1-deoxynojirimycin alleviates insulin resistance via activation of insulin signaling PI3K/AKT Pathway in skeletal muscle of db/db mice

Molecules

Volumn 20, Issue 12, 2015, Pages 21700-21714

  Liu, Qingpu ^a   Li, Xuan ^a   Li, Cunyu ^a,b   Zheng, Yunfeng ^a,b   Peng, Guoping ^a,b   McPhee, Derek J ^c  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization   (China)

^c NONE

Author keywords

1 deoxynojirimycin; Db db mice; GLUT4 translocation; Insulin resistance; Insulin signaling pathway; Mulberry leaves; PI3K AKT; Skeletal muscle

Indexed keywords

1 DEOXYNOJIRIMYCIN; ANTIDIABETIC AGENT; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN KINASE B; SLC2A4 PROTEIN, MOUSE;

ANIMAL; C57BL MOUSE; CHEMISTRY; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; INSULIN RESISTANCE; ISOLATION AND PURIFICATION; MALE; METABOLISM; MORUS; MUTANT MOUSE STRAIN; PHOSPHORYLATION; PHYSIOLOGY; PLANT LEAF; PRECLINICAL STUDY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

1-DEOXYNOJIRIMYCIN; ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG EVALUATION, PRECLINICAL; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MALE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MORUS; MUSCLE, SKELETAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PLANT LEAVES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84954357150     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules201219794     Document Type: Article

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