Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: In vivo and in vitro studies

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 7, 2011, Pages 3014-3019

  Kwon, Hye Jin ^a   Chung, Ji Young ^a   Kim, Ji Yeon ^a   Kwon, Oran ^a  

^a Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPONENTS; AREA UNDER THE CURVES; BLOOD GLUCOSE; CACO-2 CELLS; DEOXYNOJIRIMYCIN; GLUCOSE RESPONSE; GLUCOSE TRANSPORTERS; GLUCOSE UPTAKE; GLUCOSIDASE; HYPOGLYCEMIC EFFECT; IN-VITRO; IN-VIVO; LEAF EXTRACTS; PHYTOCHEMICALS; POTENT INHIBITION; PRE-TREATMENT; SINGLE COMPONENTS; SPECIFIC INHIBITORS;

ABSORPTION; CARBOHYDRATES; LOADING; PLANTS (BOTANY); RATS; SOLVENT EXTRACTION;

GLUCOSE;

1 DEOXYNOJIRIMYCIN; ANTIDIABETIC AGENT; DEOXYGLUCOSE; PLANT EXTRACT;

ANIMAL; CELL STRAIN CACO 2; CHEMISTRY; COMPARATIVE STUDY; CONFERENCE PAPER; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HUMAN; INTESTINE ABSORPTION; MALE; METABOLISM; MULBERRY; PLANT LEAF; RAT; SPRAGUE DAWLEY RAT;

1-DEOXYNOJIRIMYCIN; ANIMALS; BLOOD GLUCOSE; CACO-2 CELLS; DEOXYGLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; MALE; MORUS; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY;

MORUS (ANGIOSPERM); RATTUS;

EID: 79953858559     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf103463f     Document Type: Article

References (23)

1. Kong, W. H.; Oh, S. H.; Ahn, Y. R.; Kim, K. W.; Kim, J. H.; Seo, S. W. Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models J. Agric. Food Chem. 2008, 56, 2613-2619
2. Hanozet, G.; Pircher, H. P.; Vanni, P.; Oesch, B.; Semenza, G. An example of enzyme hysteresis. The slow and tight interaction of some fully competitive inhibitors with small intestinal sucrase J. Biol. Chem. 1981, 256, 3703-3711
3. Oku, T.; Yamada, M.; Nakamura, M.; Sadamori, N.; Nakamura, S. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity Br. J. Nutr. 2006, 95, 933-938 (Pubitemid 43805380)
4. Yatsunami, K.; Ichida, M.; Onodera, S. The relationship between 1-deoxynojirimycin content and α-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) in Kyoto, Japan Nat. Med. (Tokyo, Jpn.) 2008, 62, 63-66 (Pubitemid 351176899)
5. Asano, N. Glycosidase inhibitors: Update and perspectives on practical use Glycobiology 2003, 13, 93R-104R (Pubitemid 37337046)
6. Voss, A. A.; Díez-Sampedro, A.; Hirayama, B. A.; Loo, D. D.; Wright, E. M. Imino sugars are potent agonists of the human glucose sensor SGLT3 Mol. Pharmacol. 2007, 71, 628-634 (Pubitemid 46147927)
7. Scheen, A. J. Is there a role for α-glucosidase inhibitors in the prevention of type 2 diabetes mellitus? Drugs 2003, 63, 933-951 (Pubitemid 36570532)
8. Johnston, P. S.; Lebovitz, H. E.; Coniff, R. F.; Simonson, D. C.; Raskin, P.; Munera, C. L. Advantages of α-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients J. Clin. Endocrinol. Metab. 1998, 83, 1515-1522 (Pubitemid 28501013)
9. Koh, N.; Sakamoto, S.; Chino, F. Improvement in medication compliance and glycemic control with voglibose oral disintegrating tablet Tohoku J. Exp. Med. 2008, 216, 249-257
10. Asano, N.; Yamashita, T.; Yasuda, K.; Ikeda, K.; Kizu, H.; Kameda, Y.; Kato, A.; Nash, R. J.; Lee, H. S.; Ryu, K. S. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) J. Agric. Food Chem. 2001, 49, 4208-4213 (Pubitemid 32896411)
11. Srivastava, S.; Kapoor, R.; Thathola, A.; Srivastava, R. P. Nutritional quality of leaves of some genotypes of mulberry (Morus alba) Int. J. Food Sci. Nutr. 2006, 57, 305-313 (Pubitemid 44843178)
12. Katsube, T.; Imawaka, N.; Kawano, Y.; Yamazaki, Y.; Shiwaku, K.; Yamane, Y. Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity Food Chem. 2006, 97, 25-31 (Pubitemid 41773937)
13. Kim, J. Y.; Kwon, H. J.; Jung, J. Y.; Kwon, H. Y.; Baek, J. G.; Kim, Y. S.; Kwon, O. Comparison of absorption of 1-deoxynojirimycin from mulberry water extract in rats J. Agric. Food Chem. 2010, 58, 6666-6671
14. Kim, J.; Kim, S.; Lee, H. S.; Kim, I.; Ahn, M. Y.; Ryu, K. S. Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase high-performance liquid chromatography J. Chromatogr., A 2003, 1002, 1611-1617
15. Ohta, T.; Sasaki, S.; Oohori, T.; Yoshikawa, S.; Kurihara, H. α-Glucosidase inhibitory activity of a 70% methanol extract from ezoishige (Pelvetia babingtonii De Toni) and its effect on the elevation of blood glucose level in rats Biosci., Biotechnol., Biochem. 2002, 66, 1552-1554 (Pubitemid 39246862)
16. Leonard, M.; Creed, E.; Brayden, D.; Baird, A. W. Evaluation of the Caco-2 monolayer as a model epithelium for iontophoretic transport Pharm. Res. 2000, 17, 1181-1188
17. Kwon, O.; Eck, P.; Chen, S.; Corpe, C. P.; Lee, J. H.; Kruhlak, M.; Levine, M. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids FASEB J. 2007, 21, 366-377 (Pubitemid 46213484)
18. Park, J. M.; Bong, H. Y.; Jeong, H. I.; Kim, Y. K.; Kim, J. Y.; Kwon, O. Postprandial hypoglycemic effect of mulberry leaf in Goto-Kakizaki rats and counterpart control Wistar rats Nutr. Res. Pract. 2009, 3, 272-278
19. Mayhew, T. M.; Carson, F. L. Mechanisms of adaptation in rat small intestine: Regional differences in quantitative morphology during normal growth and experimental hypertrophy J. Anat. 1989, 164, 189-200 (Pubitemid 19161718)
20. Ou, S.; Kwok, K.; Li, Y.; Fu, L. In vitro study of possible role of dietary fiber in lowering postprandial serum glucose J. Agric. Food Chem. 2001, 49, 1026-1029 (Pubitemid 32172664)
21. Miyahara, C.; Miyazawa, M.; Satoh, S.; Sakai, A.; Mizusaki, S. Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats J. Nutr. Sci. Vitaminol. 2004, 50, 161-164 (Pubitemid 39045117)
22. Kimura, T.; Nakagawa, K.; Kubota, H.; Kojima, Y.; Goto, Y.; Yamagishi, K.; Oita, S.; Oikawa, S.; Miyazawa, T. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans J. Agric. Food Chem. 2007, 55, 5869-5874 (Pubitemid 47092969)
23. Nakagawa, K.; Kubota, H.; Kimura, T.; Yamashita, S.; Tsuzuki, T.; Oikawa, S.; Miyazawa, T. Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma J. Agric. Food Chem. 2007, 55, 8928-8933 (Pubitemid 350105538)