메뉴 건너뛰기




Volumn 11, Issue 1, 2016, Pages

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease

Author keywords

Alpha synuclein; Amyloid oligomers; Biomarkers; Cerebrospinal fluid biomarkers; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER; AMYLOID BETA PROTEIN; TAU PROTEIN;

EID: 84954348724     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-016-0072-9     Document Type: Article
Times cited : (200)

References (48)
  • 1
    • 41149163183 scopus 로고    scopus 로고
    • Parkinson's disease: Clinical features and diagnosis
    • 18344392 1:STN:280:DC%2BD1c7oslamtA%3D%3D
    • Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79:368-76.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 368-376
    • Jankovic, J.1
  • 3
    • 84871273435 scopus 로고    scopus 로고
    • Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
    • 23152586 3578379
    • Milber JM, Noorigian JV, Morley JF, Petrovitch H, White L, Ross GW, et al. Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease. Neurology. 2012;79:2307-14.
    • (2012) Neurology , vol.79 , pp. 2307-2314
    • Milber, J.M.1    Noorigian, J.V.2    Morley, J.F.3    Petrovitch, H.4    White, L.5    Ross, G.W.6
  • 4
    • 61949235512 scopus 로고    scopus 로고
    • Diagnosis and the premotor phase of Parkinson disease
    • 19221308
    • Tolosa E, Gaig C, Santamaría J, Compta Y. Diagnosis and the premotor phase of Parkinson disease. Neurology. 2009;72:S12-20.
    • (2009) Neurology , vol.72 , pp. S12-20
    • Tolosa, E.1    Gaig, C.2    Santamaría, J.3    Compta, Y.4
  • 8
    • 27844472158 scopus 로고    scopus 로고
    • Alpha-synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy
    • 16246056 1:CAS:528:DC%2BD2MXhtFCqs7nL
    • Paleologou KE, Irvine GB, El-Agnaf OM. Alpha-synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy. Biochem Soc Trans. 2005;33:1106-10.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1106-1110
    • Paleologou, K.E.1    Irvine, G.B.2    El-Agnaf, O.M.3
  • 9
    • 0031018193 scopus 로고    scopus 로고
    • Conformations of beta-amyloid in solution
    • 8978758 1:CAS:528:DyaK2sXhslOqug%3D%3D
    • el-Agnaf OM, Irvine GB, Guthrie DJ. Conformations of beta-amyloid in solution. J Neurochem. 1997;68:437-9.
    • (1997) J Neurochem , vol.68 , pp. 437-439
    • El-Agnaf, O.M.1    Irvine, G.B.2    Guthrie, D.J.3
  • 10
    • 0038038389 scopus 로고    scopus 로고
    • Soluble oligomers for the diagnosis of neurodegenerative diseases
    • 12878433
    • El-Agnaf OM, Walsh DM, Allsop D. Soluble oligomers for the diagnosis of neurodegenerative diseases. Lancet Neurol. 2003;2:461-2.
    • (2003) Lancet Neurol , vol.2 , pp. 461-462
    • El-Agnaf, O.M.1    Walsh, D.M.2    Allsop, D.3
  • 11
    • 33748325848 scopus 로고    scopus 로고
    • Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
    • 16930553 1:CAS:528:DC%2BD28XpsVKrsb8%3D
    • Tokuda T, Salem SA, Allsop D, Mizuno T, Nakagawa M, Qureshi MM, et al. Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochem Biophys Res Commun. 2006;349:162-6.
    • (2006) Biochem Biophys Res Commun , vol.349 , pp. 162-166
    • Tokuda, T.1    Salem, S.A.2    Allsop, D.3    Mizuno, T.4    Nakagawa, M.5    Qureshi, M.M.6
  • 12
  • 13
    • 79960613150 scopus 로고    scopus 로고
    • Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias
    • 21469206
    • Parnetti L, Chiasserini D, Bellomo G, Giannandrea D, De Carlo C, Qureshi MM, et al. Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias. Mov Disord. 2011;26:1428-35.
    • (2011) Mov Disord , vol.26 , pp. 1428-1435
    • Parnetti, L.1    Chiasserini, D.2    Bellomo, G.3    Giannandrea, D.4    De Carlo, C.5    Qureshi, M.M.6
  • 14
    • 78649990079 scopus 로고    scopus 로고
    • Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease
    • 20962290 1:CAS:528:DC%2BC3cXhsVans7vF
    • Tokuda T, Qureshi MM, Ardah MT, Varghese S, Shehab SA, Kasai T, et al. Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease. Neurology. 2010;75:1766-72.
    • (2010) Neurology , vol.75 , pp. 1766-1772
    • Tokuda, T.1    Qureshi, M.M.2    Ardah, M.T.3    Varghese, S.4    Shehab, S.A.5    Kasai, T.6
  • 17
    • 84925950008 scopus 로고    scopus 로고
    • CSF biomarkers and clinical progression of Parkinson disease
    • 25411441 1:CAS:528:DC%2BC2MXislWnuw%3D%3D 4336091
    • Hall S, Surova Y, Öhrfelt A, Zetterberg H, Lindqvist D, Hansson O. CSF biomarkers and clinical progression of Parkinson disease. Neurology 2015;84:57-63.
    • (2015) Neurology , vol.84 , pp. 57-63
    • Hall, S.1    Surova, Y.2    Öhrfelt, A.3    Zetterberg, H.4    Lindqvist, D.5    Hansson, O.6
  • 18
    • 84899889312 scopus 로고    scopus 로고
    • Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
    • 24662516 3999721
    • Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, et al. Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014;137:1496-513.
    • (2014) Brain , vol.137 , pp. 1496-1513
    • Rockenstein, E.1    Nuber, S.2    Overk, C.R.3    Ubhi, K.4    Mante, M.5    Patrick, C.6
  • 19
    • 65249162241 scopus 로고    scopus 로고
    • Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
    • 19155272
    • Paleologou KE, Kragh CL, Mann DM, Salem SA, Al-Shami R, Allsop D, et al. Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain. 2009;132:1093-101.
    • (2009) Brain , vol.132 , pp. 1093-1101
    • Paleologou, K.E.1    Kragh, C.L.2    Mann, D.M.3    Salem, S.A.4    Al-Shami, R.5    Allsop, D.6
  • 20
    • 0037456578 scopus 로고    scopus 로고
    • The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
    • 12597857 1:CAS:528:DC%2BD3sXhvFelt7o%3D
    • Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 2003;37:583-95.
    • (2003) Neuron , vol.37 , pp. 583-595
    • Sharon, R.1    Bar-Joseph, I.2    Frosch, M.P.3    Walsh, D.M.4    Hamilton, J.A.5    Selkoe, D.J.6
  • 21
    • 84989182833 scopus 로고    scopus 로고
    • Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease
    • 24987465 4075410
    • Hansson O, Hall S, Ohrfelt A, Zetterberg H, Blennow K, Minthon L, et al. Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease. Alzheimers Res Ther. 2014;6:25.
    • (2014) Alzheimers Res Ther , vol.6 , pp. 25
    • Hansson, O.1    Hall, S.2    Ohrfelt, A.3    Zetterberg, H.4    Blennow, K.5    Minthon, L.6
  • 22
    • 84904427435 scopus 로고    scopus 로고
    • Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease
    • 24436092 1:CAS:528:DC%2BC2cXhtFyksr3M
    • Parnetti L, Chiasserini D, Persichetti E, Eusebi P, Varghese S, Qureshi MM, et al. Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease. Mov Disord. 2014;29:1019-27.
    • (2014) Mov Disord , vol.29 , pp. 1019-1027
    • Parnetti, L.1    Chiasserini, D.2    Persichetti, E.3    Eusebi, P.4    Varghese, S.5    Qureshi, M.M.6
  • 23
    • 84907162800 scopus 로고    scopus 로고
    • Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers
    • 25309429 4174885
    • Aasly JO, Johansen KK, Brønstad G, Warø BJ, Majbour NK, Varghese S, et al. Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers. Front Aging Neurosci. 2014;6:248.
    • (2014) Front Aging Neurosci , vol.6 , pp. 248
    • Aasly, J.O.1    Johansen, K.K.2    Brønstad, G.3    Warø, B.J.4    Majbour, N.K.5    Varghese, S.6
  • 24
    • 84929996447 scopus 로고    scopus 로고
    • Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology
    • 25937088 1:CAS:528:DC%2BC2MXnvVSntLc%3D
    • Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, et al. Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology. Neurobiol Dis. 2015;79:81-99.
    • (2015) Neurobiol Dis , vol.79 , pp. 81-99
    • Vaikath, N.N.1    Majbour, N.K.2    Paleologou, K.E.3    Ardah, M.T.4    Van Dam, E.5    Van De Berg, W.D.6
  • 25
    • 33645833848 scopus 로고    scopus 로고
    • Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
    • 16507759 1:CAS:528:DC%2BD28Xis1Wlu70%3D
    • El-Agnaf OM, Salem SA, Paleologou KE, Curran MD, Gibson MJ, Court JA, et al. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J. 2006;20:419-25.
    • (2006) FASEB J , vol.20 , pp. 419-425
    • El-Agnaf, O.M.1    Salem, S.A.2    Paleologou, K.E.3    Curran, M.D.4    Gibson, M.J.5    Court, J.A.6
  • 26
  • 27
    • 84893865729 scopus 로고    scopus 로고
    • Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity
    • 23631635
    • van Dijk KD, Bidinosti M, Weiss A, Raijmakers P, Berendse HW, van de Berg WD. Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity. Eur J Neurol. 2014;21:388-94.
    • (2014) Eur J Neurol , vol.21 , pp. 388-394
    • Van Dijk, K.D.1    Bidinosti, M.2    Weiss, A.3    Raijmakers, P.4    Berendse, H.W.5    Van De Berg, W.D.6
  • 28
    • 84862916400 scopus 로고    scopus 로고
    • Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naïve patients with Parkinson's disease
    • 22259618 3259496
    • Park MJ, Cheon SM, Bae HR, Kim SH, Kim JW. Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naïve patients with Parkinson's disease. J Clin Neurol. 2011;7:215-22.
    • (2011) J Clin Neurol , vol.7 , pp. 215-222
    • Park, M.J.1    Cheon, S.M.2    Bae, H.R.3    Kim, S.H.4    Kim, J.W.5
  • 29
    • 84925498290 scopus 로고    scopus 로고
    • Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease
    • 25380583 1:CAS:528:DC%2BC2cXhvVyqtrvF
    • Compta Y, Valente T, Saura J, Segura B, Iranzo Á, Serradell M, et al. Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease. J Neurol. 2015;262:294-306.
    • (2015) J Neurol , vol.262 , pp. 294-306
    • Compta, Y.1    Valente, T.2    Saura, J.3    Segura, B.4    Iranzo, Á.5    Serradell, M.6
  • 30
    • 84897840006 scopus 로고    scopus 로고
    • Cerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort
    • 24625392 1:CAS:528:DC%2BC2cXksVWnsr4%3D 3969999
    • Stewart T, Liu C, Ginghina C, Cain KC, Auinger P, Cholerton B, et al. Cerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort. Am J Pathol. 2014;184:966-75.
    • (2014) Am J Pathol , vol.184 , pp. 966-975
    • Stewart, T.1    Liu, C.2    Ginghina, C.3    Cain, K.C.4    Auinger, P.5    Cholerton, B.6
  • 31
    • 33749570292 scopus 로고    scopus 로고
    • Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
    • 16847063 1:CAS:528:DC%2BD28XhtVahsb%2FI
    • Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, et al. Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem. 2006;281:29739-52.
    • (2006) J Biol Chem , vol.281 , pp. 29739-29752
    • Anderson, J.P.1    Walker, D.E.2    Goldstein, J.M.3    De Laat, R.4    Banducci, K.5    Caccavello, R.J.6
  • 34
    • 84904637112 scopus 로고    scopus 로고
    • Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity
    • 25140150 4122169
    • Ardah MT, Paleologou KE, Lv G, Abul Khair SB, Kazim AS, Minhas ST, et al. Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity. Front Aging Neurosci. 2014;6:197.
    • (2014) Front Aging Neurosci , vol.6 , pp. 197
    • Ardah, M.T.1    Paleologou, K.E.2    Lv, G.3    Abul Khair, S.B.4    Kazim, A.S.5    Minhas, S.T.6
  • 35
    • 0035957220 scopus 로고    scopus 로고
    • Effect of the disulfide bridge and the C-terminal extension on the oligomerization of the amyloid peptide ABri implicated in familial British dementia
    • 11297410 1:CAS:528:DC%2BD3MXhsV2nurw%3D
    • El-Agnaf OM, Sheridan JM, Sidera C, Siligardi G, Hussain R, Haris PI, et al. Effect of the disulfide bridge and the C-terminal extension on the oligomerization of the amyloid peptide ABri implicated in familial British dementia. Biochemistry. 2001;40:3449-57.
    • (2001) Biochemistry , vol.40 , pp. 3449-3457
    • El-Agnaf, O.M.1    Sheridan, J.M.2    Sidera, C.3    Siligardi, G.4    Hussain, R.5    Haris, P.I.6
  • 36
    • 1842608890 scopus 로고    scopus 로고
    • Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue
    • 15050719 1:CAS:528:DC%2BD2cXisF2nsrc%3D
    • Bodles AM, El-Agnaf OM, Greer B, Guthrie DJ, Irvine GB. Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue. Neurosci Lett. 2004;359:89-93.
    • (2004) Neurosci Lett , vol.359 , pp. 89-93
    • Bodles, A.M.1    El-Agnaf, O.M.2    Greer, B.3    Guthrie, D.J.4    Irvine, G.B.5
  • 37
    • 0024562146 scopus 로고
    • Development and application of radioimmunoassays for interleukin-1 alpha and interleukin-1 beta
    • 2783447 1:CAS:528:DyaL1MXptlWiuw%3D%3D
    • Poole S, Bristow AF, Selkirk S, Rafferty B. Development and application of radioimmunoassays for interleukin-1 alpha and interleukin-1 beta. J Immunol Methods. 1989;116:259-64.
    • (1989) J Immunol Methods , vol.116 , pp. 259-264
    • Poole, S.1    Bristow, A.F.2    Selkirk, S.3    Rafferty, B.4
  • 39
    • 79952010449 scopus 로고    scopus 로고
    • Baicalein inhibits formation of α-synuclein oligomers within living cells and prevents Aβ peptide fibrillation and oligomerisation
    • 21271629 1:CAS:528:DC%2BC3MXisVems7Y%3D
    • Lu JH, Ardah MT, Durairajan SS, Liu LF, Xie LX, Fong WF, et al. Baicalein inhibits formation of α-synuclein oligomers within living cells and prevents Aβ peptide fibrillation and oligomerisation. Chembiochem. 2011;12:615-24.
    • (2011) Chembiochem , vol.12 , pp. 615-624
    • Lu, J.H.1    Ardah, M.T.2    Durairajan, S.S.3    Liu, L.F.4    Xie, L.X.5    Fong, W.F.6
  • 40
    • 34447251553 scopus 로고    scopus 로고
    • Copper-mediated formation of hydrogen peroxide from the amylin peptide: A novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?
    • 17617411 1:CAS:528:DC%2BD2sXnslWgt7s%3D
    • Masad A, Hayes L, Tabner BJ, Turnbull S, Cooper LJ, Fullwood NJ, et al. Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus? FEBS Lett. 2007;581:3489-93.
    • (2007) FEBS Lett , vol.581 , pp. 3489-3493
    • Masad, A.1    Hayes, L.2    Tabner, B.J.3    Turnbull, S.4    Cooper, L.J.5    Fullwood, N.J.6
  • 41
    • 84913553701 scopus 로고    scopus 로고
    • Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
    • 25449909 1:CAS:528:DC%2BC2cXitVeisLvL
    • Ardah MT, Paleologou KE, Lv G, Menon SA, Abul Khair SB, Lu JH, et al. Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils. Neurobiol Dis. 2015;74:89-101.
    • (2015) Neurobiol Dis , vol.74 , pp. 89-101
    • Ardah, M.T.1    Paleologou, K.E.2    Lv, G.3    Menon, S.A.4    Abul Khair, S.B.5    Lu, J.H.6
  • 42
    • 75749143930 scopus 로고    scopus 로고
    • Amyloid-beta (1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease
    • 19833838 1:CAS:528:DC%2BC3cXhslaksLY%3D
    • Mulder C, Verwey NA, van der Flier WM, Bouwman FH, Kok A, van Elk EJ, et al. Amyloid-beta (1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clin Chem. 2010;56:248-53.
    • (2010) Clin Chem , vol.56 , pp. 248-253
    • Mulder, C.1    Verwey, N.A.2    Van Der Flier, W.M.3    Bouwman, F.H.4    Kok, A.5    Van Elk, E.J.6
  • 43
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases
    • 1564476 1:STN:280:DyaK383is1Omsg%3D%3D 1014720
    • Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55:181-4.
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 44
    • 0023037928 scopus 로고
    • CAMDEX, A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia
    • 3790869 1:STN:280:DyaL2s%2Fnslajsg%3D%3D
    • Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S, et al. CAMDEX, A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry. 1986;149:698-709.
    • (1986) Br J Psychiatry , vol.149 , pp. 698-709
    • Roth, M.1    Tym, E.2    Mountjoy, C.Q.3    Huppert, F.A.4    Hendrie, H.5    Verma, S.6
  • 45
    • 0000224448 scopus 로고
    • Unified Parkinson's disease rating scale
    • Fahn (Elton R ed., vol. 2. MacMillan Health Care Information
    • Fahn: Unified Parkinson's disease rating scale. In: Fahn S, Marsden C, Calne D, eds. Recent Development in Parkinson's Disease. (Elton R ed., vol. 2. MacMillan Health Care Information; 1987.
    • (1987) Recent Development in Parkinson's Disease
    • Fahn, S.1    Marsden, C.2    Calne, D.3
  • 46
    • 0025086894 scopus 로고
    • Variable expression of Parkinson's disease: A base-line analysis of the DATATOP cohort. The Parkinson study group
    • 2215943 1:STN:280:DyaK3M%2FhsFOltQ%3D%3D
    • Jankovic J, McDermott M, Carter J, Gauthier S, Goetz C, Golbe L, et al. Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson study group. Neurology. 1990;40:1529-34.
    • (1990) Neurology , vol.40 , pp. 1529-1534
    • Jankovic, J.1    McDermott, M.2    Carter, J.3    Gauthier, S.4    Goetz, C.5    Golbe, L.6
  • 47
    • 37849028683 scopus 로고    scopus 로고
    • Red blood cells are the major source of alpha-synuclein in blood
    • 18182779 1:CAS:528:DC%2BD1cXhsFyqtLo%3D
    • Barbour R, Kling K, Anderson JP, Banducci K, Cole T, Diep L, et al. Red blood cells are the major source of alpha-synuclein in blood. Neurodegener Dis. 2008;5:55-9.
    • (2008) Neurodegener Dis , vol.5 , pp. 55-59
    • Barbour, R.1    Kling, K.2    Anderson, J.P.3    Banducci, K.4    Cole, T.5    Diep, L.6
  • 48
    • 84878997167 scopus 로고    scopus 로고
    • Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation
    • 24009950 3755824
    • Hajian-Tilaki K. Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Caspian J Intern Med. 2013;4:627-35.
    • (2013) Caspian J Intern Med , vol.4 , pp. 627-635
    • Hajian-Tilaki, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.