetics in air and respired gases. Anal Chem 1989;61:1093-9.
22. Westhoff M, Litterst P, Freitag L, Baumbach JI. Ion mobility spectrometry in the diagnosis of sarcoidosis: results of a feasibility study. J Physiol Pharmacol 2007;58:739-51.
23. Baumbach JI, Maddula S, Sommerwerck U, Besa V, Kurth I, Bödeker B, et al. Significant different volatile biomarker during bronchoscopic ion mobility spectrometry investigation of patients suffering lung carcinoma. Int J Ion Mobil Spectrom 2011;14:159-66.
24. Neuhaus S, Seifert L, Vautz W, Nolte J, Bufe A, Peters M. Comparison of metabolites in exhaled breath and bronchoalveolar lavage fluid samples in a mouse model of asthma. J Appl Physiol 2011;111:1088-95.
25. Usuba A, Handa H, Inoue T, Azagami S, Yamano Y, Mineshita M, et al. Breath analysis for relapsing polychondritis assessed by ion mobility spectrometry. Int J Ion Mobil Spectrom 2015;18:177-83.
26. Bessa V, Darwiche K, Teschler H, Sommerwerck U, Rabis T, Baumbach JI, et al. Detection of volatile organic compounds (VOCs) in exhaled breath of patients with chronic obstructive pulmonary disease (COPD) by ion mobility spectrometry. Int J Ion Mobil Spectrom 2011;14:7-13.
27. Bach J-P, Gold M, Mengel D, Hattesohl A, Lubbe D, Schmid S, et al. Measuring compounds in exhaled air to detect Alzheimer's disease and Parkinson's disease. PLoS One 2015;10:e0132227.
28. Furtwängler R, Hauschild AC, Hübel J, Rakicioglou H, Bödeker B, Maddula S, et al. Signals of neutropenia in human breath? Int J Ion Mobil Spectrom 2014;17:19-23.
29. Brodrick E, Davies A, Neill P, Hanna L, Williams EM. Breath analysis: translation into clinical practice. J Breath Res 2015;9:027109.
30. Szymańska E, Brodrick E, Williams M, Davies AN, van Manen HJ, Buydens LMC. Data size reduction strategy for the classification of breath and air samples using multicapillary column-ion mobility spectrometry. Anal Chem 2015;87:869-75.
31. Schneider T, Hauschild AC, Baumbach JI, Baumbach J. An integrative clinical database and diagnostics platform for biomarker identification and analysis in ion mobility spectra of human exhaled air. J Integr Bioinform 2013;10:218.
32. Jazan E, Mirzaei H. Direct analysis of human breath ammonia using corona discharge ion mobility spectrometry. J Pharm Biomed Anal 2014;88:315-20.
33. Mochalski P, Rudnicka J, Agapiou A, Statheropoulos M, Amann A, Buszewski B. Near real-time VOCs analysis using an aspiration ion mobility spectrometer. J Breath Res 2013;7:26002.
34. Owlstone Nanotech. Lonestar Portable Analyzer. http://www.owlstonenanotech.com/lonestar (Accessed August 2015).
35. Vautz W, Nolte J, Fobbe R, Baumbach JI. Breath analysis-performance and potential of ion mobility spectrometry. J Breath Res 2009;3:036004.
36. Snyder AP, Blyth DA, Parsons JA. Ion mobility spectrometry as an immunoassay detection technique. J Microbiol Methods 1996;27:81-8.
37. Snyder AP, Shoff DB, Eiceman GA, Blyth DA, Parsons JA. Detection of bacteria by ion mobility spectrometry. Anal Chem 1991;526-9.
38. Perl T, Jünger M, Vautz W, Nolte J, Kuhns M, Borg-von Zepelin M, et al. Detection of characteristic metabolites of Aspergillus fumigatus and Candida species using ion mobility spectrometry-metabolic profiling by volatile organic compounds. Mycoses 2011;54:828-37.
39. Inoue T, Handa H, Inoue T, Mineshita M, Miyazawa T. Volatile organic compounds arising from tracheobronchial stent-related biofilm formation detected in patients' breath by ion mobility spectrometry. J St Marian Univ 2014;5:69-75.
40. Jünger M, Vautz W, Kuhns M, Hofmann L, Ulbricht S, Baumbach JI, et al. Ion mobility spectrometry for microbial volatile organic compounds: a new identification tool for human pathogenic bacteria. Appl Microbiol Biotechnol 2012;93:2603-14.
41. Shnayderman M, Mansfield B, Yip P, Clark HA, Krebs MD, Cohen SJ, et al. Species-specific bacteria identification using differential mobility spectrometry and bioinformatics pattern recognition. Anal Chem 2005;77:5930-7.
42. Purkhart R, Köhler H, Liebler-Tenorio E, Meyer M, Becher G, Kikowatz A, Reinhold P. Chronic intestinal Mycobacteria infection: discrimination viaVOCanalysis in exhaled breath and headspace of feces using differential ion mobility spectrometry. J Breath Res 2011;5:027103.
43. Arasaradnam RP, Ouaret N, Thomas MG, Gold P, Quraishi MN, Nwokolo CU, et al. Evaluation of gut bacterial populations using an electronic e-nose and field asymmetric ion mobility spectrometry: further insights into 'fermentomics'. J Med Eng Technol 2012;36:333-7.
44. Blankenstein T, Lytton SD, Leidl B, Atweh E, Friese K, Mylonas I. Point-of-care (POC) diagnosis of bacterial vaginosis (BV) using VGTestTM ion mobility spectrometry (IMS) in a routine ambulatory care gynecology clinic. Arch Gynecol Obstet 2015;355-62.
45. Allardyce RA, Hill AL, Murdoch DR. The rapid evaluation of bacterial growth and antibiotic susceptibility in blood cultures by selected ion flow tube mass spectrometry. Diagn Microbiol Infect Dis 2006;55:255-61.
46. Kunze N, Göpel J, Kuhns M, Jünger M, Quintel M, Perl T. Detection and validation of volatile metabolic patterns over different strains of two human pathogenic bacteria during their growth in a complex medium using multi-capillary column-ion mobility spectrometry (MCC-IMS). Appl Microbiol Biotechnol 2013;97:3665-76.
47. McLean JA, Ridenour WB, Caprioli RM. Profiling and imaging of tissues by imaging ion mobility-mass spectrometry. J Mass Spectrom 2007;42:1099-105.
48. Trim PJ, Henson CM, Avery JL, McEwen A, Snel MF, Marshall PS, et al. Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Anal Chem 2008;80:8628-34.
49. Bennett R V, Gamage CM, Galhena AS, Fernández FM. Contrast-enhanced differential mobility-desorption electrospray ionization-mass spectrometry imaging of biological tissues. Anal Chem 2014;86:3756-63.
50. Djidja MC, Francese S, Loadman PM, Sutton CW, Scriven P, Claude E, et al. Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalinfixed paraffin-embedded adenocarcinoma tissue sections. Proteomics 2009;9:2750-63.
51. Djidja MC, Claude E, Snel MF, Scriven P, Francese S, Carolan V, Clench MR. MALDI-ion mobility separationmass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffinembedded pancreatic adenocarcinoma tissue sections. J Proteome Res 2009;8:4876-84.
52. Jackson SN, Ugarov M, Post JD, Egan T, Langlais D, Schultz JA, Woods AS. A study of phospholipids by ion mobility TOFMS. J Am Soc Mass Spectrom 2008;19:1655-62.
53. Djidja MC, Claude E, Snel MF, Francese S, Scriven P, Carolan V, Clench MR. Novel molecular tumour classification using MALDI-mass spectrometry imaging of tissue micro-array. Anal Bioanal Chem 2010;397:587-601.
54. Blatherwick EQ, Svensson CI, Frenguelli BG, Scrivens JH. Localisation of adenine nucleotides in heatstabilised mouse brains using ion mobility enabled MALDI imaging. Int J Mass Spectrom 2013;345-347:19-27.
55. Hart PJ, Francese S, Woodroofe MN, Clench MR. Matrix assisted laser desorption ionisation ion mobility separation mass spectrometry imaging of ex-vivo human skin. Int J Ion Mobil Spectrom 2013;16:71-83.
56. Jackson SN, Barbacci D, Egan T, Lewis EK, Schultz JA, Woods AS. MALDI-ion mobility mass spectrometry of lipids in negative ion mode. Anal Methods 2014;6:5001.
57. Li H, Smith BK, Márk L, Nemes P, Nazarian J, Vertes A. Ambient molecular imaging by laser ablation electrospray ionization mass spectrometry with ion mobility separation. Int J Mass Spectrom 2014;377:681-9.
58. Caulfield MP, Li S, Lee G, Blanche PJ, Salameh WA, Benner WH, et al. Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clin Chem 2008;54:1307-16.
59. Hutchins PM, Ronsein GE, Monette JS, Pamir N, Wimberger J, He Y, et al. Quantification of HDL particle concentration by calibrated ion mobility analysis. Clin Chem 2014;60:1393-401.
60. Dwivedi P, Wu P, Klopsch SJ, Puzon GJ, Xun L, Hill HH. Metabolic profiling by ion mobility mass spectrometry (IMMS). Metabolomics 2008;4:63-80.
61. Dwivedi P, Schultz AJ, Hill HH. Metabolic profiling of human blood by high-resolution ion mobility mass spectrometry (IM-MS). Int J Mass Spectrom 2010;298:78-90.
62. May JC, Goodwin CR, Lareau NM, Leaptrot KL, Morris CB, Kurulugama RT, et al. Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer. Anal Chem 2014;86:2107-16.
63. Liu Y, Clemmer DE. Characterizing oligosaccharides using injected-ion mobility/mass spectrometry. Anal Chem 1997;69:2504-9.
64. Lee DS, Wu C, Hill HH. Detection of carbohydrates by electrospray ionization-ion mobility spectrometry following microbore high-performance liquid chromatography. J Chrom A 1998;822:1-9.
65. Gabryelski W, Froese KL. Rapid and sensitive differentiation of anomers, linkage, and position isomers of disaccharides using high-field asymmetric waveform ion mobility spectrometry (FAIMS). J Am Soc Mass Spectrom 2003;14:265-77.
66. Woods AS, Ugarov M, Egan T, Koomen J, Gillig KJ, Fuhrer K, et al. Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS. Anal Chem 2004;76:2187-95.
67. Castro-Perez J, Roddy TP, Nibbering NMM, Shah V, McLaren DG, Previs S, et al. Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry. J Am Soc Mass Spectrom 2011;22:1552-67.
68. Damen CWN, Isaac G, Langridge J, Hankemeier T, Vreeken RJ. Enhanced lipid isomer separation in human plasma using reversed-phase UPLC with ion-mobility/highresolution MS detection. J Lipid Res 2014;55:1772-83.
69. Paglia G, Williams JP, Menikarachchi LC, Thompson JW, Tyldesley-Worster R, Halldórsson S, et al. Ion Mobility-derived collision cross-sections to support metabolomics applications. Anal Chem 2014;86:3985-93.
70. Ray JA, Kushnir MM, Yost RA, Rockwood AL, Meikle AW. Performance enhancement in the measurement of 5 endogenous steroids by LC-MS/MS combined with differential ion mobility spectrometry. Clin Chim Acta 2015;438:330-6.
71. Ahonen L, Fasciotti M, Gennas GB, Kotiaho T, Daroda RJ, Eberlin M, Kostiainen R. Separation of steroid isomers by ion mobility mass spectrometry. J Chrom A 2013;1310:133-7.
72. Chouinard CD, Beekman CR, Garrett TJ, Yost RA. Separation of isomeric steroids using ion mobilty QTOF-LC/MS. Paper presented at: 63rd ASMS Conference on Mass Spectrometry and Allied Topics; 2015 May 31-Jun. 4; St Louis, MO.
73. Chouinard CD, Beekman CR, Garrett TJ, Yost RA. Ion mobility strategies for separation of vitamin D metabolites by LC-MS/MS. Paper presented at: Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy 2015;2015 Mar. 8-12; New Orleans, LA.
74. Huang Y, Dodds ED. Ion mobility studies of carbohydrates as group I adducts: isomer specific collisional cross section dependence on metal ion radius. Anal Chem 2013;85:9728-35.
75. Leavell MD, Gaucher SP, Leary JA, Taraszka JA, Clemmer DE. Conformational studies of Zn-ligand-hexose diastereomers using ion mobility measurements and density functional theory calculations. J Am Soc Mass Spectrom 2002;13:284-93.
76. Asbury G, Hill HH. Using different drift gases to change separation factors (alpha) in ion mobility spectrometry. Anal Chem 2000;72:580-4.