Iminosugar Glycosidase Inhibitors: Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to β-Glucosidases

Journal of the American Chemical Society

Volumn 125, Issue 47, 2003, Pages 14313-14323

  Zechel, David L ^a,c   Boraston, Alisdair B ^a,d   Gloster, Tracey ^a   Boraston, Catherine M ^a   Macdonald, James M ^b   Tilbrook, D Matthew G ^b   Stick, Robert V ^b   Davies, Gideon J ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CHEMICAL BONDS; CRYSTAL STRUCTURE; ENTHALPY; ENZYME INHIBITION; GLUCOSE; PH EFFECTS; X RAY CRYSTALLOGRAPHY;

PROTEIN BINDING; THERAPEUTICS;

BIOCHEMISTRY;

1 DEOXYNOJIRIMYCIN; BETA GLUCOSIDASE; CARBOHYDRATE DERIVATIVE; FAGOMINE; GLYCOSIDASE INHIBITOR; ISOFAGOMINE; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ALMOND; ARTICLE; BINDING AFFINITY; CALORIMETRY; CATALYSIS; CONTROLLED STUDY; ENTHALPY; ENTROPY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME STRUCTURE; IONIZATION; KINETICS; MOLECULAR MIMICRY; NONHUMAN; PH; PROTON TRANSPORT; STRUCTURE ANALYSIS; THERMODYNAMICS; THERMOTOGA MARITIMA; TITRIMETRY; X RAY CRYSTALLOGRAPHY;

1-DEOXYNOJIRIMYCIN; BETA-GLUCOSIDASE; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; IMINO PYRANOSES; KINETICS; MODELS, MOLECULAR; PIPERIDINES; THERMODYNAMICS; THERMOTOGA MARITIMA;

EID: 0344012180     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036833h     Document Type: Article

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