Point-of-care (POC) diagnosis of bacterial vaginosis (BV) using VGTest™ ion mobility spectrometry (IMS) in a routine ambulatory care gynecology clinic

Archives of Gynecology and Obstetrics

Volumn 292, Issue 2, 2015, Pages 355-362

  Blankenstein, T ^a   Lytton, S D ^b   Leidl, B ^a   Atweh, E ^c   Friese, K ^b   Mylonas, I ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b SeraDiaLogistics   (Germany)

^c 3QBD Ltd   (Israel)

Author keywords

Bacterial vaginosis; Diagnosis; Ion mobility spectrometer; Point of care testing

Indexed keywords

BIOGENIC AMINE; CADAVERINE; PUTRESCINE; TRIMETHYLAMINE; METHYLAMINE;

ADULT; AGE DISTRIBUTION; AGED; AMBULATORY CARE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL COLONIZATION; CANDIDA; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ESCHERICHIA COLI; FALSE NEGATIVE RESULT; FEMALE; FOLLOW UP; GARDNERELLA; HUMAN; ION MOBILITY SPECTROMETRY; KLEBSIELLA PNEUMONIAE; LINEAR REGRESSION ANALYSIS; POINT OF CARE TESTING; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SPECTROMETER; VAGINA DISCHARGE; VAGINITIS; BODY FLUID; HOSPITAL INFORMATION SYSTEM; MICROBIOLOGY; MIDDLE AGED; PROCEDURES; SPECTROSCOPY; VAGINOSIS, BACTERIAL;

ADULT; AMBULATORY CARE; BODY FLUIDS; CADAVERINE; FEMALE; HUMANS; METHYLAMINES; MIDDLE AGED; POINT-OF-CARE SYSTEMS; PUTRESCINE; SENSITIVITY AND SPECIFICITY; SPECTRUM ANALYSIS; VAGINOSIS, BACTERIAL;

EID: 84930539189     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-014-3613-x     Document Type: Article

References (31)

1. Gardner HL, Dukes CD (1954) New etiologic agent in nonspecific bacterial vaginitis. Science (New York, NY) 120(3125):853
2. Cohrssen A, Anderson M, Merrill A, McKee D (2005) Reliability of the whiff test in clinical practice. J Am Board Fam Pract/Am Board Fam Pract 18(6):561–562
3. Mylonas I, Bergauer F (2011) Diagnosis of vaginal discharge by wet mount microscopy: a simple and underrated method. Obstet Gynecol Surv 66(6):359–368. doi:10.1097/OGX.0b013e31822bdf31
4. Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK (1983) Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 74(1):14–22
5. Forsum U, Hallen A, Larsson PG (2005) Bacterial vaginosis—a laboratory and clinical diagnostics enigma. APMIS 113(3):153–161. doi:10.1111/j.1600-0463.2005.apm1130301.x
6. Turovskiy Y, Sutyak Noll K, Chikindas ML (2011) The aetiology of bacterial vaginosis. J Appl Microbiol 110(5):1105–1128. doi:10.1111/j.1365-2672.2011.04977.x
7. Donders G (2010) Diagnosis and management of bacterial vaginosis and other types of abnormal vaginal bacterial flora: a review. Obstet Gynecol Surv 65(7):462–473. doi:10.1097/OGX.0b013e3181e09621
8. Donders GG, Vereecken A, Dekeersmaecker A, Van Bulck B, Spitz B (2000) Wet mount microscopy reflects functional vaginal lactobacillary flora better than Gram stain. J Clin Pathol 53(4):308–313
9. Hale LP, Swidsinski A, Mendling W (2006) Bacteria associated with bacterial vaginosis. N Engl J Med 354(2):202–203. doi:10.1056/NEJMc053336 (author reply 202–203)
10. Gray JW, Milner PJ, Edwards EH, Daniels JP, Khan KS (2012) Feasibility of using microbiology diagnostic tests of moderate or high complexity at the point-of-care in a delivery suite. J Obstet Gynaecol 32(5):458–460. doi:10.3109/01443615.2012.673034
11. Hoyme UB, Saling E (2004) Efficient prematurity prevention is possible by pH-self measurement and immediate therapy of threatening ascending infection. Eur J Obstet Gynecol Reprod Biol 115(2):148–153. doi:10.1016/j.ejogrb.2004.02.038
12. Verstraelen H, Swidsinski A (2013) The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment. Curr Opin Infect Dis 26(1):86–89. doi:10.1097/QCO.0b013e32835c20cd
13. Parma M, Dindelli M, Caputo L, Redaelli A, Quaranta L, Candiani M (2013) The role of vaginal Lactobacillus rhamnosus (Normogin(R)) in preventing bacterial vaginosis in women with history of recurrences, undergoing surgical menopause: a prospective pilot study. Eur Rev Med Pharmacol Sci 17(10):1399–1403
14. Bilardi JE, Walker S, Temple-Smith M, McNair R, Mooney-Somers J, Bellhouse C, Fairley CK, Chen MY, Bradshaw C (2013) The burden of bacterial vaginosis: women’s experience of the physical, emotional, sexual and social impact of living with recurrent bacterial vaginosis. PLoS One 8(9):e74378. doi:10.1371/journal.pone.0074378
15. Mastromarino P, Vitali B, Mosca L (2013) Bacterial vaginosis: a review on clinical trials with probiotics. The new microbiologica 36(3):229–238
16. Junger M, Vautz W, Kuhns M, Hofmann L, Ulbricht S, Baumbach JI, Quintel M, Perl T (2012) Ion mobility spectrometry for microbial volatile organic compounds: a new identification tool for human pathogenic bacteria. Appl Microbiol Biotechnol 93(6):2603–2614. doi:10.1007/s00253-012-3924-4
17. Hashemian Z, Mardihallaj A, Khayamian T (2010) Analysis of biogenic amines using corona discharge ion mobility spectrometry. Talanta 81(3):1081–1087. doi:10.1016/j.talanta.2010.02.001
18. Sobel JD, Karpas Z, Lorber A (2012) Diagnosing vaginal infections through measurement of biogenic amines by ion mobility spectrometry. Eur J Obstet Gynecol Reprod Biol 163(1):81–84. doi:10.1016/j.ejogrb.2012.03.022
19. Ma B, Forney LJ, Ravel J (2012) Vaginal microbiome: rethinking health and disease. Annu Rev Microbiol 66:371–389. doi:10.1146/annurev-micro-092611-150157
20. Swidsinski A, Verstraelen H, Loening-Baucke V, Swidsinski S, Mendling W, Halwani Z (2013) Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One 8(1):e53997. doi:10.1371/journal.pone.0053997
21. Yoshida M, Kashiwagi K, Shigemasa A, Taniguchi S, Yamamoto K, Makinoshima H, Ishihama A, Igarashi K (2004) A unifying model for the role of polyamines in bacterial cell growth, the polyamine modulon. J Biol Chem 279(44):46008–46013. doi:10.1074/jbc.M404393200
22. Chen KC, Forsyth PS, Buchanan TM, Holmes KK (1979) Amine content of vaginal fluid from untreated and treated patients with non-specific vaginitis. J Clin Invest 63(5):828–835. doi:10.1172/JCI109382
23. Wolrath H, Forsum U, Larsson PG, Boren H (2001) Analysis of bacterial vaginosis-related amines in vaginal fluid by gas chromatography and mass spectrometry. J Clin Microbiol 39(11):4026–4031. doi:10.1128/jcm.39.11.4026-4031.2001
24. Wolrath H, Boren H, Hallen A, Forsum U (2002) Trimethylamine content in vaginal secretion and its relation to bacterial vaginosis. APMIS 110(11):819–824
25. Wolrath H, Stahlbom B, Hallen A, Forsum U (2005) Trimethylamine and trimethylamine oxide levels in normal women and women with bacterial vaginosis reflect a local metabolism in vaginal secretion as compared to urine. APMIS 113(7–8):513–516. doi:10.1111/j.1600-0463.2005.apm_175.x
26. Armenta S, Alcala M, Blanco M (2011) A review of recent, unconventional applications of ion mobility spectrometry (IMS). Anal Chim Acta 703(2):114–123. doi:10.1016/j.aca.2011.07.021
27. Chico RM, Mayaud P, Ariti C, Mabey D, Ronsmans C, Chandramohan D (2012) Prevalence of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review. JAMA 307(19):2079–2086. doi:10.1001/jama.2012.3428
28. Eschenbach DA, Gravett MG, Chen KC, Hoyme UB, Holmes KK (1984) Bacterial vaginosis during pregnancy. An association with prematurity and postpartum complications. Scand J Urol Nephrol Suppl 86:213–222
29. Mead PB (1993) Epidemiology of bacterial vaginosis. Am J Obstet Gynecol 169(2 Pt 2):446–449
30. Kenyon C, Colebunders R, Crucitti T (2013) The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol 209(6):505–523. doi:10.1016/j.ajog.2013.05.006
31. Yeoman CJ, Thomas SM, Berg-Miller ME, Ulanov AV, Torralba M, Lucas S, Gillis M, Cregger M, Gomez A, Ho M, Leigh SR, Stumpf R, Creedon DJ, Smith MA, Weisbaum JS, Nelson KE, Wilson BA, White BA (2013) A Multi-omic systems-based approach reveals metabolic markers of bacterial vaginosis and insight into the disease. PLOS One 8(2):e5611.1–18