Detection and validation of volatile metabolic patterns over different strains of two human pathogenic bacteria during their growth in a complex medium using multi-capillary column-ion mobility spectrometry (MCC-IMS)

Applied Microbiology and Biotechnology

Volumn 97, Issue 8, 2013, Pages 3665-3676

  Kunze, Nils ^a   Göpel, Julia ^a   Kuhns, Martin ^a   Jünger, Melanie ^a   Quintel, Michael ^a   Perl, Thorsten ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Bacteria; Escherichia coli; Headspace analyses; Identification; Pseudomonas aeruginosa

Indexed keywords

COST-EFFECTIVE METHODS; HEADSPACE ANALYSIS; METABOLIC PATTERNS; MICROBIAL CULTURE; PATHOGENIC BACTERIUM; PSEUDOMONAS AERUGINOSA; SIGNAL INTENSITIES; VOLATILE ORGANIC COMPOUNDS (VOCS);

ESCHERICHIA COLI; IDENTIFICATION (CONTROL SYSTEMS); ION MOBILITY SPECTROMETERS; SPECTROMETRY; VOLATILE ORGANIC COMPOUNDS;

BACTERIA;

2 ETHYLHEXANOL; ACETONE; ALCOHOL; DECANOL; DODECANE; INDOLE DERIVATIVE; OCTANOL; VOLATILE ORGANIC COMPOUND;

BACTERIUM; DIFFERENTIATION; METABOLISM; MOBILITY; PATHOGEN; SPECTROMETRY; STRAIN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CONTROLLED STUDY; CULTURE MEDIUM; ESCHERICHIA COLI; GROWTH CURVE; HYPOTHESIS; ION MOBILITY SPECTROMETRY; MULTI CAPILLARY ION MOBILITY SPECTROMETRY; NONHUMAN; PSEUDOMONAS AERUGINOSA; SPECIES DIFFERENCE; STRAIN DIFFERENCE;

BACTERIOLOGICAL TECHNIQUES; ESCHERICHIA COLI; HUMANS; PSEUDOMONAS AERUGINOSA; SPECTRUM ANALYSIS; VOLATILE ORGANIC COMPOUNDS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FUNGI; PSEUDOMONAS AERUGINOSA;

EID: 84876691187     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-4762-8     Document Type: Article

References (27)

1. Baumbach JI (2009) Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath. J Breath Res 3(3):034001. doi: 10.1088/1752-7155/3/3/034001
2. Borsdorf H, Eiceman GA (2006) Ion mobility spectrometry: principles and applications. Appl Spectrosc Rev 41(4):323-375. doi: 10.1080/05704920600663469
3. Chaim W, Karpas Z, Lorber A (2003) New technology for diagnosis of bacterial vaginosis. Eur J Obstet Gynecol Reprod Biol 111(1):83-87
4. Fenollar F, Goncalves A, Esterni B, Azza S, Habib G, Borg JP, Raoult D (2006) A serum protein signature with high diagnostic value in bacterial endocarditis: results from a study based on surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. J Infect Dis 194(10):1356-1366. doi: 10.1086/508429
5. Garnacho-Montero J, Aldabo-Pallas T, Garnacho-Montero C, Cayuela A, Jimenez R, Barroso S, Ortiz-Leyba C (2006) Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. Crit Care 10(4):R111. doi: 10.1186/cc4995
6. Houck PM, Bratzler DW, Nsa W, Ma A, Bartlett JG (2004) Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med 164(6):637-644. doi: 10.1001/archinte.164.6.637
7. Jünger M, Vautz W, Kuhns M, Hofmann L, Ulbricht S, Baumbach JI, Quintel M, Perl T (2012) Ion mobility spectrometry for microbial volatile organic compounds: a new identification tool for human pathogenic bacteria. Appl Microbiol Biotechnol 93(6):2603-2614. doi: 10.1007/s00253-012-3924-4
8. Kai M, Haustein M, Molina F, Petri A, Scholz B, Piechulla B (2009) Bacterial volatiles and their action potential. Appl Microbiol Biotechnol 81(6):1001-1012. doi: 10.1007/s00253-008-1760-3
9. Kollef MH, Sherman G, Ward S, Fraser VJ (1999) Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115(2):462-474
10. Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, Dodek P, Wood G, Kumar A, Simon D, Peters C, Ahsan M, Chateau D (2009) Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 136(5):1237-1248. doi: 10.1378/chest.09-0087
11. Mach KE, Du CB, Phull H, Haake DA, Shih MC, Baron EJ, Liao JC (2009) Multiplex pathogen identification for polymicrobial urinary tract infections using biosensor technology: a prospective clinical study. J Urol 182(6):2735-2741. doi: 10.1016/j.juro.2009.08.028
12. Maddula S, Blank LM, Schmid A, Baumbach JI (2009) Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry. Anal Bioanal Chem 394(3):791-800. doi: 10.1007/s00216-009-2758-0
13. Martino PD, Fursy R, Bret L, Sundararaju B, Phillips RS (2003) Indole can act as an extracellular signal to regulate biofilm formation of Escherichia coli and other indole-producing bacteria. Can J Microbiol 49(7):443-449. doi: 10.1139/w03-056
14. O'Hara M, Mayhew CA (2009) A preliminary comparison of volatile organic compounds in the headspace of cultures of Staphylococcus aureus grown in nutrient, dextrose and brain heart bovine broths measured using a proton transfer reaction mass spectrometer. J Breath Res 3(2):027001. doi: 10.1088/1752-7155/3/2/027001
15. Perl T, Bodeker B, Jünger M, Nolte J, Vautz W (2010) Alignment of retention time obtained from multicapillary column gas chromatography used for VOC analysis with ion mobility spectrometry. Anal Bioanal Chem 397(6):2385-2394. doi: 10.1007/s00216-010-3798-1
16. Perl T, Jünger M, Vautz W, Nolte J, Kuhns M, Borg-von Zepelin M, Quintel M (2011) Detection of characteristic metabolites of Aspergillus fumigatus and Candida species using ion mobility spectrometry-metabolic profiling by volatile organic compounds. Mycoses 54(6):e828-e837. doi: 10.1111/j.1439-0507.2011.02037.x
17. Ruzsanyi V, Baumbach JI, Sielemann S, Litterst P, Westhoff M, Freitag L (2005) Detection of human metabolites using multi-capillary columns coupled to ion mobility spectrometers. J Chromatography A 1084(1-2):145-151
18. Schulz S, Dickschat JS (2007) Bacterial volatiles: the smell of small organisms. Natural Product Reports 24(4):814-842. doi: 10.1039/b507392h
19. Shnayderman M, Mansfield B, Yip P, Clark HA, Krebs MD, Cohen SJ, Zeskind JE, Ryan ET, Dorkin HL, Callahan MV, Stair TO, Gelfand JA, Gill CJ, Hitt B, Davis CE (2005) Species-specific bacteria identification using differential mobility spectrometry and bioinformatics pattern recognition. Anal Chem 77(18):5930-5937. doi: 10.1021/ac050348i
20. Smith GB, Eiceman GA, Walsh MK, Critz SA, Andazola E, Ortega E, Cadena F (1997) Detection of Salmonella typhimurium by hand-held ion mobility spectrometer: a quantitative assessment of response characteristics. Field Anal Chem Tech 1(4):213-226
21. Snyder AP, Shoff DB, Eiceman GA, Blyth DA, Parsons JA (1991) Detection of bacteria by ion mobility spectrometry. Anal Chem 63(5):526-529
22. Stotzky G, Schenck S (1976) Volatile organic compounds and microorganisms. CRC Crit Rev Microbiol 4(4):333-382
23. van Veen SQ, Claas EC, Kuijper EJ (2010) High-throughput identification of bacteria and yeast by matrix-assisted laser desorption ionization-time of flight mass spectrometry in conventional medical microbiology laboratories. J Clin Microbiol 48(3):900-907. doi: 10.1128/JCM.02071-09
24. Vautz W, Bödeker B, Baumbach JI, Bader S, Westhoff M, Perl T (2009) An implementable approach to obtain reproducible reduced ion mobility. Inter J for Ion Mobility Spectrometry 12(2):47-57. doi: 10.1007/s12127-009-0018-9
25. Yoo SM, Lee SY (2008) Diagnosis of pathogens using DNA microarray. Recent Patents on Biotechnology 2(2):124-129
26. Zhu LX, Zhang ZW, Wang C, Yang HW, Jiang D, Zhang Q, Mitchelson K, Cheng J (2007) Use of a DNA microarray for simultaneous detection of antibiotic resistance genes among staphylococcal clinical isolates. J Clin Microbiol 45(11):3514-3521. doi: 10.1128/JCM.02340-06
27. Zoller HF, Clark WM (1921) The production of volatile fatty acids by bacteria of the dysentery group. J Gen Physiol 3(3):325-330