메뉴 건너뛰기




Volumn 8, Issue 10, 2009, Pages 4876-4884

MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections

Author keywords

Formalin fixed, paraffin embedded; Grp78; Imaging; Ion mobility separation; MALDI; Pancreatic cancer

Indexed keywords

FORMALDEHYDE; GLUCOSE REGULATED PROTEIN 78; TUMOR MARKER;

EID: 70349974835     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr900522m     Document Type: Article
Times cited : (109)

References (45)
  • 2
    • 33846682590 scopus 로고    scopus 로고
    • Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma
    • DOI 10.1158/0008-5472.CAN-06-1567
    • Aghdassi, A.; Phillips, P.; Dudeja, V.; Dhaulakhandi, D.; Sharif, R.; Dawra, R.; Lerch, M. M.; Saluja, A. Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma. Cancer Res. 2007, 67, 616-625. (Pubitemid 46192200)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 616-625
    • Aghdassi, A.1    Phillips, P.2    Dudeja, V.3    Dhaulakhandi, D.4    Sharif, R.5    Dawra, R.6    Lerch, M.M.7    Saluja, A.8
  • 3
    • 0031793127 scopus 로고    scopus 로고
    • Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology
    • DOI 10.1016/S0163-7258(98)00028-X, PII S016372589800028X
    • Kiang, J. G.; Tsokos, G. C. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol. Ther. 1998, 80, 183-201. (Pubitemid 28498227)
    • (1998) Pharmacology and Therapeutics , vol.80 , Issue.2 , pp. 183-201
    • Kiang, J.G.1    Tsokos, G.C.2
  • 4
    • 34248571826 scopus 로고    scopus 로고
    • GRP78 induction in cancer: Therapeutic and prognostic implications
    • DOI 10.1158/0008-5472.CAN-07-0325
    • Lee, A. S. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res. 2007, 67, 3496-3499. (Pubitemid 46762126)
    • (2007) Cancer Research , vol.67 , Issue.8 , pp. 3496-3499
    • Lee, A.S.1
  • 5
    • 53049101039 scopus 로고    scopus 로고
    • Triplex profiling of functionally distinct chaperones (ERp29/PDI/BiP) reveals marked heterogeneity of the endoplasmic reticulum proteome in cancer
    • Shnyder, S. D.; Mangum, J. E.; Hubbard, M. J. Triplex profiling of functionally distinct chaperones (ERp29/PDI/BiP) reveals marked heterogeneity of the endoplasmic reticulum proteome in cancer. J. Proteome Res. 2008, 7, 3364-3372.
    • (2008) J. Proteome Res. , vol.7 , pp. 3364-3372
    • Shnyder, S.D.1    Mangum, J.E.2    Hubbard, M.J.3
  • 6
    • 4544255170 scopus 로고    scopus 로고
    • Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
    • DOI 10.1016/j.ccr.2004.08.018, PII S1535610804002405
    • Arap, M. A.; Lahdenranta, J.; Mintz, P. J.; Hajitou, A.; Sarkis, A. S.; Arap, W.; Pasqualini, R. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell 2004, 6, 275-284. (Pubitemid 39222040)
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 275-284
    • Arap, M.A.1    Lahdenranta, J.2    Mintz, P.J.3    Hajitou, A.4    Sarkis, A.S.5    Arap, W.6    Pasqualini, R.7
  • 7
    • 33947402280 scopus 로고    scopus 로고
    • The unfolded protein response and cancer: A brighter future unfolding?
    • DOI 10.1007/s00109-006-0150-5
    • Scriven, P.; Brown, N. J.; Pockley, A. G.; Wyld, L. The unfolded protein response and cancer: a brighter future unfolding. J. Mol. Med. 2007, 85, 331-341. (Pubitemid 46452259)
    • (2007) Journal of Molecular Medicine , vol.85 , Issue.4 , pp. 331-341
    • Scriven, P.1    Brown, N.J.2    Pockley, A.G.3    Wyld, L.4
  • 8
    • 0026843954 scopus 로고
    • Mammalian stress response: Induction of the glucose-regulated protein family
    • Lee, A. S. Mammalian stress response: induction of the glucose-regulated protein family. Curr. Opin. Cell Biol. 1992, 4, 267-273.
    • (1992) Curr. Opin. Cell Biol. , vol.4 , pp. 267-273
    • Lee, A.S.1
  • 9
    • 28844470269 scopus 로고    scopus 로고
    • The unfolded protein response: A novel component of the hypoxic stress response in tumors
    • DOI 10.1158/1541-7786.MCR-05-0221
    • Feldman, D. E.; Chauhan, V.; Koong, A. C. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol. Cancer Res. 2005, 3, 597-605. (Pubitemid 41780915)
    • (2005) Molecular Cancer Research , vol.3 , Issue.11 , pp. 597-605
    • Feldman, D.E.1    Chauhan, V.2    Koong, A.C.3
  • 10
    • 0000166773 scopus 로고
    • Complex regulation of heat shockand glucose-responsive genes in human cells
    • Watowich, S. S.; Morimoto, R. I. Complex regulation of heat shockand glucose-responsive genes in human cells. Mol. Cell. Biol. 1988, 8, 393-405.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 393-405
    • Watowich, S.S.1    Morimoto, R.I.2
  • 11
    • 33748076770 scopus 로고    scopus 로고
    • GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer
    • DOI 10.1158/0008-5472.CAN-06-1660
    • Lee, E.; Nichols, P.; Spicer, D.; Groshen, S.; Yu, M. C.; Lee, A. S. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res. 2006, 66, 7849-7853. (Pubitemid 44299145)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 7849-7853
    • Lee, E.1    Nichols, P.2    Spicer, D.3    Groshen, S.4    Yu, M.C.5    Lee, A.S.6
  • 13
    • 41449094913 scopus 로고    scopus 로고
    • Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus
    • Langer, R.; Feith, M.; Siewert, J. R.; Wester, H. J.; Hoefler, H. Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC Cancer 2008, 8, 70.
    • (2008) BMC Cancer , vol.8 , pp. 70
    • Langer, R.1    Feith, M.2    Siewert, J.R.3    Wester, H.J.4    Hoefler, H.5
  • 14
  • 15
    • 32944457371 scopus 로고    scopus 로고
    • Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values
    • Luk, J. M.; Lam, C. T.; Siu, A. F.; Lam, B. Y.; Ng, I. O.; Hu, M. Y.; Che, C. M.; Fan, S. T. Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values. Proteomics 2006, 6, 1049-1057.
    • (2006) Proteomics , vol.6 , pp. 1049-1057
    • Luk, J.M.1    Lam, C.T.2    Siu, A.F.3    Lam, B.Y.4    Ng, I.O.5    Hu, M.Y.6    Che, C.M.7    Fan, S.T.8
  • 16
    • 28744450158 scopus 로고    scopus 로고
    • Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance
    • DOI 10.1016/j.cdp.2005.09.010, PII S0361090X05001510
    • Wang, Q.; He, Z.; Zhang, J.; Wang, Y.; Wang, T.; Tong, S.; Wang, L.; Wang, S.; Chen, Y. Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance. Cancer Detect. Prev. 2005, 29, 544-551. (Pubitemid 41758494)
    • (2005) Cancer Detection and Prevention , vol.29 , Issue.6 , pp. 544-551
    • Wang, Q.1    He, Z.2    Zhang, J.3    Wang, Y.4    Wang, T.5    Tong, S.6    Wang, L.7    Wang, S.8    Chen, Y.9
  • 17
    • 0031304362 scopus 로고    scopus 로고
    • Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
    • Caprioli, R. M.; Farmer, T. B.; Gile, J. Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 1997, 69, 4751-4760. (Pubitemid 127485123)
    • (1997) Analytical Chemistry , vol.69 , Issue.23 , pp. 4751-4760
    • Caprioli, R.M.1    Farmer, T.B.2    Gile, J.3
  • 18
    • 33746672483 scopus 로고    scopus 로고
    • Molecular imaging of thin mammalian tissue sections by mass spectrometry
    • DOI 10.1016/j.copbio.2006.06.002, PII S0958166906000863
    • Chaurand, P.; Cornett, D. S.; Caprioli, R. M. Molecular imaging of thin mammalian tissue sections by mass spectrometry. Curr. Opin. Biotechnol. 2006, 17, 431-436. (Pubitemid 44163451)
    • (2006) Current Opinion in Biotechnology , vol.17 , Issue.4 , pp. 431-436
    • Chaurand, P.1    Cornett, D.S.2    Caprioli, R.M.3
  • 19
    • 0242608321 scopus 로고    scopus 로고
    • Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry
    • DOI 10.1002/pmic.200300474
    • Chaurand, P.; Fouchécourt, S.; DaGue, B. B.; Xu, B. J.; Reyzer, M. L.; Orgebin-Crist, M.; Caprioli, R. M. Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry. Proteomics 2003, 3, 2221-2239. (Pubitemid 37414087)
    • (2003) Proteomics , vol.3 , Issue.11 , pp. 2221-2239
    • Chaurand, P.1    Fouchecourt, S.2    Dague, B.B.3    Xu, B.J.4    Reyzer, M.L.5    Orgebin-Crist, M.-C.6    Caprioli, R.M.7
  • 21
    • 33847657120 scopus 로고    scopus 로고
    • Imaging Matrix Assisted Laser Desorption Ionization Mass Spectrometry: A technique to map plant metabolites within tissues at high spatial resolution
    • Burrell, M.; Earnshaw, C.; Clench, M. Imaging Matrix Assisted Laser Desorption Ionization Mass Spectrometry: a technique to map plant metabolites within tissues at high spatial resolution. J. Exp. Bot. 2007, 58, 757-763.
    • (2007) J. Exp. Bot. , vol.58 , pp. 757-763
    • Burrell, M.1    Earnshaw, C.2    Clench, M.3
  • 22
    • 45149130891 scopus 로고    scopus 로고
    • Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging
    • Djidja, M.; Carolan, V.; Loadman, P. M.; Clench, M. R. Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid Commun. Mass Spectrom. 2008, 22, 1615-1618.
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 1615-1618
    • Djidja, M.1    Carolan, V.2    Loadman, P.M.3    Clench, M.R.4
  • 23
    • 45149121677 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption/ionisation mass spectrometry imaging of lipids in rat brain tissue with integrated unsupervised and supervised multivariant statistical analysis
    • Trim, P. J.; Atkinson, S. J.; Princivalle, A. P.; Marshall, P. S.; West, A.; Clench, M. R. Matrix-assisted laser desorption/ionisation mass spectrometry imaging of lipids in rat brain tissue with integrated unsupervised and supervised multivariant statistical analysis. Rapid Commun. Mass. Spectrom. 2008, 22, 1503-1509.
    • (2008) Rapid Commun. Mass. Spectrom. , vol.22 , pp. 1503-1509
    • Trim, P.J.1    Atkinson, S.J.2    Princivalle, A.P.3    Marshall, P.S.4    West, A.5    Clench, M.R.6
  • 24
    • 45749088580 scopus 로고    scopus 로고
    • Tissue imaging using MALDI-MS: A new frontier of histopathology proteomics
    • DOI 10.1586/14789450.5.3.413
    • Fournier, I.; Wisztorski, M.; Salzet, M. Tissue imaging using MALDI-MS: a new frontier of histopathology proteomics. Expert Rev Proteomics 2008, 5, 413-424. (Pubitemid 351871117)
    • (2008) Expert Review of Proteomics , vol.5 , Issue.3 , pp. 413-424
    • Fournier, I.1    Wisztorski, M.2    Salzet, M.3
  • 25
    • 1042290316 scopus 로고    scopus 로고
    • Protein profiling in brain tumors using mass spectrometry: Feasibility of a new technique for the analysis of protein expression
    • Schwartz, S. A.; Weil, R. J.; Johnson, M. D.; Toms, S. A.; Caprioli, R. M. Protein profiling in brain tumors using mass spectrometry: feasibility of a new technique for the analysis of protein expression. Clin. Cancer Res. 2004, 10, 981-987.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 981-987
    • Schwartz, S.A.1    Weil, R.J.2    Johnson, M.D.3    Toms, S.A.4    Caprioli, R.M.5
  • 26
    • 0035491863 scopus 로고    scopus 로고
    • Profiling proteins from azoxymethane-induced colon tumors at the molecular level by matrix-assisted laser desorption/ionization mass spectrometry
    • Chaurand, P.; DaGue, B. B.; Pearsall, R. S.; Threadgill, D. W.; Caprioli, R. M. Profiling proteins from azoxymethane-induced colon tumors at the molecular level by matrix-assisted laser desorption/ionization mass spectrometry. Proteomics 2001, 1, 1320-1326. (Pubitemid 33587887)
    • (2001) Proteomics , vol.1 , Issue.10 , pp. 1320-1326
    • Chaurand, P.1    Dague, B.B.2    Pearsall, R.S.3    Threadgill, D.W.4    Caprioli, R.M.5
  • 27
  • 29
    • 34248230245 scopus 로고    scopus 로고
    • Direct analysis and MALDI imaging of formalin-fixed, paraffin-embedded tissue sections
    • DOI 10.1021/pr060549i
    • Lemaire, R.; Desmons, A.; Tabet, J. C.; Day, R.; Salzet, M.; Fournier, I. Direct analysis and MALDI imaging of formalin-fixed, paraffin-embedded tissue sections. J. Proteome Res. 2007, 6, 1295-1305. (Pubitemid 46724026)
    • (2007) Journal of Proteome Research , vol.6 , Issue.4 , pp. 1295-1305
    • Lemaire, R.1    Desmons, A.2    Tabet, J.C.3    Day, R.4    Salzet, M.5    Fournier, I.6
  • 30
    • 33846838319 scopus 로고    scopus 로고
    • A Novel Approach to in situ Proteome Analysis Using Chemical Inkjet Printing Technology and MALDI-QIT-TOF Tandem Mass Spectrometer
    • Shimma, S.; Furuta, M.; Ichimura, K.; Yoshida, Y.; Setou, M. A Novel Approach to in situ Proteome Analysis Using Chemical Inkjet Printing Technology and MALDI-QIT-TOF Tandem Mass Spectrometer. J. Mass Spectrom. Soc. Jpn. 2006, 54, 133-140.
    • (2006) J. Mass Spectrom. Soc. Jpn. , vol.54 , pp. 133-140
    • Shimma, S.1    Furuta, M.2    Ichimura, K.3    Yoshida, Y.4    Setou, M.5
  • 31
    • 33847018143 scopus 로고    scopus 로고
    • Identification of proteins directly from tissue: In situ tryptic digestions coupled with imaging mass spectrometry
    • Groseclose, M. R.; Andersson, M.; Hardesty, W. M.; Caprioli, R. M. Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry. J. Mass Spectrom. 2007, 42, 254-262.
    • (2007) J. Mass Spectrom. , vol.42 , pp. 254-262
    • Groseclose, M.R.1    Andersson, M.2    Hardesty, W.M.3    Caprioli, R.M.4
  • 32
    • 44449141537 scopus 로고    scopus 로고
    • MALDI imaging of formalin-fixed paraffin-embedded tissues: Application to model animals of Parkinson disease for biomarker hunting
    • Stauber, J.; Lemaire, R.; Franck, J.; Bonnel, D.; Croix, D.; Day, R.; Wisztorski, M.; Fournier, I.; Salzet, M. MALDI imaging of formalin-fixed paraffin-embedded tissues: application to model animals of Parkinson disease for biomarker hunting. J. Proteome Res. 2008, 7, 969-978.
    • (2008) J. Proteome Res. , vol.7 , pp. 969-978
    • Stauber, J.1    Lemaire, R.2    Franck, J.3    Bonnel, D.4    Croix, D.5    Day, R.6    Wisztorski, M.7    Fournier, I.8    Salzet, M.9
  • 33
    • 53549111100 scopus 로고    scopus 로고
    • High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry
    • Groseclose, M. R.; Massion, P. P.; Chaurand, P.; Caprioli, R. M. High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics 2008, 8, 3715-3724.
    • (2008) Proteomics , vol.8 , pp. 3715-3724
    • Groseclose, M.R.1    Massion, P.P.2    Chaurand, P.3    Caprioli, R.M.4
  • 34
    • 53549127586 scopus 로고    scopus 로고
    • Protein unlocking procedures of formalin-fixed paraffin-embedded tissues: Application to MALDI-TOF imaging MS investigations
    • Ronci, M.; Bonanno, E.; Colantoni, A.; Pieroni, L.; Di Ilio, C.; Spagnoli, L. G.; Federici, G.; Urbani, A. Protein unlocking procedures of formalin-fixed paraffin-embedded tissues: application to MALDI-TOF imaging MS investigations. Proteomics 2008, 8, 3702-3714.
    • (2008) Proteomics , vol.8 , pp. 3702-3714
    • Ronci, M.1    Bonanno, E.2    Colantoni, A.3    Pieroni, L.4    Di Ilio, C.5    Spagnoli, L.G.6    Federici, G.7    Urbani, A.8
  • 35
    • 0030905633 scopus 로고    scopus 로고
    • Ion Mobility Measurements and their Applications to Clusters and Biomolecules
    • Clemmer, D. E.; Jarrold, M. F. Ion Mobility Measurements and their Applications to Clusters and Biomolecules. J. Mass Spectrom. 1997, 32, 577-592.
    • (1997) J. Mass Spectrom. , vol.32 , pp. 577-592
    • Clemmer, D.E.1    Jarrold, M.F.2
  • 37
    • 56449126797 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections
    • Trim, P. J.; Henson, C. M.; Avery, J. L.; McEwen, A.; Snel, M. F.; Claude, E.; Marshall, P. S.; West, A.; Princivalle, A. P.; Clench, M. R. Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Anal. Chem. 2008, 80, 8628-8634.
    • (2008) Anal. Chem. , vol.80 , pp. 8628-8634
    • Trim, P.J.1    Henson, C.M.2    Avery, J.L.3    McEwen, A.4    Snel, M.F.5    Claude, E.6    Marshall, P.S.7    West, A.8    Princivalle, A.P.9    Clench, M.R.10
  • 38
    • 66449091490 scopus 로고    scopus 로고
    • Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections
    • Djidja, M.; Francese, S.; Loadman, P. M.; Sutton, C. W.; Scriven, P.; Claude, E.; Snel, M. F.; Franck, J.; Salzet, M.; Clench, M. R. Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections. Proteomics 2009, 9, 2750-2763.
    • (2009) Proteomics , vol.9 , pp. 2750-2763
    • Djidja, M.1    Francese, S.2    Loadman, P.M.3    Sutton, C.W.4    Scriven, P.5    Claude, E.6    Snel, M.F.7    Franck, J.8    Salzet, M.9    Clench, M.R.10
  • 40
    • 0035417099 scopus 로고    scopus 로고
    • Ionic liquids as matrixes for matrix-assisted laser desorption/ionization mass spectrometry
    • DOI 10.1021/ac010259f
    • Armstrong, D. W.; Zhang, L. K.; He, L.; Gross, M. L. Ionic liquids as matrixes for matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 2001, 73, 3679-3686. (Pubitemid 32867301)
    • (2001) Analytical Chemistry , vol.73 , Issue.15 , pp. 3679-3686
    • Armstrong, D.W.1    Zhang, L.-K.2    He, L.3    Gross, M.L.4
  • 41
    • 33747594954 scopus 로고    scopus 로고
    • Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry-applications and perspectives
    • DOI 10.1007/s00216-006-0600-5
    • Tholey, A.; Heinzle, E. Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry-applications and perspectives. Anal. Bioanal. Chem. 2006, 386, 24-37. (Pubitemid 44268046)
    • (2006) Analytical and Bioanalytical Chemistry , vol.386 , Issue.1 , pp. 24-37
    • Tholey, A.1    Heinzle, E.2
  • 44
    • 41049113428 scopus 로고    scopus 로고
    • Evidence for Structural Variants of a- And b-Type Peptide Fragment Ions Using Combined Ion Mobility/Mass Spectrometry
    • Riba-Garcia, I.; Giles, K.; Bateman, R. H.; Gaskell, S. J. Evidence for Structural Variants of a- and b-Type Peptide Fragment Ions Using Combined Ion Mobility/Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2008, 19, 609-613.
    • (2008) J. Am. Soc. Mass Spectrom. , vol.19 , pp. 609-613
    • Riba-Garcia, I.1    Giles, K.2    Bateman, R.H.3    Gaskell, S.J.4
  • 45
    • 16644363159 scopus 로고    scopus 로고
    • Nano-ESI-MS/MS identification on differentiation-associated proteins in M1 mouse myeloid leukemia cells induced by IL-6
    • Xia, Q.; Wang, H. X.; Wang, J.; Liu, B. Y.; Hu, M. R.; Zhang, X. M.; Shen, B. F. Nano-ESI-MS/MS identification on differentiation-associated proteins in M1 mouse myeloid leukemia cells induced by IL-6. Acta Acad. Med. Sin. 2004, 26, 483-487.
    • (2004) Acta Acad. Med. Sin. , vol.26 , pp. 483-487
    • Xia, Q.1    Wang, H.X.2    Wang, J.3    Liu, B.Y.4    Hu, M.R.5    Zhang, X.M.6    Shen, B.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.