Significant different volatile biomarker during bronchoscopic ion mobility spectrometry investigation of patients suffering lung carcinoma

International Journal for Ion Mobility Spectrometry

Volumn 14, Issue 4, 2011, Pages 159-166

  Baumbach, J I ^a   Maddula, S ^a   Sommerwerck, U ^b   Besa, V ^b   Kurth, I ^b   Bodeker B ^c   Teschler, H ^b   Freitag, L ^b   Darwiche, K ^b  

^a KIST Europe   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

Author keywords

Adeno carconoma; Bronchoscopic ion mobility spectrometry; Exhaled breath; Lung carcinoma; Squamous cell carcinoma; Volatile biomarker

Indexed keywords

ADENO CARCONOMA; BRONCHOSCOPIC ION MOBILITY SPECTROMETRY; EXHALED BREATH; LUNG CARCINOMA; SQUAMOUS CELL CARCINOMA;

ALCOHOLS; CELLS; ENDOSCOPY; IONS; POLYTETRAFLUOROETHYLENES; SPECTROMETRY; TUMORS; VOLATILE ORGANIC COMPOUNDS;

BIOLOGICAL ORGANS;

EID: 82355190246     PISSN: 14356163     EISSN: 18654584     Source Type: Journal    
DOI: 10.1007/s12127-011-0078-5     Document Type: Article

References (50)

1. Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo RN (1999) Variation in volatile organic compounds in the breath of normal humans. J Chromatogr B Biomed Sci Appl 729: 75-88.
2. Amann A, Corradi M, Mazzone P, Mutti A (2011) Lung cancer biomarkers in exhaled breath. Expert Rev Mol Diagn 11: 207-217. doi: 10. 1586/erm. 10. 112.
3. Amann A, Poupart G, Telser S, Ledochowski M, Schmid A, Mechtcheriakov S (2004) Applications of breath gas analysis in medicine. Int J Mass Spectrom 239: 227-233.
4. Barker M, Hengst M, Schmid J, Buers HJ, Mittermaier B, Klemp D, Koppmann R, Barker M, Hengst M, Schmid J, Buers HJ, Mittermaier B, Klemp D, Koppmann R (2006) Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis. Eur Respir J 27: 929-936, Epub 2006 Feb 2002.
5. Basanta M et al (2010) Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst 135: 315-320. doi: 10. 1039/b916374c.
6. Bunkowski A, Maddula S, Davies AN, Westhoff M, Litterst P, Bödecker B, Baumbach JI (2010) One-year time series of investigations of analytes within human breath using ion mobility spectrometry. Int J Ion Mobility Spectrom 13: 141-148. doi: 10. 1007/s12127-010-0052-7.
7. Cho SM, Kim YJ, Heo GS, Shin S-M (2006) Two-step preconcentration for analysis of exhaled gas of human breath with electronic nose. Sensors and Actuators B: Chemical 117: 50-57.
8. Fens N, Zwinderman AH, van der Schee MP, de Nijs SB, Dijkers E, Roldaan AC, Cheung D, Bel EH, Sterk PJ (2009) Exhaled Breath Profiling Enables Discrimination of Chronic Obstructive Pulmonary Disease and Asthma. Am J Respir Crit Care Med 180: 1076-1082. doi: 10. 1164/rccm. 200906-0939OC.
9. Jünger M, Bödeker B, Baumbach JI (2010) Peak assignment in multi-capillary column - ion mobility spectrometry using comparative studies with gas chromatography - mass spectrometry for exhalred breath analysis. Anal Bioanal Chem 396: 471-482. doi: 10. 1007/s00216-009-3168-z.
10. Machado RF et al (2005) Detection of lung cancer by sensor array analyses of exhaled breath. Am J Respir Crit Care Med 171: 1286-1291. doi: 10. 1164/rccm. 200409-1184OC.
11. Machado Roberto F et al (2005) Detection of lung cancer by sensor array analyses of exhaled breath. Am J Respir Crit Care Med 171: 1286-1291.
12. Martin AN, Farquar GR, Jones AD, Frank M (2010) Human breath analysis: methods for sample collection and reduction of localized background effects. Anal Bioanal Chem 396: 739-750.
13. Mazzone PJ, Hammel J, Dweik R, Na J, Czich C, Laskowski D, Mekhail T (2007) Diagnosis of lung cancer by the analysis of exhaled breath with a colorimetric sensor array. Thorax 62: 565-568. doi: 10. 1136/thx. 2006. 072892.
14. Miekisch W, Hengstenberg A, Kischkel S, Beckmann U, Mieth M, Schubert JK (2010) Construction and Evaluation of a Versatile CO2 Controlled Breath Collection Device. IEEE Sens J 10: 211-215. doi: 10. 1109/jsen. 2009. 2035757.
15. Mieth M, Kischkel S, Schubert JK, Hein D, Miekisch W (2009) Multibed Needle Trap Devices for on Site Sampling and Preconcentration of Volatile Breath Biomarkers. Anal Chem 81: 5851-5857. doi: 10. 1021/ac9009269.
16. Mieth M, Schubert JK, Groger T, Sabel B, Kischkel S, Fuchs P, Hein D, Zimmermann R, Miekisch W (2010) Automated Needle Trap Heart-Cut GC/MS and Needle Trap Comprehensive Two-Dimensional GC/TOF-MS for Breath Gas Analysis in the Clinical Environment. Anal Chem 82: 2541-2551. doi: 10. 1021/ac100061k.
17. Moretti M, Phillips M, Abouzeid A, Cataneo RN, Greenberg J (2004) Increased breath markers of oxidative stress in normal pregnancy and in preeclampsia. Am J of Obstetics and Gynecology 190: 1184-1190.
18. Phillips M, Cataneo RN, Cheema T, Greenberg J (2004) Increased breath biomarkers of oxidative stress in diabetes mellitus. Clin Chim Acta 344: 189-194.
19. Phillips M, Cataneo RN, Greenberg J, Munawar M, Nachnani S, Samtani S (2005) Pilot study of a breath test for volatile organic compounds associated with oral malodor: evidence for the role of oxidative stress. Oral Dis 11(Suppl 1): 32-34.
20. Pleil JD, Lindstrom AB (1997) Exhaled Human Breath Measurement Method for Assessing Exposure to Halogenated Volatile Organic Compounds. Clin Chem 43: 723-730.
21. van Berkel J, Dallinga JW, Moller GM, Godschalk RWL, Moonen EJ, Wouters EFM, van Schooten FJ (2010) A profile of volatile organic compounds in breath discriminates COPD patients from controls. Respir Med 104: 557-563. doi: 10. 1016/j. rmed. 2009. 10. 018.
22. Westhoff M, Litterst P, Freitag L, Urfer W, Bader S, Baumbach JI (2009) Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: results of a pilot study. Thorax 64: 744-748. doi: 10. 1136/thx. 2008. 099465.
23. Buszewski B, Kesy M, Ligor T, Amann A (2007) Human exhaled air analytics: biomarker of diseases. Biomed Chromatogr 21: 553-566.
24. Horvath I, Lazar Z, Gyulai N, Kollai M, Losonczy G (2009) Exhaled biomarkers in lung cancer. Eur Respir J 34: 261-275. doi: 10. 1183/09031936. 00142508.
25. Bunkowski A, Boedeker B, Bader S, Westhoff M, Litterst P, Baumbach JI (2009) MCC/IMS signals in human breath related to sarcoidosis-results of a feasibility study using an automated peak finding procedure. J Breath Res 3, 046001/046001-046001/046010.
26. Westhoff M, Litterst P, Freitag L, Baumbach JI (2007) Ion mobility spectrometry in the diagnosis of Sarcoidosis: Results of a feasibility study. J Physiol Pharmacol 58: 739-751.
27. Baumbach JI, Westhoff M (2006) Ion mobility spectrometry to detect lung cancer and airway infections. Spectroscopy Europe 18: 22-27.
28. Baumbach JI (2006) Process analysis using ion mobility spectrometry. Anal Bioanal Chem 384: 1059-1070.
29. Westhoff M, Litterst P, Maddula S, Bödecker B, Rahmann S, Davies AN, Baumbach JI (2010) Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometry Int. J Ion Mobility Spectrom 13: 131-139.
30. Bödecker B, Davies AN, Maddula S, Baumbach JI (2010) Biomarker validation-room air variation during human breath investigations. Int J Ion Mobility Spectrom 13: 177-184. doi: 10. 1007/s12127-010-0044-7.
31. Maddula S, Blank L, Schmid A, Baumbach JI (2009) Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry. Anal Bioanal Chem 394: 791-800.
32. Bödeker B, Baumbach JI (2009) Analytical Description of IMS-Signals. Int J Ion Mobility Spectrom 12: 103-108. doi: 10. 1007/s12127-009-0024-y.
33. Bödeker B, Vautz W, Baumbach JI (2008) Peak Finding and Referencing in MCC/IMS - Data. Int J Ion Mobility Spectrom 11: 83-88.
34. Bödeker B, Vautz W, Baumbach JI (2008) Peak Comparison in MCC/IMS - Data - Searching for potential biomarkers in human breath data. Int J Ion Mobility Spectrom 11: 89-93.
35. Bödeker B, Vautz W, Baumbach JI (2008) Visualisation of MCC/IMS - Data. Int J Ion Mobility Spectrom 11: 77-82.
36. Hu Y, Qiu Y, Chen E, Ying K, Yu J, Wang P (2010) Determination of volatile organic compounds in lung cancer cell lines and lung cancer tissue. Zhejiang Daxue Xuebao, Yixueban 39: 278-284. doi: 10. 3785/j. issn. 1008-9292. 2010. 03. 011.
37. Gaspar EM, Lucena AF, Duro CJ, Chaves NH (2009) Organic metabolites in exhaled human breath - A multivariate approach for identification of biomarkers in lung disorders. J. Chromatogr., A 1216, 2749-2756, doi: 10. 1016/j. chroma. 2008. 10. 125.
38. Phillips M, Cataneo RN, Sounders C, Hope P, Schmitt P, Wai J (2010) Volatile biomarkers in the breath of women with breast cancer. J Breath Res 4. doi: 10. 1088/1752-7155/4/2/026003.
39. van Berkel JJBN, Dallinga JW, Moeller GM, Godschalk RWL, Moonen E, Wouters EFM, van Schooten FJ (2008) Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air. J Chromatogr B: Anal Technol Biomed Life Sci 861: 101-107.
40. Sanchez JM, Sacks RD (2006) Development of a Multibed Sorption Trap, Comprehensive Two-Dimensional Gas Chromatography, and Time-of-Flight Mass Spectrometry System for the Analysis of Volatile Organic Compounds in Human Breath. Anal Chem 78: 3046-3054.
41. Muehlberger F, Streibel T, Wieser J, Ulrich A, Zimmermann R (2005) Single Photon Ionization Time-of-Flight Mass Spectrometry with a Pulsed Electron Beam Pumped Excimer VUV Lamp for On-Line Gas Analysis: Setup and First Results on Cigarette Smoke and Human Breath. Anal Chem 77: 7408-7414.
42. Buszewski B, Ulanowska A, Ligor T, Denderz N, Amann A (2009) Analysis of exhaled breath from smokers, passive smokers and non-smokers by solid-phase microextraction gas chromatography/mass spectrometry. Biomed Chromatogr 23: 551-556.
43. Zechman JM, Aldinger S, Labows JN Jr (1986) Characterization of pathogenic bacteria by automated headspace concentration-gas chromatography. J Chromatogr 377: 49-57.
44. Ruzsanyi V, Baumbach JI, Eiceman GA (2003) Detection of the mold markers using ion mobility spectrometry. Int J Ion Mobility Spectrom 6: 53-57.
45. Bajtarevic A et al (2009) Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer9, doi: 10. 1186/1471-2407-9-348.
46. Ulanowska A, Ligor M, Amann A, Buszewski B (2008) Determination of volatile organic compounds in exhaled breath by ion mobility spectrometry. Chem Anal (Warsaw, Pol) 53: 953-965.
47. Basanta M, Koimtzis T, Singh D, Wilson I, Thomas CLP (2007) An adaptive breath sampler for use with human subjects with an impaired respiratory function. Analyst (Cambridge, U K 132: 153-163.
48. Fuchs P, Loeseken C, Schubert JK, Miekisch W (2010) Breath gas aldehydes as biomarkers of lung cancer. Int J Cancer 126: 2663-2670.
49. O'Neill HJ, Gordon SM, O'Neill MH, Gibbons RD, Szidon JP (1988) A computerized classification technique for screening for the presence of breath biomarkers in lung cancer. Clin Chem 34: 1613-1618.
50. Corradi M, Rubinstein I, Andreoli R, Manini P, Caglieri A, Poli D, Alinovi R, Mutti A (2003) Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 167: 1380-1386.